PAPERS PUBLISHED IN 2001

This list is arranged by the name of the first author. Any omissions, mistakes and inconsistencies please communicate to the authors of compilation (michal@5z.com). (If you are pointing to any reference, please use its ID# -- the last number in the reference.) You are welcome to use this compilation in your work. Proper way to quote it in your paper is: Lebl M., Leblova Z.: Dynamic database of references in molecular diversity. Internet http://www.5z.com.

Recently added entries are marked in bold

1. Anonymous. (2001) Combinatorial chemistry: A revolution in drug discovery, but still in need of logic to drive it forward. Leprosy Review, 72, 118-119. #16718

2. Acharya,A.N., Nefzi,A., Ostresh,J.M., & Houghten,R.A. (2001) Tethered libraries: Solid-phase synthesis of substituted urea-linked bicyclic guanidines. Journal of Combinatorial Chemistry, 3, 189-195. #16505

3. Adang,A.E.P., & Hermkens,P.H.H. (2001) The contribution of combinatorial chemistry to lead generation: An interim analysis. Curr. Med. Chem., 8, 985-998. #16720

4. Afargan,M., Janson,E.T., Gelerman,G., Rosenfeld,R., Ziv,O., Karpov,O., Wolf,A., Bracha,M., Shohat,D., Liapakis,G., Gilon,C., Hoffman,A., Stephensky,D., & Oberg,K. (2001) Novel long-acting somatostatin analog with endocrine selectivity: Potent suppression of growth hormone but not of insulin. Endocrinology, 142, 477-486. #16233

5. Affleck,R.L. (2001) Solutions for library encoding to create collections of discrete compounds. Curr. Opin. Chem. Biol., 5, 257-263. #16722

6. Agrafiotis,D.K. (2001) A constant time algorithm for estimating the diversity of large chemical libraries. Journal of Chemical Information and Computer Sciences, 41, 159-167. #16235

7. Agrafiotis,D.K., & Rassokhin,D.N. (2001) Design and prioritization of plates for high-throughput screening. Journal of Chemical Information and Computer Sciences, 41, 798-805. #16723

8. Agrafiotis,D.K., Rassokhin,D.N., & Lobanov,V.S. (2001) Multidimensional scaling and visualization of large molecular similarity tables. J. Comput. Chem., 22, 488-500. #16724

9. Aguilar,R.C., Boehm,M., Gorshkova,I., Crouch,R.J., Tomita,K., Saito,T., Ohno,H., & Bonifacino,J.S. (2001) Signal-binding specificity of the mu 4 subunit of the adaptor protein complex AP-4. Journal of Biological Chemistry, 276, 13145-13152. #16725

10. Ahn,J.M., Medeiros,M., Trivedi,D., & Hruby,V.J. (2001) Development of potent truncated glucagon antagonists. J. Med. Chem., 44, 1372-1379. #16671

11. Aistars,A., Simpson,N.J.K., & Jones,D.C. (2001) Solid-phase extraction methods developed in a modular 96-well plate format. Amer. Lab., 33, 50. #16729

12. Akritopoulou-Zanze,I., & Sowin,T.J. (2001) Solid-phase synthesis of macrolide analogues. Journal of Combinatorial Chemistry, 3, 301-311. #16628

13. Albericio,F., Bryman,L.M., Garcia,J., Michelotti,E.L., Nicolas,E., & Tice,C.M. (2001) Synthesis of a sulfahydantoin library. Journal of Combinatorial Chemistry, 3, 290-300. #16627

14. Alexander,T., & Tran,C.D. (2001) Near-infrared spectrometric determination of di- and tripeptides synthesized by a combinatorial solid-phase method. Anal. Chem., 73, 1062-1067. #17078

15. Andersson,P.M., Sjostrom,M., Wold,S., & Lundstedt,T. (2001) Strategies for subset selection of parts of an in-house chemical library. Journal of Chemometrics, 15, 353-369. #16732

16. Andrews,K., & Hsiao,G. (2001) Parallel catalyst screening instrumentation. Chim. Oggi, 19, 53-55. #16632

17. Andrus,M.B., Turner,T.M., Updegraff,E.P., Sauna,Z.E., & Ambudkar,S.V. (2001) Synthesis and analysis of polyethylene glycol linked P-glycoprotein-specific homodimers based on (-)-stipiamide. Tetrahedron Lett., 42, 3819-3822. #16734

18. Antal,J., Pal,G., Asboth,B., Buzas,Z., Patthy,A., & Graf,L. (2001) Specificity assay of serine proteinases by reverse-phase high-performance liquid chromatography analysis of competing oligopeptide substrate library. Anal. Biochem., 288, 156-167. #16240

19. Argyris,E.G., Vanderkooi,J.M., & Paterson,Y. (2001) Mutagenesis of key residues identifies the connection subdomain of HIV-1 reverse transcriptase as the site of inhibition by heme. Eur. J. Biochem., 268, 925-931. #16735

20. Aria,F. (2001) Automated multistep solution phase synthesis of diamines and allylic amines. In I.Sucholeiki (Ed.), High-Throughput Synthesis. (pp. 223-227). Marcel Dekker, Inc., New York. #16467

21. Aris,L., Gilchrist,A., Rens-Domiano,S., Meyer,C., Schatz,P.J., Dratz,E.A., & Hamm,H.E. (2001) Structural requirements for the stabilization of metarhodopsin II by the C terminus of the alpha subunit of transducin. Journal of Biological Chemistry, 276, 2333-2339. #16242

22. Arnold,F.H. (2001) Combinatorial and computational challenges for biocatalyst design. Nature, 409, 263-257. #16533

23. Aronov,A.M., Munagala,N.R., Kuntz,I.D., & Wang,C.C. (2001) Virtual screening of combinatorial libraries across a gene family: In search of inhibitors of Giardia lamblia guanine phosphoribosyltransferase. Antimicrob. Agents Chemother., 45, 2571-2576. #17109

24. Arsequell,G., Gonzalez,A., & Valencia,G. (2001) Visible light promoted organic reaction on a solid support. Tetrahedron Lett., 42, 2685-2687. #16611

25. Assa-Munt,N., Jia,X., Laakkonen,P., & Ruoslahti,E. (2001) Solution structures and integrin binding activities of an RGD peptide with two isomers. Biochemistry, 40, 2373-2378. #16737

26. Atrash,B., Bradley,M., Kobylecki,R., Cowell,D., & Reader,J. (2001) Revolutionizing resin handling for combinatorial synthesis. Angew. Chem. Int. Ed., 40, 938-941. #16738

27. Attardi,M.E., Falchi,A., & Taddei,M. (2001) A sensitive visual test for detection of OH groups on resin[2000, Vol 41,No 38, 7395-7399]. Tetrahedron Lett., 42, 2927. #16608

28. Attardi,M.E., & Taddei,M. (2001) The Barton radical decarboxylation on solid phase. A versatile synthesis of peptides containing modified amino acids. Tetrahedron Lett., 42, 3519-3522. #16566

29. Aubagnac,J.L., & Enjalbal,C. (2001) Monitoring in combinatorial chemistry - Preface. Comb. Chem. High Throughput Screening, 4, NIL. #16740

30. Bachand,B., Tarazi,M., St-Denis,Y., Edmunds,J.J., Winocour,P.D., Leblond,L., & Siddiqui,M.A. (2001) Potent and selective bicyclic lactam inhibitors of thrombin. Part 4. Transition state inhibitors. Bioorg. Med. Chem. Lett., 11, 287-290. #17069

31. Bae,Y.S., Bae,H., Kim,Y., Lee,T.G., Suh,P.G., & Ryu,S.H. (2001) Identification of novel chemoattractant peptides for human leukocytes. Blood, 97, 2854-2862. #16741

32. Baer,R., & Masquelin,T. (2001) A novel solid-phase approach to 2,4-diaminothiazoles. Journal of Combinatorial Chemistry, 3, 16-19. #16136

33. Balass,M., Kalef,E., Fuchs,S., & Katchalski-Katzir,E. (2001) A cyclic peptide with high affinity to alpha-bungarotoxin protects mice from the lethal effect of the toxin. Toxicon, 39, 1045-1051. #16742

34. Barkley,A., & Arya,P. (2001) Combinatorial chemistry toward understanding the function(s) of carbohydrates and carbohydrate conjugates. Chem. Eur. J., 7, 555-563. #16247

35. Barnes,C.A.S., & Clemmer,D.E. (2001) Assessment of purity and screening of peptide libraries by nested ion mobility TOFMS: Identification of RNase S-protein binders. Anal. Chem., 73, 424-433. #16248

36. Barone,R., Arbelot,M., & Chanon,M. (2001) GASP: A computer program to generate automatically polycyclic structures. Tetrahedron, 57, 6035-6042. #16743

