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Papers on solid phase organic synthesis published in 1996

This list is arranged by the name of the first author. Any omissions, mistakes and inconsistencies please communicate to the authors of compilation (michal@5z.com). (If you are pointing to any reference, please use its ID# -- the last number in the reference.) You are welcome to use this compilation in your work. Proper way to quote it in your paper is: Lebl M., Leblova Z.: Dynamic database of references in molecular diversity. Internet http://www.5z.com.


Recently added entries are marked in bold

  1. Acevedo, O.L., & Andrews, R.S. (1996) Synthesis of propane-2,3-diol combinatorial monomers. Tetrahedron Lett., 37, 3931-3934. #4601

  2. Adamczyk, M., & Fishpaugh, J.R. (1996) A solid supported synthesis of thiol esters. Tetrahedron Lett., 37, 4305-4308. #4983

  3. Adamczyk, M., & Fishpaugh, J.R. (1996) Expeditious synthesis of Mosher amides using a solid supported carbodiimide. Tetrahedron Lett., 37, 7171-7172. #5527

  4. Adinolfi, M., Barone, G., De Napoli, L., Iadonisi, A., & Piccialli, G. (1996) Solid phase synthesis of oligosaccharides. Tetrahedron Lett., 37, 5007-5010. #4905

  5. Allin, S.M., & Shuttleworth, S.J. (1996) The preparation and first application of a polymer-supported "Evans" oxazolidines. Tetrahedron Lett., 37, 8023-8026. #5753

  6. Alvarado Urbina, G., Voelter, W., Weiler, A., Echner, H., Stoeva, S., Schernthaner, J.P., Reinig, W., Glubler, G. & Gross, W. (1996) Optimized automated solid phase synthesis of oligonucleotides and their derivatives. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 135-140). Mayflower Scientific Limited, Birmingham. #8913

  7. Appell, K.C., Chung, T.D.Y., Ohlmeyer, M.H.J., Sigal, N.H., Baldwin, J.J., & Chelsky, D. (1996) Biological screening of a large combinatorial library. J. Biomol. Screen., 1, 27-31. #10039

  8. Armstrong, R.W., Tempest, P.A., & Cargill, J.F. (1996) Microchip encoded combinatorial libraries. Generation of a spatially encoded library from a pool synthesis. Chimia, 50, 258-260. #5857

  9. Atuegbu, A., Maclean, D., Nguyen, C., Gordon, E.M., & Jacobs, J.W. (1996) Combinatorial modification of natural products: Preparation of unencoded and encoded libraries of Rauwolfia alkaloids. Bioorg. Med. Chem., 4, 1097-1106. #4896

  10. Backes, B.J., Virgilio, A.A., & Ellman, J.A. (1996) Activation method to prepare a highly reactive acylsulfonamide "safety-catch" linker for solid-phase synthesis. J. Amer. Chem. Soc., 118, 3055-3056. #4137

  11. Baird, E.E., & Dervan, P.B. (1996) Solid phase synthesis of polyamides containing imidazole and pyrrole amino acids. J. Amer. Chem. Soc., 118, 6141-6146. #4829

  12. Baldwin, J.J. (1996) Solid phase chemistry in combinatorial library construction. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-158. American Chemical Society,Washington,D, #5894

  13. Baldwin, J.J., & Henderson, I. (1996) Recent advances in the generation of small-molecule combinatorial libraries: Encoded split synthesis and solid-phase synthetic methodology. Med. Res. Rev., 16, 391-405. #5281

  14. Balkenhohl, F., von dem Bussche-Hunnefeld, C., Lansky, A., & Zechel, C. (1996) Combinatorial synthesis of small organic molecules. Angew. Chem. Int. Ed., 35, 2289-2337. #5694

  15. Barn, D.R., Morphy, J.R., & Rees, D.C. (1996) Synthesis of an array of amides by aluminium chloride assisted cleavage of resin-bound esters. Tetrahedron Lett., 37, 3213-3216. #4746

  16. Beaver, K.A., Siegmund, A.C., & Spear, K.L. (1996) Application of the sulfonamide functional group as an anchor for solid phase organic synthesis (SPOS). Tetrahedron Lett., 37, 1145-1148. #3882

  17. Berg, R.H., Hvilsted, S., & Ramanujam, P.S. (1996) Peptide oligomers for holographic data storage. Nature, 383, 505-508. #5956

  18. Bicknell, A.J., & Hird, N.W. (1996) Synthesis of a highly functionalized rigid template by solid-phase azomethine ylide cycloadditon. Bioorg. Med. Chem. Lett., 6, 2441-2444. #5750

