PAPERS PUBLISHED IN 2004
This list is arranged by the name of the first author. Any omissions, mistakes and inconsistencies please communicate to the authors of compilation (m@5z.com). (If you are pointing to any reference, please use its ID# -- the last number in the reference.) You are welcome to use this compilation in your work. Proper way to quote it in your paper is: Lebl M.: Dynamic database of references in molecular diversity. Internet http://www.5z.com/divinfo.
Recently added entries are marked in bold
- Adams,N., Arts,H.J., Bolton,P.D., Cowell,D., Dubberley,S.R., Friederichs,N., Grant,C.M., Kranenburg,M., Sealey,A.J., Wang,B., Wilson,P.J., Cowley,A.R., Mountford,P., & Schroeder,M. (2004) Discovery and evaluation of highly active imidotitanium ethylene polymerisation catalysts using high throughput catalyst screening. Chemical Communications (Cambridge, United Kingdom), 434-435. #20163
- Akavia,A., Senderowitz,H., Lerner,A., & Shamir,R. (2004) Designing a Multiroute Synthesis Scheme in Combinatorial Chemistry. Journal of Combinatorial Chemistry, 6, 540-548. #20097
- Amaya,T., Tanaka,H., & Takahashi,T. (2004) Combinatorial synthesis of carbohydrate cluster on tree-type linker with orthogonally cleavable parts. Synlett, 497-502. #20145
- Anon. (2004) Combinatorial chemistry-product focus. Nature (London, United Kingdom), 430, No. #20037
- Anon. (2004) Analytical currents: combinatorial chemistry for biological targets. Anal. Chem., 76, 221A. #20059
- Ansede,J.H., & Thakker,D.R. (2004) High-throughput screening for stability and inhibitory activity of compounds toward cytochrome P450-mediated metabolism. J. Pharm. Sci., 93, 239-255. #20149
- Apostolidis,A., Klimant,I., Andrzejewski,D., & Wolfbeis,O.S. (2004) A Combinatorial Approach for Development of Materials for Optical Sensing of Gases. Journal of Combinatorial Chemistry, 6, 325-331. #20160
- Arakawa,M., & Funatsu,K. (2004) Development of multi-dimensional data-modeling software. Journal of Computer Chemistry, Japan, 3, 77-84. #20046
- Arseniyadis,S., Wagner,A., & Mioskowski,C. (2004) Resin-bound 4-phenyl-1,2-dihydroquinoline (DHQ): a new safety-catch linker for solid-phase organic synthesis (SPOS). Tetrahedron Lett., 45, 2251-2253. #20155
- Arya,P., Wei,C.Q., Barnes,M.L., & Daroszewska,M. (2004) A Solid Phase Library Synthesis of Hydroxyindoline-Derived Tricyclic Derivatives by Mitsunobu Approach. Journal of Combinatorial Chemistry, 6, 65-72. #20180
- Ayesa,S., Argyropoulos,D., Maltseva,T., Sund,C., & Samuelsson,B. (2004) An expeditious library synthesis of N-monoalkylated aminopiperidines and -pyrrolidines. Eur. J. Org. Chem., 2723-2737. #20056
- Babine,R.E., Rynkiewicz,M.J., Jin,L., & Abdel-Meguid,S.S. (2004) Towards an experimental de Novo design protocol. The use of protein crystallography to deconvolute dynamic combinatorial processes. Letters in Drug Design & Discovery, 1, 173-177. #20102
- Bao,Y., Li,C., Shen,H., & Nan,F. (2004) Determination of Saikosaponin Derivatives in Radix bupleuri and in Pharmaceuticals of the Chinese Multiherb Remedy Xiaochaihu-tang Using Liquid Chromatographic Tandem Mass Spectrometry. Anal. Chem., 76, 4208-4216. #20088
- Battersby, Bronwyn J., Grondahl, Lisbeth, Lawrie, Gwendolyn A., and Trau, Matt Colloids for encoding chemical libraries: applications in biological screening. In: Anonymous. (Eds.) Colloids and Colloid Assemblies. #20448NEW
- Baurin,N., Baker,R., Richardson,C., Chen,I., Foloppe,N., Potter,A., Jordan,A., Roughley,S., Parratt,M., Greaney,P., Morley,D., & Hubbard,R.E. (2004) Drug-like Annotation and Duplicate Analysis of a 23-Supplier Chemical Database Totaling 2.7 Million Compounds. Journal of Chemical Information and Computer Sciences, 44, 643-651. #20162
- Baytas,S.N., & Linhardt,R.J. (2004) Combinatorial carbohydrate synthesis. Mini-Reviews in Organic Chemistry, 1, 27-39. #20157
- Berezin,V., & Bock,E. (2004) NCAM mimetic peptides: Pharmacological and therapeutic potential. Journal of Molecular Neuroscience, 22, 33-39. #20154
- Bianchi,I., La Porta,E., Barlocco,D., & Raveglia,L.F. (2004) Solid-Phase Convergent Synthesis of a Benzimidazolone Library via the Combination of Two Smaller Arrays of Carboxylic Acids and Secondary Amines. Journal of Combinatorial Chemistry, 6, 835-845. #20040
- Blake,J.F. (2004) Integrating cheminformatic analysis in combinatorial chemistry. Curr. Opin. Chem. Biol., 8, 407-411. #20045
- Boas,U., Gertz,H., Christensen,J.B., & Heegaard,P.M.H. (2004) Facile synthesis of aliphatic isothiocyanates and thioureas on solid phase using peptide coupling reagents. Tetrahedron Lett., 45, 269-272. #20182
- Bonaccurso,E., Butt,H.J., & Graf,K. (2004) Microarrays by structured substrate swelling. Eur. Polym. J., 40, 975-980. #20115
- Bork,J.T., Lee,J.W., & Chang,Y.T. (2004) The combinatorial synthesis of purine, pyrimidine and triazine-based libraries. QSAR & Combinatorial Science, 23, 245-260. #20064