37. Barzik,M., Carl,U.D., Schubert,W.D., Frank,R., Wehland,J., & Heinz,D.W. (2001) The N-terminal domain of Homer/Vesl is a new class II EVH1 domain. J. Mol. Biol., 309, 155-169. #16744

38. Battersby,B.J., Lawrie,G.A., & Trau,M. (2001) Optical encoding of microbeads for gene screening: Alternatives to microarrays. Drug Disc. Today, 6, S19-S26. #16746

39. Baumann,M., Bischoff,H., Schmidt,D., & Griesinger,C. (2001) Combinatorial synthesis of cholesterol ester transfer protein-mRNA ligands and screening by nondenaturating gel-electrophoresis. J. Med. Chem., 44, 2172-2177. #16747

40. Beebe,X., Wodka,D., & Sowin,T.J. (2001) Solid-phase synthesis of benzoxazoles from 3-nitrotyrosine. Journal of Combinatorial Chemistry, 360-366. #17038

41. Belvisi,L., Bernardi,A., Checchia,A., Manzoni,L., Potenza,D., Scolastico,C., Castorina,M., Cupelli,A., Giannini,G., Carminati,P., & Pisano,C. (2001) Potent integrin antagonists from a small library of RGD-including cyclic pseudopeptides. Organic Letters, 3, 1001-1004. #16749

42. Benguric,D.R., Dungu,B., Thiaucourt,F., & du,P.D. (2001) Phage displayed peptides and anti-idiotype antibodies recognised by a monoclonal antibody directed against a diagnostic antigen of Mycoplasma capricolum subsp capripneumoniae. Vet. Microbiol., 81, 165-179. #16751

43. Bennett,J.M., Campbell,A.D., Campbell,A.J., Carr,M.G., Dunsdon,R.M., Greening,J.R., Hurst,D.N., Jennings,N.S., Jones,P.S., Jordan,S., Kay,P.B., O'Brien,M.A., King-Underwood,J., Raynham,T.M., Wilkinson,C.S., Wilkinson,T.C., & Wilson,F.X. (2001) The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase. Bioorg. Med. Chem. Lett., 11, 355-357. #17060

44. Beno,B.R., & Mason,J.S. (2001) The design of combinatorial libraries using properties and 3D pharmacophore fingerprints. Drug Disc. Today, 6, 251-258. #16752

45. Bertenshaw,G.P., Turk,B.E., Hubbard,S.J., Matters,G.L., Bylander,J.E., Crisman,J.M., Cantley,L.C., & Bond,J.S. (2001) Marked differences between metalloproteases meprin A and B in substrate and peptide bond specificity. Journal of Biological Chemistry, 276, 13248-13255. #16753

46. Bhattacharyya,T., & Nilsson,U.J. (2001) An efficient and convergent route towards water-soluble, chiral and amphiphilic macrocycles. Tetrahedron Lett., 42, 2873-2875. #16607

47. Bickler,J.R., & Rahn,P.C. (2001) High-throughput parallel flash purification using an automated, multichannel UV flash chromatography system. Amer. Lab., 33, 46. #16754

48. Boger,D.L., Goldberg,J., Silletti,S., Kessler,T., & Cheresh,D.A. (2001) Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin alpha(v)beta(3). J. Amer. Chem. Soc., 123, 1280-1288. #16755

49. Bookser,B.C., & Zhu,S. (2001) Solid phase extraction purification of carboxylic acid products from 96-well format solution phase synthesis with DOWEX x8-400 formate anion exchange resin. Journal of Combinatorial Chemistry, 3, 205-215. #16507

50. Bottari,B., Maccari,R., Monforte,F., Ottana,R., Rotondo,E., & Vigorita,M.G. (2001) Antimycobacterial in vitro activity of cobalt(II) isonicotinoylhydrazone complexes. Part 10. Bioorg. Med. Chem. Lett., 11, 301-303. #17066

51. Bouloc,N., Walshe,N., & Bradley,M. (2001) Polyethers: A solid-phase iterative approach. Journal of Combinatorial Chemistry, 3, 6-8. #16134

52. Bounaga,S., Galleni,M., Laws,A.P., & Page,M.I. (2001) Cysteinyl peptide inhibitors of Bacillus cereus zinc beta-lactamase. Bioorg. Med. Chem., 503-510. #17130

53. Bracci,L., Lozzi,L., Lelli,B., Pini,A., & Neri,P. (2001) Mimotopes of the nicotinic receptor binding site selected by a combinatorial peptide library. Biochemistry, 40, 6611-6619. #16756

54. Brauer,A.B.E., Kelly,G., McBride,J.D., Cooke,R.M., Matthews,S.J., & Leatherbarrow,R.J. (2001) The Bowman-Birk inhibitor reactive site loop sequence represents an independent structural beta-hairpin motif. J. Mol. Biol., 306, 799-807. #16757

55. Braxmeier,T., Demarcus,M., Fessmann,T., McAteer,S., & Kilburn,J.D. (2001) Identification of sequence selective receptors for peptides with a carboxylic acid terminus. Chem. Eur. J., 7, 1889-1898. #16759

56. Bray,M.R., Bisland,S., Perampalam,S., Lim,W.M., & Gariepy,J. (2001) Probing the surface of eukaryotic cells using combinatorial toxin libraries. Curr. Biol., 11, 697-701. #16760

57. Bressi,J.C., Verlinde,C.L., Aronov,A.M., Shaw,M.L., Shin,S.S., Nguyen,L.N., Suresh,S., Buckner,F.S., Van Voorhis,W.C., Kuntz,I.D., Hol,W.G., & Gelb,M.H. (2001) Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. J. Med. Chem., 44, 2080-2093. #17036

58. Brockunier,L.L., Candelore,M.R., Cascieri,M.A., Liu,Y., Tota,L., Wyvratt,M.J., Fisher,M.H., Weber,A.E., & Parmee,E.R. (2001) Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties. Bioorg. Med. Chem. Lett., 11, 379-382. #17057

59. Brouwer,A.J., Mulders,S.J.E., & Liskamp,R.M.J. (2001) Convergent synthesis and diversity of amino acid based dendrimers. Eur. J. Org. Chem., 1903-1915. #16763

60. Brummer,O., Clapham,B., & Janda,K.D. (2001) Solid-phase synthesis of oligoesters using a JandaJelTM resin. Tetrahedron Lett., 42, 2257-2259. #16577

61. Bugli,F., Bastidas,R., Burton,D.R., Williamson,R.A., Clementi,M., & Burioni,R. (2001) Molecular profile of a human monoclonal antibody Fab fragment specific for Epstein-Barr virus gp350/220 antigen. Hum. Immunol., 62, 362-367. #16764

62. Bunyapaiboonsri,T., Ramstrom,O., Lohmann,S., Lehn,J.M., Peng,L., & Goeldner,M. (2001) Dynamic deconvolution of a pre-equilibrated dynamic combinatorial library of acetylcholinesterase inhibitors. Chembiochem, 2, 438-444. #16766

63. Burgess,K., Han,I., Zhang,A., Zheng,W.H., Shanmugam,K., Featherstone,M.S., & Saragovi,H.U. (2001) DiSSiMiL: Diverse Small Size Mini-Libraries applied to simple and rapid epitope mapping of a monoclonal antibody. J. Pept. Res., 57, 68-76. #16259

64. Castagnoli,L., Zucconi,A., Quondam,M., Rossi,M., Vaccaro,P., Panni,S., Paoluzi,S., Santonico,E., Dente,L., & Cesareni,G. (2001) Alternative bacteriophage display systems. Comb. Chem. High Throughput Screening, 121-133. #16703

65. Cawse,J.N. (2001) Experimental strategies for combinatorial and high-throughput materials development. Account. Chem. Res., 34, 213-221. #16644

66. Chakraborty,T.K. (2001) Future directions in organic synthesis? J. Ind. Chem. Soc., 78, 211-223. #16768

67. Chang,H. & Xiang,X.D. (2001) Studies of ferroelectric/dielectric materials using combinatorial materials chips. In I.Sucholeiki (Ed.), High-Throughput Synthesis. (pp. 251-263). Marcel Dekker, Inc., New York. #16469

68. Chataigner,I., Gennari,C., Ongeri,S., Piarulli,U., & Ceccarelli,S. (2001) Discovery of a new efficient chiral ligand for copper-catalyzed enantioselective Michael additions by high-throughput screening of a parallel library. Chem. Eur. J., 7, 2628-2634. #16772

69. Chaturvedi,S., Fisher,P.V., Otteson,K.M. & Bergot,B.J. (2001) Automated robotic parallel synthesis of a small-molecule library using multistep reactions on solid support. In I.Sucholeiki (Ed.), High-Throughput Synthesis. (pp. 169-186). Marcel Dekker, Inc., New York. #16462

70. Chauhan,P.M.S., & Srivastava,S.K. (2001) Recent developments in the combinatorial synthesis of nitrogen heterocycles using solid phase technology. Comb. Chem. High Throughput Screening, 4, 35-51. #16664

