Papers on solid phase organic synthesis published in 1999

This list is arranged by the name of the first author. Any omissions, mistakes and inconsistencies please communicate to the authors of compilation (michal@5z.com). (If you are pointing to any reference, please use its ID# -- the last number in the reference.) You are welcome to use this compilation in your work. Proper way to quote it in your paper is: Lebl M., Leblova Z.: Dynamic database of references in molecular diversity. Internet http://www.5z.com.

Recently added entries are marked in bold

1. Abate, P., Conroy, J.L., & Seto, C.T. (1999) Combinatorial library of serine and cysteine protease inhibitors that interact with both the S and S' binding sites. J. Med. Chem., 42, 4001-4009. #13895

2. Adamczyk, M., Fishpaugh, J.R., & Mattingly, P.G. (1999) Preparation and use of N-hydroxysuccinimidyl active ester resins. Tetrahedron Lett., 40, 463-466. #12234

3. Adams, J.H., Cook, R.M., Hudson, D., Jammalamadaka, V., Lyttle, M.H. & Songster, M.F. (1999) Improved supports and methods for solid phase mediated transformations. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 23-30). Mayflower Scientific Limited, Birmingham. #13454

4. Adams, J.P., & Box, D.S. (1999) Nitro and related compounds. J. Chem. Soc., 749-764. #12920

5. Adang, A.E.P., Peters, C.A.M., Gerritsma, S., De Zwart, E., & Veeneman, G. (1999) Solution-phase and solid-phase synthesis of novel transition state inhibitors of coagulation enzymes incorporating a piperidinyl moiety. Bioorg. Med. Chem. Lett., 9, 1227-1232. #12857

6. Adinolfi, M., Barone, G., De Napoli, L., Guariniello, L., Iadonisi, A., & Piccialli, G. (1999) Solid phase glycosidation of oligonucleotides. Tetrahedron Lett., 40, 2607-2610. #12621

7. Ahn, I.A., Kim, S.W., & Ro, S. (1999) Solid phase synthesis of azapeptides using an automatic synthesizer. Mol. Diversity, 4, 23-24. #12922

8. Ajikumar, P.K., & Devaky, K.S. (1999) Solid phase synthesis of diazepam binding inhibitor fragments 32-38 and 45-50 on a flexible butanediol dimethacrylate crosslinked polystyrene support. Ind. J. Chem. B-Org. Chem. Med. Chem., 38, 783-788. #14912

9. Akerblom, E.B. (1999) Six new photolabile linkers for solid phase synthesis. 2. Coupling of various building blocks and photolytic cleavage. Mol. Diversity, 4, 53-69. #12923

10. Al-Obeidi, F., & Ostrem, J.A. (1999) Factor Xa inhibitors. Exp. Opin. Ther. Patents, 9, 931-953. #13469

11. Alfaro-Lopez, J., Okayama, T., Hosohata, K., Davis, P., Porreca, F., Yamamura, H.I., & Hruby, V.J. (1999) Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand. J. Med. Chem., 42, 5359-5368. #13899

12. Alsina, J., Jensen, K.J., Albericio, F., & Barany, G. (1999) Solid-phase synthesis with tris(alkoxy)benzyl backbone amide linkage (BAL). Chem. Eur. J., 5, 2787-2795. #14915

13. Alsina, J., Yokum, T.S., Albericio, F., & Barany, G. (1999) Backbone amide linker (BAL) strategy for N-alpha-9-fluorenylmethoxycarbonyl (Fmoc) solid-phase synthesis of unprotected peptide p-nitroanilides and thioesters. The Journal of Organic Chemistry, 64, 8761-8769. #13900

14. Altman, R.K., Schwope, I., Sarracino, D.A., Tetzlaff, C.N., Bleczinski, C.F., & Richert, C. (1999) Selection of modified oligonucleotides with increased target affinity via MALDI-monitored nuclease survival assays. Journal of Combinatorial Chemistry, 1, 493-508. #13901

15. Altreuter, D.H., & Clark, D.S. (1999) Combinatorial biocatalysis: Taking the lead from Nature. Curr. Opin. Biotechnol., 10, 130-136. #12706

16. Alvarez, K., Vasseur, J.J., Beltran, T., & Imbach, J.L. (1999) Photocleavable protecting groups as nucleobase protections allowed the solid-phase synthesis of base-sensitive SATE-prooligonucleotides. J. Org. Chem., 64, 6319-6328. #13791

17. Alvarez, K., Vasseur, J.J., & Imbach, J.L. (1999) Use of photolabile amino-protecting groups in the synthesis of base-sensitive DNA SATE-phosphotriesters. Nucleosides Nucleotides, 18, 1435-1436. #13470

18. Andres, C.J., Swann, R.T., Grant-Young, K., D'Andrea, S.V., & Deshpande, M.S. (1999) A novel cleavage protocol for use with Rf-encoded split pool synthesis technology: Product cleavage and collection in standard 96 well format. Comb. Chem. High Throughput Screening, 2, 29-32. #12848

19. Andres, C.J., Denhart, D.J., Deshpande, M.S., & Gillman, K.W. (1999) Recent advances in the solid phase synthesis of drug-like heterocyclic small molecules. Comb. Chem. High Throughput Screening, 2, 191-210. #13903

20. Andrus, A., Cox, S., Beavers, S., Parker, A., Anuskiewicz, J. & Mullah, B. (1999) High-throughput synthesis of functionalized oligonucleotides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 67-70). Mayflower Scientific Limited, Birmingham. #13462

21. Angell, Y.M., Jensen, K.J., Gross, C.M. & Barany, G. (1999) Solid-phase synthesis of peptide nucleic analogue (PNA) sequences taken to new lengths. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 59-62). Mayflower Scientific Limited, Birmingham. #13460

22. Angell, Y.M., Raman, P., Flentke, G.R. & Rich, D.H. (1999) Solid phase synthesis of cyclosporins involving on-resin and solution cyclizations. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 135-138). Mayflower Scientific Limited, Birmingham. #13664

23. Antopolsky, M., & Azhayev, A. (1999) Stepwise solid-phase synthesis of peptide-oligonucleotide conjugates on new solid supports. Helv. Chim. Acta, 82, 2130-2140. #13905

24. Antopolsky, M., Azhayeva, E., Tengvall, U., Auriola, S., Jaaskelainen, I., Ronkko, S., Honkakoski, P., Urtti, A., Lonnberg, H., & Azhayev, A. (1999) Peptide-oligonucleotide phosphorothioate conjugates with membrane translocation and nuclear localization properties. Bioconjug. Chem., 10, 598-606. #13472

25. Aoki, Y., & Kobayashi, S. (1999) Development of a reductive alkylation method using p-benzyloxybenzylamine (BOBA) resin for the synthesis of N-alkylated amides. Journal of Combinatorial Chemistry, 1, 371-372. #13650

26. Appel, J.R., Johnson, J., Narayanan, V.L., & Houghten, R.A. (1999) Identification of novel antitumor agents from mixture-based synthetic combinatorial libraries using cell-based assays. Mol. Diversity, 4, 91-102. #12926

27. Arsequell, G., & Valencia, G. (1999) Recent advances in the synthesis of complex N-glycopeptides. Tetrahedron-Asymmetry, 10, 3045-3094. #14922

28. Arsequell, G., Espuna, G., Valencia, G., Barluenga, J., Perez Carlon, R., & Gonzalez, J.M. (1999) Selective solid-phase iodination of phenolic groups with bis(pyridine)iodonium (I) tetrafluoroborate. Tetrahedron Lett., 40, 7279-7282. #13775

29. Ast, T., Heine, N., Germeroth, L., Schneider-Mergener, J., & Wenschuh, H. (1999) Efficient assembly of peptomers on continuous surfaces. Tetrahedron Lett., 40, 4317-4318. #12928

30. Attanasi, O.A., Filippone, P., Guidi, B., Hippe, T., Mantellini, F., & Tietze, L.F. (1999) First preparation and reaction of polymer-bound 1,2-diaza-1,3-butadienes. A convenient entry to 4-triphenylphosphoranylidene-4,5-dihydropyrazol-5-ones. Tetrahedron Lett., 40, 9277-9280. #13879

31. Aubagnac, J.L., Amblard, M., Enjalbal, C., Subra, G., Martinez, J., Durand, P., & Renaut, P. (1999) Identification of synthetic by-products in combinatorial libraries using high performance liquid chromatography-electrospray ionization mass spectrometry. Comb. Chem. High Throughput Screening, 2, 289-296. #13909

32. Azhayev, A.V. (1999) A new universal solid support for oligonucleotide synthesis. Tetrahedron, 55, 787-800. #12217

33. Backes, B.J., & Ellman, J.A. (1999) An alkanesulfonamide "safety-catch" linker for solid-phase synthesis. J. Org. Chem., 64, 2322-2330. #12858

34. Backes, B.J., Dragoli, D.R., & Ellman, J.A. (1999) Chiral N-acyl-tert-butanesulfinamides: The "safety-catch" principle applied to diastereoselective enolate alkylations. J. Org. Chem., 64, 5472-5478. #13477

35. Bailey, E., Bottomley, M.J., Westwell, S., Pringle, J.H., Furness, P.N., Feehally, J., Brenchley, P.E.C., & Harper, S.J. (1999) Vascular endothelial growth factor mRNA expression in minimal change, membranous, and diabetic nephropathy demonstrated by non-isotopic in situ hybridisation. J. Clin. Pathol., 52, 735-738. #13910

36. Bankaitis-Davis, D., Beaton, G., Bjergarde, K., Callaway, W., Cook, A., Curtis, M., Herrera, C., Huang, L., Josey, J., Munson, M. & Tarlton, C. (1999) Flexible approaches for high-speed synthesis: A multiple platform strategy. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 257-258). Mayflower Scientific Limited, Birmingham. #13689

37. Banwell, M.G., Flynn, B.L., Willis, A.C., & Hamel, E. (1999) Synthesis, X-ray crystal structure and tubulin-binding properties of a benzofuran analogue of the potent cytotoxic agent combretastatin A4. Aust. J. Chem., 52, 767-774. #14926

38. Barber, A.M., Hardcastle, I.R., Rowlands, M.G., Nutley, B.P., Marriott, J.H., & Jarman, M. (1999) Solid-phase synthesis of novel inhibitors of farnesyl transferase. Bioorg. Med. Chem. Lett., 9, 623-626. #12623

39. Barfod, R., Bendahl, L., Hammershoi, A., Jensen, D.K., Sargeson, A.M., & Willis, A.C. (1999) Novel metal complex synthons for chiral 4-azaleucine, 2,3-diaminopropanoic acid and its elaboration. Journal of the Chemical Society-Dalton Transactions, 449-457. #12708

40. Barlaam, B., Koza, P., & Berriot, J. (1999) Solid-phase synthesis of hydroxamic acid based TNF-alpha convertase inhibitors. Tetrahedron, 55, 7221-7232. #12931

41. Barn, D.R., & Morphy, J.R. (1999) Solid-phase synthesis of cyclic imides. Journal of Combinatorial Chemistry, 1, 151-156. #12700

42. Barrett, A.G.M., Cramp, S.M., & Roberts, R.S. (1999) ROMP-spheres: A novel high-loading polymer support using cross metathesis between vinyl polystyrene and norbornene derivatives. Organic Letters, 1, 1083-1086. #14930

43. Barry, J.F., Davis, A.P., Perez-Payan, M.N., Elsegood, M.R.J., Jackson, R.F.W., Gennari, C., Piarulli, U., & Gude, M. (1999) A trifunctional steroid-based scaffold for combinatorial chemistry. Tetrahedron Lett., 40, 2849-2852. #12624

44. Bazin, H. & Livache, T. (1999) Translation of an electrochemically addressed DNA-chip into an immunosensor via peptide- or antibody-oligonucleotide conjugates. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 101-104). Mayflower Scientific Limited, Birmingham. #13657

45. Behrens, C., & Dahl, O. (1999) Synthesis of achiral linker reagents for direct labelling of oligonucleotides on solid supports. Nucleosides Nucleotides, 18, 291-305. #12625

46. Beier, M., & Pfleiderer, W. (1999) Nucleotides. Part LXI. Phthaloyl strategy: A new concept of oligonucleotide synthesis. Helv. Chim. Acta, 82, 633-644. #12934

47. Beier, M., & Pfleiderer, W. (1999) Nucleotides. Part LXII. Pyridinium salts: An effective class of catalysts for oligonucleotide synthesis. Helv. Chim. Acta, 82, 879-887. #12933

48. Belfield, A.J., Brown, G.R., & Foubister, A.J. (1999) Recent synthetic advances in the nucleophilic amination of benzenes. Tetrahedron, 55, 11399-11428. #13917

49. Ben, R.N., Eniade, A.A., & Hauer, L. (1999) Synthesis of a C-linked antifreeze glycoprotein (AFGP) mimic: Probes for investigating the mechanism of action. Organic Letters, 1, 1759-1762. #14938

50. Benaglia, M., Cinquini, M., & Cozzi, F. (1999) Improved procedure for the purification of PEG bound molecules by the use of trioctylamine. Tetrahedron Lett., 40, 2019-2020. #12607

51. Bergbreiter, D.E. (1999) Alternative polymer supports for organic chemistry. Med. Res. Rev., 19, 439-450. #13919

52. Bergeron, R.J., Bussenius, J., Muller, R., McCosar, B.H., & McManis, J.S. (1999) (R)- And (S)-N-(benzyloxycarbonyl)-3,4-epoxybutylamine. New 4-amino-2-bydroxybutyl synthons for the synthesis of hypusine reagents and (R)-6-and (S)-7-hydroxyspermidine. Tetrahedron:Asymmetry, 10, 4285-4294. #14941

53. Berlinck, R.G.S. (1999) Natural guanidine derivatives. Natural Product Reports, 16, 339-365. #12936

54. Berteina, S., De Mesmaeker, A., & Wendeborn, S. (1999) Functionalization via radical cyclization of cyclohexenediol derivatives bound to polystyrene. Synlett, 1121-1123. #13482

55. Bhalay, G. (1999) Chemists' toolkit: A lottery for chemists. Chem. Brit., 35, 25-29. #12710

56. Bhandari, A., Li, B., & Gallop, M.A. (1999) Solid-phase synthesis of pyrrolo[3,4-b]pyridines and related pyridine-fused heterocycles. Synthesis-Stuttgart, 1951-1960. #13863

57. Blackburn, C., Barany, G., Albericio, F. & Kates, S.A. (1999) Handles for solid-phase chemistry: Progress from peptide to small molecule synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 31-38). Mayflower Scientific Limited, Birmingham. #13455

58. Blettner, C.G., Konig, W.A., Stenzel, W., & Schotten, T. (1999) Highly stereoselective preparation of 3,3-disubstituted acrylates on polyethylene glycol. Tetrahedron Lett., 40, 2101-2102. #12612