- Brown,J.X., Buckett,P.D., & Wessling-Resnick,M. (2004) Identification of Small Molecule Inhibitors that Distinguish between Non-Transferrin Bound Iron Uptake and Transferrin-Mediated Iron Transport. Chemistry & Biology, 11, 407-416. #20124
- Buelow,A., Sinning,S., Wiborg,O., & Bols,M. (2004) Two- and Three Dimensional Combinatorial Chemistry from Multicomponent Grignard Reagents. Journal of Combinatorial Chemistry, 6, 509-519. #20108
- Bugaut,A., Toulime,J.J., & Rayner,B. (2004) Use of dynamic combinatorial chemistry for the identification of covalently appended residues that stabilize oligonucleotide complexes. Angewandte Chemie, International Edition, 43, 3144-3147. #20061
- Burke,M.D., & Schreiber,S.L. (2004) A planning strategy for diversity-oriented synthesis. Angewandte Chemie, International Edition, 43, 46-58. #20175
- Byeon,W.H., & Weisblum,B. (2004) Affinity adsorbent based on combinatorial phage display peptides that bind a-cobratoxin. Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences, 805, 361-363. #20104
- Caturla,F., Enjo,J., Bernabeu,M.C., & Le Serre,S. (2004) New fluorescent probes for testing combinatorial catalysts with phosphodiesterase and esterase activities. Tetrahedron, 60, 1903-1911. #20455
- Cavazzini,A., Massi,A., Bergamaschi,G., Braga,S., Dondi,F., & Dondoni,A. (2004) Combining Synthetic and Analytical Strategies for Preparative HPLC Enantioseparation of Monastrol Racemic Mixture. Biotechnol. Progr., 20, 603-612. #20401
- Cawse,J.N., Baerns,M., & Holena,M. (2004) Efficient Discovery of Nonlinear Dependencies in a Combinatorial Catalyst Data Set. Journal of Chemical Information and Computer Sciences, 44, 143-146. #20186
- Chakraborty,T.K., Srinivasu,P., Tapadar,S., & Mohan,B.K. (2004) Sugar amino acids and related molecules: Some recent developments. Journal of Chemical Sciences (Bangalore, India), 116, 187-207. #20039
- Chen,D., Hackbarth,C., Ni,Z.J., Wu,C., Wang,W., Jain,R., He,Y., Bracken,K., Weidmann,B., Patel,D.V., Trias,J., White,R.J., & Yuan,Z. (2004) Peptide deformylase inhibitors as antibacterial agents: Identification of VRC3375, a proline-3-alkylsuccinyl hydroxamate derivative, by using an integrated combinatorial and medicinal chemistry approach. Antimicrob. Agents Chemother., 48, 250-261. #20168
- Chen,H., Li,Q., Yao,X., Fan,B., Yuan,S., Panaye,A., & Doucet,J.P. (2004) CoMFA/CoMSIA/HQSAR and docking study of the binding mode of selective cyclooxygenase (COX-2) inhibitors. QSAR & Combinatorial Science, 23, 36-55. #20132
- Chen,L., Bao,J., Gao,C., Huang,S., Liu,C., & Liu,W. (2004) Combinatorial Synthesis of Insoluble Oxide Library from Ultrafine/Nano Particle Suspension Using a Drop-on-Demand Inkjet Delivery System. Journal of Combinatorial Chemistry, 6, 699-702. #20063
- Chen,Y.T., & Seto,C.T. (2004) Parallel synthesis of a library of bidentate protein tyrosine phosphatase inhibitors based on the a-ketoacid motif. Bioorganic & Medicinal Chemistry, 12, 3289-3298. #20093
- Cheng,C.W., Lin,K.C., Pan,F.M., Sinchaikul,S., Wong,C.H., Su,W.C., Hsu,C.H., & Chen,S.t. (2004) Facile synthesis of metal-chelating peptides on chip for protein array. Bioorganic & Medicinal Chemistry Letters, 14, 1987-1990. #20120
- Christensen,C., Tornoe,C.W., & Meldal,M. (2004) Pyrazines on solid support from peptides by periodinane oxidation of threonine side-chains. A quantitative chemical transformation (QCT) for combinatorial chemistry. QSAR & Combinatorial Science, 23, 109-116. #20081
- Cipolla,L. (2004) Combinatorial libraries of biocatalysts: application and screening. Comb. Chem. High Throughput Screening, 7, 101-114. #20110
- Corbett,A.D., Cheeseman,J.D., Kazlauskas,R.J., & Gleason,J.L. (2004) Pseudodynamic combinatorial libraries: A receptor-assisted approach for drug discovery. Angew. Chem. Int. Ed., 43, 2432-2436. #20028
- Cozzi,P., Mongelli,N., & Suarato,A. (2004) Recent anticancer cytotoxic agents. Current Medicinal Chemistry: Anti-Cancer Agents, 4, 93-121. #20118
- Cui,Z., Sun,L., & Zhang,B. (2004) A peptidyl transferase ribozyme capable of combinatorial peptide synthesis. Bioorganic & Medicinal Chemistry, 12, 927-933. #20150
- de Graaf,K.L., Barth,S., Herrmann,M.M., Storch,M.K., Otto,C., Olsson,T., Melms,A., Jung,G., Wiesmueller,K.H., & Weissert,R. (2004) MHC Class II Isotype- and Allele-Specific Attenuation of Experimental Autoimmune Encephalomyelitis. Journal of Immunology, 173, 2792-2802. #20043
- de la Hoz,A., Diaz-Ortiz,A., & Moreno,A. (2004) Selectivity in organic synthesis under microwave irradiation. Current Organic Chemistry, 8, 903-918. #20067
- Delpiccolo,C.M.L., & Mata,E.G. (2004) Efficient and selective solid-phase synthesis of trans 3-alkyl b-lactams from nonactivated acid chlorides. Tetrahedron Lett., 45, 4085-4088. #20106