71. Chen,J.J., Golebiowski,A., McClenaghan,J., Klopfenstein,S.R., & West,L. (2001) Universal Rink-isonitrile resin: Application for the traceless synthesis of 3-acylamino imidazo[1,2-a]pyridines. Tetrahedron Lett., 42, 2269-2271. #16578

72. Chhabra,S.R., Parekh,H., Khan,A.N., Bycroft,B.W., & Kellam,B. (2001) A Dde-based carboxy linker for solid-phase synthesis. Tetrahedron Lett., 42, 2189-2192. #16489

73. Cho,A., Glinka,T.W., Ludwikow,M., Fan,A.T., Wang,M., & Hecker,S.J. (2001) New anti-MRSA cephalosporins with a basic aminopyridine at the C-7 position. Bioorg. Med. Chem. Lett., 11, 137-140. #17098

74. Choi,Y.H., Rho,W.S., Kim,N.D., Park,S.J., Shin,D.H., Kim,J.W., Im,S.H., Won,H.S., Lee,C.W., Chae,C.B., & Sung,Y.C. (2001) Short peptides with induced beta-turn inhibit the interaction between HIV-1 gp120 and CD4. J. Med. Chem., 44, 1356-1363. #16775

75. Chollet,A.M., Le Diguarher,T., Murray,L., Bertrand,M., Tucker,G.C., Sabatini,M., Pierr,A., Atassi,G., Bonnet,J., & Casara,P. (2001) General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors. Bioorg. Med. Chem. Lett., 11, 295-299. #17067

76. Cochran,A.G., Tong,R.T., Starovasnik,M.A., Park,E.J., McDowell,R.S., Theaker,J.E., & Skelton,N.J. (2001) A minimal peptide scaffold for beta-turn display: Optimizing a strand position in disulfide-cyclized beta-hairpins. J. Amer. Chem. Soc., 123, 625-632. #16264

77. Coffen,D.L., & Xiao,X.Y. (2001) A natural approach to combinatorial chemistry. Chim. Oggi, 19, 9-11. #16690

78. Colletti,S.L., Myers,R.W., Darkin-Rattray,S.J., Gurnett,A.M., Dulski,P.M., Galuska,S., Allocco,J.J., Ayer,M.B., Li,C., Lim,J., Crumley,T.M., Cannova,C., Schmatz,D.M., Wyvratt,M.J., Fisher,M.H., & Meinke,P.T. (2001) Broad spectrum antiprotozoal agents that inhibit histone deacetylase: Structure-activity relationships of apicidin. Part 2. Bioorg. Med. Chem. Lett., 11, 113-117. #17101

79. Colletti,S.L., Myers,R.W., Darkin-Rattray,S.J., Gurnett,A.M., Dulski,P.M., Galuska,S., Allocco,J.J., Ayer,M.B., Li,C., Lim,J., Crumley,T.M., Cannova,C., Schmatz,D.M., Wyvratt,M.J., Fisher,M.H., & Meinke,P.T. (2001) Broad spectrum antiprotozoal agents that inhibit histone deacetylase: Structure-activity relationships of apicidin. Part 1. Bioorg. Med. Chem. Lett., 11, 107-111. #17102

80. Collins,D.C., & Lee,M.L. (2001) Electrospray ionization gas-phase electrophoresis under ambient conditions and it's potential or high-speed separations. Fresenius J. Anal. Chem., 369, 225-233. #16778

81. Congreve,M.S., Ladlow,M., Marshall,P., Parr,N., Scicinski,J.J., Sheppard,T., Vickerstaffe,E., & Carr,R.A.E. (2001) Reporter resins for solid-phase chemistry. Organic Letters, 3, 507-510. #16780

82. Corbett,J.W., Pan,S., Markwalder,J.A., Cordova,B.C., Klabe,R.M., Garber,S., Rodgers,J.D., & Erickson-Viitanen,S.K. (2001) 3,3a-Dihydropyrano 4,3,2-de quinazolin-2(1H)-ones are potent non-nucleoside reverse transcriptase inhibitors. Bioorg. Med. Chem. Lett., 11, 211-214. #17092

83. Corbett,J.W., Kresge,K.J., Pan,S., Cordova,B.C., Klabe,R.M., Rodgers,J.D., & Erickson-Viitanen,S.K. (2001) Trifluoromethyl-containing 3-alkoxymethyl- and 3-aryloxymethyl-2-pyridinones are potent inhibitors of HIV-1 non-nucleoside reverse transcriptase. Bioorg. Med. Chem. Lett., 11, 309-312. #17065

84. Cousins,G.R.L., Furlan,R.L.E., Ng,Y.F., Redman,J.E., & Sanders,J.K.M. (2001) Identification and isolation of a receptor for N-methyl alkylammonium salts: Molecular amplification in a pseudo-peptide dynamic combinatorial library. Angew. Chem. Int. Ed., 40, 423-428. #16268

85. Cox,P.B., Loh,V.M.Jr., Monteils,C., Baxter,A.D., & Boyd,E.A. (2001) The solid phase synthesis of unsymmetrical phosphinic acids. Tetrahedron Lett., 42, 125-128. #16229

86. Crameri,R., & Kodzius,R. (2001) The powerful combination of phage surface display of cDNA libraries and high throughput screening. Comb. Chem. High Throughput Screening, 145-155. #16701

87. Curran,D.P., & Oderaotoshi,Y. (2001) Thiol additions to acrylates by fluorous mixture synthesis: Relative control of elution order in demixing by the fluorous tag and the thiol substituent. Tetrahedron, 57, 5243-5253. #16783

88. D'Mello,F., & Howard,C.R. (2001) An improved selection procedure for the screening of phage display peptide libraries. J. Immunol. Method, 247, 191-203. #16270

89. da Silva,A.J.M., Melo,P.A., Silva,M.N., Brito,F.V., Buarque,C.D., de Souza,D.V., Rodrigues,V.P., Pocas,E.S., Noel,F., Albuquerque,E.X., & Costa,P.R. (2001) Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation. Bioorg. Med. Chem. Lett., 11, 283-286. #17070

90. Dallavalle,S., Ferrari,A., Merlini,L., Penco,S., Carenini,N., De Cesare,M., Perego,P., Pratesi,G., & Zunino,F. (2001) Novel cytotoxic 7-iminomethyl and 7-aminomethyl derivatives of camtothecin. Bioorg. Med. Chem. Lett., 11, 291-294. #17068

91. de Julian-Ortiz,J.V. (2001) Virtual Darwinian drug design: QSAR inverse problem, virtual combinatorial chemistry, and computational screening. Comb. Chem. High Throughput Screening, 4, 295-310. #16786

92. de Lamotte,F., Boze,H., Blanchard,C., Klein,C., Moulin,G., Gautier,M.F., & Delsuc,M.A. (2001) NMR monitoring of accumulation and folding of N-15-labeled protein overexpressed in Pichia pastoris. Protein Express. Purif., 22, 318-324. #16788

93. De Lorenzi,E., Massolini,G., Molinari,P., Galbusera,C., Longhi,R., Marinzi,C., Consonni,R., & Chiari,M. (2001) Chiral capillary electrophoresis and nuclear magnetic resonance investigation on the structure-enantioselectivity relationship in synthetic cyclopeptides as chiral selectors. Electrophoresis, 22, 1373-1384. #16789

94. Dekker,N., Cox,R.C., Kramer,R.A., & Egmond,M.R. (2001) Substrate specificity of the integral membrane protease OmpT determined by spatially addressed peptide libraries. Biochemistry, 40, 1694-1701. #16271

95. Deo,S.K., & Daunert,S. (2001) Luminescent proteins from Aequorea victoria: Applications in drug discovery and in high throughput analysis. Fresenius J. Anal. Chem., 369, 258-266. #16791

96. Deroo,S., & Muller,C.P. (2001) Antigenic and immunogenic phage displayed mimotopes as substitute antigens: Applications and limitations. Comb. Chem. High Throughput Screening, 4, 75-110. #16675

97. Diaz,D.D., Yao,S., & Finn,M.G. (2001) Measurement of enantiomeric excess of amines by mass spectrometry following kinetic resolution with solid-phase chiral acylating agents. Tetrahedron Lett., 42, 2617-2619. #16609

98. Diggelmann,M., Ehrler,J., & Lutz,W. (2001) Parallel synthesis at Novartis Crop Protection: Concept and realization. ACS Symp. Ser., 774, 196-204. #16581

99. Diggelmann,M., Sporri,H., & Gassmann,E. (2001) Preparative LC/MS technology: A key component of the existing high speed synthesis platform at Syngenta. Chimia, 55, 23-25. #16793

100. Diller,D.J., & Merz,K.M. (2001) High throughput docking for library design and library prioritization. Proteins: Structure, Function and Genetics, 43, 113-124. #16794

