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"Classical" Papers in Molecular Diversity and Solid Phase Synthesis

This list is being compiled based on your input. If any paper which you may consider "seminal" or "classic" is missing in this compilation, please, let us know). If you are not the only one who value the particular paper, the paper will be included in the list. If we will obtain substantial response from the diversity community, we will compile top-ten (or fifty) list of combinatorial/diversity papers. This list does not try to rank any papers, it is just a selection of papers which may be useful to read for people who are entering the field of molecular diversity. It is far from being complete -- your input is needed to make it more representative. We would like to thank to all list contributors for their additions and comments. Suggestions for other paper categories are welcome. (If you will be pointing to any reference from our compilations, please use its ID# -- the last number in the reference, if available.)


LIBRARY TECHNIQUES

Deprez, B., Williard, X., Bourel, L., Coste, H., Hyafil, F., and Tartar, A. 1995. Orthogonal combinatorial chemical libraries. J. Amer. Chem. Soc. 117, 5405-5406 ID# 2724

Erb, E., Janda, K.D., and Brenner, S. 1994. Recursive deconvolution of combinatorial chemical libraries. Proc. Natl. Acad. Sci. USA, 91, 11422-11426 ID# 1923

Fleckenstein, B., Wiesmüller, K.H., Brich, M., and Jung, G. 1994. Novel heterobifunctionalized polystyrene-polyethylene glycol resin for simultaneous preparation of free and immobilized peptides and biological activity detected by confocal microscopy. Lett. Peptide Sci. 1, 117-126 ID# 1850

Fodor, S.P.A., Leighton, R.J., Pirrung, M.C., Stryer, L., Lu, A.T., and Solas, D. 1991. Light-directed, spatially addressable parallel chemical synthesis. Science, 251, 767-773. ID# 145

Furka, A., Sebestyén, F., Asgedom, M., and Dibó, G. 1991. General method for rapid synthesis of multicomponent peptide mixtures. Int. J. Peptide Prot. Res. 37, 487-493 ID# 96

Geysen, H.M., Rodda, S.J., and Mason, T.J. 1986. A priori delineation of a peptide which mimics a discontinuous antigenic determinant. Mol. Immunol. 23, 709-715 ID# 144

Geysen, H.M., Meloen, R.H., and Barteling, S.J. 1984. Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proc. Natl. Acad. Sci. USA, 81, 3998-4002 ID# 130

Han, H., Wolfe, M.M., Brenner, S., and Janda, K.D. 1995. Liquid-phase combinatorial synthesis. Proc. Natl. Acad. Sci. USA, 92, 6419-6423 ID# 2733

Houghten, R.A. 1985. General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids. Proc. Natl. Acad. Sci. USA, 82, 5131-5135 ID# 501

Houghten, R.A., Pinilla, C., Blondelle, S.E., Appel, J.R., Dooley, C.T., and Cuervo, J.H. 1991. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature, 354, 84-86 ID# 112

Lam, K.S., Salmon, S.E., Hersh, E.M., Hruby, V.J., Kazmierski, W.M., and Knapp, R.J. 1991. A new type of synthetic peptide library for identifying ligand-binding activity. Nature, 354, 82-84 ID# 111

Lam, K.S., Wade, S., Abdul-Latif, F., and Lebl, M. 1995. Application of a dual color detection scheme in the screening of a random combinatorial peptide library. J. Immunol. Method, 180, 219-223 ID# 2219

Meldal, M., Svendsen, I. 1995. Direct visualization of enzyme inhibitors using a portion mixing inhibitor library containing a quenched fluorogenic peptide substrate. Part 1.Inhibitors for subtilisin Carlsberg. J. Chem. Soc. Perkin Trans. 1, 1591-1596 ID# 2907

Meldal, M., Svendsen, I., Breddam, K., and Auzanneau, F.I. 1994. Portion-mixing peptide libraries of quenched fluorogenic substrates for complete subsite mapping of endoprotease specificity. Proc. Natl. Acad. Sci. USA, 91, 3314-3318 ID# 771

Ostresh, J.M., Husar, G.M., Blondelle, S.E., Dörner, B., Weber, P.A., and Houghten, R.A. 1994. "Libraries from libraries": Chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity. Proc. Natl. Acad. Sci. USA, 91, 11138-11142 ID# 1921