- Dikmans,A.J., Morr,M.Z.N., Adler,F., Turk,G., & Frank,R. (2004) A new compact disc format of high density array synthesis applied to peptide nucleic acids and in situ MALDI analysis. Mol. Diversity, 8, 197-207. #20025
- Diness,F., Beyer,J., & Meldal,M. (2004) Synthesis of 3-Boc-(1,3)-oxazinane-protected amino aldehydes from amino acids and their conversion into urea precursors. Novel building blocks for combinatorial synthesis. QSAR & Combinatorial Science, 23, 130-144. #20080
- Ding,K., Du,H., Yuan,Y., & Long,J. (2004) Combinatorial chemistry approach to chiral catalyst engineering and screening: Rational design and serendipity. Chemistry--A European Journal, 10, 2872-2884. #20057
- Dong,Y., Roberge,J.Y., Wang,Z., Wang,X., Tamasi,J., Dell,V., Golla,R., Corte,J.R., Liu,Y., Fang,T., Anthony,M.N., Schnur,D.M., Agler,M.L., Dickson,J.K., Lawrence,R.M., Prack,M.M., Seethala,R., & Feyen,J.H.M. (2004) Characterization of a new class of selective nonsteroidal progesterone receptor agonists. Steroids, 69, 201-217. #20114
- Edwards,A.A., Ichihara,O., Murfin,S., Wilkes,R., Whittaker,M., Watkin,D.J., & Fleet,G.W.J. (2004) Tetrahydrofuran-Based Amino Acids as Library Scaffolds. Journal of Combinatorial Chemistry, 6, 230-238. #20165
- El Araby,M., Guo,H., Pottorf,R.S., & Player,M.R. (2004) Solid-Phase Synthesis of an Alkylaminobenzanilide Library. Journal of Combinatorial Chemistry, 6, 789-795. #20065
- Erlanson,D.A., McDowell,R.S., & O'Brien,T. (2004) Fragment-Based Drug Discovery. J. Med. Chem., 47, 3463-3482. #20082
- Fechner,U., & Schneider,G. (2004) Optimization of a pharmacophore-based correlation vector descriptor for similarity searching. QSAR & Combinatorial Science, 23, 19-22. #20134
- Fernandez,D., Ahaidar,A., Danelon,G., Cironi,P., Marfil,M., Perez,O., Cuevas,C., Albericio,F., Joule,J.A., & Alvarez,M. (2004) Synthesis of Polyheterocyclic Nitrogen-Containing Marine Natural Products. Monatshefte fuer Chemie, 135, 615-627. #20098
- Fischer,P.M. (2004) The design of drug candidate molecules as selective inhibitors of therapeutically relevant protein kinases. Curr. Med. Chem., 11, 1563-1583. #20089
- Floriano,W.B., Vaidehi,N., Zamanakos,G., & Goddard,W.A., III. (2004) HierVLS Hierarchical Docking Protocol for Virtual Ligand Screening of Large-Molecule Databases. J. Med. Chem., 47, 56-71. #20185
- Fonseca,M.H., & List,B. (2004) Combinatorial chemistry and high-throughput screening for the discovery of organocatalysts. Curr. Opin. Chem. Biol., 8, 319-326. #20071
- Frantzen,A., Scheidtmann,J., Frenzer,G., Maier,W.F., Jockel,J., Brinz,T., Sanders,D., & Simon,U. (2004) High-throughput method for the impedance spectroscopic characterization of resistive gas sensors. Angewandte Chemie, International Edition, 43, 752-754. #20152
- Fricker,P.C., Gastreich,M., & Rarey,M. (2004) Automated Drawing of Structural Molecular Formulas under Constraints. Journal of Chemical Information and Computer Sciences, 44, 1065-1078. #20113
- Ganesan,A. (2004) Combinatorial chemistry. Curr. Opin. Chem. Biol., 8, 209-210. #20077
- Garbacia,S., Touzani,R., & Lavastre,O. (2004) Image Analysis as a Quantitative Screening Test in Combinatorial Catalysis: Discovery of an Unexpected Ruthenium-Based Catalyst for the Sonogashira Reaction. Journal of Combinatorial Chemistry, 6, 297-300. #20164
- Garcia-Junceda,E., Garcia-Garcia,J.F., Bastida,A., & Fernandez-Mayoralas,A. (2004) Enzymes in the synthesis of bioactive compounds: the prodigious decades. Bioorganic & Medicinal Chemistry, 12, 1817-1834. #20125
- Giacomelli,G., Porcheddu,A., & De Luca,L. (2004) [1,3,5]-triazine: A versatile heterocycle in current applications of organic chemistry. Current Organic Chemistry, 8, 1497-1519. #20031
- Gil,C., Schwoegler,A., & Braese,S. (2004) The Synthesis of 3-Substituted 6-Aryl-3 H-benzo[a][1,2,3]triazinones Using Polymer-Bound Triazenes. Journal of Combinatorial Chemistry, 6, 38-42. #20183
- Gilabert,M. (2004) Combinatorial chemical paper in the drug discovery process. Tecnicas de Laboratorio, 26, 140-143. #20398
- Girard,C., Tranchant,I., Gorteau,V., Potey,L., & Herscovici,J. (2004) Development of a DNA interaction test with small molecules still grafted on solid phase. Journal of Combinatorial Chemistry, 6, 275-278. #20454
- Gooding,O.W. (2004) Process optimization using combinatorial design principles: parallel synthesis and design of experiment methods. Curr. Opin. Chem. Biol., 8, 297-304. #20399
- Graham,D.J., Malarkey,C., & Schulmerich,M.V. (2004) Information Content in Organic Molecules: Quantification and Statistical Structure via Brownian Processing. Journal of Chemical Information and Computer Sciences, 44, 1601-1611. #20050
- Graham,D.J., & Schulmerich,M.V. (2004) Information Content in Organic Molecules: Reaction Pathway Analysis via Brownian Processing. Journal of Chemical Information and Computer Sciences, 44, 1612-1622. #20049