59. Blettner, C.G., Konig, W.A., Ruhter, G., Stenzel, W., & Schotten, T. (1999) Parallel synthesis of poly(ethylene)glycol supported biaryl benzimidazoles and imidazopyridines. Synlett, 307-310. #15615

60. Blondelle, S.E., Takahashi, E., Robles, B.L., Houghten, R.A. & Perez-Paya, E. (1999) Design of catalytic mimics for the decarboxylation of oxaloacetate using synthetic combinatorial libraries. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 163-166). Mayflower Scientific Limited, Birmingham. #13669

61. Boeijen, A., & Liskamp, R.M.J. (1999) Solid-phase synthesis of oligourea peptidomimetics. Eur. J. Org. Chem., 2127-2135. #14947

62. Boldi, A.M., Johnson, C.R., & Eissa, H.O. (1999) Solid-phase library synthesis of triazolopyridazines via [4+2] cycloadditions. Tetrahedron Lett., 40, 619-622. #12220

63. Bologna, J.C., Morvan, F., & Imbach, J.L. (1999) The prooligonucleotide approach: Synthesis of mixed phosphodiester and SATE phosphotriester prooligonucleotides using H-phosphonate and phosphoramidite chemistries. Eur. J. Org. Chem., 2353-2358. #14951

64. Bolton, G.L., & Hodges, J.C. (1999) Solid-phase synthesis of substituted benzazepines via intramolecular Heck cyclization. Journal of Combinatorial Chemistry, 1, 130-133. #12697

65. Bongardt, P., Gerster, M. & Bayer, E. (1999) Synthesis and characterization of very short peptide-oligonucleotide conjugates used for the transport of antisense oligonucleotides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 267-270). Mayflower Scientific Limited, Birmingham. #13691

66. Bonnet, D., Rommens, C., Gras-Masse, H., & Melnyk, O. (1999) A novel and mild solid phase hydroperoxydeamination reaction. Tetrahedron Lett., 40, 7315-7318. #13766

67. Boudjabi, S., Dewynter, G., Voyer, N., Toupet, L., & Montero, J.L. (1999) Sulfahydantoins as tripeptide constraints: Synthesis and structure of chiral substituted 3-oxo-1,2,5-thiadiazolidine 1,1-dioxides. Eur. J. Org. Chem., 2275-2283. #14955

68. Boussie, T.R., Murphy, V., Hall, K.A., Coutard, C., Dales, C., Petro, M., Carlson, E., Turner, H.W., & Powers, T.S. (1999) Parallel solid-phase synthesis, screening, and encoding strategies for olefin-polymerization catalysts. Tetrahedron, 55, 11699-11710. #13794

69. Brase, S., Dahmen, S., and Lormann, M. Nitrogen-based linker. Part. 2. The T1 linker: Multidirectional cleavage for solid phase organic synthesis. In: E. Pombo-Villar, R. Neier, & S.K. Lin. (Eds.) Proceedings of ECSOC 1999 Sep 01; MDPI, Basel #14569OLD

70. Brase, S., Enders, D., Kobberling, J., & Avemaria, F. (1999) A surprising solid-phase effect: Development of a recyclable "traceless" linker system for reactions on solid support. Angew. Chem. Int. Ed., 37, 3413-3415. #12141

71. Brase, S., & Schroen, M. (1999) Efficient cleavage. Cross-coupling strategy for solid-phase synthesis: A modular building system for combinatorial chemistry. Angew. Chem. Int. Ed., 38, 1071-1073. #12938

72. Brase, S., Kobberling, J., Enders, D., Lazny, R., Wang, M., & Brandtner, S. (1999) Triazenes as robust and simple linkers for amines in solid-phase organic synthesis. Tetrahedron Lett., 40, 2105-2108. #12613

73. Brase, S., Dahmen, S., & Heuts, J. (1999) Solid-phase synthesis of substituted cinnolines by a Richter type cleavage protocol. Tetrahedron Lett., 40, 6201-6203. #13484

74. Broddefalk, J., Forsgren, M., Sethson, I., & Kihlberg, J. (1999) Preparation of a diglycosylated hydroxylysine building block used in solid-phase synthesis of a glycopeptide from type II collagen. J. Org. Chem., 64, 8948-8953. #13924

75. Brody, M.S., & Finn, M.G. (1999) Palladium-catalyzed coupling of functionalized bromoarenes to a polystyrene-bound aryl tributylstannane. Tetrahedron Lett., 40, 415-418. #12238

76. Brooking, P., Crawshaw, M., Hird, N.W., Jones, C., MacLachlan, W.S., Readshaw, S.A., & Wilding, S. (1999) The development of a solid phase Tsuge reaction and its application in high throughput robotic synthesis. Synthesis-Stuttgart, 1986-1992. #13867

77. Brown, A., Akinsanya, A.A., Barker, S.J., Brophy, M., Dobb, A.K., Doyle, S.M., Hudson, I.R., Minter, S.J., Wraith, M.J., & Oultram, J.D. (1999) Automated system for capture and detection of nucleic acids. BioTechniques, 27, 176-180. #13105

78. Brown, A.R. (1999) Vapor-phase Hofmann elimination: A rapid one-pot method for the cleavage of tertiary amines from radio frequency encoded solid-phase synthesis. Journal of Combinatorial Chemistry, 1, 283-285. #13486

79. Brown, C.A., Barnes, C.L., & Serafinowski, P.J. (1999) Synthesis and properties of some (2'-5') linked dinucleoside monophosphates modified with 3'-difluoromethylene groups. Nucleosides Nucleotides, 18, 1249-1250. #13487

80. Brown, R.C.D., & Fisher, M. (1999) Solid-phase synthesis of pyrrolidines employing a cyclisation-cleavage strategy. Chem. Commun., 1547-1548. #13488

81. Brummond, K.M., & Gesenberg, K.D. (1999) a-Chlorination of ketones using p-toluenesulfonyl chloride. Tetrahedron Lett., 40, 2231-2234. #12609

82. Brummond, K.M., & Lu, J.L. (1999) Solid-phase synthesis of BRL 49653. J. Org. Chem., 64, 1723-1726. #12629

83. Bucci, E., De Napoli, L., Di Fabio, G., Messere, A., Montesarchio, D., Romanelli, A., Piccialli, G., & Varra, M. (1999) A new ferrocenemethyl-thymidine nucleoside: Synthesis, incorporation into oligonucleotides and optical spectroscopic studies on the resulting single strand, duplex and triplex structures. Tetrahedron, 55, 14435-14450. #13925

84. Buchardt, J., Ferreras, M., Krog-Jensen, C., Delaisse, J.M., Foged, N.T., & Meldal, M. (1999) Phosphinic peptide matrix metalloproteinase-9 inhibitors by solid-phase synthesis using a building block approach. Chem. Eur. J., 5, 2877-2884. #14968

85. Buchele, J., & Mayer, H.A. (1999) Chemistry in interphases: The solid-phase synthesis of well defined rhodium and iridium phosphine complexes. Chem. Commun., 2165-2166. #14231

86. Bui, C.T., Bray, A.M., Pham, Y., Campbell, R., Ercole, F., Rasoul, F.A., & Maeji, N.J. (1999) Comparative study of reductive amination on 5-(4-formyl-3,5-dimethoxyphenoxy)valeric acid and its monomethoxy analog using the MultipinTM approach. Mol. Diversity, 4, 155-163. #14388

87. Bui, C.T., Bray, A.M., Ercole, F., Pham, Y., Rasoul, F.A., & Maeji, N.J. (1999) Acetophenone-based linker for solid phase synthesis of secondary amides and sulfonamides on the MultipinTM support. Tetrahedron Lett., 40, 3471-3474. #12685

88. Bui, C.T., Maeji, N.J., Rasoul, F., & Bray, A.M. (1999) A simple method for the generation of chloromethyl polystyrene on the MultipinTM solid support. Tetrahedron Lett., 40, 5383-5386. #13120

89. Bunin, B.A., Dener, J.M., & Livingston, D.A. (1999) Application of combinatorial and parallel synthesis to medicinal chemistry. Annu. Rep. Med. Chem., 34, 267-286. #14354

90. Burkett, B.A., & Chai, C.L.L. (1999) The Diels-Alder reactions of polymer bound dehydroalanine derivatives. Tetrahedron Lett., 40, 7035-7038. #13763

91. Butenandt, J., Burgdorf, L.T., & Carell, T. (1999) Synthesis of DNA lesions and DNA-lesion-containing oligonucleotides for DNA-repair studies. Synthesis-Stuttgart, 1085-1105. #13490

92. Cabrele, C., Langer, M., & Beck-Sickinger, A.G. (1999) Amino acid side chain attachment approach and its application to the synthesis of tyrosine-containing cyclic peptides. J. Org. Chem., 64, 4353-4361. #12940

93. Caddick, S., Hamza, D., & Wadman, S.N. (1999) Solid-phase intermolecular radical reactions. 1. Sulfonyl radical addition to isolated alkenes and alkynes. Tetrahedron Lett., 40, 7285-7288. #13777

94. Caldarelli, M., Habermann, J., & Ley, S.V. (1999) Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents. Bioorg. Med. Chem. Lett., 9, 2049-2052. #13491

95. Caldwell, J., & Markley, J.L. (1999) Structure-function relationships in sweet-tasting proteins. Journal of the Chemical Society of Pakistan, 21, 268-280. #14972

96. Cao, L.Q., Bornscheuer, U.T., & Schmid, R.D. (1999) Lipase-catalyzed solid-phase synthesis of sugar esters. Influence of immobilization on productivity and stability of the enzyme. Journal of Molecular Catalysis B-Enzymatic, 6, 279-285. #12718

97. Carboni, B., Pourbaix, C., Carreaux, F., Deleuze, H., & Maillard, B. (1999) Boronic ester as a linker system for solid phase synthesis. Tetrahedron Lett., 40, 7979-7983. #13853

98. Carrington, S., Renault, J., Tomasi, S., Corbel, J.C., Uriac, P., & Blagbrough, I.S. (1999) A novel solid-phase reductive alkylation route to acridine and dansyl polyamine conjugates. Chem. Commun., 1341-1342. #13795

99. Casale, R.A., Paul, C.H., Jensen, I.S., Moyer, M.L., Kates, S.A. & Egholm, M. (1999) A comparison of solid supports for PNA synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 139-142). Mayflower Scientific Limited, Birmingham. #13665

100. Cavallaro, C.L., Herpin, T., McGuinness, B.F., Shimshock, Y.C., & Dolle, R.E. (1999) Allylindium and allylboronic acid pinacolate: Mild reagents for the allylation of resin-bound aldehydes. Application to the solid-phase synthesis of hydroxypropylamines. Tetrahedron Lett., 40, 2711-2714. #12631

101. Cestra, G., Castagnoli, L., Dente, L., Minenkova, O., Petrelli, A., Migone, N., Hoffmuller, U., Schneider-Mergener, J., & Cesareni, G. (1999) The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. Journal of Biological Chemistry, 274, 32001-32007. #13927

102. Chai, W., & Murray, W.V. (1999) Solid phase synthesis of highly substituted 2,4-dioxopiperidines. Tetrahedron Lett., 40, 7185-7188. #13772

103. Chakhmakhcheva, O., Andrianov, M., Buryakova, A., Choob, M., & Efimov, V. (1999) Synthesis and properties of some morpholino oligonucleotide analogues. Nucleosides Nucleotides, 18, 1427-1428. #13492

104. Chandrasekhar, S., Padmaja, M.B., & Raza, A. (1999) Solid phase-solid-state synthesis of N-alkyl imides from anhydrides. Synlett, 1597-1599. #15618

105. Chandrasekhar, S., Raza, A., & Padmaja, M.B. (1999) Novel solid state reduction of organic functional groups on solid support (Merrifield's resin). Synlett, 1061-1062. #13493

106. Chang, J., Oyelaran, O., Esser, C.K., Kath, G.S., King, G.W., Uhrig, B.G., Konteatis, Z., Kim, R.M., & Chapman, K.T. (1999) Synthesis of di- and trisubstituted guanidines on multivalent soluble supports. Tetrahedron Lett., 40, 4477-4480. #12942

107. Chang, Y.T., & Schultz, P.G. (1999) Versatile fluorescence labeling method using activated esters on solid support. Bioorg. Med. Chem. Lett., 9, 2479-2482. #13796

108. Chaturvedi, S., Otteson, K., & Bergot, J. (1999) Carbon-carbon bond formation via the Mitsunobu reaction on solid supports. Tetrahedron Lett., 40, 8205-8209. #13840

109. Chen, C., & Munoz, B. (1999) Solid phase synthesis of 2-acyl-3,7,8-substituted-5-oxo-2-azabicyclo[2.2.2]octane and triaza analogs: Resin activation/capture approach/REACAP technolgy. Tetrahedron Lett., 40, 3491-3494. #12686

110. Cheng, C.C., & Chu, Y.H. (1999) Characterization of spatially addressable libraries: Stereoisomer analysis of tetrahydro-beta-carbolines as an example. Journal of Combinatorial Chemistry, 1, 461-466. #13933

111. Cheng, W.C., Halm, C., Evarts, J.B., Olmstead, M.M., & Kurth, M.J. (1999) Allylic sulfones in solid-phase synthesis: Preparation of cyclobutylidenes. J. Org. Chem., 64, 8557-8562. #13934

112. Cheruvallath, Z.S., Wheeler, P.D., Cole, D.L., & Ravikumar, V.T. (1999) Use of phenylacetyl disulfide (PADS) in the synthesis of oligodeoxyribonucleotide phosphorothioates. Nucleosides Nucleotides, 18, 485-492. #12943

113. Chiu, C., Tang, Z., & Ellingboe, J.W. (1999) Solid-phase synthesis of 2,4,6-trisubstituted pyridines. Journal of Combinatorial Chemistry, 1, 73-77. #12042 (Available on Internet)

114. Chong, P.Y., & Petillo, P.A. (1999) Solid phase urea synthesis: An efficient and direct conversion of Fmoc-protected amines to ureas. Tetrahedron Lett., 40, 4501-4504. #13090

115. Chong, P.Y., & Petillo, P.A. (1999) Solid phase hydantoin synthesis: An efficient and direct conversion of Fmoc-protected dipeptides to hydantoins. Tetrahedron Lett., 40, 2493-2496. #12632

116. Cobb, J.M., Fiorini, M.T., Goddard, C.R., Theoclitou, M.E., & Abell, C. (1999) A decarboxylative traceless linker approach for the solid phase synthesis of quinazolines. Tetrahedron Lett., 40, 1045-1048. #12222

117. Cockerill, G.S., Easterfield, H.J., & Percy, J.M. (1999) Facile syntheses of aryldifluorophosphonate building blocks. Tetrahedron Lett., 40, 2601-2604. #12726