101. Ding,X., Vera,M.D., Liang,B., Zhao,Y., Leonard,M.S., & Joulli,M.M. (2001) Structure-activity relationships of the side-chain modified didemnins. Bioorg. Med. Chem. Lett., 11, 231-234. #17088

102. Dolle,R.E. (2001) Comprehensive survey of combinatorial library synthesis: 1999. Mod. Drug Dis., 4, 43-48. #16433

103. Dolle,R.E., Herpin,T.F., & Shimshock,Y.C. (2001) Solid-phase synthesis of a-hydroxy phosphonates and hydroxystatine amides. Transition-state isosteres derived from resin-bound amino acid aldehydes. Tetrahedron Lett., 42, 1855-1858. #16482

104. Dorff,P.H., & Garigipati,R.S. (2001) Novel solid-phase preparation of 2,6,9-trisubstituted purines for combinatorial library generation. Tetrahedron Lett., 42, 2771-2773. #16605

105. Dorn,C.P., Finke,P.E., Oates,B., Budhu,R.J., Mills,S.G., MacCoss,M., Malkowitz,L., Springer,M.S., Daugherty,B.L., Gould,S.L., DeMartino,J.A., Siciliano,S.J., Carella,A., Carver,G., Holmes,K., Danzeisen,R., Hazuda,D., Kessler,J., Lineberger,J., Miller,M., Schleif,W.A., & Emini,E.A. (2001) Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part. 1. Discovery and initial structure-activity relationships for 1-amino-2-phenyl-4-(piperidin-1-yl)butanes. Bioorg. Med. Chem. Lett., 11, 259-264. #17083

106. Dyer,U.C., Shapland,P.D., & Tiffin,P.D. (2001) Preparation of enantiopure 4-arylmandelic acids via a Pd/C catalyzed Suzuki coupling of enantiopure 4-bromomandelic acid. Tetrahedron Lett., 42, 1765-1767. #16496

107. Eda,M., & Kurth,M.J. (2001) Solid-phase Zincke route to pyridinium, tetrahydropyridine, and piperidine derivatives: Vesamicol analogs. Tetrahedron Lett., 42, 2063-2068. #16486

108. Edwards,B.S., Kuckuck,F.W., Prossnitz,E.R., Ransom,J.T., & Sklar,L.A. (2001) HTPS flow cytometry: A novel platform for automated high throughput drug discovery and characterization. J. Biomol. Screen., 6, 83-90. #16798

109. Eguchi,M., Lee,M.S., Stasiak,M., & Kahn,M. (2001) Solid-phase synthesis and solution structure of bicyclic beta-turn peptidomimetics: Diversity at the i position. Tetrahedron Lett., 42, 1237-1239. #16281

110. Elokdah,H., Chai,S.Y., Ho,D., & Sulkowski,T. (2001) Design and synthesis of tricyclic derivatives as high density lipoprotein cholesterol enhancers. Bioorg. Med. Chem. Lett., 11, 339-342. #17063

111. Enjalbal,C., Maux,D., Martinez,J., Combarieu,R., & Aubagnac,J.L. (2001) Mass spectrometry and combinatorial chemistry: New approaches for direct support-bound compound identification. Comb. Chem. High Throughput Screening, 4, 363-373. #16800

112. Epstein,D.M., Choudhary,S., Churchill,M.R., Keil,K.M., Eliseev,A.V., & Morrow,J.R. (2001) Chloroform-soluble Schiff-base Zn(II) or Cd(II) complexes from a dynamic combinatorial library. Inorg. Chem., 40, 1591-1596. #16801

113. Fahey,M.S., Dawbarn,D., Allen,S.J., Paterson,I.C., & Prime,S.S. (2001) Expression of recombinant extracellular domain of the type II transforming growth factor-ss receptor: Utilization in a modified enzyme-linked immunoabsorbent assay to screen TGF-ss agonists and antagonists. Anal. Biochem., 290, 272-276. #16802

114. Falsey,J.R., Renil,M., Park,S., Li,S.J., & Lam,K.S. (2001) Peptide and small molecule microarray for high throughput cell adhesion and functional assays. Bioconjug. Chem., 12, 346-353. #16803

115. Fang,L., Pan,J., & Yan,B. (2001) High-throughput determination of identity, purity, and quantity of combinatorial library members using LC/MS/UV/ELSD. Biotechnol. Bioeng., 71, 162-171. #16650

116. Felten,C., Foret,F., Minarik,M., Goetzinger,W., & Karger,B.L. (2001) Automated high-throughput infusion ESI-MS with direct coupling to a microtiter plate. Anal. Chem., 73, 1449-1454. #16805

117. Fenwick,A.E., Gribble,A.D., Ife,R.J., Stevens,N., & Witherington,J. (2001) Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K. Bioorg. Med. Chem. Lett., 11, 199-202. #17094

118. Fenwick,A.E., Garnier,B., Gribble,A.D., Ife,R.J., Rawlings,A.D., & Witherington,J. (2001) Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K. Bioorg. Med. Chem. Lett., 11, 195-198. #16283

119. Finke,P.E., Meurer,L.C., Oates,B., Mills,S.G., MacCoss,M., Malkowitz,L., Springer,M.S., Daugherty,B.L., Gould,S.L., DeMartino,J.A., Siciliano,S.J., Carella,A., Carver,G., Holmes,K., Danzeisen,R., Hazuda,D., Kessler,J., Lineberger,J., Miller,M., Schleif,W.A., & Emini,E.A. (2001) Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part. 2. Structure-activity relationships for substituted 2-aryl-1-N-(methyl)-N-(phenylsulfonyl)amino-4-(piperidin-1-yl)butanes. Bioorg. Med. Chem. Lett., 11, 265-270. #17082

120. Firooznia,F., Gude,C., Chan,K., Fink,C.A., Qiao,Y., Satoh,Y., Macropoulos,N., Savage,P., Beil,M.E., Bruseo,C.W., Trapani,A.J., & Jeng,A.Y. (2001) Synthesis and biological activity of novel potent endothelin-converting enzyme-1 inhibitors. Bioorg. Med. Chem. Lett., 11, 375-378. #17058

121. Fisch,I. (2001) Peptide display in functional genomics. Comb. Chem. High Throughput Screening, 157-169. #16700

122. Flicker,S., Vrtala,S., Steinberger,P., Vangelista,L., Kraft,D., & Valenta,R. (2001) A highly allergenic fragment of the major timothy grass pollen allergen, Phl p 5, defined by a human monoclonal IgE antibody. Int. Arch. Allergy Immunol., 124, 80-84. #16807

123. Fox,S.J., & Khoury,R. (2001) HTS laboratories expand responsibilities. Chim. Oggi, 19, 12-14. #16691

124. Frick,S., Ounaroon,A., & Kutchan,T.M. (2001) Combinatorial biochemistry in plants: The case of O-methyltransferases. Phytochemistry, 56, 1-4. #16285

125. Fruchtel,J.S., Pflugseder,K., & Gstach,H. (2001) Symmetric building blocks and combinatorial functional group transformation as versatile strategies in combinatorial chemistry. Biotechnol. Bioeng., 71, 94-103. #16648

126. Fujii,I., Takaoka,Y., Suzuki,K., & Tanaka,T. (2001) A conformationally purified a-helical peptide library. Tetrahedron Lett., 42, 3323-3325. #16570

127. Funakubo,H., He,G., & Iijima,T. (2001) Combinatorial approach for ferroelectric thin film using solution based process. Proc. SPIE Int. Soc. Opt. Eng., 4281, 77-86. #17114

128. Galietta,L.J., Springsteel,M.F., Eda,M., Niedzinski,E.J., By,K., Haddadin,M.J., Kurth,M.J., Nantz,M.H., & Verkman,A.S. (2001) Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds. Journal of Biological Chemistry, 276, 19723-19728. #16695

129. Ganglberger,E., Grunberger,K., Wiedermann,U., Vermes,M., Sponer,B., Breiteneder,H., Scheiner,O., Boltz,G., & Jensen-Jarolim,E. (2001) IgE mimotopes of birch pollen allergen Bet v 1 induce blocking IgG in mice. Int. Arch. Allergy Immunol., 124, 395-397. #16809

130. Gao,H. (2001) Application of BCUT metrics and genetic algorithm in binary QSAR analysis. Journal of Chemical Information and Computer Sciences, 41, 402-407. #16673

131. Gaskin,D.J.H., Starck,K., Turner,N.A., & Vulfson,E.N. (2001) Phage display combinatorial libraries of short peptides: Ligand selection for protein purification. Enzyme Microb. Technol., 28, 766-772. #16810

132. Gazarian,K.G., Rowley,M.J., Gazarian,T.G., Sotelo,J., Garcia-Mendoza,E., & Hernandez,R. (2001) Post-panning computer-aided analysis of phagotope collections selected with neurocysticercosis patient polyclonal antibodies: Separation of disease-relevant and irrelevant peptide sequence. Comb. Chem. High Throughput Screening, 221-235. #17041