Pinilla, C., Appel, J.R., Blanc, P., and Houghten, R.A. 1992. Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries. BioTechniques, 13, 901-905 ID# 495

Salmon, S.E., Lam, K.S., Lebl, M., Kandola, A., Khattri, P.S., Wade, S., Pátek, M., Kocis, P., Krchnák, V., Thorpe, D., and Felder, S. 1993. Discovery of biologically active peptides in random libraries: Solution-phase testing after staged orthogonal release from resin beads. Proc. Natl. Acad. Sci. USA, 90, 11708-11712 ID# 518

Sepetov, N.F., Krchnák, V., Stanková, M., Wade, S., Lam, K.S., and Lebl, M. 1995. Library of libraries: Approach to synthetic combinatorial library design and screening of "pharmacophore" motifs. Proc. Natl. Acad. Sci. USA, 92, 5426-5430 ID# 977

Stanková, M., Wade, S., Lam, K.S., and Lebl, M. 1994. Synthesis of combinatorial libraries with only one representation of each structure. Peptide Res. 7, 292-298 ID# 1754

Wu, J., Ma, Q.N., and Lam, K.S. 1994. Identifying substrate motifs of protein kinases by a random library approach. Biochemistry, 33, 14825-14833 ID# 1460


NUCLEIC ACID LIBRARIES

Bell, G.I., Merryweather, J.P., Sanchez-Pescador, R., Stempien, M.M., Priestley, L., Scott, J., & Rall, L.B. (1984) Sequence of a cDNA clone encoding human preproinsulin-like growth factor II. Nature, 310, 775. #9596

Elmblad, A., Josephson, S., & Palm, G. (1982) Synthesis of mixed oligodeoxyribonucleotides following the solid phase method. Nucl. Acid. Res., 10, 3291. #9589

Frank, R., Heikens, W., Heisterberg-Moutsis, G., & Blöcker, H. (1983) A new general approach for the simultaneous chemical synthesis of large numbers of oligonucleotides: Segmental solid supports. Nucl. Acid. Res., 11, 4365-4377. #2973

Gubler, U., Mohanan, J.J., Lomedico, P.T., Bhatt, R.S., Collier, K.J., Hoffman, B.J., Böhlen, P., Esch, F., Ling, N., Zeytin, F., Brazeau, P., Poonian, M.S., & Gage, L.P. (1983) Cloning and sequene analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin. Proc. Natl. Acad. Sci. USA, 80, 4311-4314. #9594

Ike, Y., Ikuta, S., Sato, M., Huang, T., & Itakura, K. (1983) Solid phase synthesis of polynucleotides. VIII. Synthesis of mixed oligodeoxyribonucleotides by the phosphotriester solid phase method. Nucl. Acid. Res., 11, 477. #9591

Nakayama, K., Ohkubo, H., Hirose, T., Inayama, S., & Nakanishi, S. (1984) mRNA sequence for human cardiodilatin-atrial natriuretic factor precursor and regulation of precursor mRNA in rat atria. Nature, 310, 699. #9597

Ott, J., & Eckstein, F. (1984) Filter disc supported oligonucleotide synthesis by the phosphite method. Nucl. Acid. Res., 12, 9137. #9595

Suggs, S.V., Wallace, R.B., Hirose, T., Kawashima, E.H., & Itakura, K. (1981) Use of synthetic oligonucleotides as hybridization probes: Isolation of cloned cDNA sequences for human beta(2)-microglobulin. Proc. Natl. Acad. Sci. USA, 78, 6613-6617. #9588

Wallace, R.B., Johnson, M.J., Hirose, T., Miyake, T., Kawashima, E.H., & Itakura, K. (1981) The use of synthetic oligonucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit beta-globin DNA. Nucl. Acid. Res., 9, 879. #9587

Whitehead, A.S., Goldberger, G., Woods, D.E., Markham, A.F., & Colten, H.R. (1983) Use of a cDNA clone for the fourth component of human complement (C4) for analysis of a genetic deficiency of C4 in guinea pig. Proc. Natl. Acad. Sci. USA, 80, 5387-5391. #9593

Zon, G., Gallo, K.A., Samson, C.J., Shao, K.L., Summers, M.F., & Byrd, R.A. (1985) Analytical studies of 'mixed sequence' oligodeoxyribonucleotides synthesized by competitive coupling of either methyl- or beta-cyanoethyl-N,N-diisopropylamino phosphoramidite reagents, including 2'-deoxyinosine. Nucl. Acid. Res., 13, 8181. #9598


PHAGE LIBRARIES

New category suggested, no papers submitted yet.