118. Collet, H., Boiteau, L., Taillades, J., & Commeyras, A. (1999) Solid phase decarbamoylation of monoalkylureas and N-carbamoylpeptides using gaseous NOx: A new easy deprotection reaction with minimum waste. Tetrahedron Lett., 40, 3355-3358. #12682

119. Collingwood, S.P., Douglas, M.E., Natt, F., & Pieles, U. (1999) The synthesis of novel modified nucleic acid monomers and their subsequent solid phase oligomerisation to give 3'-methylene phosphonate DNA (3MP). Phosphorus Sulfur and Silicon and the Related Elements, 146, 645-648. #14988

120. Combs, A.P., Saubern, S., Rafalski, M., & Lam, P.Y.S. (1999) Solid supported aryl/heteroaryl C-N cross-coupling reactions. Tetrahedron Lett., 40, 1623-1626. #12591

121. Comely, A.C., Gibson, S.E., & Hales, N.J. (1999) Polymer supported cobalt carbonyl complexes as novel traceless alkyne linkers for solid-phase synthesis. Chem. Commun., 2075-2076. #14233

122. Cosquer, A., Pichereau, V., Le Mee, D., Le Roch, M., Renault, J., Carboni, B., Uriac, P., & Bernard, T. (1999) Toxicity and osmoprotective activities of analogues of glycine betaine obtained by solid phase organic synthesis towards Sinorhizobium meliloti. Bioorg. Med. Chem. Lett., 9, 49-54. #12239

123. Cottney, J., Rankovic, Z., & Morphy, J.R. (1999) Synthesis of novel analogues of the delta opioid ligand SNC-80 using REM resin. Bioorg. Med. Chem. Lett., 9, 1323-1328. #12863

124. Coupal, M., De Lean, A., McNicoll, N., & Fournier, A. (1999) Development of p-benzoylbenzoylated [N,C,rANP(1-28)]pBNP32 (pBNP1) derivatives and affinity photolabeling of the bovine NPR-A receptor. Biochem. Biophys. Res. Commun., 258, 81-86. #12948

125. Crabtree, R.H. (1999) Speeding catalyst discovery and optimization. Chemtech, 29, 21-26. #12727

126. Cramer, H., & Pfleiderer, W. (1999) Nucleotides. Part LX. Synthesis and characterization of new 2'-O-methylriboside 3'-O-phosphoramidites useful for the solid-phase synthesis of 2'-O-methyloligoribonucleotides. Helv. Chim. Acta, 82, 614-632. #12864

127. Creighton, C.J., Zapf, C.W., Bu, J.H., & Goodman, M. (1999) Solid-phase synthesis of pyridones and pyridopyrazines as peptidomimetic scaffolds. Organic Letters, 1, 1407-1409. #14997

128. Cuny, G.D., Cao, J.R., Sidhu, A., & Hauske, J.R. (1999) Solution-phase ring opening cross-metathesis of bicyclic alkenes with styrene derivatives and its application to "resin capture" solid-phase synthesis. Tetrahedron, 55, 8169-8178. #12949

129. Curtet, S., & Langlois, M. (1999) Solid-phase synthesis of 2-methoxyaniline derivatives by the traceless silicon linker strategy. Tetrahedron Lett., 40, 8563-8566. #13846

130. Czarnik, A.W. (1999) Editorial. Journal of Combinatorial Chemistry, 1, 1-2. #13498

131. Danjo, H., Tanaka, D., Hayashi, T., & Uozumi, Y. (1999) Allylic substitution in water catalyzed by amphiphilic resin-supported palladium-phosphine complexes. Tetrahedron, 55, 14341-14352. #13941

132. Darlak, K., Narayana, C. & Spatola, A.F. (1999) Applications of CLEAR resin for solid phase organic synthesis: Comparison with polystyrene based resin. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 275-276). Mayflower Scientific Limited, Birmingham. #13692

133. Davioud-Charvet, E., Becker, K., Landry, V., Gromer, S., Loge, C., & Sergheraert, C. (1999) Synthesis of 5,5'-dithiobis(2-nitrobenzamides) as alternative substrates for trypanothione reductase and thioredoxin reductase: A microtiter colorimetric assay for inhibitor screening. Anal. Biochem., 268, 1-8. #12731

134. Davis, B.G. (1999) Recent developments in glycoconjugates. J. Chem. Soc. Perkin Trans. 1, 3215-3237. #13943

135. Dax, S.L., McNally, J.J., & Youngman, M.A. (1999) Multi-component methodologies in solid-phase organic synthesis. Curr. Med. Chem., 6, 255-270. #12633

136. de Bont, D.B.A., Sliedregt-Bol, K.M., Hofmeyer, L.J.F., & Liskamp, R.M.J. (1999) Increased stability of peptidesulfonamide peptidomimetics towards protease catalyzed degradation. Bioorg. Med. Chem., 7, 1043-1047. #13499

137. de Julian-Ortiz, J.V., Galvez, J., Munoz-Collado, C., Garcia-Domenech, R., & Gimeno-Cardona, C. (1999) Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds. J. Med. Chem., 42, 3308-3314. #13946

138. de Kort, M., Ebrahimi, E., Wijsman, E.R., van der Marel, G.A., & van Boom, J.H. (1999) Synthesis of oligodeoxynucleotides containing 5-(beta-D-glycopyranosyloxymethyl)-2'-deoxyuridine, a modified nucleoside in the DNA of Trypanosoma Brucei. Eur. J. Org. Chem., 2337-2344. #15004

139. de la Torre, B.G., Albericio, F., Saison-Behmoaras, E., Bachi, A., & Eritja, R. (1999) Synthesis and binding properties of oligonucleotides carrying nuclear localization sequences. Bioconjug. Chem., 10, 1005-1012. #13947

140. de Meijere, A., Nuske, H., Es-Sayed, M., Labahn, T., Schroen, M., & Brase, S. (1999) New efficient multicomponent reactions with C-C coupling for combinatorial application in liquid and on solid phase. Angew. Chem. Int. Ed., 38, 3669-3672. #13948

141. De Napoli, L., Di Fabio, G., Messere, A., Montesarchio, D., Musumeci, D., & Piccialli, G. (1999) Synthesis and characterization of new 3'-3' linked oligodeoxyribonucleotides for alternate strand triple helix formation. Tetrahedron, 55, 9899-9914. #13500

142. De Napoli, L., Messere, A., Montesarchio, D., Piccialli, G., Benedetti, E., Bucci, E., & Rossi, F. (1999) A new solid-phase synthesis of oligonucleotides 3'-conjugated with peptides. Bioorg. Med. Chem., 7, 395-400. #12733

143. Dell'Aquila, C., Vives, E., Imbach, J.L., & Rayner, B. (1999) Synthesis and cellular uptake of fluorescently labeled oligodeoxynucleotide prodrugs. Nucleosides Nucleotides, 18, 1683-1684. #13501

144. Delpiccolo, C.M.L., & Mata, E.G. (1999) Solid-phase synthesis of 2b-methyl substituted penam derivatives through penicillin sulfoxide rearrangement. Tetrahedron:Asymmetry, 10, 3893-3897. #14633

145. Devivar, R.V., Koontz, S.L., Peltier, W.J., Pearson, J.E., Guillory, T.A., & Fabricant, J.D. (1999) A new solid-phase support for oligonucleotide synthesis. Bioorg. Med. Chem. Lett., 9, 1239-1242. #12866

146. DeWitt, S.H. (1999) Microreactors for chemical synthesis. Curr. Opin. Chem. Biol., 3, 350-356. #15500

147. Doi, T., Hijikuro, I., & Takahashi, T. (1999) An efficient solid-phase synthesis of the vitamin D-3 system. J. Amer. Chem. Soc., 121, 6749-6750. #13503

148. Doi, T., Sugiki, M., Yamada, H., & Takahashi, T. (1999) Glycosidation of solid-supported glycosyl donors tethered by a trialkylsilane linker. Tetrahedron Lett., 40, 2141-2144. #12614

149. Doi, T., Hijikuro, I., & Takahashi, T. (1999) A novel strategy for the automated synthesis of bis-amides of 1,2-diamines. Synlett, 1751-1753. #15012

150. Dolle, R.E., Barden, M.C., Brennan, P.E., Ahmed, G., Tran, V., & Ho, D.M. (1999) Application of the intramolecular azomethine imine cycloaddition to the construction of a novel, orthogonally protected spirodiamino acid scaffold. Tetrahedron Lett., 40, 2907-2908. #12634

151. Dolle, R.E. (1999) Comprehensive survey of combinatorial libraries with undisclosed biological activity: 1992-1997. Mol. Diversity, 4, 233-256. #14538

152. Dolle, R.E., & Nelson, K.H.Jr. (1999) Comprehensive survey of combinatorial library synthesis: 1998. Journal of Combinatorial Chemistry, 1, 235-282. #13427

153. Dondoni, A., & Marra, A. (1999) Thiazolylketoses: A new class of versatile intermediates for glycoside synthesis. Chem. Commun., 2133-2145. #15013

154. Dorner, B., Steinauer, R., & White, P. (1999) Solid-phase organic chemistry: Linkers and functionalized solid supports. Chimia, 53, 11-17. #12734

155. Dragoli, D.R., Thompson, L.A., O'Brien, J., & Ellman, J.A. (1999) Parallel synthesis of prostaglandin E1 analogues. Journal of Combinatorial Chemistry, 1, 534-539. #14749

156. Dumas, J., Brittelli, D., Chen, J.S., Dixon, B., Hatoum-Mokdad, H., Konig, G., Sibley, R., Witowsky, J., & Wong, S. (1999) Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors. Bioorg. Med. Chem. Lett., 9, 2531-2536. #13955

157. Duus, J.O., St Hilaire, P.M., Meldal, M., & Bock, K. (1999) Carbohydrate chemistry: Synthetic and structural challenges towards the end of the 20th century. Pure Appl. Chem., 71, 755-765. #15017

158. Ede, N.J., James, I.W., Krywult, B.M., Griffiths, R.M., Eagle, S.N., Gubbins, B., Leitch, J.A., Sampson, W.R., & Bray, A.M. (1999) Synthesis of hydroxamic acids using SynPhaseTM crowns: Development of the hydroxylamine trityl handle. Lett. Peptide Sci., 6, 157-163. #14299

159. Edwards, P.J., Gardner, M., Klute, W., Smith, G.F., & Terrett, N.K. (1999) Applications of combinatorial chemistry to drug design and development. Curr. Opin. Drug. Disc. Develop., 2, 321-331. #13381

160. Efimov, V.A., Buryakova, A.A., Choob, M.V., & Chakhmakhcheva, O.G. (1999) Peptide nucleic acids and their phosphonate analogues. II. Synthesis and physicochemical properties of hybrids containing serine and 4-hydroxyproline residues. Bioorganicheskaia Khimiia, 25, 611-622. #13957

161. Eguchi, M., Lee, M.S., Nakanishi, H., Stasiak, M., Lovell, S., & Kahn, M. (1999) Solid-phase synthesis and structural analysis of bicyclic beta-turn mimetics incorporating functionality at the i to i+3 positions. J. Amer. Chem. Soc., 121, 12204-12205. #13958

162. Elhalabi, J.M., & Rice, K.G. (1999) Synthesis and applications for unnatural sugar nucleotides. Curr. Med. Chem., 6, 93-116. #12737

163. Ellingboe, J.W. (1999) Solid-phase synthesis in lead optimization and drug discovery. Curr. Opin. Drug. Disc. Develop., 2, 350-357. #13384

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165. Falkiewicz, B. (1999) Peptide nucleic acids and their structural modifications. Acta Biochim. Polon., 46, 509-529. #13961

166. Far, A.R., & Tidwell, T.T. (1999) Soluble polymer-bound allenecarboxylates: Useful beta-ketoester equivalents. Journal of Combinatorial Chemistry, 1, 458-460. #13962

167. Felder, E.R. (1999) Resins, linkers, and reactions for solid-phase synthesis of organic libraries. In Anonymous, Combinatorial Chemistry and Technology: Principles, Methods, and Applications. (pp. 35-51). #13509

168. Felder, E.R. (1999) Solid-phase synthesis of organic libraries. In Anonymous, Combinatorial Chemistry and Technology: Principles, Methods, and Applications. (pp. 23-33). #13508

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170. Feng, Y., Pattarawarapan, M., Wang, Z., & Burgess, K. (1999) Solid-phase SN2 macrocyclization reactions to form b-turn mimics. Organic Letters, 121-124. #15622

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173. Ferraz, H.M.C., Silva, L.F., & Vieira, T.D. (1999) Thallium(III) in organic synthesis. Synthesis-Stuttgart, 2001-2023. #13964

174. Ferreira, P.M.T., Maia, H.L.S., & Monteiro, L.S. (1999) High yielding synthesis of heterocyclic b-substituted alanine derivatives. Tetrahedron Lett., 40, 4099-4102. #14209

175. Fevig, J.M., & Wexler, R.R. (1999) Anticoagulants: Thrombin and factor Xa inhibitors. Annu. Rep. Med. Chem., 34, 81-100. #15034

176. Filigheddu, S.N., Masala, S., & Taddei, M. (1999) Solid phase synthesis of aziridine 2-carboxylates. Tetrahedron Lett., 40, 6503-6506. #13759

177. Fink, B.E., Mortensen, D.S., Stauffer, S.R., Aron, Z.D., & Katzenellenbogen, J.A. (1999) Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens. Chem. Biol., 6, 205-219. #13967

178. Finn, P.J., Smith, C.L., Fallon, R.A., Hamilton, A.L. & Brown, T. (1999) The synthesis, melting studies and primer extension assay of PNA/DNA chimeric oligomers. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 293-294). Mayflower Scientific Limited, Birmingham. #13697

179. Fitch, W.L. (1999) Analytical methods for quality control of combinatorial libraries. Mol. Diversity, 4, 39-45. #12962

180. Fitch, W.L., Baer, T.A., Chen, W.W., Holden, F., Holmes, C.P., Maclean, D., Shah, N.H., Sullivan, E., Tang, M., Waybourn, P., Fischer, S.M., Miller, C.A., & Synder, L.R. (1999) Improved methods for encoding and decoding dialkylamine-encoded combinatorial libraries. Journal of Combinatorial Chemistry, 1, 188-194. #13511

181. Flohr, S., Jungmann, V., & Waldmann, H. (1999) Chemoenzymatic synthesis of nucleopeptides. Chem. Eur. J., 5, 669-681. #12740

182. Fodili, M., Amari, M., Kolli, B., Robert, A., Baudy-Floch, M., & Le Grel, P. (1999) An efficient synthesis of new 2-pyronyl-1,5-benzodiazepine derivatives. Synthesis-Stuttgart, 811-814. #12963