133. Geginat,G., Schenk,S., Skoberne,M., Goebel,W., & Hof,H. (2001) A novel approach of direct ex vivo epitope mapping identifies dominant and subdominant CD4 and CD8 T cell epitopes from Listeria monocytogenes. Journal of Immunology, 166, 1877-1884. #16288

134. Gellerman,G., Elgavi,A., Salitra,Y., & Kramer,I. (2001) Facile synthesis of orthogonally protected amino acid building blocks for combinatorial N-backbone cyclic peptide chemistry. J. Pept. Res., 57, 277-291. #16812

135. Ghosh,A.K., Hol,W.G., & Fan,E. (2001) Solid-phase synthesis of N-acyl-N'-alkyl/aryl disubstituted guanidines. J. Org. Chem., 66, 2161-2164. #17047

136. Gilden,D.H., Burgoon,M.P., Kleinschmidt-DeMasters,B.K., Williamson,R.A., Ghausi,O., Burton,D.R., & Owens,G.P. (2001) Molecular immunologic strategies to identify antigens and B-cell responses unique to multiple sclerosis. Archives of Neurology, 58, 43-48. #16290

137. Glass,B.M. & Combs,A.P. (2001) Rapid parallel synthesis utilizing microwave irradiation. In I.Sucholeiki (Ed.), High-Throughput Synthesis. (pp. 123-128). Marcel Dekker, Inc., New York. #16456

138. Gless,R.D., Fisher,K.J., & James,D.R. (2001) Combinatorial chemistry in the agrochemical discovery process at Zeneca. ACS Symp. Ser., 774, 214-225. #16555

139. Golebiowski,A., Klopfenstein,S.R., & Portlock,D.E. (2001) Lead compounds discovered from libraries. Curr. Opin. Chem. Biol., 5, 273-284. #16817

140. Gopalsamy,A., & Yang,H. (2001) Combinatorial synthesis of heterocycles: Solid-phase synthesis of 6-amino-2,4-dioxo-3,4-dihydro-1,3,5-triazine derivatives. Journal of Combinatorial Chemistry, 3, 278-283. #16625

141. Goral,V., Nelen,M.I., Eliseev,A.V., & Lehn,J.M. (2001) Double-level "orthogonal" dynamic combinatorial libraries on transition metal template. Proc. Natl. Acad. Sci. USA, 98, 1347-1352. #16291

142. Grabherr,R., & Ernst,W. (2001) The baculovirus expression system as a tool for generating diversity by viral surface display. Comb. Chem. High Throughput Screening, 185-192. #16698

143. Green,L.S., Bell,C., & Janjic,N. (2001) Aptamers as reagents for high-throughput screening. BioTechniques, 30, 1094. #16822

144. Grell,D., Richardson,J.S., & Mutter,M. (2001) Protein design and folding: Template trapping of self-assembled helical bundles. J. Peptide Sci., 146-151. #17075

145. Grether,U., & Waldmann,H. (2001) An enzyme-labile safety catch linker for synthesis on a soluble polymeric support. Chem. Eur. J., 7, 959-971. #16823

146. Grieco,P., Gitu,P.M., & Hruby,V.J. (2001) Preparation of 'side-chain-to-side-chain' cyclic peptides by allyl and alloc strategy: Potential for library synthesis. J. Pept. Res., 57, 250-256. #16618

147. Groth,T., & Meldal,M. (2001) N-Terminal peptide aldehydes as electrophiles in combinatorial solid phase synthesis of novel peptide isosteres. Journal of Combinatorial Chemistry, 3, 45-63. #16140

148. Groth,T., & Meldal,M. (2001) Synthesis of aldehyde building blocks protected as acid labile N-Boc N,O-acetals: Toward combinatorial solid phase synthesis of novel peptide isosteres. Journal of Combinatorial Chemistry, 3, 34-44. #16139

149. Grotli,M., Rademan,J., Groth,T., Lubell,W.D., Miranda,L.P., & Meldal,M. (2001) Surfactant mediated cationic and anionic suspension polymerization of PEG-based resins in silicon oil: Beaded SPOCC 1500 and POEPOP 1500. Journal of Combinatorial Chemistry, 3, 28-33. #16138

150. Gulini,U., Angeli,P., Marucci,G., Buccioni,M., Giardina,D., Antolini,L., Franchini,S., Sorbi,C., & Brasili,L. (2001) Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of 1-(2,2-diphenyl-1,3-dioxan-4-yl)-ethyl-dimethyl-amine. Bioorg. Med. Chem. Lett., 11, 247-250. #17085

151. Guo,Z., & Schultz,A.G. (2001) Reactions of 4,4'-difluoro-biphenyl-3,3'-dicarboxylic acid dimethyl ester with amino alcohols. A convenient route to biphenyl tetra-alcohols. Tetrahedron Lett., 42, 1603-1606. #16491

152. Gustafsson,M., Olsson,R., & Andersson,C.M. (2001) General combinatorial synthesis of tertiary amines on solid support. A novel conditional release strategy based on traceless linking at nitrogen. Tetrahedron Lett., 42, 133-136. #16230

153. Haag,R. (2001) Dendrimers and hyperbranched polymers as high-loading supports for organic synthesis. Chem. Eur. J., 7, 327-335. #16296

154. Hall,D.G., Manku,S., & Wang,F. (2001) Solution- and solid-phase strategies for the design, synthesis, and screening of libraries based on natural product templates: A comprehensive survey. Journal of Combinatorial Chemistry, 3, 125-150. #16497

155. Hann,M.M., Leach,A.R., & Harper,G. (2001) Molecular complexity and its impact on the probability of finding leads for drug discovery. Journal of Chemical Information and Computer Sciences, 41, 856-864. #16828

156. Hansen,M.H., Ostenstad,B., & Sioud,M. (2001) Antigen-specific IgG antibodies in stage IV long-time survival breast cancer patients. Molecular Medicine, 7, 230-239. #16829

157. Hansson,M., Samuelson,P., Gunneriusson,E., & Stahl,S. (2001) Surface display on gram positive bacteria. Comb. Chem. High Throughput Screening, 4, 171-184. #16699

158. Hany,R., Rentsch,D., Dhanapal,B., & Obrecht,D. (2001) Quantitative determination of resin loading in solid-phase organic synthesis using 13C MAS NMR. Journal of Combinatorial Chemistry, 3, 85-89. #16145

159. Hardcastle,I.R., Barber,A.M., Marriott,J.H., & Jarman,M. (2001) Polymer-assisted solution-phase library synthesis of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids. Tetrahedron Lett., 42, 1363-1365. #16414

160. He,B., Li,H., Ou,Z., Shi,Z., Xu,M., Xu,M., & Yu,S. (2001) Combinatorial synthesis and screening of polystyrene-supported quaternary ammonium salt phase transfer catalysts. Reactive and Functional Polymers, 48, 85-95. #16639

161. Heine,N., Germeroth,L., Schneider-Mergener,J., & Wenschuh,H. (2001) A modular approach to the SPOT synthesis of 1,3,5-trisubstituted hydantoins on cellulose membranes. Tetrahedron Lett., 42, 227-230. #16183

162. Heinelt,U., Herok,S., Matter,H., & Wildgoose,P. (2001) Solid-phase optimisation of achiral amidinobenzyl indoles as potent and selective factor Xa inhibitors. Bioorg. Med. Chem. Lett., 11, 227-230. #17089

163. Henlin,J.M., Boutin,J.A., Kucharczyk,N., Desmet-Beaufort,C., Loynel,A., Bertrand,M., Genton,A., Tucker,G.C., Atassi,G., & Fauchere,J.L. (2001) From peptide libraries to optimized nonpeptide ligands in the search for S-farnesyltransferase inhibitors. J. Pept. Res., 57, 85-96. #16425

164. Henlin,J.M., Boutin,J.A., Duchene-Roger,F., Nicolas,J.P., Desmet-Beaufort,C., Levens,N., & Fauchere,J.L. (2001) Parallel synthesis and pharmacological screening of nonpeptide ligands of the neuropeptide Y receptor subtype Y-5. J. Pept. Res., 57, 419-427. #16832

165. Heras,M., Ventura,M., Linden,A., & Villalgordo,J.M. (2001) Reaction of alpha-iminomethylene amino esters with mono- and bidentate nucleophiles: A straightforward route to 2-amino-1H-5-imidazolones. Tetrahedron, 57, 4371-4388. #16833

166. Hiemstra,H.S., Schloot,N.C., Van Veelen,P.A., Willemen,S.J.M., Franken,K.L.M.C., van Rood,J.J., de Vries,R.R.P., Chaudhuri,A., Behan,P.O., Drijfhout,J.W., & Roep,B.O. (2001) Cytomegalovirus in autoimmunity: T cell crossreactivity to viral antigen and autoantigen glutamic acid decarboxylase. Proc. Natl. Acad. Sci. USA, 98, 3988-3991. #16835