- Gros,P., Doudouh,A., & Fort,Y. (2004) New polystyrene-supported stable source of 2-pyridylboron reagent for Suzuki couplings in combinatorial chemistry. Tetrahedron Lett., 45, 6239-6241. #20048
- Hahn,H.G., Oh,H.S., Cheon,S.H., Oak,M.H., Kim,Y.R., & Kim,K.M. (2004) Excavation of lead compounds that inhibit mast cell degranulation by combinatorial chemistry and activity-guided. Archives of Pharmacal Research, 27, 518-523. #20066
- Han,Y., Giroux,A., Grimm,E.L., Aspiotis,R., Francoeur,S., Bayly,C.I., McKay,D.J., Roy,S., Xanthoudakis,S., Vaillancourt,J.P., Rasper,D.M., Tam,J., Tawa,P., Thornberry,N.A., Paterson,E.P., Garcia-Calvo,M., Becker,J.W., Rotonda,J., Nicholson,D.W., & Zamboni,R.J. (2004) Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors. Bioorganic & Medicinal Chemistry Letters, 14, 805-808. #20169
- Harper,G., Pickett,S.D., & Green,D.V.S. (2004) Design of a compound screening collection for use in high throughput screening. Comb. Chem. High Throughput Screening, 7, 63-71. #20126
- Hattori,K., Kido,Y., Yamamoto,H., Ishida,J., Kamijo,K., Murano,K., Ohkubo,M., Kinoshita,T., Iwashita,A., Mihara,K., Yamazaki,S., Matsuoka,N., Teramura,Y., & Miyake,H. (2004) Rational Approaches to Discovery of Orally Active and Brain-Penetrable Quinazolinone Inhibitors of Poly(ADP-ribose)polymerase. J. Med. Chem., 47, 4151-4154. #20053
- Heeren,R.M.A., Kleinnijenhuis,A.J., McDonnell,L.A., & Mize,T.H. (2004) A mini-review of mass spectrometry using high-performance FTICR-MS methods. Analytical and Bioanalytical Chemistry, 378, 1048-1058. #20151
- Hobbs,J.S., Simonian,M.H., Betgovargez,E., Ioffe,V., Movsisyan,A., Yu,J., James,C., & Bogler,O. (2004) The fast and the curious: fragment-based lead discovery and optimization via high-throughput X-ray crystallography. Mod. Drug Dis., 7, 53-54, 56. #20069
- Hou,T.J., Zhang,W., Xia,K., Qiao,X.B., & Xu,X.J. (2004) ADME Evaluation in Drug Discovery. 5. Correlation of Caco-2 Permeation with Simple Molecular Properties. Journal of Chemical Information and Computer Sciences, 44, 1585-1600. #20060
- Houghten,R.A. Anonymous. (2004) Silicagel-HF. This Book.#20024
- Houghten,R.A., Dooley,C.T., & Appel,J.R. (2004) De novo identification of highly active fluorescent kappa opioid ligands from a rhodamine labeled tetrapeptide positional scanning library. Bioorganic & Medicinal Chemistry Letters, 14, 1947-1951. #20121
- Hu,Y., Nawoschik,K.J., Liao,Y., Ma,J., Fathi,R., & Yang,Z. (2004) Synthesis of Conformationally Restricted 2,3-Diarylbenzo[b]furan by the Pd-Catalyzed Annulation of o-Alkynylphenols: Exploring a Combinatorial Approach. J. Org. Chem., 69, 2235-2239. #20139
- Huenger,U., Ohnsmann,J., & Kunz,H. (2004) Carbohydrate scaffolds for combinatorial syntheses that allow selective deprotection of all four positions independent of the sequence. Angewandte Chemie, International Edition, 43, 1104-1107. #20137
- Jensen,A.A., & Spalding,T.A. (2004) Allosteric modulation of G-protein coupled receptors. European Journal of Pharmaceutical Sciences, 21, 407-420. #20147
- Ji,Y.F., Pan,X.D., & Wei,X.Y. (2004) A solid-phase approach to fluorobenzimidazoles and fluoro-2-hydroxyquinoxalines using 'one-bead-two-compound' method. Synlett, 1607-1609. #20437
- Joensson,D., Warrington,B.H., & Ladlow,M. (2004) Automated Flow-Through Synthesis of Heterocyclic Thioethers. Journal of Combinatorial Chemistry, 6, 584-595. #20100
- Juskowiak,G.L., Stachel,S.J., Tivitmahaisoon,P., & Van Vranken,D.L. (2004) Fluorogenic Peptide Sequences - Transformation of Short Peptides into Fluorophores under Ambient Photooxidative Conditions. J. Amer. Chem. Soc., 126, 550-556. #20179
- Kaempke,T. (2004) Scalable distance similarity of chemical structures. Comb. Chem. High Throughput Screening, 7, 11-21. #20127
- Kam,Y.L., Rhee,S.J., & Choo,H.Y. (2004) Solution-phase combinatorial synthesis of nonpeptide bradykinin antagonists. Bioorganic & Medicinal Chemistry, 12, 3543-3552. #20079
- Kenseth,J.R., He,Y., Tallman,D., Pang,H.m., & Coldiron,S.J. (2004) Techniques for high-throughput characterization of peptides, oligonucleotides and catalysis efficiency. Curr. Opin. Chem. Biol., 8, 327-333. #20070
- Knepper,K., Lormann,M.E.P., & Braese,S. (2004) Efficient Synthesis of Highly Substituted Diaryl Ethers on Solid Supports Using the Ullmann Reaction. Journal of Combinatorial Chemistry, 6, 460-463. #20109
- Kohler,J.M., Henkel,T., Grodrian,A., Kirner,T., Roth,M., Martin,K., & Metze,J. (2004) Digital reaction technology by micro segmented flow - components, concepts and applications. Chemical Engineering Journal (Amsterdam, Netherlands), 101, 201-216. #20087
- Koinuma,H., & Takeuchi,I. (2004) Combinatorial solid-state chemistry of inorganic materials. Nature Materials, 3, 429-438. #20396
- Lai,G. (2004) A convenient preparation of tetrahydrofuran-based diamines. Syn. Commun., 34, 1981-1987. #20062