183. Foldesi, A., Trifonova, A., Dinya, Z., & Chattopadhyaya, J. (1999) Selective cleavage of the O6-diphenylcarbamoyl group from sugar-modified guanosines for incorporation into oligo-RNA. Tetrahedron Lett., 40, 7283-7284. #13776

184. Francis, M.B., & Jacobsen, E.N. (1999) Discovery of novel catalysts for alkene epoxidation from metal-binding combinatorial libraries. Angew. Chem. Int. Ed., 38, 937-941. #12741

185. Frieden, M., Grandas, A., & Pedroso, E. (1999) Making cyclic RNAs easily available. Chem. Commun., 1593-1594. #13516

186. Fruchart, J.S., Gras-Masse, H., & Melnyk, O. (1999) A new linker for the synthesis of C-terminal peptide alpha-oxo-aldehydes. Tetrahedron Lett., 40, 6225-6228. #13517

187. Fu, M.M., Fernandez, M., Smith, M.L., & Flygare, J.A. (1999) Solid-phase synthesis of 2-aminoimidazolones. Organic Letters, 1, 1351-1353. #15039

188. Fujita, K., Watanabe, K., Oishi, A., Ikeda, Y., & Taguchi, Y. (1999) Preparation of polymer-supported selenocyanates and their application to solid-phase oxyselenenylation-deselenenylation. Synlett, 1760-1762. #15041

189. Fukase, K., Nakai, Y., Egusa, K., Porco, J.A., & Kusumoto, S. (1999) A novel oxidatively removable linker and its application to alpha-selective solid-phase oligosaccharide synthesis on a macroporous polystyrene support. Synlett, 1074-1078. #13518

190. Fukuda, H., Shimizu, T., Nakajima, M., Mori, H., & Shirasawa, T. (1999) Synthesis, aggregation, and neurotoxicity of the Alzheimer's Ab1-42 amyloid peptide and its isoaspartyl isomers. Bioorg. Med. Chem. Lett., 9, 953-956. #12867

191. Furka, A., & Bennett, W.D. (1999) Combinatorial libraries by portioning and mixing. Comb. Chem. High Throughput Screening, 2, 105-122. #12853

192. Furman, B., Thurmer, R., Kaluza, Z., Voelter, W., & Chmielewski, M. (1999) A new acetal resin valuable for the solid-phase synthesis of 1-oxacephams via a cyclization/cleavage step. Tetrahedron Lett., 40, 5909-5912. #13520

193. Furman, B., Thurmer, R., Kaluza, Z., Lysek, R., Voelter, W., & Chmielewski, M. (1999) Stereoselective solid-phase synthesis of beta-lactams. A novel cyclization/cleavage step towards 1-oxacephams. Angew. Chem. Int. Ed., 38, 1121-1123. #12964

194. Gangamani, B.P., Kumar, V.A., & Ganesh, K.N. (1999) Chiral analogues of peptide nucleic acids: Synthesis of 4-aminoprolyl nucleic acids and DNA complementation studies using UV/CD spectroscopy. Tetrahedron, 55, 177-192. #12357

195. Ganguly, D., & Rodriguez, M.J. (1999) Cyclopeptamine lipopeptide antifungal agents. Exp. Opin. Ther. Patents, 9, 67-71. #12358

196. Garibay, P., Toy, P.H., Hoeg-Jensen, T., & Janda, K.D. (1999) Application of a new solid-phase resin: Benzamide ortho-lithiation and the synthesis of a phthalide library. Synlett, 1438-1440. #15045

197. Garner, P., Dey, S., Huang, Y.M., & Zhang, X. (1999) Modular nucleic acid surrogates. Solid phase synthesis of alpha-helical peptide nucleic acids (alpha PNAs). Organic Letters, 1, 403-405. #15046

198. Gauzy, L., Le Merrer, Y., Depezay, J.C., Clerc, F., & Mignani, S. (1999) Synthesis of azepane scaffolds on solid support for combinatorial chemistry. Tetrahedron Lett., 40, 6005-6008. #13521

199. Geethakumari, K., & Sreekumar, K. (1999) Polystyrene supported t-butyl chromates: Preparation and use as oxidising reagents. Reactive and Functional Polymers, 42, 11-19. #15049

200. Geurtsen, R., Cote, F., Hahn, M.G., & Boons, G.J. (1999) Chemoselective glycosylation strategy for the convergent assembly of phytoalexin-elicitor active oligosaccharides and their photoreactive derivatives. J. Org. Chem., 64, 7828-7835. #13979

201. Ghose, A.K., Viswanadhan, V.N., & Wendoloski, J.J. (1999) A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases. Journal of Combinatorial Chemistry, 1, 55-68. #12031 (Available on Internet)

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203. Gibson, S.E., Hales, N.J., & Peplow, M.A. (1999) Chromium carbonyl complexes as novel traceless linkers. Tetrahedron Lett., 40, 1417-1418. #12533

204. Gilchrist, T.L. (1999) Synthesis of aromatic heterocycles. J. Chem. Soc. Perkin Trans. 1, 2849-2866. #13982

205. Goff, D., & Fernandez, J. (1999) The preparation of 2,4-disubstituted thiazoles on solid support. Tetrahedron Lett., 40, 423-426. #12224

206. Goff, D.A. (1999) Combinatorial synthesis of indolizines on solid support. Tetrahedron Lett., 40, 8741-8745. #13855

207. Goldberg, M., Smith, L., Tamayo, N., & Kiselyov, A.S. (1999) Solid support synthesis of 14-membered macrocycles containing 4-hydroxyproline structural unit via SNAr methodology. Tetrahedron, 55, 13887-13898. #13986

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209. Gomez, L., Gellibert, F., Wagner, A., & Mioskowski, C. (1999) An efficient procedure for traceless solid-phase synthesis of N,N'-substituted thioureas by thermolytic cleavage of resin-bound dithiocarbamates. Journal of Combinatorial Chemistry, 2, 75-79. #13988

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214. Gosselin, F., Van Betsbrugge, J., Hatam, M., & Lubell, W.D. (1999) A novel linking-protecting group strategy for solid-phase organic chemistry with configurationally stable a-[N-(phenylfluorenyl)]amino carbonyl compounds: Synthesis of enantiopure norephedrines on solid support. J. Org. Chem., 64, 2486-2493. #12868

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217. Greenlee, M.L., Laub, J.B., Balkovec, J.M., Hammond, M.L., Hammond, G.G., Pompliano, D.L., & Epstein-Toney, J.H. (1999) Synthesis and sar of thioester and thiol inhibitors of IMP-1 metallo-beta-lactamase. Bioorg. Med. Chem. Lett., 9, 2549-2554. #13993

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227. Habermann, J. & Kunz, H. (1999) Pentafluorophenyluronium reagents and allylic anchoring groups in solid phase glycopeptide synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 217-220). Mayflower Scientific Limited, Birmingham. #13679

228. Hajipour, A.R., Mohammadpoor-Baltork, I., Nikbaghat, K., & Imanzadeh, G. (1999) Solid-phase synthesis of oximes. Syn. Commun., 29, 1697-1701. #12869

229. Hall, D.G., Laplante, C., Manku, S., & Nagendran, J. (1999) Mild oxidative cleavage of borane-amine adducts from amide reductions: Efficient solution- and solid-phase synthesis of N-alkylamino acids and chiral oligoamines. J. Org. Chem., 64, 698-699. #12595

230. Hall, D.G., Tailor, J., & Gravel, M. (1999) N,N-diethanolaminomethyl polystyrene: An efficient solid support to immobilize boronic acids. Angew. Chem. Int. Ed., 38, 3064-3067. #14001

231. Hall, S.E. (1999) Recent advances in solid phase synthesis. Mol. Diversity, 4, 131-142. #12974

232. Hammond, J., Kellam, B., Moffat, A.C., & Jee, R.D. (1999) Non-destructive real-time reaction monitoring in solid phase synthesis by near-infrared reflectance spectroscopy-esterification of a resin-bound alcohol. Anal. Commun., 36, 127-129. #12975

233. Hamper, B.C., Gan, K.Z., & Owen, T.J. (1999) Solid phase synthesis of dihydropyrimidinones and pyrimidinone carboxylic acids from malonic acid resin. Tetrahedron Lett., 40, 4973-4976. #13110

234. Hamper, B.C., Snyderman, D.M., Owen, T.J., Scates, A.M., Owsley, D.C., Kesselring, A.S., & Chott, R.C. (1999) High-throughput 1H NMR and HPLC characterization of a 96-member substituted methylene malonamic acid library. Journal of Combinatorial Chemistry, 1, 140-150. #12699

235. Hamuro, Y., Marshall, W.J., & Scialdone, M.A. (1999) Solid-phase synthesis of acyclic and cyclic amino acid derived urea peptidomimetics using phoxime resin. Journal of Combinatorial Chemistry, 1, 163-172. #12702

236. Hamuro, Y., Scialdone, M.A., & DeGrado, W.F. (1999) Resin-to-resin acyl- and aminoacyl-transfer reactions using oxime supports. J. Amer. Chem. Soc., 121, 1636-1644. #12641

237. Han, Y., Giroux, A., Lepine, C., Laliberte, F., Huang, Z., Perrier, H., Bayly, C.I., & Young, R.N. (1999) Solid phase parallel synthesis of highly substituted thiophene derivatives and identification of novel phosphodiesterase-4 (PDE-4) inhibitors. Tetrahedron, 55, 11685. #15641

238. Han, Y.X., Giroux, A., Lepine, C., Laliberte, F., Huang, Z., Perrier, H., Bayly, C.I., & Young, R.N. (1999) Solid phase parallel synthesis of highly substituted thiophene derivatives and identification of novel phosphodiesterase-4 (PDE-4) inhibitors. Tetrahedron, 55, 11669-11685. #13801

239. Hanessian, S., Ma, J., & Wang, W. (1999) Stereocontrolled solution and solid phase enolate alkylations and hydroxylations: Generation of three and four contiguous stereogenic carbon atoms in acyclic systems. Tetrahedron Lett., 40, 4631-4634. #13092

240. Hanessian, S., & Huynh, H.K. (1999) Solution and solid phase p-alkoxybenzylation of alcohols under neutral conditions. Tetrahedron Lett., 40, 671-674. #12243

241. Haque, T.S., Skillman, A.G., Lee, C.E., Habashita, H., Gluzman, I.Y., Ewing, T.J.A., Goldberg, D.E., Kuntz, I.D., & Ellman, J.A. (1999) Potent, low-molecular-weight non-peptide inhibitors of malarial aspartyl protease plasmepsin II. J. Med. Chem., 42, 1428-1440. #12976

242. Hari, A., & Miller, B.L. (1999) Transfer catalysis between two solids: Application to the reduction of nitroarenes. Angew. Chem. Int. Ed., 38, 2777-2779. #14005

243. Hari, A., & Miller, B.L. (1999) A new method for the mild and selective reduction of aryl nitro groups on solid support. Tetrahedron Lett., 40, 245-248. #12105

244. Hay, A.M., DeWitt, S.H., MacDonald, A.A., & Ramage, R. (1999) Use of tetrabenzo[a,c,g,i]fluorene as an anchor group for the solid/solution phase synthesis of the quinolone antibacterical, ciprofloxacin. Synthesis-Stuttgart, 1979-1985. #13866

245. Hay, A.M., DeWitt, S.H., Leonard, D., MacDonald, A.A. & Ramage, R. (1999) Use of tetrabenzo[a,c,g,i]fluorene as an anchor group towards the synthesis of ciprofloxacin. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 235-238). Mayflower Scientific Limited, Birmingham. #13684

246. Hebert, N., Hannah, A.L., & Sutton, S.C. (1999) Synthesis of oxadiazoles on solid support. Tetrahedron Lett., 40, 8547-8550. #13845

247. Heetebrij, R.J., Tromp, R.A., van der Marel, G.A., van Boom, J.H., & Reedijk, J. (1999) A novel approach to site-specifically platinated oligonucleotides applying combinations of nucleobase protecting groups. Chem. Commun., 1693-1694. #15079

248. Heidenhain, S.B., & Hayakawa, Y. (1999) Improved methods for the preparation of 2 '-deoxyribonucleoside and ribonucleoside 3 '-phosphoramidites with allylic protectors. Nucleosides Nucleotides, 18, 1771-1787. #13526

249. Heinonen, P., Virta, P., & Lonnberg, H. (1999) Synthesis of achiral alpha,alpha-disubstituted beta-alanines, and their use in construction of libraries of beta-peptide conjugates of N-2-alkyl-1,2,3,4-tetrahydroisoquinolines on a solid support. Tetrahedron, 55, 7613-7624. #12979

250. Heizmann, G., Hildebrand, P., Tanner, H., Ketterer, S., Pansky, A., Froidevaux, S., Beglinger, C., & Eberle, A.N. (1999) A combinatorial peptoid library for the identification of novel MSH and GRP/bombesin receptor ligands. Journal of Receptor and Signal Transduction Research, 19, 449-466. #12746

251. Henke, L., & Krull, U.J. (1999) Immobilization technologies used for nucleic acid biosensors: A review. Canadian Journal of Analytical Sciences and Spectroscopy, 44, 61-70. #15081

252. Hennequin, L.F., & Piva-Le Blanc, S. (1999) Novel synthesis of oxindole quinazolines using solid phase multiparallel chemistry. Tetrahedron Lett., 40, 3881-3884. #12870

253. Henry, C. (1999) Combinatorial chemistry gains a new dimension. C&EN, 77, 9-9. #13754

254. Hermkens, P.H.H., & Hamersma, H. (1999) Functional group transformation: An efficacy-enhancing approach in combinatorial chemistry. Journal of Combinatorial Chemistry, 1, 307-316. #13527

255. Herpin, T.F., Morton, G.C., Dunn, A.K., Fillon, C., Menard, P.R., Tang, S.Y., Salvino, J.M., & Labaudiniere, R.F. (1999) Synthesis and diversity analysis of lead discovery piperazine-2-carboxamide libraries. Mol. Diversity, 4, 221-232. #14537

256. Hidai, Y., Kan, T., & Fukuyama, T. (1999) Total synthesis of polyamine toxin HO-416b utilizing the 2-nitrobenzenesulfonamide protecting group. Tetrahedron Lett., 40, 4711-4714. #13091

257. Hird, N., Morrison, M.G.J.T., Sherrington, D.C., & Trillow, J.C. (1999) Tailoring of 4-vinylpyridine-based resins for hydrolytic degradation and solubilisation. Tetrahedron, 55, 9585-9594. #13408

258. Hird, N., Hughes, I., Hunter, D., Morrison, M.G.J.T., Sherrington, D.C., & Stevenson, L. (1999) Polymer discs: An alternative support format for solid phase synthesis. Tetrahedron, 55, 9575-9584. #13407