  19. Bilodeau, M.T., & Danishefsky, S.J. (1996) Glycals in organic synthesis: The evolution of comprehensive strategies for the assembly of oligosaccharides and glycoconjugates of biological consequence. Angew. Chem. Int. Ed., 35, 1380. #14281 NEWOLD

  20. Boas, U., Heegaard, P. & Jacobsen, M.H. (1996) Solid phase coupling of unprotected reducing carbohydrates to the N-terminus of peptides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 327-328). Mayflower Scientific Limited, Birmingham. #8943

  21. Boehm, T.L. & Showalter, H.D.H. (1996) Development of a silicon-based traceless linker for solid-phase organic synthesis. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. BIOT-121. American Chemical Society,Washington,D, #6004

  22. Boehm, T.L., & Showalter, H.D.H. (1996) Development of a novel silyl ether linker for solid-phase organic synthesis. J. Org. Chem., 61, 6498-6499. #5392

  23. Bolton, G.L. (1996) Solid phase synthesis of azabicyclo[4.3.0]nonen-8-one amino acid derivatives via intramolecular Pauson-Khand cyclization. Tetrahedron Lett., 37, 3433-3436. #4574

  24. Bondy, S., Cheng, S., Saunders, J., Tarby, C., & Wheeler, K. (1996) Molecular diversity and solid-phase synthesis. Drug Disc. Today, 1, 132-133. #6010

  25. Bonnat, M., Bradley, M., & Kilburn, J.D. (1996) The solid phase synthesis of a guanidinium based 'tweezer' receptor. Tetrahedron Lett., 37, 5409-5412. #5086

  26. Borman, S. (1996) Unnatural peptide synthesis automated. C&EN, 32-32. #4928

  27. Borman, S. (1996) Combinatorial chemists focus on small molecules, molecular recognition, and automation. C&EN, 74, 29-54. #4611

  28. Boyd, E.A., Chan, W.C., & Loh, V.M.J. (1996) Multiple solid phase synthesis of (RS)-1-aminophosphinic acids. Tetrahedron Lett., 37, 1647-1650. #4061

  29. Breipohl, G., Will, D.W., Langner, D., Knolle, J. & Uhlmann, E. (1996) Synthesis of polyamide nucleic acids using a new protection scheme which is fully compatible with oligonucleotide synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 61-64). Mayflower Scientific Limited, Birmingham. #8899

  30. Broddefalk, J., Bergquist, K.E., & Kihlberg, J. (1996) Preparation of a glycopeptide analogue of type II collagen use of acid labile protective groups for carbohydrate moieties in solid phase synthesis of O-linked glycopeptides. Tetrahedron Lett., 37, 3011-3014. #6052

  31. Brown, J.M., & Ramsden, J.A. (1996) Supports for solid-phase synthesis with high fluidity and high functionality. J. Chem. Soc. Chem. Commun., 2117-2118. #8533

  32. Brown, R. (1996) Recent developments in solid-phase organic synthesis. Contemp. Org. Synt., 216-237. #9600

  33. Brummel, C.L., Vickerman, J.C., Carr, S.A., Hemling, M.E., Roberts, G.D., Johnson, W., Weinstock, J., Gaitanopoulos, D., Benkovic, S.J., & Winograd, N. (1996) Evaluation of mass spectrometric methods applicable to the direct analysis of non-peptide bead-bound combinatorial libraries. Anal. Chem., 68, 237-242. #3927

  34. Buckman, B.O., & Mohan, R. (1996) Solid-phase synthesis of 1,3-dialkyl quinazoline-2,4-diones. Tetrahedron Lett., 37, 4439-4442. #4798

  35. Bunin, B.A., Plunkett, M.J. & Ellman, J.A. (1996) Synthesis and evaluation of three 1,4-benzodiazepine libraries. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 405-424). VCH, Weinheim. #2160

  36. Bunin, B.A., Plunkett, M.J., & Ellman, J.A. (1996) Synthesis and evaluation of 1,4-benzodiazepine libraries. Methods Enzymol., 267, 448-466. #3671

  37. Burgess, K., Shin, H. & Totani, R. (1996) Methodology for syntheses of ureas libraries. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. ORGN-279. American Chemical Society,Washington,D, #6080

  38. Cao, X., & Mjalli, A.M.M. (1996) Combinatorial method for the synthesis of a-hydroxy phosphonates on Wang resin. Tetrahedron Lett., 37, 6073-6076. #5227

  39. Cargill, J.F., & Maiefski, R.R. (1996) Automated combinatorial chemistry on solid phase. Lab. Robotics Automation, 8, 139-148. #5344

  40. Case-Green, S.C., Mir, K.U., Milner, N. & Southern, E.M. (1996) Synthesis and applications of spatially addressable oligonucleotide arrays. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 57-60). Mayflower Scientific Limited, Birmingham. #8898