- Larsson,R., Pei,Z., & Ramstroem,O. (2004) Catalytic self-screening of cholinesterase substrates from a dynamic combinatorial thioester library. Angewandte Chemie, International Edition, 43, 3716-3718. #20047
- Lavastre,O., Bonnette,F., & Gallard,L. (2004) Parallel and combinatorial approaches for synthesis of ligands. Curr. Opin. Chem. Biol., 8, 311-318. #20072
- Lee,H.K., & Rana,T.M. (2004) Microwave-Assisted Parallel Synthesis of a 4,6-Diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine Library. Journal of Combinatorial Chemistry, 6, 504-508. #20084
- Lee,M.J., & Sun,C.M. (2004) Traceless synthesis of hydantoin by focused microwave irradiation. Tetrahedron Lett., 45, 437-440. #20181
- Lemmo,A.V., Hobbs,S., & Patel,P. (2004) Micro Parallel Liquid Chromatography: Enabling Technology for Discovery Analytical Chemistry. Assay and Drug Development Technologies, 2, 389-395. #20034
- Leonard,J.T., & Roy,K. (2004) Classical QSAR modeling of HIV-1 reverse transcriptase inhibitor 2-amino-6-arylsulfonylbenzonitriles and congeners. QSAR & Combinatorial Science, 23, 23-35. #20133
- Li,W., Chen,Y., & Lam,Y. (2004) A facile solid-phase synthesis of 3,4,6-trisubstituted-2-pyridones using sodium benzenesulfinate as a traceless linker. Tetrahedron Lett., 45, 6545-6547. #20042
- Lin,M.J., & Sun,C.M. (2004) Focused microwave-assisted parallel synthesis of bis-benzimidazoles. Synlett, 663-666. #20130
- Lindsay,J.P., Clark,D.S., & Dordick,J.S. (2004) Combinatorial formulation of biocatalyst preparations for increased activity in organic solvents: Salt activation of penicillin amidase. Biotechnol. Bioeng., 85, 553-560. #20143
- Liu,R., Hsieh,C.Y., & Lam,K.S. (2004) New approaches in identifying drugs to inactivate oncogene products. Seminars in Cancer Biology, 14, 13-21. #20457
- Ma,Y., Margarida,L., Brookes,J., Makara,G.M., & Berk,S.C. (2004) Combinatorial Synthesis of Substituted Biaryls and Heterocyclic Arylamines. Journal of Combinatorial Chemistry, 6, 426-430. #20123
- Maclean,D., Holden,F., Davis,A.M., Scheuerman,R.A., Yanofsky,S., Holmes,C.P., Fitch,W.L., Tsutsui,K., Barrett,R.W., & Gallop,M.A. (2004) Agonists of the Follicle Stimulating Hormone Receptor from an Encoded Thiazolidinone Library. Journal of Combinatorial Chemistry, 6, 196-206. #20177
- Maclean,D., & Martin,E.J. (2004) On the representation of combinatorial libraries. Journal of Combinatorial Chemistry, 6, 1-11. #20184
- Maison,W., Grohs,D.C., & Prenzel,A.H.G.P. (2004) Efficient synthesis of structurally diverse diazabicycloalkanes: scaffolds for modular dipeptide mimetics with tunable backbone conformations. Eur. J. Org. Chem., 1527-1543. #20116
- Maltais,R., Tremblay,M.R., Ciobanu,L.C., & Poirier,D. (2004) Steroids and Combinatorial Chemistry. Journal of Combinatorial Chemistry, 6, 443-456. #20101
- Matikainen,J.K.T., & Elo,H.O. (2004) A Novel Intramolecular Cyclization Reaction: Facile Solvent-Free Microscale Synthesis Suitable for Rapid Production of Libraries of 3-Amino-1,2,4-Triazines and for Combinatorial Chemistry. Microchimica Acta, 146, 49-53. #20103
- Matsuura,T., Ernst,A., Zechel,D.L., & Plueckthun,A. (2004) Combinatorial approaches to novel proteins. Chembiochem, 5, 177-182. #20148
- McCarthy,J.F., Marx,K.A., Hoffman,P.E., Gee,A.G., O'Neil,P., Ujwal,M.L., & Hotchkiss,J. (2004) Applications of machine learning and high-dimensional visualization in cancer detection, diagnosis, and management. Annals of the New York Academy of Sciences, 1020, 239-262. #20054
- Meier,M.A.R., Gohy,J.F., Fustin,C.A., & Schubert,U.S. (2004) Combinatorial Synthesis of Star-Shaped Block Copolymers: Host-Guest Chemistry of Unimolecular Reversed Micelles. J. Amer. Chem. Soc., 126, 11517-11521. #20038
- Mekenyan,O., Nikolova,N., Schmieder,P., & Veith,G. (2004) COREPA-M: a multi-dimensional formulation of COREPA. QSAR & Combinatorial Science, 23, 5-18. #20135
- Meldal,M. (2004) One bead two compound libraries' for detecting chemical and biochemical conversions. Curr. Opin. Chem. Biol., 8, 238-244. #20076
- Miller,S.J. (2004) In Search of Peptide-Based Catalysts for Asymmetric Organic Synthesis. Account. Chem. Res., 37, 601-610. #20141
- Mitscher,L.A. (2004) Analysis and Purification Methods in Combinatorial Chemistry, Edited by Bing Yang. Journal of Natural Products, 67, 1076-1077. #20096
- Musonda,C.C., & Chibale,K. (2004) Application of combinatorial and parallel synthesis chemistry methodologies to antiparasitic drug discovery. Curr. Med. Chem., 11, 2519-2533. #20030
- Nad,S., & Breinbauer,R. (2004) Electroorganic synthesis on the solid phase using polymer beads as supports. Angewandte Chemie, International Edition, 43, 2297-2299. #20105
- Nefzi,A., Ostresh,J.M., Yu,Y., & Houghten,R.A. (2004) Combinatorial Chemistry: Libraries from Libraries, the Art of the Diversity-Oriented Transformation of Resin-Bound Peptides and Chiral Polyamides to Low Molecular Weight Acyclic and Heterocyclic Compounds. [Vol. 69, 2004]. J. Org. Chem., 69, 5516. #20055