259. Hird, N.W. (1999) Automated synthesis: New tools for the organic chemist. Drug Disc. Today, 4, 265-274. #14014

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262. Hodge, P., & Peng, P.P. (1999) Polymer-supported syntheses of some cyclic oligoamides and some cyclic alternating oligo(amide-ester)s. Polymer, 40, 1871-1879. #12371

263. Hoel, A.M.L., & Nielsen, J. (1999) Microwave-assisted solid-phase Ugi four-component condensations. Tetrahedron Lett., 40, 3941-3944. #12872

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266. Horn, T., Chang, C.A. & Urdea, M.S. (1999) Chemical synthesis of branched oligodeoxyribonucleotides (bDNA) fgor use in nucleic acid quantification assays. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 71-74). Mayflower Scientific Limited, Birmingham. #13463

267. Horvath, G., & Huszthy, P. (1999) Chromatographic enantioseparation of racemic a-(1-naphthyl)ethylammonium perchlorate by a Merrifield resin-bound enantiomerically pure chiral dimethylpyridino-18-crown-6 ligand. Tetrahedron:Asymmetry, 10, 4573-4583. #14238

268. Houghten, R.A., Pinilla, C., Appel, J.R., Blondelle, S.E., Dooley, C.T., Eichler, J., Nefzi, A., & Ostresh, J.M. (1999) Mixture-based synthetic combinatorial libraries. J. Med. Chem., 42, 3743-3778. #13738

269. Houghten, R.A., Dooley, C.T., Giulianotti, M.A., Hamashin, V.T., Schoner, C.C., Ostresh, J.M. & Nefzi, A. (1999) Solid phase synthesis of heterocyclic positional scanning combinatorial libraries. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 11-14). Mayflower Scientific Limited, Birmingham. #13451

270. Hu, Y., & Porco, J.A.Jr. (1999) Ester enolate Claisen rearrangement using a polymer-supported silyl triflate. Tetrahedron Lett., 40, 3289-3292. #12681

271. Hu, Y.H., Baudart, S., & Porco, J.A. (1999) Parallel synthesis of 1,2,3-thiadiazoles employing a "catch and release" strategy. J. Org. Chem., 64, 1049-1051. #12749

272. Huang, S.L., & Tour, J.M. (1999) Rapid solid-phase synthesis of oligo(1,4-phenylene ethynylene)s by a divergent convergent tripling strategy. J. Amer. Chem. Soc., 121, 4908-4909. #12983

273. Huang, S.L., & Tour, J.M. (1999) Rapid solid-phase syntheses of conjugated homooligomers and [AB] alternating block cooligomers of precise length and constitution. J. Org. Chem., 64, 8898-8906. #14021

274. Huang, W.L., & Scarborough, R.M. (1999) A new "traceless" solid-phase synthesis strategy: Synthesis of a benzimidazole library. Tetrahedron Lett., 40, 2665-2668. #12644

275. Huber, C.G., & Krajete, A. (1999) Analysis of nucleic acids by capillary ion-pair reversed-phase HPLC coupled to negative-ion electrospray ionization mass spectrometry. Anal. Chem., 71, 3730-3739. #14022

276. Huber, W., Bubendorf, A., Grieder, A., & Obrecht, D. (1999) Monitoring solid phase synthesis by infrared spectroscopic techniques. Anal. Chim. Acta, 393, 213-221. #13532

277. Huck, B.R., Langenhan, J.M., & Gellman, S.H. (1999) Non-hydrogen-bonded secondary structure in beta-peptides: Evidence from circular dichroism of (S)-pyrrolidine-3 carboxylic acid oligomers and (S)-nipecotic acid oligomers. Organic Letters, 1, 1717-1720. #15103

278. Hudson, D. (1999) Matrix assisted synthetic transformations: A mosaic of diverse contributions. II. The pattern is completed. Journal of Combinatorial Chemistry, 1, 403-457. #13833

279. Hudson, D. (1999) Matrix assisted synthetic transformations: A mosaic of diverse contributions. I. The pattern emerges. Journal of Combinatorial Chemistry, 1, 333-360. #13444

280. Hummel, G., & Hindsgaul, O. (1999) Solid-phase synthesis of thio-oligosaccharides. Angew. Chem. Int. Ed., 38, 1782-1784. #13410

281. Hung, L.W., Kohmura, M., Ariyoshi, Y., & Kim, S.H. (1999) Structural differences in D and L-monellin in the crystals of racemic mixture. J. Mol. Biol., 285, 311-321. #12373

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283. Iwai, S., Mizukoshi, T., Fujiwara, Y., Masutani, C., Hanaoka, F., & Hayakawa, Y. (1999) Benzimidazolium triflate-activated synthesis of (6-4) photoproduct-containing oligonucleotides and its application. Nucl. Acid. Res., 27, 2299-2303. #12985

284. James, I.W. (1999) Linkers for solid phase organic synthesis. Tetrahedron, 55, 4855-4946. #12873

285. Jefferson, E.A., & Swayze, E.E. (1999) b-Amino acid facilitates macrocyclic ring closure in a combinatorial library. Tetrahedron Lett., 40, 7757-7760. #13778

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292. Kantchev, A.B., & Parquette, J.R. (1999) Disaccharide synthesis on a soluble hyperbranched polymer. Tetrahedron Lett., 40, 8049-8053. #13841

293. Karet, G. (1999) Bead-picking made simple. Drug. Dis. Develop., 55-55. #12918

294. Karnbrock, W., Deeg, M., Gerhardt, J., & Rapp, W. (1999) Solid phase synthesis of hydantoins by thermal cyclization and screening of reaction conditions using APOS 1200. Mol. Diversity, 4, 165-171. #14389

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350. Lebl, M. & Krchnak, V. (1999) Techniques for massively parallel synthesis of small organic molecules. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 43-46). Mayflower Scientific Limited, Birmingham. #10056

351. Lebl, M., Pires, J., Poncar, P., & Pokorny, V. (1999) Evaluation of gaseous hydrogen fluoride as a convenient reagent for parallel cleavage from the solid support. Journal of Combinatorial Chemistry, 1, 474-479. #13836

352. Lebl, M. (1999) Solid-phase synthesis of combinatorial libraries. Curr. Opin. Drug. Disc. Develop., 2, 385-395. #13357

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355. Lee, A., Huang, L., & Ellman, J.A. (1999) General solid-phase method for the preparation of mechanism-based cysteine protease inhibitors. J. Amer. Chem. Soc., 121, 9907-9914. #14052

356. Lee, H.B., & Balasubramanian, S. (1999) Studies on a dithiane-protected benzoin photolabile safety catch linker for solid-phase synthesis. J. Org. Chem., 64, 3454-3460. #12877

357. Lee, H.B., & Balasubramanian, S. (1999) Studies on a dithiane-protected benzoin photolabile safety catch linker for solid-phase synthesis. (vol 64, pg 3454, 1999). J. Org. Chem., 64, 5728. #13547

358. Lee, H.K., & Chui, W.K. (1999) Combinatorial mixture synthesis and biological evaluation of dihydrophenyl triazine antifolates. Bioorg. Med. Chem., 7, 1255-1262. #13548

359. Lee, J., Gauthier, D., & Rivero, R.A. (1999) Solid-phase synthesis of 3,4,5-substituted 1,5-benzodiazepin-2-ones. J. Org. Chem., 64, 3060-3065. #12878

360. Lee, K.J., Angulo, A., Ghazal, P., & Janda, K.D. (1999) Soluble-polymer supported synthesis of a prostanoid library: Identification of antiviral activity. Organic Letters, 1, 1859-1861. #15648

361. Lee, M.S., Nakanishi, H., & Kahn, M. (1999) Enlistment of combinatorial techniques in drug development. Curr. Opin. Drug. Disc. Develop., 2, 332-3341. #13382

362. Lee, Y., & Silverman, R.B. (1999) Efficient solid-phase synthesis of compounds containing phenylalanine and its derivatives via side-chain attachment to the polymer support. J. Amer. Chem. Soc., 121, 8407-8408. #14053

363. Lee, Y., & Silverman, R.B. (1999) Solid-phase syntheses of Nomega-propylarginine-containing dipeptides, dipeptide esters, and dipeptide amides. Synthesis-Stuttgart, 1495-1499. #13809

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365. Lepore, S.D., & Wiley, M.R. (1999) Use of the Kaiser oxime resin in the solid-phase synthesis of 3-aminobenzisoxazoles. J. Org. Chem., 64, 4547-4550. #12999

366. Lew, A., & Chamberlin, A.R. (1999) Blockers of human T cell Kv1.3 potassium channels using de novo ligand design and solid-phase parallel combinatorial chemistry. Bioorg. Med. Chem. Lett., 9, 3267-3272. #14054

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368. Lewis, J.R. (1999) Miscellaneous alkaloids: Amaryllidaceae, Sceletium, muscarine, imidazole, oxazole, peptide and other miscellaneous alkaloids. Natural Product Reports, 16, 389-416. #13000

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370. Li, H.T., Jiang, X.H., Ye, Y.H., Fan, C.X., Romoff, T., & Goodman, M. (1999) 3-(Diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one (DEPBT): A new coupling reagent with remarkable resistance to racemization. Organic Letters, 1, 91-93. #15170

371. Li, W., & Burgess, K. (1999) A new solid-phase linker for Suzuki coupling with concomitant macrocyclization: Synthesis of b-turn mimics. Tetrahedron Lett., 40, 6527-6530. #13760

372. Li, W., Xiao, X., & Czarnik, A.W. (1999) Kinetic comparison of amide formation on various cross-linked polystyrene resins. Journal of Combinatorial Chemistry, 1, 127-129. #12696

373. Li, W.R., & Yo, Y.C. (1999) Synthesis of acetoxyamides and acetates by zinc bromide assisted cleavage of Merrifield resin-bound ethers. Tetrahedron Lett., 40, 9085-9089. #13860

374. Li, X.X., Cheng, Y.Z., Zhang, L.G., & Zhang, L.H. (1999) Synthesis of spin labeled conjugate of peptide and peptide nucleic acid. Syn. Commun., 29, 1519-1525. #13002

375. Liang, G.B., & Qian, X.X. (1999) Oxadiazole synthesis on solid supports. Bioorg. Med. Chem. Lett., 9, 2101-2104. #13810

376. Licking, E. (1999) The great DNA chip derby. Business Week, 90-92. #13739

377. Lin, J.L., & Shaw, B.R. (1999) Synthesis and properties of a novel phosphodiester analogue, nucleoside boranophosphorothioate. Chem. Commun., 1517-1518. #13549

378. Linkletter, B.A., Szabo, I.E., & Bruice, T.C. (1999) Solid-phase synthesis of deoxynucleic guanidine (DNG) oligomers and melting point and circular dichroism analysis of binding fidelity of octameric thymidyl oligomers with DNA oligomers. J. Amer. Chem. Soc., 121, 3888-3896. #12879

379. Linn, J.A., Gerritz, S.W., Handlon, A.L., Hyman, C.E., & Heyer, D. (1999) Solid phase synthesis of 1,3,5-trisubstituted pyridin-2-ones. Tetrahedron Lett., 40, 2227-2230. #12608

380. Linton, B., & Hamilton, A.D. (1999) Host-guest chemistry: Combinatorial receptors. Curr. Opin. Chem. Biol., 3, 307-312. #15502

381. Lippens, G., Bourdonneau, M., Dhalluin, C., Warrass, R., Richert, T., Seetharaman, C., Boutillon, C., & Piotto, M. (1999) Study of compounds attached to solid supports using high resolution magic angle spinning NMR. Current Organic Chemistry, 3, 147-169. #12774

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383. Lopez-Rodriguez, M.L., Viso, A., Benhamu, B., Rominguera, J.L., & Murcia, M. (1999) Synthesis of new (benzimidazolyl)piperazines with affinity for the 5-HT1a receptor via Pd(0) amination of bromobenzimidazoles. Bioorg. Med. Chem. Lett., 9, 2339-2342. #13552

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387. Lundquist, J.T., & Dix, T.A. (1999) Synthesis and human neurotensin receptor binding activities of neurotensin(8-13) analogues containing position 8 alpha-azido-N-alkylated derivatives of ornithine, lysine, and homolysine. J. Med. Chem., 42, 4914-4918. #14066

388. Lutz, M.J., Will, D.W., Breipohl, G., Benner, S.A., & Uhlmann, E. (1999) Synthesis of a monocharged peptide nucleic acid (PNA) analog and its recognition as substrate by DNA polymerases. Nucleosides Nucleotides, 18, 393-401. #13007

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391. Madder, A., Farcy, N., Hosten, N.G.C., De Muynck, H., De Clercq, P.J., Barry, J., & Davis, A.P. (1999) A novel sensitive colorimetric assay for visual detection of solid-phase bound amines. Eur. J. Org. Chem., 2787-2791. #1334

392. Madder, A., Farcy, N., Hosten, N.G.C., De Muynck, H., De Clercq, P.J., Barry, J., & Davis, A.P. (1999) A novel sensitive colorimetric assay for visual detection of solid-phase bound amines. Eur. J. Org. Chem., 2787-2791. #15987

393. Mahajan, A., Chhabra, S.R., & Chan, W.C. (1999) Resin-bound dendrimers as high loading supports for solid phase chemistry. Tetrahedron Lett., 40, 4909-4912. #13115

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395. Majewski, M., Ulaczyk, A., & Wang, F. (1999) Chiral lithium amides on solid support: Synthesis and applications in enantioselective deprotonation of cyclic ketones. Tetrahedron Lett., 40, 8755-8758. #13856

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398. Marchan, V., Debethune, L., Beltran, M., Robles, J., Travesset, I., Fabregas, G., Pedroso, E., & Grandas, A. (1999) The stepwise solid-phase synthesis methodology is suitable for the preparation of a great variety of nucleopeptides. Nucleosides Nucleotides, 18, 1493-1494. #13558

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404. Mata, E.G. (1999) Solid-phase and combinatorial synthesis in beta-lactam chemistry. Current Pharmaceutical Design, 5, 955-964. #14078

405. Matsuo, J., Odashima, K., & Kobayashi, S. (1999) A novel chiral pentamine ligand for enantioselective alpha-alkylation of acyclic lithium amide enolates. Optimization of chiral ligands for asymmetric reactions using solid-phase organic synthesis. Organic Letters, 1, 345-347. #15201

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407. Matysiak, S., Hauser, N.C., Wurtz, S., & Hoheisel, J.D. (1999) Improved solid supports and spacer/linker systems for the synthesis of spatially addressable PNA-libraries. Nucleosides Nucleotides, 18, 1289-1291. #13811

408. Mayfield, L.D., & Corey, D.R. (1999) Enhancing solid phase synthesis by a noncovalent protection strategy-efficient coupling of rhodamine to resin-bound peptide nucleic acids. Bioorg. Med. Chem. Lett., 9, 1419-1422. #12881