PEPTIDE LIBRARIES

Ostresh, J.M., Winkle, J.M., Hamashin, V.T., and Houghten, R.A. 1994. Peptide libraries: Determination of relative reaction rates of amino acids in competitive couplings. Biopolymers, 34, 1681-1689 ID# 996

Owens, R.A., Gesellchen, P.D., Houchins, B.J., and DiMarchi, R.D. 1991. The rapid identification of HIV protease inhibitors through the synthesis and screening of defined peptide mixtures. Biochem.Biophys.Res.Commun. 181:402-408 ID# 131

Pinilla, C., Appel, J.R., and Houghten, R.A. 1994. Investigation of antigen-antibody interactions using a soluble, non-support-bound synthetic dacapeptide library composed of four trillion [4x10(12)] sequences. Biochem.J. 301:847-853 ID# 1306

Spatola, A.F., Crozet, Y. 1996. Rediscovering an endothelin antagonist (BQ-123): A self-deconvoluting cyclic pentapetide library. J. Med. Chem. 39, 3842-3846 ID# 5275

Udaka, K., Wiesmüller, K.H., Kienle, S., Jung, G., and Walden, P. 1995. Decrypting the structure of major histocompatability complex class I: Restricted cytotoxic T lymphocyte epitopes with complex peptide libraries. J.Exp.Med. 181:2097-2108 ID# 3440


NON-PEPTIDE LIBRARIES

Cho, C.Y., Moran, E.J., Cherry, S.R., Stephans, J.C., Fodor, S.P.A., Adams, C.L., Sundaram, A., Jacobs, J.W., and Schultz, P.G. 1993. An unnatural biopolymer. Science, 261, 1303-1305 ID# 478

DeWitt, S.H.H., Kiely, J.K., Stankovic, C.J., Schroeder, M.C., Cody, D.M.R., and Pavia, M.R. 1993. "Diversomers": An approach to nonpeptide, nonoligomeric chemical diversity. Proc. Natl. Acad. Sci. USA, 90, 6909-6913 ID# 2372

Simon, R.J., Kaina, R.S., Zuckermann, R.N., Huebner, V.D., Jewell, D.A., Banville, S., Ng, S., Wang, L., Rosenberg, S., Marlowe, C.K., Spellmeyer, D.C., Tan, R., Frankel, A.D., Santi, D.V., Cohen, F.E., et al. 1992. Peptoids: A modular approach to drug discovery. Proc. Natl. Acad. Sci. USA, 89, 9367-9371 ID# 13

Zuckermann, R.N., Kerr, J.M., Kent, S.B.H., and Moos, W.H. 1992. Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis. J. Amer. Chem. Soc. 114, 10646-10647 ID# 104

Zuckermann, R.N., Martin, E.J., Spellmeyer, D.C., Stauber, G.B., Shoemaker, K.R., Kerr, J.M., Figliozzi, G.M., Goff, D.A., Siani, M.A., Simon, R.J., Banville, S.C., Brown, E.G., Wang, L., Richter, L.S., and Moos, W.H. 1994. Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library. J. Med. Chem. 37, 2678-2685 ID# 1171


ANALYTICAL TECHNIQUES

Chu, Y.H., Avila, L.Z., Biebuyck, H.A., and Whitesides, G.M. 1993. Using affinity capillary electrophoresis to identify the peptide in a peptide library that binds most tightly to vancomycin. J. Org. Chem. 58, 648-652 ID# 135

Fitch, W.L., Detre, G., & Holmes, C.P. (1994) High-resolution (1)H NMR in solid-phase organic synthesis. J. Org. Chem., 59, 7955-7956. #2141

Gao, J., Cheng, X., Chen, R., Sigal, G.B., Bruce, J.E., Schwartz, B.L., Hofstadler, S.A., Anderson, G.A., Smith, R.D., and Whitesides, G.M. 1996. Screening derivatized peptide libraries for tight binding inhibitors to carbonic anhydrase II by electrospray ionization mass spectrometry. J. Med. Chem. 39, 1949-1955 ID# 4696