- Nolte,M., & Fery,A. (2004) Coupling of individual polyelectrolyte capsules onto patterned substrates. Langmuir, 20, 2995-2998. #20131
- Oerfi,L., Waczek,F., Pato,J., Varga,I., Hegymegi-Barakonyi,B., Houghten,R.A., & Keri,G. (2004) Improved, high yield synthesis of 3H-quinazolin-4-ones, the key intermediates of recently developed drugs. Curr. Med. Chem., 11, 2549-2553. #20029
- Ohno,H., Tanaka,H., & Takahashi,T. (2004) Solid-phase synthesis of N-alkylated naltrindoles using a 3-nitrobenzyl safety-catch linker. Synlett, 508-511. #20144
- Omata,K., Hashimoto,M., Watanabe,Y., Sutarto, Umegaki,T., & Yamada,M. (2004) Design of low cost pipe fitting device for high-throughput screening reactor for screening of methanol synthesis catalyst. Journal of the Japan Petroleum Institute, 47, 218-221. #20099
- Ortholand,J.Y., & Ganesan,A. (2004) Natural products and combinatorial chemistry: back to the future. Curr. Opin. Chem. Biol., 8, 271-280. #20074
- Ott,T., Kern,A., Schuffenhauer,A., Popov,M., Acklin,P., Jacoby,E., & Stoop,R. (2004) Sequential Superparamagnetic Clustering for Unbiased Classification of High-Dimensional Chemical Data. Journal of Chemical Information and Computer Sciences, 44, 1358-1364. #20083
- Park,J.G., Langenwalter,K.J., Weinbaum,C.A., Casey,P.J., & Pang,Y.P. (2004) Improved Loading and Cleavage Methods for Solid-Phase Synthesis Using Chlorotrityl Resins: Synthesis and Testing of a Library of 144 Discrete Chemicals as Potential Farnesyltransferase Inhibitors. Journal of Combinatorial Chemistry, 6, 407-413. #20119
- Parr,N.J., McKeown,S.C., Lindvall,M.K., Lorthioir,O.E., Congreve,M.S., & Watson,S.P. (2004) The application of quantitative analytical constructs for chemistry optimization, monomer rehearsal and reactivity prediction in solid phase library synthesis. Letters in Organic Chemistry, 1, 87-92. #20453
- Patek,M., Safar,P., Smrcina,M., Wegrzyniak,E., Bjergarde,K., Weichsel,A., & Strop,P. (2004) 2D and 3D Spatially Addressed Arrays for High-Throughput Automated Synthesis of Combinatorial Libraries. Journal of Combinatorial Chemistry, 6, 43-49. #20189
- Petrenko,V.A., & Sorokulova,I.B. (2004) Detection of biological threats. A challenge for directed molecular evolution. J. Microbiol. Methods, 58, 147-168. #20058
- Pirrung,M.C., & Das Sarma,K. (2004) Multicomponent Reactions Are Accelerated in Water. J. Amer. Chem. Soc., 126, 444-445. #20178
- Piscopio,A.D., & Robinson,J.E. (2004) Recent applications of olefin metathesis to combinatorial chemistry. Curr. Opin. Chem. Biol., 8, 245-254. #20075
- Porcheddu,A., Giacomelli,G., De Luca,L., & Ruda,A.M. (2004) A \"Catch and Release\" Strategy for the Parallel Synthesis of 2,4,5-Trisubstituted Pyrimidines. Journal of Combinatorial Chemistry, 6, 105-111. #20190
- Prakash,G.K.S., & Etzkorn,M. (2004) Direct oxidation of azides to nitro compounds. Angewandte Chemie, International Edition, 43, 26-28. #20176
- Rachakonda,S., & Cartee,L. (2004) Challenges in antimicrobial drug discovery and the potential of nucleoside antibiotics. Curr. Med. Chem., 11, 775-793. #20128
- Raghavendra,M.S., & Lam,Y. (2004) Regiospecific solid-phase synthesis of substituted 1,2,3-triazoles. Tetrahedron Lett., 45, 6129-6132. #20051
- Ralets,I., Ostergaard,S., Holm,A., Kohler,L., Bock,E., & Berezin,V. (2004) Identification of neurite extension inducing peptides by means of soluble combinatorial peptide libraries. J. Neurosci. Meth., 137, 61-69. #20443
- Ramstroem,O., Lohmann,S., Bunyapaiboonsri,T., & Lehn,J.M. (2004) Dynamic combinatorial carbohydrate libraries: probing the binding site of the Concanavalin A lectin. Chemistry--A European Journal, 10, 1711-1715. #20111
- Richards,W.G., Grant,G.H., & Harrison,K.N. (2004) Combating bioterrorism with personal computers. Journal of Molecular Graphics & Modelling, 22, 473-478. #20078
- Roque,A.C., Taipa,M.A., & Lowe,C.R. (2004) A new method for the screening of solid-phase combinatorial libraries for affinity chromatography. J. Mol. Recog., 17, 262-267. #20086
- Sanchez-Martin,R.M., Mittoo,S., & Bradley,M. (2004) The impact of combinatorial methodologies on medicinal chemistry. Current Topics in Medicinal Chemistry (Sharjah, United Arab Emirates), 4, 653-669. #20447
- Savchuk,N.P., Balakin,K.V., & Tkachenko,S.E. (2004) Exploring the chemogenomic knowledge space with annotated chemical libraries. Curr. Opin. Chem. Biol., 8, 412-417. #20044
- Schimmer,A.D., Welsh,K., Pinilla,C., Wang,Z., Krajewska,M., Bonneau,M.J., Pedersen,I.M., Kitada,S., Scott,F.L., Bailly-Maitre,B., Glinsky,G., Scudiero,D., Sausville,E., Salvesen,G., Nefzi,A., Ostresh,J.M., Houghten,R.A., & Reed,J.C. (2004) Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell, 5, 25-35. #20158