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418. Mendonca, A.J., & Xiao, X.Y. (1999) Optimization of solid supports for combinatorial chemical synthesis. Med. Res. Rev., 19, 451-462. #13812

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423. Micura, R. (1999) Cyclic oligoribonucleotides (RNA) by solid-phase synthesis. Chem. Eur. J., 5, 2077-2082. #13564

424. Miertus, S., & Fassina, G. (1999) Combinatorial Chemistry and Technology. Principles, Methods, and Applications. Marcel Dekker, Inc., New York, Basel. ISBN 0824719603 #13875

425. Milecki, J., Zamaratski, E., Maltseva, T.V., Foldesi, A., Adamiak, R.W., & Chattopadhyaya, J. (1999) The first example of sequence-specific non-uniformly C-13(5) labelled RNA: Synthesis of the 29mer HIV-1 TAR RNA with C-13 relaxation window. Tetrahedron, 55, 6603-6622. #13017

426. Miller, P.C., Owen, T.J., Molyneaux, J.M., Curtis, J.M., & Jones, C.R. (1999) A novel solid-phase synthesis of carboxypyrrolinones. Journal of Combinatorial Chemistry, 1, 223-234. #13566

427. Minard-Basquin, C., Chaix, C., Pichot, C., & Mandrand, B. (1999) Oligonucleotide synthesis on linear reactive polymer grafted onto solid support, medical diagnostics applications. Nucleosides Nucleotides, 18, 1285-1287. #13813

428. Miyabe, H., Fujishima, Y., & Naito, T. (1999) Novel synthesis of a-amino acid derivatives through triethylborane-induced solid-phase radical reactions. J. Org. Chem., 64, 2174-2175. #12882

429. Miyabe, H., Tanaka, H., & Naito, T. (1999) Triethylborane-induced solid-phase radical cyclization of oxime ethers. Tetrahedron Lett., 40, 8387-8390. #13838

430. Mizuno, M., Muramoto, I., Kobayashi, K., Yaginuma, H., & Inazu, T. (1999) A simple method for the synthesis of N-beta-glycosylated-asparagine and -glutamine derivatives. Synthesis-Stuttgart, 162-165. #12410

431. Mortezaei, R., Ida, S., & Campbell, D.A. (1999) Preparation of N-alkylated 5-oxo-3-carboxamyl-1,4-thiazinanes on solid support. Mol. Diversity, 4, 143-148. #13019

432. Mujica, M.T., & Jung, G. (1999) A novel approach to the solid-phase synthesis of (acyloxy)methyl ketones. Synlett, 1933-1935. #15210

433. Munch, G., Schicktanz, D., Behme, A., Gerlach, M., Riederer, P., Palm, D., & Schinzel, R. (1999) Amino acid specificity of glycation and protein-AGE crosslinking reactivities determined with a dipeptide SPOT library. Nat. Biotech., 17, 1006-1010. #14087

434. Murray, P.J., Kay, C., Scicinski, J.J., McKeown, S.C., Watson, S.P., & Carr, R.A.E. (1999) Rapid reaction scanning of solid phase chemistry using resins incorporating analytical constructs. Tetrahedron Lett., 40, 5609-5612. #13123

435. Nakamura, K., Hanai, N., Kanno, M., Kobayashi, A., Ohnishi, Y., Ito, Y., & Nakahara, Y. (1999) Design and synthesis of silyl ether-based linker for solid-phase synthesis of glycopeptides. Tetrahedron Lett., 40, 515-518. #12177

436. Nakamura, K., Ishii, A., Ito, Y., & Nakahara, Y. (1999) A novel silyl linker: Motif for side chain tethered approach to solid-phase glycopeptide synthesis. Tetrahedron, 55, 11253-11266. #13815

437. Nanda, S., Rao, A.B., & Yadav, J.S. (1999) Enzyme catalysed kinetic resolution of racemic 2,2-dimethyl-3-(2,2-disubstituted vinyl) cyclopropane carboxylic acids anchored on polymer supports. Tetrahedron Lett., 40, 5905-5908. #13571

438. Nefzi, A., Ostresh, J.M., Giulianotti, M., & Houghten, R.A. (1999) Solid-phase synthesis of trisubstituted 2-imidazolidones and 2-imidazolidinethiones. Journal of Combinatorial Chemistry, 1, 195-198. #13573

439. Nefzi, A., Ostresh, J.M., & Houghten, R.A. (1999) Parallel solid phase synthesis of tetrasubstituted diethylenetriamines via selective amide alklylation and exhaustive reduction of N-acylated dipeptides. Tetrahedron, 55, 335-344. #12178

440. Nefzi, A., Giulianotti, M.A., & Houghten, R.A. (1999) Solid phase synthesis of 1,6-disubstituted 2,3-diketopiperazines and 1,2-disubstituted piperazines from N-acylated amino acids. Tetrahedron Lett., 40, 8539-8542. #13844

441. Nefzi, A., Ong, N.A., Giulianotti, M.A., Ostresh, J.M., & Houghten, R.A. (1999) Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives. Tetrahedron Lett., 40, 4939-4942. #13109

442. Neilands, O., Liepinsh, V., & Turovska, B. (1999) Synthesis of novel tetrathiafulvalene system containing redox-active ribonucleoside and oligoribonucleotide. Organic Letters, 1, 2065-2067. #15215

443. Neilly, J.P., & Hochlowski, J.E. (1999) Elemental analysis of individual combinatorial chemistry library members by energy-dispersive X-ray spectroscopy. Appl. Spectrosc., 53, 74-81. #12415

444. Nicolaou, K.C., Hepworth, D., King, N.P., & Finlay, M.R.V. (1999) Chemistry, biology and medicine of selected tubulin polymerizing agents. Pure Appl. Chem., 71, 989-997. #15219

445. Nicolaou, K.C., Pfefferkorn, J.A., Cao, G.Q., Kim, S., & Kessabi, J. (1999) A facile method for the solution and solid-phase synthesis of substituted [3.3.1] bicycles. Organic Letters, 1, 807-810. #15220

446. Nukada, T., Berces, A., & Whitfield, D.M. (1999) Acyl transfer as a problematic side reaction in polymer-supported oligosaccharide synthesis. J. Org. Chem., 64, 9030-9045. #14091

447. Nuss, J.M., & Renhowe, P.A. (1999) Advances in solid-supported organic synthesis methods, 1998 to 1999. Curr. Opin. Drug. Disc. Develop., 2, 631-650. #14223

448. O'Donnell, M.J., Delgado, F., Drew, M.D., Pottorf, R.S., Zhou, C.Y., & Scott, W.L. (1999) Solid-phase synthesis of unnatural a-amino acid derivatives using a resin-bound glycine cation equivalent. Tetrahedron Lett., 40, 5831-5835. #13575

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450. Oh, J.E., Hong, S.Y., & Lee, K.H. (1999) The comparison of characteristics between membrane-active antifungal peptide and its pseudopeptides. Bioorg. Med. Chem., 7, 2509-2515. #14093

451. Oh, J.E., & Lee, K.H. (1999) Synthesis of novel unnatural amino acid as a building block and its incorporation into an antimicrobial peptide. Bioorg. Med. Chem., 7, 2985-2990. #14092

452. Olejnik, J., Ludemann, H.C., Krzymanska-Olejnik, E., Berkenkamp, S., Hillenkamp, F., & Rothschild, K.J. (1999) Photocleavable peptide-DNA conjugates: synthesis and applications to DNA analysis using MALDI-MS. Nucl. Acid. Res., 27, 4626-4631. #14094

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454. Ortmans, I., Content, S., Boutonnet, N., Kirsch-De, M.A., Bannwarth, W., Constant, J.F., Defrancq, E., & Lhomme, J. (1999) Ru-labeled oligonucleotides for photoinduced reactions on targeted DNA guanines. Chem. Eur. J., 5, 2712-2721. #15231

455. Osborn, H.M.I., & Khan, T.H. (1999) Recent developments in polymer supported syntheses of oligosaccharides and glycopeptides. Tetrahedron, 55, 1807-1850. #12792

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457. Ouyang, X., Tamayo, N., & Kiselyov, A.S. (1999) Solid support synthesis of 2-substituted dibenz[b,f]oxazepin-11(10H)-ones via SNAr methodology on AMEBA resin. Tetrahedron, 55, 2827-2834. #12653

458. Overkleeft, H.S., Verhelst, S.H.L., Pieterman, E., Meeuwenoord, N.J., Overhand, M., Cohen, L.H., van der Marel, G.A., & van Boom, J.H. (1999) Design and synthesis of a protein: Farnesyltransferase inhibitor based on sugar amino acids. Tetrahedron Lett., 40, 4103-4106. #12898

459. Padiya, K.J., & Salunkhe, M.M. (1999) A new and selective oxidising reagent for oligonucleotide synthesis. Journal of Chemical Research-S, 804-805. #12795

460. Page, P., Bradley, M., Walters, I., & Teague, S. (1999) Solid-phase synthesis sf tyrosine peptide aldehydes. Analogues of (S)-MAPI. J. Org. Chem., 64, 794-799. #12597

461. Paio, A., Zaramella, A., Ferritto, R., Conti, N., Marchioro, C., & Seneci, P. (1999) Solid-supported benzotriazoles: Synthetic auxiliaries and traceless linkers for the combinatorial synthesis of amine libraries. Journal of Combinatorial Chemistry, 1, 317-325. #13635

462. Palacios, F., de Retana, A.M.O., & Pagalday, J. (1999) A regioselective synthesis of 5-pyrazolones and pyrazoles from phosphazenes derived from hydrazines and acetylenic esters. Tetrahedron, 55, 14451-14458. #14099

463. Palacios, F., Aparicio, D., de Retana, A.M.O., Garcia, J., & Oyarzabal, J. (1999) An easy strategy for the synthesis of 5-phosphorylated pyrimidin-2,4-diones from beta-phosphine oxide and phosphonate enamines. Tetrahedron, 55, 3105-3116. #12797

464. Palacios, F., de Retana, A.M.O., & Oyarzabal, J. (1999) A simple synthesis of 3-phosphonyl-4-aminoquinolines from beta-enaminophosphonates. Tetrahedron, 55, 5947-5964. #13025

465. Paris, M., Pothion, C., Goulleux, L., Heitz, A., Martinez, J., & Fehrentz, J.A. (1999) Synthesis of peptide aldehydes on solid support. Reactive and Functional Polymers, 41, 255-261. #13577

466. Paris, M., Pothion, C., Heitz, A., Rocheblave, L., Rouch, F., Fehrentz, J.A. & Martinez, J. (1999) Solid phase synthesis of peptide aldehydes. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 15-18). Mayflower Scientific Limited, Birmingham. #13452

467. Park, K.H., & Kurth, M.J. (1999) Solid-phase synthesis of novel heterocycles containing thiohydantoin and isoxazole rings. J. Org. Chem., 64, 9297-9300. #14101

468. Park, K.H., & Kurth, M.J. (1999) An uncatalyzed cyclo-elimination process for the release of N-3-alkylated hydantoins from solid-phase: synthesis of novel isoxazoloimidazolidinediones. Tetrahedron Lett., 40, 5841-5844. #13578

469. Parrot, I., Wermuth, C.G., & Hibert, M. (1999) Resin-bound thiophenols as SNAR-labile linkers: Application to the solid phase synthesis of aminopyridazines. Tetrahedron Lett., 40, 7975-7978. #13852

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473. Peluso, S., Dumy, P., Nkubana, C., Yokokawa, Y., & Mutter, M. (1999) Solid-phase strategies for the assembly of template-based protein mimetics. J. Org. Chem., 64, 7114-7120. #13816

474. Peng, G., Sohn, A., & Gallop, M.A. (1999) Stereoselective solid-phase synthesis of a triaza tricyclic ring system: A new chemotype for lead discovery. J. Org. Chem., 64, 8342-8349. #14103

475. Pernerstorfer, J., Schuster, M., & Blechert, S. (1999) A solid-phase synthesis of functionalized 6-, 7- and 8-membered azacycles via olefin metathesis. Synthesis-Stuttgart, 138-144. #12229

476. Perumattam, J., Chakravarty, S. & McEnroe, G. (1999) Strategies for rapid generation of small molecule libraries on solid support. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 123-126). Mayflower Scientific Limited, Birmingham. #13661

477. Peyrottes, S., Mestre, B., Burlina, F., & Gait, M.J. (1999) Studies towards the synthesis of peptide-oligonucleotide conjugates. Nucleosides Nucleotides, 18, 1443-1448. #13583

478. Phoon, C.W., & Abell, C. (1999) Use of quinic acid as template in solid-phase combinatorial synthesis. Journal of Combinatorial Chemistry, 1, 485-492. #14748

479. Pinilla, C., Appel, J.R. & Houghten, R.A. (1999) Positional scanning combinatorial libraries: How and why complex mixtures work. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 159-162). Mayflower Scientific Limited, Birmingham. #13668

480. Piro, J., Rubiralta, M., Giralt, E., & Diez, A. (1999) 3-Amino-2-piperidones as constrained pseudopeptides: Preparation of a new Ser-Leu surrogate. Tetrahedron Lett., 40, 4865-4868. #13114

481. Piscopio, A.D., Miller, J.F., & Koch, K. (1999) Ring closing metathesis in organic synthesis: Evolution of a high speed, solid phase method for the preparation of b-turn mimetics. Tetrahedron, 55, 8189-8198. #13415

482. Pivonka, D.E., & Palmer, D.L. (1999) Direct infrared spectroscopic analysis of reagent partitioning in polystyrene bead supported solid phase reaction chemistry. Journal of Combinatorial Chemistry, 1, 294-296. #13634

483. Pivonka, D.E., Palmer, D.L., & Gero, T.W. (1999) Infrared investigation of acid activation by PyBOP in polystyrene/divinylbenzene supported solid-phase synthesis. Appl. Spectrosc., 53, 1027-1032. #15253

484. Planas, M., Bardaji, E., Jensen, K.J., & Barany, G. (1999) Use of the dithiasuccinoyl (Dts) amino protecting group for solid-phase synthesis of protected peptide nucleic acid (PNA) oligomers. J. Org. Chem., 64, 7281-7289. #14108

485. Pon, R.T., Yu, S., Guo, Z., Yang, X., & Sanghvi, Y.S. (1999) Reusable solid-phase supports for oligonucleotide synthesis using hydroquinone-O,O'-diacetic acid ("Q-linker"). Nucleosides Nucleotides, 18, 1237-1238. #13819

486. Pon, R.T., Yu, S.Y., & Sanghvi, Y.S. (1999) Rapid esterification of nucleosides to solid-phase supports for oligonucleotide synthesis using uronium and phosphonium coupling reagents. Bioconjug. Chem., 10, 1051-1057. #14247

487. Pon, R.T. & Yu, S. (1999) New methods for the rapid derivatization and cleavage of solid-phase supports for oligonucleotide synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 373-376). Mayflower Scientific Limited, Birmingham. #13716