Keifer, P.A. (1996) Influence of resin structure, tether length, and solvent upon the high-resolution (1)H NMR spectra of solid-phase-synthesis resins. J. Org. Chem., 61, 1558-1559. #4128

Metzger, J.W., Wiesmüller, K.H., Gnau, V., Brünjes, J., and Jung, G. 1993. Ion-spray mass spectrometry and high-performance liquid chromatography. Mass spectrometry of synthetic peptide libraries. Angew. Chem. Int. Ed. 32, 894-896 ID# 678

Stevanovic, S., Jung, G. 1993. Multiple sequence analysis: Pool sequencing of synthetic and natural peptide libraries. Anal. Biochem. 212, 212-220 ID# 679

Youngquist, R.S., Fuentes, G.R., Lacey, M.P., and Keough, T. 1994. Matrix-assisted laser desorption ionization for rapid determination of the sequences of biologically active peptides isolated from support-bound combinatorial peptide libraries. Rapid Commun. Mass Spectrom. 8, 77-81 ID# 770


CODING

Brenner, S., Lerner, R.A. 1992. Encoded combinatorial chemistry. Proc. Natl. Acad. Sci. USA, 89, 5381-5383. ID# 4

Geysen, H.M., Wagner, C.D., Bodnar, W.M., Markworth, C.J., Parke, G.J., Schoenen, F.J., Wagner, D.S., and Kinder, D.S. 1996. Isotope or mass encoding of combinatorial libraries. Chemistry & Biology, 3, 679-688 ID# 5398

Kerr, J.M., Banville, S.C., and Zuckermann, R.N. 1993. Encoded combinatorial peptide libraries containing non-natural amino acids. J. Amer. Chem. Soc. 115, 2529-2531 ID# 101

Moran, E.J., Sarshar, S., Cargill, J.F., Shahbaz, M.M., Lio, A., Mjalli, A.M.M., and Armstrong, R.W. 1995. Radio frequency tag encoded combinatorial library method for the discovery of tripeptide-substituted cinnamic acid inhibitors of the protein tyrosine phosphatase PTP1B. J. Amer. Chem. Soc. 117, 10787-10788 ID# 3431

Nestler, H.P., Bartlett, P.A., and Still, W.C. 1994. A general method for molecular tagging of encoded combinatorial chemistry libraries. J. Org. Chem. 59, 4723-4724 ID# 1312

Nicolaou, K.C., Xiao, X.Y., Parandoosh, Z., Senyei, A., and Nova, M.P. 1995. Radiofrequency encoded combinatorial chemistry. Angew. Chem. Int. Ed. 34, 2289-2291 ID# 3463

Nielsen, J., Brenner, S., and Janda, K.D. 1993. Synthetic methods for the implementation of encoded combinatorial chemistry. J. Amer. Chem. Soc. 115, 9812-9813 ID# 477

Nikolaiev, V., Stierandová, A., Krchnák, V., Seligmann, B., Lam, K.S., Salmon, S.E., and Lebl, M. 1993. Peptide-encoding for structure determination of nonsequenceable polymers within libraries synthesized and tested on solid-phase supports. Peptide Res. 6, 161-170 ID# 509

Ohlmeyer, M.H.J., Swanson, R.N., Dillard, L.W., Reader, J.C., Asouline, G., Kobayashi, R., Wigler, M., and Still, W.C. 1993. Complex synthetic chemical libraries indexed with molecular tags. Proc. Natl. Acad. Sci. USA, 90, 10922-10926 ID# 700

Vágner, J., Barany, G., Lam, K.S., Krchnák, V., Sepetov, N.F., Ostrem, J.A., Strop, P., and Lebl, M. 1996. Enzyme-mediated spatial segregation on individual polymeric support beads: Application to generation and screening of encoded combinatorial libraries. Proc. Natl. Acad. Sci. USA, 93, 8194-8199 ID# 147


SOLID PHASE SYNTHESIS

Bunin, B.A., Plunkett, M.J., and Ellman, J.A. 1994. The combinatorial synthesis and chemical and biological evaluation of 1,4-benzodiazepine library. Proc. Natl. Acad. Sci. USA, 91, 4708-4712 ID# 1041