- Schmidt,F.R. (2004) The challenge of multidrug resistance: actual strategies in the development of novel antibacterials. Applied Microbiology and Biotechnology, 63, 335-343. #20174
- Schwabacher,A.W., Johnson,C.W., & Geissinger,P. (2004) Linear combinatorial synthesis with Fourier transform library analysis. Macromolecular Rapid Communications, 25, 108-118. #20456
- Sebestik,J., Matejka,P., Hlavacek,J., & Stibor,I. (2004) Solid-phase synthesis of head and tail bis-acridinylated peptides. Tetrahedron Lett., 45, 1203-1205. #20170
- Shannon,S.K., & Barany,G. (2004) Colorimetric monitoring of solid-phase aldehydes using 2,4-dinitrophenylhydrazine. Journal of Combinatorial Chemistry, 6, 165-170. #20161
- Song,A., Zhang,J., & Lam,K.S. (2004) Synthesis and Reactions of 7-Fluoro-4-methyl-6-nitro-2-oxo-2H-1-benzopyran-3-carboxylic Acid: A Novel Scaffold for Combinatorial Synthesis of Coumarins. Journal of Combinatorial Chemistry, 6, 112-120. #20188
- Song,A., Zhang,J., Lebrilla,C.B., & Lam,K.S. (2004) Solid-Phase Synthesis and Spectral Properties of 2-Alkylthio-6H-pyrano[2,3-f]benzimidazole-6-ones: A Combinatorial Approach for 2-Alkylthioimidazocoumarins. Journal of Combinatorial Chemistry, 6, 604-610. #20444
- Song,A., Wang,X., Zhang,J., Marik,J., Lebrilla,C.B., & Lam,K.S. (2004) Synthesis of hydrophilic and flexible linkers for peptide derivatization in solid phase. Bioorganic & Medicinal Chemistry Letters, 14, 161-165. #20461
- Song,A., Marik,J., & Lam,K.S. (2004) Solid-phase synthesis of 3-alkyl-2-arylamino-3,4-dihydroquinazolines. Tetrahedron Lett., 45, 2727-2730. #20138
- Song,Y., Yu,J., Li,Y., Li,G., & Xu,R. (2004) Hydrogen-bonded helices in the layered aluminophosphate (C2H8N)2[Al2(HPO4)(PO4)2]. Angewandte Chemie, International Edition, 43, 399-2402. #20094
- Spivey,A.C., Turner,D.J., Turner,M.L., & Yeates,S. (2004) A tuneable Ge-based linker that enables application-led solid phase synthesis optimization - towards a robust iterative synthesis of oligothiophenes. Synlett, 111-115. #20167
- Srinivasan,N., & Kilburn,J.D. (2004) Combinatorial approaches to synthetic receptors. Curr. Opin. Chem. Biol., 8, 305-310. #20073
- Stock,N., & Bein,T. (2004) High-throughput synthesis of phosphonate-based inorganic-organic hybrid compounds under hydrothermal conditions. Angewandte Chemie, International Edition, 43, 749-752. #20153
- Ternon,M., Diaz-Mochon,J.J., Belsom,A., & Bradley,M. (2004) Dendrimers and combinatorial chemistry-tools for fluorescent enhancement in protease assays. Tetrahedron, 60, 8721-8728. #20036
- Tornoe,C.W., Sanderson,S.J., Mottram,J.C., Coombs,G.H., & Meldal,M. (2004) Combinatorial Library of Peptidotriazoles: Identification of [1,2,3]-Triazole Inhibitors against a Recombinant Leishmania mexicana Cysteine Protease. Journal of Combinatorial Chemistry, 6, 312-324. #20122
- Tounge,B.A., & Reynolds,C.H. (2004) Defining Privileged Reagents Using Subsimilarity Comparison. Journal of Chemical Information and Computer Sciences, 44, 1810-1815. #20052
- Troitskaya,L.A., & Kodadek,T. (2004) Peptides as modulators of enzymes and regulatory proteins. Methods (San Diego, CA, United States), 32, 406-415. #20146
- Tung,C.L., & Sun,C.M. (2004) Liquid phase synthesis of chiral quinoxalinones by microwave irradiation. Tetrahedron Lett., 45, 1159-1162. #20171
- Uttamchandani,M., Chen,G.Y.J., Lesaicherre,M.L., & Yao,S.Q. (2004) Site-specific peptide immobilization strategies for the rapid detection of kinase activity on microarrays. Methods in Molecular Biology (Totowa, NJ, United States), 264, 191-204. #20445
- Vasilyev,V., & Bliznyuk,A. (2004) Application of semiempirical quantum chemical methods as a scoring function in docking. Theoretical Chemistry Accounts, 112, 313-317. #20033
- Ventura,M., Farrell,W., Aurigemma,C., Tivel,K., Greig,M., Wheatley,J., Yanovsky,A., Milgram,K.E., Dalesandro,D., DeGuzman,R., Tran,P., Nguyen,L., Chung,L., Gron,O., & Koch,C.A. (2004) High-throughput preparative process utilizing three complementary chromatographic purification technologies. Journal of Chromatography, A, 1036, 7-13. #20112
- Vess,C.J., Gilmore,J., Kohrt,N., & McGinn,P.J. (2004) Combinatorial Synthesis of Oxide Powders with an Autopipetting System. Journal of Combinatorial Chemistry, 6, 86-90. #20191
- Vickerstaffe,E., Warrington,B.H., Ladlow,M., & Ley,S.V. (2004) Fully Automated Polymer-Assisted Synthesis of 1,5-Biaryl Pyrazoles. Journal of Combinatorial Chemistry, 6, 332-339. #20129
- Viljanen,J., Tegler,L., & Broo,K.S. (2004) Combinatorial Chemical Reengineering of the Alpha Class Glutathione Transferases. Bioconjug. Chem., 15, 718-727. #20091
- Villard,A.L., Warrington,B.H., & Ladlow,M. (2004) A Fluorous-Tagged, Acid-Labile Protecting Group for the Synthesis of Carboxamides and Sulfonamides. Journal of Combinatorial Chemistry, 6, 611-622. #20085
- Virta,P., Leppaenen,M., & Loennberg,H. (2004) Pentaerythrityltetramine scaffolds for solid-phase combinatorial chemistry. J. Org. Chem., 69, 2008-2016. #20156