488. Pon, R.T., Yu, S.Y., Guo, Z.Q., & Sanghvi, Y.S. (1999) Multiple oligodeoxyribonucleotide syntheses on a reusable solid-phase CPG support via the hydroquinone-O,O'-diacetic acid (Q-Linker) linker arm. Nucl. Acid. Res., 27, 1531-1538. #12657

489. Poupart, M.A., Fazal, G., Goulet, S., & Mar, L.T. (1999) Solid-phase synthesis of peptidyl trifluoromethyl ketones. J. Org. Chem., 64, 1356-1361. #12658

490. Powers, D.G., & Coffen, D.L. (1999) Convergent automated parallel synthesis. Drug Disc. Today, 4, 377-383. #13585

491. Prasad, V., Hashim, S., Mukhopadhyay, A., Basu, S.K., & Roy, R.P. (1999) Oligonucleotides tethered to a short polyguanylic acid stretch are targeted to macrophages: Enhanced antiviral activity of a vesicular stomatitis virus-specific antisense oligonucleotide. Antimicrob. Agents Chemother., 43, 2689-2696. #14109

492. Rademann, J., Meldal, M., & Bock, K. (1999) Solid-phase synthesis of peptide isosters by nucleophilic reactions with N-terminal peptide aldehydes on a polar support tailored for solid-phase organic chemistry (vol 5, pg 1218, 1999). Chem. Eur. J., 5, 1376. #13030

493. Rademann, J., Grotli, M., Meldal, M., & Bock, K. (1999) SPOCC: A resin for solid-phase organic chemistry and enzymatic reactions on solid phase. J. Amer. Chem. Soc., 121, 5459-5466. #13416

494. Rademann, J., Meldal, M., & Bock, K. (1999) Solid-phase synthesis of peptide isosters by nucleophilic reactions with N-terminal peptide aldehydes on a polar support tailored for solid-phase organic chemistry. Chem. Eur. J., 5, 1218-1225. #12802

495. Rajwanshi, V.K., Kumar, R., Kofod-Hansen, M., & Wengel, J. (1999) Synthesis and restricted furanose conformations of three novel bicyclic thymine nucleosides: A xylo-LNA nucleoside, a 3 '-O,5 '-C-methylene-linked nucleoside, and a 2 '-O,5 '-C-methylene-linked nucleoside. J. Chem. Soc., 1407-1414. #13031

496. Rajwanshi, V.K., Hakansson, A.E., Dahl, B.M., & Wengel, J. (1999) LNA stereoisomers: xylo-LNA (beta-D-xylo configured locked nucleic acid) and alpha-L-LNA (alpha-L-ribo configured locked nucleic acid). Chem. Commun., 1395-1396. #13588

497. Rana, S., White, P., & Bradley, M. (1999) Synthesis of magnetic beads for solid phase synthesis and reaction scavenging. Tetrahedron Lett., 40, 8137-8140. #13843

498. Rapp, W. & Karnbrock, W. (1999) A novel modular synthesis strategy for automated parallel synthesis of small organic molecules. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 47-50). Mayflower Scientific Limited, Birmingham. #13457

499. Redemann, T., Bandel, H., & Jung, G. (1999) Synthesis of peptidomimetics using a polymer-bound Boc-linker. Mol. Diversity, 4, 191-197. #14393

500. Redemann, T., Brooks, M.E. & Jung, G. (1999) Discovery of a novel gyrase inhibitor by combinatorial solid phase synthesis of 1,2,3,4-tetrahydro-b-carbolines. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 377-380). Mayflower Scientific Limited, Birmingham. #13717

501. Reese, C.B., & Song, Q.L. (1999) A new approach to the synthesis of branched and branched cyclic oligoribonucleotides. Nucl. Acid. Res., 27, 2672-2681. #14115

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503. Ren, S.M., Cai, L.S., & Segal, B.M. (1999) Synthesis and characterization of monodeoxynucleotide tethered platinum-(II) and -(IV) complexes. Journal of the Chemical Society-Dalton Transactions, 1413-1422. #13033

504. Renneberg, B., & Labadie, J.W. (1999) Polymeric supports for solid phase synthesis. Chim. Oggi, 17, 7-9. #13369

505. Renwinkel, J.B.M., & Adang, A.E.P. (1999) Strategies and progress towards the ideal orally active thrombin inhibitor. Current Pharmaceutical Design, 5, 1043-1075. #14117

506. Richter, H., Holtzel, A. & Jung, G. (1999) Formation of allylic alcohols via Baylis-Hilman reaction for the synthesis of isoxazolines. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 381-384). Mayflower Scientific Limited, Birmingham. #13718

507. Richter, H., Walk, T., Holtzel, A., & Jung, G. (1999) Polymer bound 3-hydroxy-2-methylidenepropionic acids. A template for multiple core structure libraries. J. Org. Chem., 64, 1362-1365. #15654

508. Robertson, N., & Ramage, R. (1999) Total chemical synthesis of deglycosylated human erythropoietin. J. Chem. Soc., 1015-1021. #13038

509. Robles, J., Beltran, M., Marchan, V., Perez, Y., Travesset, I., Pedroso, E., & Grandas, A. (1999) Towards nucleopeptides containing any trifunctional amino acid. Tetrahedron, 55, 13251-12264. #14119

510. Robles, J., Ibanez, V., Grandas, A., & Pedroso, E. (1999) Synthesis and triple helix-forming ability of oligonucleotides with N,N-dimethylaminoethyl phosphoramidate linkages. Tetrahedron Lett., 40, 7131-7134. #13765

511. Rockwell, A.L., Rafalski, M., Pitts, W.J., Batt, D.G., Petraitis, J.J., DeGrado, W.F., Mousa, S., & Jadhav, P.K. (1999) Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase: Identification of avb3 antagonists lead compounds. Bioorg. Med. Chem. Lett., 9, 937-942. #12885

512. Roesch, K.R., & Larock, R.C. (1999) Synthesis of isoquinolines and pyridines by the palladium- and copper-catalyzed coupling and cyclization of terminal acetylenes. Organic Letters, 1, 553-556. #15275

513. Romieu, A., Gasparutto, D., Molko, D., Ravanat, J.L., & Cadet, J. (1999) Synthesis of oligonucleotides containing the (4R) and (4S) diastereoisomers of 4,8-dihydro-4-hydroxy-8-oxo-2 '-deoxyguanosine. Eur. J. Org. Chem., 49-56. #12426

514. Romieu, A., Gasparutto, D., & Cadet, J. (1999) Synthesis and characterization of oligodeoxynucleotides containing the two 5R and 5S diastereomers of (5 ' S,6S)-5 ',6-cyclo-5,6-dihydrothymidine; radiation-induced tandem lesions of thymidine. J. Chem. Soc., 1257-1263. #13039

515. Rose, D. (1999) Microdispensing technologies in drug discovery. Drug Disc. Today, 4, 411-419. #15492

516. Rosse, G., Ouertani, F., & Schroder, H. (1999) Efficient solid-phase synthesis of b-aminosubstituted piperidinols. Journal of Combinatorial Chemistry, 1, 397-401. #13655

517. Rottlander, M., & Knochel, P. (1999) Synthesis of 2,4-disubstituted 2,5-dihydrofurans and 1-substituted 1,3-dihydroisobenzofurans via an iodine-magnesium exchange reaction. Journal of Combinatorial Chemistry, 1, 181-183. #13594

518. Roussel, P., Bradley, M., Kane, P., Bailey, C., Arnold, R., & Cross, A. (1999) Inhibition of the tissue factor factor VIIa complex: Lead optimisation using combinatorial chemistry. Tetrahedron, 55, 6219-6230. #13040

519. Ryu, J.H., & Jeong, J.H. (1999) Development of new dihydropyran linker for solid-phase reaction. Archives of Pharmacal Research, 22, 585-591. #14124

520. Sabatino, G., Chelli, M., Mazzucco, S., Ginanneschi, M., & Papini, A.M. (1999) Cyclisation of histidine containing peptides in the solid-phase by anchoring the imidazole ring to trityl resins. Tetrahedron Lett., 40, 809-812. #12186

521. Salvino, J.M., Mervic, M., Mason, H.J., Kiesow, T., Teager, D., Airey, J., & Labaudiniere, R. (1999) Parallel synthesis of aldehydes and ketone facilitated by a new solid-phase Weinreb amide. J. Org. Chem., 64, 1823-1830. #12661

522. Salvino, J.M., Kiesow, T.J., Darnbrough, S., & Labaudiniere, R. (1999) Solid-phase Horner-Emmons synthesis of olefins. Journal of Combinatorial Chemistry, 1, 134-139. #12698

523. Sams, C.K., & Lau, J. (1999) Solid-phase synthesis of 1,2,4-oxadiazoles. Tetrahedron Lett., 40, 9359-9362. #13883

524. Sauer, M., Brecht, A., Charisse, K., Maier, M., Gerster, M., Stemmler, I., Gauglitz, G., & Bayer, E. (1999) Interaction of chemically modified antisense oligonucleotides with sense DNA: A label-free interaction study with reflectometric interference spectroscopy. Anal. Chem., 71, 2850-2857. #13597

525. Savin, K.A., Woo, J.C., & Danishefsky, S.J. (1999) A new polymer support silylene linking method for hindered hydroxyl-bearing systems. J. Org. Chem., 64, 4183-4186. #14227

526. Schiemann, K., & Showalter, H.D.H. (1999) Development of polymer-supported benzotriazole as a novel traceless linker for solid-phase organic synthesis. J. Org. Chem., 64, 4972-4975. #13419

527. Schneider, S.E., & Anslyn, E.V. (1999) Molecular recognition and solid phase organic synthesis: Synthesis of unnatural oligomers, techniques for monitoring reactions, and the analysis of combinatorial libraries. Advances in Supramolecular Chemistry, 5, 55-120. #13045

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529. Schurer, S.C., & Blechert, S. (1999) Sequences of yne-ene cross metathesis and Diels-Alder cycloaddition reactions. Modular solid phase synthesis of substituted octahydrobenzazepinones. Synlett, 1879-1882. #15305

530. Schwan, A.L., & Strickler, R.R. (1999) Synthesis and reactions of sulfinyl chlorides. An update. Organic Preparations and Procedures International, 31, 579. #15306

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533. Schweizer, F., & Hindsgaul, O. (1999) Combinatorial synthesis of carbohydrates. Curr. Opin. Chem. Biol., 3, 291-298. #13046

534. Seeberger, P.H., Caruthers, M.H., Bankaitis-Davis, D., & Beaton, G. (1999) Synthesis of phosphorodithioate DNA by the H-phosphonothioate method. Tetrahedron, 55, 5759-5772. #13048

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537. Seela, F., & Wei, C.F. (1999) The base-pairing properties of 7-deaza-2'-deoxyisoguanosine and 2'-deoxyisoguanosine in oligonucleotide duplexes with parallel and antiparallel chain orientation. Helv. Chim. Acta, 82, 726-745. #13049

538. Seela, F., & Zulauf, M. (1999) Incorporation of 2'-deoxysangivamycin in DNA duplexes: The conversion of a pyrrolo[2,3-d]pyrimidine nitrile to a carboxamide upon oligonucleotide deprotection. Nucleosides Nucleotides, 18, 2697-2709. #14134

539. Seela, F., & Zulauf, M. (1999) Synthesis of oligonucleotides containing pyrazolo[3,4-d]pyrimidines: The influence of 7-substituted 8-aza-7-deazaadenines on the duplex structure and stability. J. Chem. Soc., 479-488. #12809

540. Seela, F., & Becher, G. (1999) Oligonucleotides containing pyrazolo[,4-d]pyrimidines: The influence of 7-substituted 8-aza-7-deaza-2'-deoxyguanosines on the duplex structure and stability. Helv. Chim. Acta, 82, 1640-1655. #14135

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543. Seitz, O. (1999) Solid phase synthesis of protected peptide nucleic acids. Tetrahedron Lett., 40, 4161-4164. #12889

544. Sekine, M., & Hata, T. (1999) Chemical synthesis of oligonucleotides by use of phenylthio group. Current Organic Chemistry, 3, 25-66. #12438

545. Shakespeare, W.C., Bohacek, R.S., Narula, S.S., Azimioara, M.D., Yuan, R.W., Dalgarno, D.C., Madden, L., Botfield, M.C., & Holt, D.A. (1999) An efficient synthesis of a 4'-phosphonodifluoromethyl-3'-formyl-phenylalanine containing Src SH2 ligand. Bioorg. Med. Chem. Lett., 9, 3109-3112. #14137

546. Shapiro, M.J., Chin, J., Chen, A.D., Wareing, J.R., Tang, Q., Tommasi, R.A., & Marepalli, H.R. (1999) Covalent or trapped? PFG diffusion MAS NMR for combinatorial chemistry. Tetrahedron Lett., 40, 6141-6143. #13602

547. Shapiro, M.J., & Gounarides, J.S. (1999) NMR methods utilized in combinatorial chemistry research. Progress in Nuclear Magnetic Resonance Spectroscopy, 35, 153-200. #15312

548. Sharma, S.K., Wu, A.D., Chandramouli, N., Fotsch, C., Kardash, G., & Bair, K.W. (1999) Solid-phase total synthesis of polymyxin B1. J. Pept. Res., 53, 501-506. #13050

549. Shaughnessy, K.H., Kim, P., & Hartwig, J.F. (1999) A fluorescence-based assay for high-throughput screening of coupling reactions. Application to Heck chemistry. J. Amer. Chem. Soc., 121, 2123-2132. #12812

550. Shchepinov, M.S., Chalk, R., & Southern, E.M. (1999) Trityl mass-tags for encoding in combinatorial oligonucleotide synthesis. Nucleic Acid. Symp. Ser., 107-108. #14704

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553. Siev, D.V., Gaudette, J.A., & Semple, J.E. (1999) Novel protocol for the solid-phase synthesis of peptidyl and peptidomimetic P1-argininal derivatives. Tetrahedron Lett., 40, 5123-5127. #13117

554. Silva, D.J., Wang, H.M., Allanson, N.M., Jain, R.K., & Sofia, M.J. (1999) Stereospecific solution- and solid-phase glycosylations. Synthesis of b-linked saccharides and construction of disaccharide libraries using phenylsulfenyl 2-deoxy-2-trifluoroacetamido glycopyranosides as glycosyl donors. J. Org. Chem., 64, 5926-5929. #13823

555. Simpson, J., Rathbone, D.L., & Billington, D.C. (1999) New solid phase Knoevenagel catalyst. Tetrahedron Lett., 40, 7031-7033. #13762

556. Singh-Gasson, S., Green, R.D., Yue, Y., Nelson, C., Blattner, F., Sussman, M.R., & Cerrina, F. (1999) Maskless fabrication of light-directed oligonucleotide microarrays using a digital micromirror array. Nat. Biotech., 17, 974-978. #13742