Bunin, B.A., Ellman, J.A. 1992. A general and expedient method for the solid phase synthesis of 1,4-benzodiazepine derivatives. J. Amer. Chem. Soc. 114, 10997-10998 ID# 108

Meldal, M. 1992. PEGA: A flow stable polyethylene glycol dimethyl acryamide copolymer for solid phase synthesis. Tetrahedron Lett. 33, 3077 ID# 28

Merrifield, R.B. 1985. Solid phase synthesis (Nobel lecture). Angew. Chem. 97, 801 ID# 3976


LINKERS

Backes, B.J., Virgilio, A.A., and Ellman, J.A. 1996. Activation method to prepare a highly reactive acylsulfonamide "safety-catch" linker for solid-phase synthesis. J. Amer. Chem. Soc. 118, 3055-3056 ID# 4137

Backes, B.J., Ellman, J.A. 1994. Carbon-carbon bond-forming methods on solid support. Utilization of Kenner's "Safety-Catch" linker. J. Amer. Chem. Soc. 116, 11171-11172 ID# 2039

Hoffmann, S., Frank, R. 1994. A new safety-catch peptide-resin linkage for the direct release of peptides into aqueous buffers. Tetrahedron Lett. 35, 7763-7766 ID# 1841

Kocis, P., Krchnák, V., and Lebl, M. 1993. Symmetrical structure allowing the selective multiple release of a defined quantity of peptide from a single bead of polymeric support. Tetrahedron Lett. 34, 7251-7252 ID# 519

Plunkett, M.J., Ellman, J.A. 1995. A silicon-based linker for traceless solid-phase synthesis. J. Org. Chem. 60, 6006-6007 ID# 3307


MULTIPLE SYNTHESIS

DeWitt, S.H.H., Kiely, J.K., Stankovic, C.J., Schroeder, M.C., Cody, D.M.R., and Pavia, M.R. 1993. "Diversomers": An approach to nonpeptide, nonoligomeric chemical diversity. Proc. Natl. Acad. Sci. USA, 90, 6909-6913 ID# 2372

Eichler, J., Bienert, M., Stierandová, A., and Lebl, M. 1991. Evaluation of cotton as a carrier for solid phase peptide synthesis. Peptide Res. 4, 296-307 ID# 596

Fodor, S.P.A., Leighton, R.J., Pirrung, M.C., Stryer, L., Lu, A.T., and Solas, D. 1991. Light-directed, spatially addressable parallel chemical synthesis. Science, 251, 767-773. ID# 145

Frank, R. 1993. Strategies and techniques in simultaneous solid phase synthesis based on the segmentation of membrane type supports. Bioorg. Med. Chem. Lett. 3, 425-430 ID# 548

Frank, R. 1992. Spot synthesis: An easy technique for the positionally addressable, parallel chemical synthesis on a membrane support. Tetrahedron, 48, 9217-9232 ID# 1316

Frank, R., Döring, R. 1988. Simultaneous multiple peptide synthesis under continuous flow conditions on cellulose paper discs as segmental solid supports. Tetrahedron, 44, 6031-6040 ID# 98

Geysen, H.M., Meloen, R.H., and Barteling, S.J. 1984. Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proc. Natl. Acad. Sci. USA, 81, 3998-4002 ID# 130

Houghten, R.A. 1985. General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids. Proc. Natl. Acad. Sci. USA, 82, 5131-5135 ID# 501

Peters, S., Bielfeldt, T., Meldal, M., Bock, K., and Paulsen, H. 1992. Multiple-column solid-phase glycopeptide synthesis. J. Chem. Soc. Perkin Trans. 1, 1163-1171 ID# 30


AUTOMATION

Cargill, J.F., Maiefski, R.R. 1996. Automated combinatorial chemistry on solid phase. Lab. Robotics. Automation, 8, 139-148 ID# 5344

Zuckermann, R.N., Kerr, J.M., Siani, M.A., and Banville, S.C. 1992. Design, construction and application of a fully automated equimolar peptide mixture synthesizer. Int. J. Peptide Prot. Res. 40, 497-506 ID# 100


RESULTS FROM LIBRARY SCREENING

Dooley, C.T., Chung, N.N., Wilkes, B.C., Schiller, P.W., Bidlack, J.M., Pasternak, G.W., and Houghten, R.A. 1994. An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library. Science, 266, 2019-2022 ID# 2075