167. Hijikuro,I., Doi,T., & Takahashi,T. (2001) Parallel synthesis of a vitamin D-3 library in the solid-phase. J. Amer. Chem. Soc., 123, 3716-3722. #16836

168. Hilty,P., Hubschwerlen,C., & Thomas,A.W. (2001) Expeditious solution phase synthesis of fluoroquinolone antibacterial agents using polymer supported reagents. Tetrahedron Lett., 42, 1645-1646. #16493

169. Hodge,C.N., Bousse,L. & Knapp,M.R. (2001) Microfluidic analysis, screening, and synthesis. In I.Sucholeiki (Ed.), High-Throughput Synthesis. (pp. 303-330). Marcel Dekker, Inc., New York. #16474

170. Hoeprich,P.D.Jr. (2001) Automating high-throughput organic synthesis. In I.Sucholeiki (Ed.), High-Throughput Synthesis. (pp. 157-167). Marcel Dekker, Inc., New York. #16461

171. Hoffren,A.M., Murray,C.M., & Hoffmann,R.D. (2001) Structure-based focusing using pharmacophores derived from the active site of 17beta-hydroxysteroid dehydrogenase. Current Pharmaceutical Design, 547-566. #17073

172. Holzem,A., Nahring,J.M., & Fischer,R. (2001) Rapid identification of a tobacco mosaic virus epitope by using a coat protein gene-fragment-pVIII fusion library. J. Gen. Virol., 82, 9-15. #16302

173. Horrobin,D.F. (2001) New drug discovery techniques are not so revolutionary. BMJ, 322, 239. #16588

174. Hu,J.Y., Le,Y.Y., Gong,W.H., Dunlop,N.M., Gao,J.L., Murphy,P.M., & Wang,J.M. (2001) Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1. Journal of Leukocyte Biology, 70, 155-161. #16838

175. Hu,Y., Meuillet,E.J., Berggren,M., Powis,G., & Kozikowski,A.P. (2001) 3-Deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth. Bioorg. Med. Chem. Lett., 11, 173-176. #17096

176. Hu,Y., Baudart,S. & Porco,J.A.Jr. (2001) Multistep synthesis of 1,2,3-thiadiazoles using "Catch and release". In I.Sucholeiki (Ed.), High-Throughput Synthesis. (pp. 215-222). Marcel Dekker, Inc., New York. #16466

177. Hu,Y., & Yang,Z. (2001) Palladium-mediated intramolecular carbonylative annulation of o-alkynylphenols to synthesiza benzo b furo 3,4-d furan-1-ones. Organic Letters, 1387-1390. #17042

178. Huang,C.F., De Sanctis,G.T., O'Brien,P.J., Mizgerd,J.P., Friend,D.S., Drazen,J.M., Brass,L.F., & Stevens,R.L. (2001) Evaluation of the substrate specificity of human mast cell tryptase beta I and demonstration of its importance in bacterial infections of the lung. Journal of Biological Chemistry, 276, 26276-26284. #16839

179. Huang,K.T., & Sun,C.M. (2001) Liquid-phase parallel synthesis of ureas. Bioorg. Med. Chem. Lett., 11, 271-273. #17081

180. Huc,I., & Nguyen,R. (2001) Dynamic combinatorial chemistry. Comb. Chem. High Throughput Screening, 4, 53-74. #16655

181. Hughes,I., & Hunter,D. (2001) Techniques for analysis and purification in high-throughput chemistry. Curr. Opin. Chem. Biol., 5, 243-247. #16840

182. Hull,R.D., Singh,S.B., Nachbar,R.B., Sheridan,R.P., Kearsley,S.K., & Fluder,E.M. (2001) Latent semantic structure indexing (LaSSI) for defining chemical similarity. J. Med. Chem., 44, 1177-1184. #17077

183. Hurskainen,P., Ollikka,P., Karvinen,J., & Hemmila,I. (2001) Time-resolved fluorometry in bioanalytical assays. Chim. Oggi, 19, 22-24. #16694

184. Huuskonen,J. (2001) Estimation of aqueous solubility in drug design. Comb. Chem. High Throughput Screening, 311-316. #17039

185. Iimura,S., Uoto,K., Ohsuki,S., Chiba,J., Yoshino,T., Iwahana,M., Jimbo,T., Terasawa,H., & Soga,T. (2001) Orally active docetaxel analogue: Synthesis of 10-deoxy-10-C-morpholinoethyl docetaxel analogues. Bioorg. Med. Chem. Lett., 11, 407-410. #17053

186. Ijaz,T., Tran,P., Ruparelia,K.C., Teesdale-Spittle,P.H., Orr,S., & Patterson,L.H. (2001) Anthraquinone-peptides as inhibitors of AP-1 transcription factor. Bioorg. Med. Chem. Lett., 11, 351-353. #17061

187. Ingelman-Sundberg,M. (2001) Implications of polymorphic cytochrome P450-dependent drug metabolism for drug development. Drug Metabolism and Disposition, 29, 570-573. #16841

188. Inoue,S. (2001) Approach to new glasses through combinatorial chemistry. Kino Zairyo, 21, 23-29. #16479

189. Iorio,E.J., Shao,Y.F., Chen,C.T., Wagner,H., & Still,W.C. (2001) Sequence-selective peptide detection by small synthetic chemosensors selected from an encoded combinatorial chemosensor library. Bioorg. Med. Chem. Lett., 11, 1635-1638. #16842

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191. Irving,M.B., Pan,O., & Scott,J.K. (2001) Random-peptide libraries and antigen-fragment libraries for epitope mapping and the development of vaccines and diagnostics. Curr. Opin. Chem. Biol., 5, 314-324. #16844

192. Isacsson,J., & Westman,G. (2001) Solid-phase synthesis of asymmetric cyanine dyes. Tetrahedron Lett., 42, 3207-3210. #16571

193. Isalan,M., Patel,S.D., Balasubramanian,S., & Choo,Y. (2001) Selection of zinc fingers that bind single-stranded telomeric DNA in the G-quadruplex conformation. Biochemistry, 40, 830-836. #16587

194. Iwata,Y., Arisawa,M., Hamada,R., Kita,Y., Mizutani,M.Y., Tomioka,N., Itai,A., & Miyamoto,S. (2001) Discovery of novel aldose reductase inhibitors using a protein structure-based approach: 3D-Database search followed by design and synthesis. J. Med. Chem., 44, 1718-1728. #16647

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196. Jenne,A., Hartig,J.S., Piganeau,N., Tauer,A., Samarsky,D.A., Green,M.R., Davies,J., & Famulok,M. (2001) Rapid identification and characterization of hammerhead-ribozyme inhibitors using fluorescence-based technology. Nat. Biotech., 19, 56-61. #16307

197. Jeong,S., Eom,T.Y., Kim,S.J., Lee,S.W., & Yu,J. (2001) In vitro selection of the RNA aptamer against the Sialyl Lewis X and its inhibition of the cell adhesion. Biochem. Biophys. Res. Commun., 281, 237-243. #16847

198. Jiang,Y., & Lee,C.S. (2001) On-line coupling of hollow fiber membranes with electrospray ionization mass spectrometry for continuous affinity selection, concentration and identification of small-molecule libraries. J. Mass Spectrom., 36, 664-669. #16848

199. Jimonet,P., Bohme,G.A., Bouquerel,J., Boireau,A., Damour,D., Debono,M.W., Genevois-Borella,A., Hardy,J.C., Hubert,P., Manfre,F., Nemecek,P., Pratt,J., Randle,J.C., Ribeill,Y., Stutzmann,J.M., Vuilhorgne,M., & Mignani,S. (2001) Bioisosteres of 9-carboxymethyl-4-oxo-imidazo 1,2-a indeno-1,2-e pyrazin-2-carboxylic acid derivatives. Progress toward selective, potent in vivo AMPA antagonists with longer durations of action. Bioorg. Med. Chem. Lett., 11, 127-132. #17099

200. Jin,J., Graybill,T.L., Wang,M.A., Davis,L.D., & Moore,M.L. (2001) Convenient preparation of 4-formyl-3,5-dimethoxyphenol and its incorporation into linkers and resins for solid-phase synthesis. Journal of Combinatorial Chemistry, 3, 97-101. #16147

201. Jin,Y., Chen,X., Cote,M., Roland,A., Korba,B., Mounir,S., & Iyer,R.P. (2001) Parallel solid-phase synthesis of nucleoside phosphoramidate libraries. Bioorg. Med. Chem. Lett., 11, 2057-2060. #17107

202. Kamal,A., Reddy,G.S.K., & Raghavan,S. (2001) Solid-phase synthesis of pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones. Bioorg. Med. Chem. Lett., 11, 387-389. #16308