557. Singh, R., & Nuss, J.M. (1999) Solid phase synthesis of beta-lactams via the Staudinger reaction. Tetrahedron Lett., 40, 1249-1252. #12443

558. Sjolin, P., George, S.K., Bergquist, K.E., Roy, S., Svensson, A., & Kihlberg, J. (1999) Synthesis of deoxy and alanine-substituted derivatives of a T cell stimulating glycopeptide: An investigation of conditions for cleavage from the solid phase and deprotection. J. Chem. Soc. Perkin Trans. 1, 1731-1742. #13421

559. Slade, R.M., Phillips, M.A., & Berger, J.G. (1999) Application of an almost traceless linker in the synthesis of 2-alkylthiobenzimidazole combinatorial libraries. Mol. Diversity, 4, 215-219. #14536

560. Smith, A.B., Benowitz, A.B., Sprengeler, P.A., Barbosa, J., Guzman, M.C., Hirschmann, R., Schweiger, E.J., Bolin, D.R., Nagy, Z., Campbell, R.M., Cox, D.C., & Olson, G.L. (1999) Design and synthesis of a competent pyrrolinone-peptide hybrid ligand for the class II major histocompatibility complex protein HLA-DR1. J. Amer. Chem. Soc., 121, 9286-9298. #14147

561. Smith, E.M. (1999) A polymer-supported silyl triflate and subsequent functionalization: Synthesis and solid-phase Diels-Alder reactions of silyloxydienes. Tetrahedron Lett., 40, 3285-3288. #12680

562. Smith, H.K., & Bradley, M. (1999) Comparison of resin and solution screening methodologies in combinatorial chemistry and the identification of a 100 nM inhibitor of trypanothione reductase. Journal of Combinatorial Chemistry, 1, 326-332. #13603

563. Smith, J.M., & Krchnak, V. (1999) A solid phase traceless synthesis of benzimidazoles with three combinatorial steps. Tetrahedron Lett., 40, 7633-7636. #13770

564. Smith, J.M., Gard, J., Cummings, W., Kanizsai, A., & Krchnak, V. (1999) Necklace-coded polymer-supported combinatorial synthesis of 2-arylaminobenzimidazoles. Journal of Combinatorial Chemistry, 1, 368-370. #13649

565. Smith, M.D., & Fleet, G.W.J. (1999) Designing secondary structures: 5-Azidomethyl tetrahydrofuran-2-carboxylates as carbohydrate-derived dipeptide isosteres. J. Peptide Sci., 5, 425-441. #14435

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568. Soth, M.J., & Nowick, J.S. (1999) A peptide/oligourea/azapeptide hybrid that adopts a hairpin turn. J. Org. Chem., 64, 276-281. #12447

569. Souers, A.J., Schurer, S., Kwack, H., Virgilio, A.A., & Ellman, J.A. (1999) Preparation of enantioenriched alpha-bromo acids incorporating diverse functionality. Synthesis-Stuttgart, 583-585. #13052

570. Souers, A.J., Virgilio, A.A., Rosenquist, A., Fenuik, W., & Ellman, J.A. (1999) Identification of a potent heterocyclic ligand to somatostatin receptor subtype 5 by the synthesis and screening of beta-turn mimetic libraries. J. Amer. Chem. Soc., 121, 1817-1825. #12814

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572. Spivey, A.C., Diaper, C.M., & Rudge, A.J. (1999) A new germanium based linker for solid phase synthesis of aromatic compounds. Chem. Commun., 835-836. #12890

573. Sproat, B.S., Rupp, T., Menhardt, N., Keane, D., & Beijer, B. (1999) Fast and simple purification of chemically modified hammerhead ribozymes using a lipophilic capture tag. Nucl. Acid. Res., 27, 1950-1955. #13053

574. Srivastava, S.K., Haq, W., Murthy, P.K., & Chauhan, F.M.S. (1999) Solid phase synthesis of quinolones. Bioorg. Med. Chem. Lett., 9, 1885-1888. #13604

575. Srivastava, S.K., Haq, W., & Chauhan, P.M.S. (1999) A solid phase approach to substituted pyrimidines and their conversion into condensed heterocycles for potential use in combinatorial chemistry. Comb. Chem. High Throughput Screening, 2, 33-38. #12849

576. Srivastava, S.K., Haq, W., & Chauhan, P.M.S. (1999) Solid phase synthesis of structurally diverse pyrimido[4,5-d] pyrimidines for the potential use in combinatorial chemistry. Bioorg. Med. Chem. Lett., 9, 965-966. #12891

577. Stano, A., Mucha, A., & Kafarski, P. (1999) Reaction of N-(benzyloxycarbonyl)aminobenzylphosphonous acid with ethyl orthoformate. Syn. Commun., 29, 4269-4277. #15328

578. Stephensen, H., & Zaragoza, F. (1999) Solid-phase synthesis of N-hydroxyindoles and benzo[c]isoxazoles by C-arylation of substituted acetonitriles and 1,3-dicarbonyl compounds with polystyrene-bound aryl fluorides. Tetrahedron Lett., 40, 5799-5802. #13128

579. Stieber, F., Grether, U., & Waldmann, H. (1999) An oxidation-labile traceless linker for solid-phase synthesis. Angew. Chem. Int. Ed., 38, 1073-1077. #13055

580. Subramanian, R., Sweedler, J.V., & Webb, A.G. (1999) Rapid two-dimensional inverse detected heteronuclear correlation experiments with < 100 nmol samples with solenoidal microcoil NMR probes. J. Amer. Chem. Soc., 121, 2333-2334. #12817

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583. Suguro, T., & Yanai, M. (1999) Solid-phase synthesis of cyclooctadepsipeptide N-4909 using a cyclization-cleavage method with oxime resin. Journal of Antibiotics, 52, 835-838. #14157

584. Sun, S.G., & Murray, W.V. (1999) Solid phase Diels-Alder reactions of amino acid derived trienes. J. Org. Chem., 64, 5941-5945. #13826

585. Sunami, S., Sagara, T., Ohkubo, M., & Morishima, H. (1999) Solid phase synthesis of aryl and heteroaryl amines using the Curtius rearrangement. Tetrahedron Lett., 40, 1721-1724. #12602

586. Surovoy, A.Y., Egorova, N.S., Grebennikova, Z.O., & Shamborant, O.G. (1999) The solid phase synthesis of cationic lipids [Russian]. Bioorganicheskaia Khimiia, 25, 153-155. #13057

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589. Sylvain, C., Wagner, A., & Mioskowski, C. (1999) An efficient procedure for the esterification of nitroacetic acid: Application to the preparation of Merrifield resin-bound nitroacetate. Tetrahedron Lett., 40, 875-878. #12231

590. Tadesse, S., Bhandari, A., & Gallop, M.A. (1999) Solid-phase synthesis of highly functionalized 2,2'-bipyridines. Journal of Combinatorial Chemistry, 1, 184-187. #13606

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592. Tam, J.P. & Zhang, L. (1999) From small to large molecules: Versatility of orthogonal ligation chemistry. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 1-6). Mayflower Scientific Limited, Birmingham. #13449

593. Tamilarasu, N., Huq, I., & Rana, T.M. (1999) High affinity and specific binding of HIV-1 TAR RNA by a Tat-derived oligourea. J. Amer. Chem. Soc., 121, 1597-1598. #12818

594. Tan, D.S., Foley, M.A., Stockwell, B.R., Shair, M.D., & Schreiber, S.L. (1999) Synthesis and preliminary evaluation of a library of polycyclic small molecules for use in chemical genetic assays. J. Amer. Chem. Soc., 121, 9073-9087. #14160

595. Tanaka, K., & Shionoya, M. (1999) Synthesis of a novel nucleoside for alternative DNA base pairing through metal complexation. J. Org. Chem., 64, 5002-5003. #13607

596. Tang, X.Q., Liao, X.M., & Piccirilli, J.A. (1999) 2'-C-Branched ribonucleosides: Synthesis of the phosphoramidite derivatives of 2'-C-beta-methylcytidine and their incorporation into oligonucleotides. J. Org. Chem., 64, 747-754. #12819

597. Terrett, N. (1999) Combinatorial chemistry: High-affinity SH2-targeted ligands. Drug Disc. Today, 4, 442-443. #13608

598. Terrett, N. (1999) Combinatorial chemistry. Drug Disc. Today, 4, 481-482. #15490

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601. Terrett, N. (1999) Combinatorial chemistry: Peptidyl trifluoromethyl ketones. Drug Disc. Today, 4, 291-292. #14165

602. Terrett, N. (1999) Combinatorial chemistry: Bicyclic guanidine libraries. Drug Disc. Today, 4, 187-188. #12822

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607. Tietze, L.F., & Zhou, Y.F. (1999) Highly efficient, enantioselective total synthesis of the active anti-influenza A virus indole alkaloid hirsutine and related compounds by domino reactions. Angew. Chem., 2045-2047. #13610

608. Todd, M.H., Oliver, S.F., & Abell, C. (1999) A novel safety-catch linker for the solid-phase synthesis of amides and esters. Organic Letters, 1, 1149-1151. #15338

609. Todd, M.H., Oliver, S.F., & Abell, C. (1999) A novel safety-catch linker for the solid-phase synthesis of amides and esters. (vol 1, pg 1151, 1999). Organic Letters, 1, 1687. #15337

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613. Tsai, J.H., Waldman, A.S., & Nowick, J.S. (1999) Two new beta-strand mimics. Bioorg. Med. Chem., 7, 29-38. #12824

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627. Vinayak, R. (1999) A convenient solid phase coupling of rhodamine dye acids to 5' amino-oligonucleotides. Tetrahedron Lett., 40, 7611-7613. #13769

628. Vives, E., Dell'Aquila, C., Bologna, J.C., Morvan, F., Rayner, B., & Imbach, J.L. (1999) Lipophilic pro-oligonucleotides are rapidly and efficiently internalized in HeLa cells. Nucl. Acid. Res., 27, 4071-4076. #14182

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646. Wilk, A., Grajkowski, A., Phillips, L.R., & Beaucage, S.L. (1999) The 4-[N-methyl-N-(2,2,2-trifluoroacetyl)amino]butyl group as an alternative to the 2-cyanoethyl group for phosphate protection in the synthesis of oligodeoxyribonucleotides. J. Org. Chem., 64, 7515-7522. #14189

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648. Wipf, P., & Reeves, J.T. (1999) Synthesis and applications of a highly fluorous alkoxy ethyl ether protective group. Tetrahedron Lett., 40, 5139-5142. #13623

649. Wojczewski, C., Stolze, K., & Engels, J.W. (1999) Fluorescent oligonucleotides: Versatile tools as probes and primers for DNA and RNA analysis. Synlett, 1667-1678. #15377

650. Wozniak, L.A. (1999) Stereodefined methanephosphonate analogues of nucleic acids. Reviews on Heteroatom Chemistry, 19, 173-202. #12836

651. Wu, X.L., & Pitsch, S. (1999) Functionalization of the sugar moiety of oligoribonucleotides on solid support. Bioconjug. Chem., 10, 921-924. #14252

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653. Xia, J., Piskorz, C.F., Locke, R.D., Chandrasekaran, E.V., Alderfer, J.L., & Matta, K.L. (1999) An efficient synthesis of two monosulfated trisaccharides with the Gal beta 1,3GlcNAc beta 1,3Gal beta-O-allyl backbone. Bioorg. Med. Chem. Lett., 9, 2941-2946. #14196

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655. Xiao, X.Y., Nova, M.P., & Czarnik, A.W. (1999) A cyclitively cleavable linker for alcohols: Linker preparation and cleavage conditions. Journal of Combinatorial Chemistry, 1, 379-382. #13652

656. Xu, J.X., Liang, B., & Jin, S. (1999) Synthesis of 1,5-benzothiazepine-1-oxide/-1,1-dioxide derivatives and 1,2-oxazirino[2,3-a] [1,5] benzodiazepine. Phosphorus Sulfur and Silicon and the Related Elements, 152, 1-8. #15379

657. Yamada, H., Kato, T., & Takahashi, T. (1999) One-pot sequential glycosylation: A new method for the synthesis of branched oligosaccharides. Tetrahedron Lett., 40, 4581-4584. #13082

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659. Yamamoto, Y., Tanabe, K., & Okonogi, T. (1999) Application of polymer supported base in solid phase synthesis: Convenient synthesis of N-aryl-N'-benzyl piperazine derivatives. Chem. Lett., 103-104. #12673

660. Yamashita, D.S., Dong, X.Y., Oh, H.J., Brook, C.S., Tomaszek, T.A., Szewczuk, L., Tew, D.G., & Veber, D.F. (1999) Solid-phase synthesis of a combinatorial array of 1,3-bis(acylamino)-2-butanones, inhibitors of the cysteine proteases cathepsins K and L. Journal of Combinatorial Chemistry, 1, 207-215. #13624

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666. Yang, C., & Yang, W.D. (1999) A mild and selective solid phase oxidation of polythioether to octopus polysulfoxide using UHP under supersonic wave. Syn. Commun., 29, 2575-2581. #13426

667. Yao, Z.J., Gao, Y., Voigt, J.H., Ford, H., & Burke, T.R. (1999) Synthesis of Fmoc-protected 4-carboxydifluoromethyl-L-phenylalanine: A phosphotyrosyl mimetic of potential use for signal transduction studies. Tetrahedron, 55, 2865-2874. #12838

668. Yeh, C.M., & Sun, C.M. (1999) Rapid parallel synthesis of benzimidazoles. Synlett, 810-812. #13625

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675. Zehavi, U. (1999) Perspectives of oligosaccharide and glycosphingolipid synthesis on polymer supports. Reactive and Functional Polymers, 41, 59-68. #13628

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677. Zhang, H., Wang, Y.L., Thurmer, R., Parvez, K., Choudhary, I., Atta, u.R., & Voelter, W. (1999) Neighbouring group participation of C-6 substituents of glucose derivatives on the stereoselectivity of the N-glycosidic linkage of glycopeptides. Zeitschrift fur Naturforschung Section B-A Journal of Chemical Sciences, 54, 692-698. #13089

678. Zhang, W., Xie, W., Fang, J., & Wang, P.G. (1999) Ytterbium (III) trifluoromethanesulfonate catalyzed solid phase aza Diels-Alder reaction and subsequent facile adduct release. Tetrahedron Lett., 40, 7929-7933. #13850

679. Zhang, Y.S., Li, D.M., Houtman, J.C., Witiak, D.T., Seltzer, J., Bertics, P.J., & Lauhon, C.T. (1999) Design, combinatorial chemical synthesis and in vitro characterization of novel urea based gelatinase inhibitors. Bioorg. Med. Chem. Lett., 9, 2823-2826. #14203

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