Dooley, C.T., Chung, N.N., Schiller, P.W., and Houghten, R.A. 1993. Acetalins: Opioid receptor antagonists determined through the use of synthetic peptide combinatorial libraries. Proc. Natl. Acad. Sci. USA, 90, 10811-10815 ID# 563

Eichler, J., Lucka, A.W., Pinilla, C., and Houghten, R.A. 1996. Novel ŕ-glucosidase inhibitors identified using multiple cyclic peptide combinatorial libraries. Molecular Diversity, 1, 233-240 ID# 4843

Lam, K.S., Lebl, M. 1992. Streptavidin and avidin recognize peptide ligands with different motifs. Immunomethods, 1, 11-15 ID# 141

Zuckermann, R.N., Kerr, J.M., Siani, M.A., Banville, S.C., and Santi, D.V. 1992. Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis. Proc. Natl. Acad. Sci. USA, 89, 4505-4509. ID# 5

Zuckermann, R.N., Martin, E.J., Spellmeyer, D.C., Stauber, G.B., Shoemaker, K.R., Kerr, J.M., Figliozzi, G.M., Goff, D.A., Siani, M.A., Simon, R.J., Banville, S.C., Brown, E.G., Wang, L., Richter, L.S., and Moos, W.H. 1994. Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library. J. Med. Chem. 37, 2678-2685 ID# 1171


REVIEWS

Ellman, J.A. 1996. Design, synthesis, and evaluation of small-molecule libraries. Account. Chem. Res. 29, 132-143 ID# 3993

Gallop, M.A., Barrett, R.W., Dower, W.J., Fodor, S.P.A., and Gordon, E.M. 1994. Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries. J. Med. Chem. 37, 1233-1251 ID# 833

Gordon, E.M., Barrett, R.W., Dower, W.J., Fodor, S.P.A., and Gallop, M.A. 1994. Applications of combinatorial technologies to drug discovery.2. Combinatorial organic synthesis, library screening strategies, and future directions. J. Med. Chem. 37, 1385-1401 ID# 1001

Jung, G., Beck-Sickinger, A.G. 1992. Multiple peptide synthesis methods and their applications. Angew. Chem. Int. Ed. 31, 367-386. ID# 10

Krchnák, V., Lebl, M. 1996. Synthetic library techniques: Subjective (biased and generic) thoughts and views. Molecular Diversity, 1, 193-216 (Available on Internet) ID# 4806

Pinilla, C., Appel, J., Blondelle, S.E., Dooley, C.T., Dorner, B., Eichler, J., Ostresh, J., and Houghten, R.A. 1995. A review of the utility of soluble peptide combinatorial libraries. Biopolymers (Pept. Sci.), 37, 221-240 ID# 2424

Thompson, L.A., Ellman, J.A. 1996. Synthesis and application of small molecule libraries. Chem. Rev. 96, 555-600 ID# 3665

Stewart, J.M., Young, J.D. 1984. Solid Phase Peptide Synthesis. Rockford, Illinois, Pierce Chemical Company, ID# 756.


"COOK-BOOKS"

Houghten, R.A. 1994. Soluble combinatorial libraries: Extending the range and repetoire of chemical diversity. Methods: A Companion to Methods in Enzymology, 6, 354-360 ID# 572

Kramer, A., Schuster, A., Reineke, U., Malin, R., Volkmer-Engert, R., Landgraf, C., and Schneider-Mergener, J. 1994. Combinatorial cellulose-bound peptide libraries: Screening tools for the identification of peptides that bind ligands with predefined specifity. Methods: A Companion to Methods in Enzymology, 6, 388-395 ID# 2208

Meldal, M. 1994. Multiple column synthesis of quenched solid-phase bound fluorogenic substrates for characterization of endoprotease specificity. Methods: A Companion to Methods in Enzymology, 6, 417-424 ID# 993

Turck, C.W. 1994. Radioactive screening of synthetic peptide libraries. Methods: A Companion to Methods in Enzymology, 6, 396-400 ID# 2209

Lowman, H.B., Wells, J.A. 1991. Monovalent phage display: A method for selecting variant proteins from random libraries. Methods: A Companion to Methods in Enzymology, 3, 205-216 ID# 1044


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