203. Kang,K.H., Pae,A.N., Choi,K.I., Cho,Y.S., Chung,B.Y., Lee,J.E., Jung,S.H., Koh,H.Y., & Lee,H.Y. (2001) Solution-phase combinatorial synthesis of isoxazolines and isoxazoles using [2+3] cycloaddition rezction of nitrile oxides. Tetrahedron Lett., 42, 1057-1060. #16415

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205. Kappe,C.O. (2001) Speeding up solid-phase chemistry by microwave irradiation: A tool for high-throughput synthesis. Amer. Lab., 33, 13. #16849

206. Karan,C., & Miller,B.L. (2001) RNA-Selective coordination complexes identified via dynamic combinatorial chemistry. J. Amer. Chem. Soc., 123, 7455-7456. #17072

207. Kashiwada,Y., Chiyo,J., Ikeshiro,Y., Nagao,T., Okabe,H., Cosentino,L.M., Fowke,K., & Lee,K.H. (2001) 3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents. Bioorg. Med. Chem. Lett., 11, 183-185. #17095

208. Kassel,D.B. (2001) Combinatorial chemistry and mass spectrometry in the 21st century drug discovery laboratory. Chem. Rev., 101, 255-267. #16428

209. Katritzky,A.R., Pastor,A., Voronkov,M., & Tymoshenko,D. (2001) Polymer-supported triazole and benzotriazole leaving groups. Three new examples and a comparison of their efficiency. Journal of Combinatorial Chemistry, 3, 167-170. #16501

210. Kay,B.K., Kasanov,J., & Yamabhai,M. (2001) Screening phage-displayed combinatorial peptide libraries. Methods (Duluth), 24, 240-246. #16850

211. Keilty,A.T., Vavilin,D.V., & Vermaas,W.F. (2001) Functional analysis of combinatorial mutants with changes in the C-terminus of the CD loop of the D2 protein in photosystem II of Synechocystis sp. PCC 6803. Biochemistry, 40, 4131-4139. #16643

212. Kilburn,J.P., Lau,J., & Jones,R.C.F. (2001) 1,3,4-Oxadiazole formation: A novel solid support strategy. Tetrahedron Lett., 42, 2583-2586. #16575

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323. Oliver,W.R., Shenk,J.L., Snaith,M.R., Russell,C.S., Plunket,K.D., Bodkin,N.L., Lewis,M.C., Winegar,D.A., Sznaidman,M.L., Lambert,M.H., Xu,H.E., Sternbach,D.D., Kliewer,S.A., Hansen,B.C., & Willson,T.M. (2001) A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc. Natl. Acad. Sci. USA, 98, 5306-5311. #16912

324. Ongeri,S., Piarulli,U., Jackson,R.F.W., & Gennari,C. (2001) Optimization of new chiral ligands for the copper-catalysed enantioselective conjugate addition of Et2Zn to nitroolefins by high-throughput screening of a parallel library. Eur. J. Org. Chem., 803-807. #16913

325. Oprea,T.I., & Gottfries,J. (2001) Chemography: The art of navigating in chemical space. Journal of Combinatorial Chemistry, 3, 157-166. #16500

326. Orain,D., & Bradley,M. (2001) Solid phase synthesis of trypanothione reductase inhibitors. Towards single bead screening. Tetrahedron Lett., 42, 515-518. #16180

327. Organ,M.G., Mayhew,D., Cooper,J.T., Dixon,C.E., Lavorato,D.J., Kaldor,S.W., & Siegel,M.G. (2001) Solution phase synthesis of libraries of variably substituted olefin scaffolds: A library of allylic amines. Journal of Combinatorial Chemistry, 3, 64-67. #16141

328. Osterberg,T., & Norinder,U. (2001) Prediction of drug transport processes using simple parameters and PLS statistics. The use of ACD/logP and ACD/ChemSketch descriptors. European Journal of Pharmaceutical Sciences, 12, 327-337. #16656

329. Ostuni,E., Chen,C.S., Ingber,D.E., & Whitesides,G.M. (2001) Selective deposition of proteins and cells in arrays of microwells. Langmuir, 17, 2828-2834. #16915

330. Pan,L., Ho,Q., Tsutsui,K., & Takahashi,L. (2001) Comparison of chromatographic and spectroscopic methods used to rank compounds for aqueous solubility. J. Pharm. Sci., 90, 521-529. #16916

331. Papac,D.I., & Shahrokh,Z. (2001) Mass spectrometry innovations in drug discovery and development. Pharmaceut. Res., 18, 131-145. #16917

332. Park,C., & Burgess,K. (2001) Facile macrocyclizations to b-turn mimics with diverse structural, physical, and conformational properties. Journal of Combinatorial Chemistry, 3, 257-266. #16623

333. Park,K.H., Ehrler,J., Spoerri,H., & Kurth,M.J. (2001) Preparation of a 990-member chemical compound library of hydantoin- and isoxazoline-containing heterocycles using multipin technology. Journal of Combinatorial Chemistry, 3, 171-176. #16502

334. Parlow,J.J., Dice,T.A. & South,M.S. (2001) Polymer-assisted solution phase synthesis of a-ketoamides. In I.Sucholeiki (Ed.), High-Throughput Synthesis. (pp. 143-151). Marcel Dekker, Inc., New York. #16459

335. Patel,A., & Lindhorst,T.K. (2001) A modular approach for the synthesis of oligosaccharide mimetics. J. Org. Chem., 66, 2674-2680. #16708

336. Pattarawarapan,M., Chen,J., Steffensen,M., & Burgess,K. (2001) A rigid linker-scaffold for solid-phase synthesis of dimeric pharmacophores. Journal of Combinatorial Chemistry, 3, 102-116. #16148

337. Pavia,M.R. (2001) High-throughput organic synthesis: A perspective looking back on 10 years of combinatorial chemistry. In I.Sucholeiki (Ed.), High-Throughput Synthesis. (pp. 43-53). Marcel Dekker, Inc., New York. #16449

338. Peelle,B., Lorens,J., Li,W.Q., Bogenberger,J., Payan,D.G., & Anderson,D.C. (2001) Intracellular protein scaffold-mediated display of random peptide libraries for phenotypic screens in mammalian cells. Chem. Biol., 8, 521-534. #16920

339. Pender,B.A., Wu,X., Axelsen,P., & Cooperman,B.S. (2001) Toward a rational design of peptide inhibitors of ribonucleotide reductase: Structure-function and modeling studies. J. Med. Chem., 44, 36-46. #16527

340. Pereboev,A.V., Ahmed,N., Man,N.T., & Morris,G.E. (2001) Epitopes in the interacting regions of beta-dystroglycan (PPxY motif) and dystrophin (WW domain). Biochimica et Biophysica Acta - General Subjects, 1527, 54-60. #16922

341. Perez,J.M. (2001) Methods of analysis to determine the progress of a chemical reaction on solid support. In I.Sucholeiki (Ed.), High-Throughput Synthesis. (pp. 27-39). Marcel Dekker, Inc., New York. #16448

342. Petersen,G., Hahn,C., & Gehring,U. (2001) Dissection of the ATP-binding domain of the chaperone hsc70 for interaction with the cofactor Hap46. Journal of Biological Chemistry, 276, 10178-10184. #16923

343. Petrassi,H.M., Sharpless,K.B., & Kelly,J.W. (2001) The copper-mediated cross-coupling of phenylboronic acids and N-hydroxyphthalimide at room temperature: Synthesis of aryloxyamines. Organic Letters, 139-142. #17035

344. Pichurin,P., Guo,J., Yan,X.M., Rapoport,B., & McLachlan,S.M. (2001) Human monoclonal autoantibodies to B-cell epitopes outside the thyroid peroxidase autoantibody immunodominant region. Thyroid, 11, 301-313. #16925

345. Pinciroli,V., Biancardi,R., Colombo,N., Colombo,M., & Rizzo,V. (2001) Characterization of small combinatorial chemistry libraries by (1)H NMR. Quantitation with a convenient and novel internal standard. Journal of Combinatorial Chemistry, 434-440. #17104

346. Pinder,R.M. (2001) On the feasibility of designing new antidepressants. Human Psychopharmacology, 16, 53-59. #16926

347. Pinilla,C., Rubio-Godoy,V., Dutoit,V., Guillaume,P., Simon,R., Zhao,Y.D., Houghten,R.A., Cerottini,J.C., Romero,P., & Valmori,D. (2001) Combinatorial peptide libraries as an alternative approach to the identification of ligands for tumor-reactive cytolytic T lymphocytes. Cancer Res., 61, 5153-5160. #16927

348. Piro,J., Rubiralta,M., Giralt,E., & Diez,A. (2001) Solid phase synthesis of enantiomerically pure polyhydroxyvalerolactams. Tetrahedron Lett., 42, 871-873. #16232

349. Pirrung,M.C., & Pansare,S.V. (2001) Trityl isothiocyanate support for solid-phase synthesis. Journal of Combinatorial Chemistry, 3, 90-96. #16146