- Wang,G., De,J., Schoeniger,J.S., Roe,D.C., & Carbonell,R.G. (2004) A hexamer peptide ligand that binds selectively to staphylococcal enterotoxin B: Isolation from a solid phase combinatorial library. J. Pept. Res., 64, 51-64. #20436
- Wang,X., Zhang,J., Song,A., Lebrilla,C.B., & Lam,K.S. (2004) Encoding method for OBOC small molecule libraries using a biphasic approach for ladder-synthesis of coding tags. J. Amer. Chem. Soc., 126, 5740-5749. #20446
- Watts,J., Benn,A., Flinn,N., Monk,T., Ramjee,M., Ray,P., Wang,Y., & Quibell,M. (2004) Functionalised 2,3-dimethyl-3-aminotetrahydrofuran-4-one and N-(3-oxo-hexahydrocyclopenta[b]furan-3a-yl)acylamide based scaffolds: synthesis and cysteinyl proteinase inhibition. Bioorganic & Medicinal Chemistry, 12, 2903-2925. #20095
- Watts,P., & Haswell,S.J. (2004) Combinatorial synthesis in micro reactors. Comb. Chem. High Throughput Screening, 7, 397-405. #20035
- Wermuth,C.G. (2004) Selective Optimization of Side Activities: Another Way for Drug Discovery. J. Med. Chem., 47, 1303-1314. #20159
- Whitney,A.M., Ladame,S., & Balasubramanian,S. (2004) Templated ligand assembly by using G-quadruplex DNA and dynamic covalent chemistry. Angewandte Chemie, International Edition, 43, 1143-1146. #20136
- Wiczling,P., Markuszewski,M.J., & Kaliszan,R. (2004) Determination of pKa by pH Gradient Reversed-Phase HPLC. Anal. Chem., 76, 3069-3077. #20107
- Willand,N., Beghyn,T., Nowogrocki,G., Gesquiere,J.C., & Deprez,B. (2004) Synthesis and structural studies of a novel scaffold for drug discovery: a 4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4'-piperidine]. Tetrahedron Lett., 45, 1051-1054. #20173
- Wittmann,V., & Seeberger,S. (2004) Spatial screening of cyclic neoglycopeptides: Identification of polyvalent wheat-germ agglutinin ligands. Angewandte Chemie, International Edition, 43, 900-903. #20452
- Wu,X., Ding,S., Ding,Q., Gray,N.S., & Schultz,P.G. (2004) Small molecules that induce cardiomyogenesis in embryonic stem cells. J. Amer. Chem. Soc., 126, 1590-1591. #20166
- Xie,W., & Firestine,S.M. (2004) A Simple, Inexpensive Reactor with Condenser for Use in Combinatorial Chemistry. Journal of Combinatorial Chemistry, 6, 24-26. #20187
- Xu,J., Szakal,C.W., Martin,S.E., Peterson,B.R., Wucher,A., & Winograd,N. (2004) Molecule-Specific Imaging with Mass Spectrometry and a Buckminsterfullerene Probe: Application to Characterizing Solid-Phase Synthesized Combinatorial Libraries. J. Amer. Chem. Soc., 126, 3902-3909. #20140
- Yan,B. (2004) New combichem QC standards guard the supply of compounds and ensure HTS results. Mod. Drug Dis., 7, 30-32, 34. #20142
- Yao,H., Costache,A.D., & Sem,D.S. (2004) Chemical proteomic tool for ligand mapping of CYP antitargets: An NMR-compatible 3D QSAR descriptor in the heme-based coordinate system. Journal of Chemical Information and Computer Sciences, 44, 1456-1465. #20090
- Yao,N.H., He,W.Y., Lam,K.S., & Liu,G. (2004) Solid-Phase Synthesis of O-Glycosylated Na-Fmoc Amino Acids and Analysis by High-Resolution Magic Angle Spinning NMR. Journal of Combinatorial Chemistry, 6, 214-219. #20459
- Yeh,W.B., & Sun,C.M. (2004) Soluble polymer-supported synthesis of thioxotetrapyrimidinone by focused microwave irradiation. Journal of Combinatorial Chemistry, 6, 279-282. #20172
- Yeo,D.S.Y., Panicker,R.C., Tan,L.P., & Yao,S.Q. (2004) Strategies for immobilization of biomolecules in a microarray. Comb. Chem. High Throughput Screening, 7, 213-221. #20442
- Yingyongnarongkul,B.E., Howarth,M., Elliott,T., & Bradley,M. (2004) DNA transfection screening from single beads. Journal of Combinatorial Chemistry, 6, 753-760. #20438
- Young,S.S., & Ge,N. (2004) Design of diversity and focused combinatorial libraries in drug discovery. Current Opinion in Drug Discovery & Development, 7, 318-324. #20041
- Zablotna,E., Dysasz,H., Lesner,A., Jaskiewicz,A., Kazmierczak,K., Miecznikowska,H., & Rolka,K. (2004) A simple method for selection of trypsin chromogenic substrates using combinatorial chemistry approach. Biochem. Biophys. Res. Commun., 319, 185-188. #20092
- Zajdel,P., Subra,G., Bojarski,A.J., Duszynska,B., Pawlowski,M., & Martinez,J. (2004) A New Class of Arylpiperazine Derivatives: the Library Synthesis on SynPhase Lanterns and Biological Evaluation on Serotonin 5-HT1A and 5-HT2A Receptors. Journal of Combinatorial Chemistry, 6, 761-767. #20068
- Zaks-Makhina,E., Kim,Y., Aizenman,E., & Levitan,E.S. (2004) Novel neuroprotective K+ channel inhibitor identified by high-throughput screening in yeast. Mol. Pharmacol., 65, 214-219. #20117
- Zhou,F.X., Bonin,J., & Predki,P.F. (2004) Development of functional protein microarrays for drug discovery: Progress and challenges. Comb. Chem. High Throughput Screening, 7, 539-546. #20032
Wednesday, September 29, 2004
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