350. Pitcovsky,T.A., Mucci,J., Alvarez,P., Leguizamon,M.S., Burrone,O., Alzari,P.M., & Campetella,O. (2001) Epitope mapping of trans-sialidase from Trypanosoma cruzi reveals the presence of several cross-reactive determinants. Infec. Immunity, 69, 1869-1875. #16928

351. Pitsinos,E.N., Lehn,J.M., & De Cian,A. (2001) Vicinal tetraamines of defined geometry: Potential scaffolds for assembly. Helv. Chim. Acta, 84, 22-31. #16361

352. Poirot,E., Zhang,X., Whittaker,N.F., & Kovac,P. (2001) Syntheses of the L-manno and some other analogs of the terminal determinants of the O-PS of Vibrio cholerae O:1. Carbohyd. Res., 330, 6-20. #17128

353. Poloni,F., Puddu,P., Moretti,F., Flego,M., Romagnoli,G., Tombesi,M., Capone,I., Chersi,A., Feleci,F., & Cianfriglia,M. (2001) Identification of a LFA-1 region involved in the HIV-1-induced syncytia formation through phage-display technology. Eur. J. Immunol., 31, 57-63. #16362

354. Poulain,R.F., Tartar,A.L., & Deprez,B.P. (2001) Parallel synthesis of 1,2,4-oxadiazoles from carboxylic acids using an improved, uronium-based, activation. Tetrahedron Lett., 42, 1495-1498. #16422

355. Poupart,M.A., Cameron,D.R., Chabot,C., Ghiro,E., Goudreau,N., Goulet,S., Poirier,M., & Tsantrizos,Y.S. (2001) Solid-phase synthesis of peptidomimetic inhibitors for the hepatitis C virus NS3 protease. J. Org. Chem., 66, 4743-4751. #16932

356. Price,C.P. (2001) Application of chemistry to in vitro diagnostic tests. Chem. Soc. Rev., 30, 1-7. #16363

357. Prince,B.J., Schwabacher,A.W., & Geissinger,P. (2001) A readout scheme providing high spatial resolution for distributed fluorescent sensors on optical fibers. Anal. Chem., 73, 1007-1015. #16934

358. Prokai,L., Prokai-Tatrai,K., Zharikova,A., Li,X., & Rocca,J.R. (2001) Combinatorial lead optimization of a neuropeptide FF antagonist. J. Med. Chem., 44, 1623-1626. #17044

359. Qiu,W., Gu,X., Soloshonok,V.A., Carducci,M.D., & Hruby,V.J. (2001) Stereoselective synthesis of conformationally constrained reverse turn dipeptide mimetics. Tetrahedron Lett., 42, 145-148. #16181

360. Rader,C. (2001) Antibody libraries in drug and target discovery. Drug Disc. Today, 6, 36-43. #16936

361. Rajan,P., Vedernikova,I., Cos,P., Berghe,D.V., Augustyns,K., & Haemers,A. (2001) Synthesis and evaluation of caffeic acid amides as antioxidants. Bioorg. Med. Chem. Lett., 11, 215-217. #17091

362. Rana,S., White,P., & Bradley,M. (2001) Influence of resin cross-linking on solid-phase chemistry. Journal of Combinatorial Chemistry, 3, 9-15. #16135

363. Rarey,M., & Stahl,M. (2001) Similarity searching in large combinatorial chemistry spaces. J. Comput. Aid. Molec. Design, 15, 497-520. #16937

364. Rassokhin,D.N., Lobanov,V.S., & Agrafiotis,D.K. (2001) Nonlinear mapping of massive data sets by fuzzy clustering and neural networks. J. Comput. Chem., 22, 373-386. #16938

365. Rausch,J.M., & Wimley,W.C. (2001) A high-throughput screen for identifying transmembrane pore-forming peptides. Anal. Biochem., 293, 258-263. #16939

366. Reddy,M.V.R., Brown,H.C., & Ramachandran,P.V. (2001) Asymmetric allylboration for the synthesis of beta-hydroxy-delta-lactone unit of statin drug analogs. J. Organomet. Chem., 624, 239-243. #16940

367. Reese,G., Ayuso,R., Leong-Kee,S.M., Plante,M.J., & Lehrer,S.B. (2001) Characterization and identification of allergen epitopes: Recombinant peptide libraries and synthetic, overlapping peptides. Journal of Chromatography B, 756, 157-163. #16941

368. Reetz,M.T. (2001) Combinatorial and evolution-based methods in the creation of enantioselective catalysts. Angew. Chem. Int. Ed., 40, 284-310. #16366

369. Reineke,U., Volkmer-Engert,R., & Schneider-Mergener,J. (2001) Application of peptide arrays prepared by the SPOT-technology. Curr. Opin. Biotechnol., 12, 59-64. #16662

370. Reiser,U., & Jauch,J. (2001) Synthetic studies towards mniopetals (III). Solid phase organic synthesis of a key intermediate for combinatorial synthesis of mniopetals, kuehneromycins and marasmanes. Synlett, 90-92. #16367

371. Rens,W., Yang,F., O'Brien,P.C., Solanky,N., & Ferguson-Smith,M.A. (2001) A classification efficiency test of spectral karyotyping and multiplex fluorescence in situ hybridization: Identification of chromosome homologies between Homo sapiens and Hylobates leucogenys. Genes Chromosomes Cancer, 31, 65-74. #16653

372. Ribeiro,S.C.F., Schreier,S., Nakaie,C.R., & Cilli,E.M. (2001) Effect of temperature on peptide chain aggregation: An EPR study of model peptidyl-resins. Tetrahedron Lett., 42, 3243-3246. #16567

373. Rice,E., & Hughey,R. (2001) Molecular fingerprinting on the SIMD parallel processor Kestrel. Pac. Symp. Biocomput., 323-334. #17127

374. Rieger,J.M., Brown,M.L., Sullivan,G.W., Linden,J., & Macdonald,T.L. (2001) Design, synthesis, and evaluation of novel A2A adenosine receptor agonists. J. Med. Chem., 44, 531-539. #16558

375. Ripka,W.C., Barker,G., & Krakover,J. (2001) High-throughput purification of compound libraries. Drug Disc. Today, 6, 471-477. #16942

376. Ro,S., Lee,H.J., Ahn,I.A., Shin,D.K., Lee,K.B., Yoon,C.J., & Choi,Y.S. (2001) Torsion angle based design of peptidomimetics: A dipeptidic template adopting beta-I turn (Ac-Aib-AzGly-NH2). Bioorg. Med. Chem., 9, 1837-1841. #16943

377. Roepe,P.D. (2001) A peptide needle in a signaling haystack. Nature Genetics, 27, 6-8. #16371

378. Roland,A., Xiao,Y.F., Jin,Y., & Iyer,R.P. (2001) A novel linker for the solid-phase synthesis of a library of 3'-thiophosphorylated dinucleotides. Tetrahedron Lett., 42, 3669-3672. #16945

379. Rosse,G., Gerber,F., Specklin,J.L., & Hubschwerlen,C. (2001) A novel synthesis of beta-sulfinyl- and beta-sulfonyl-hydroxamic acids via CsF-mediated ring opening of substituted beta-lactones. Synlett, 538-540. #16946

380. Ruijtenbeek,R., Kruijtzer,J.A.W., van de Wiel,W., Fischer,M.J.E., Fluck,M., Redegeld,F.A.M., Liskamp,R.M.J., & Nijkamp,F.P. (2001) Peptoid-peptide hybrids that bind Syk SH2 domains involved in signal transduction. Chembiochem, 2, 171-179. #16948

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382. Salvino,J.M., Patel,S., Drew,M., Krowlikowski,P., Orton,E., Kumar,N.V., Caulfield,T., & Labaudiniere,R. (2001) Synthesis of a new fluoro-Wang resin for solid-phase reaction monitoring by 19F NMR spectroscopy. Journal of Combinatorial Chemistry, 3, 177-180. #16503

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384. Sammelson,R.E., & Kurth,M.J. (2001) Oxidation-Cope elimination: A REM-resin cleavage protocol for the solid-phase synthesis of hydroxylamines. Tetrahedron Lett., 42, 3419-3422. #16564

385. Schlitzer,M., Winter-Vann,A., & Casey,P.J. (2001) Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1. Bioorg. Med. Chem. Lett., 11, 425-427. #17050

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387. Schmid,D.G., Grosche,P., & Jung,G. (2001) High-resolution analysis of a 144-membered pyrazole library from combinatorial solid phase synthesis by using electrospray ionisation Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun. Mass Spectrom., 15, 341-347. #16954

388. Schnepf,R., Horth,P., Bill,E., Wieghardt,K., Hildebrandt,P., & Haehnel,W. (2001) De novo design and characterization of copper centers in synthetic four-helix-bundle proteins. J. Amer. Chem. Soc., 123, 2186-2195. #16955

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