  41. Cernerud, M., Reina, J.A., Tegenfeldt, J., & Moberg, C. (1996) Chiral polymers via asymmetric epoxidation and asymmetric dihydroxylation. Tetrahedron:Asymmetry, 7, 2863-2870. #8534

  42. Chabala, J.C., Baldwin, J.J., Burbaum, J.J., Chelsky, D., Dillard, L.W., Henderson, I., Li, G., Ohlmeyer, M.H.J., Randle, T.L., Reader, J.C., Rokosz, L. & Sigal, N.H. (1996) Synthesis of binary encoded small molecule libraries and their application to drug discovery and optimization. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 101-106). Mayflower Scientific Limited, Birmingham. #8905

  43. Chaiken, I., Myszka, D., & Morton, T. (1996) New opportunities for using immobilized ligands to characterize macromolecular recognition and design recognition molecules. Adv. Mol. Cell Biol., 15B, 553-568. #8649

  44. Chan, T.Y., Chen, A., Allanson, N., Chen, R., Liu, D., & Sofia, M.J. (1996) Solid phase synthesis of peptidoglycan monomers for the generation of a combinatorial library. Tetrahedron Lett., 37, 8097-8100. #5747

  45. Chan, T.Y., Chen, A., Allanson, N., Chen, R., Liu, D. & Sofia, M.J. (1996) Solid supported glycopeptide synthesis for the construction of a glycopeptide combinatorial library. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. MEDI-198. American Chemical Society,Washington,D, #6143

  46. Chiron, S., Torres, J.A., Fernandes-Alba, A., Alpendurada, M.F., & Barcelo, D. (1996) Identification of carbofuran and methiocarb and their transformation products in estuarine waters by online solid phase extraction liquid chromatography-mass spectrometry. Int. J. Environ. Anal. Chem., 65, 37-52. #8461

  47. Choong, I.C., & Ellman, J.A. (1996) Solid-phase synthesis: Applications to combinatorial libraries. Annu. Rep. Med. Chem., 31, 309-318. #8134

  48. Chucholowski, A., Masquelin, T., Obrecht, D., Stadlwieser, J., & Villalgordo, J.M. (1996) Novel solution- and solid-phase strategies for the parallel and combinatorial synthesis of small-molecular-weight compound libraries. Chimia, 50, 525-530. #8188

  49. Cole, B.M., Shimizu, K.D., Krueger, C.A., Harrity, J.P.A., Snapper, M.L., & Hoveyda, A.H. (1996) Discovery of chiral catalysts through ligand diversity: Ti-catalyzed enantioselective addition of TMSCN to meso epoxides. Angew. Chem. Int. Ed., 35, 1668-1671. #5273

  50. Cook, P.D., Kiely, J.S., & Sprankle, K. (1996) C.C.U. ISIS Pharmaceuticals Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis. US Patent. 5,539,083. 200,742, #12296

  51. Crespin, M.A., Ballesteros, E., Gallero, M., & Valcarcel, M. (1996) Automatic preconcentration of chlorophenols and gas chromatographic determination with electron capture detection. Chromatographia, 43, 633-639. #8468

  52. Czarnik, A.W., & DeWitt, S.H. (1996) Small molecule combinatorial libraries via Parke-Davis' DIVERSOMER method. Chem. Brit., #2420

  53. Dankwardt, S.M., Phan, T.M., & Krstenansky, J.L. (1996) Combinatorial synthesis of small-molecule libraries using 3- amino-5-hydroxybenzoic acid. Mol. Diversity, 1, 113-120. #2825 (Available on Internet)

  54. de Bont, D.B.A., Moree, W.J., & Liskamp, R.M.J. (1996) Molecular diversity of peptidomimetics: Approaches to the solid- phase synthesis of peptidosulfonamides. Bioorg. Med. Chem., 4, 667-672. #4623

  55. de Bont, D.B.A., Dijkstra, G.D.H., den Hartog, J.A.J., & Liskamp, R.M.J. (1996) Solid-phase synthesis of peptidosulfonamide containing peptides derived from Leu-enkephalin. Bioorg. Med. Chem. Lett., 6, 3035-3040. #8259

  56. Devraj, R., & Cushman, M. (1996) A versatile solid phase synthesis of lavendustin A and certain biologically active analogs. J. Org. Chem., 61, 9368-9373. #8250

  57. DiCesare, J.C., McComas, C.B., Thomas, J. & Carroll, F.I. (1996) Modification of the titanium isopropoxide catalyzed reductive amination reaction and its application to solid phase synthesis. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. ORGN-91. American Chemical Society,Washington,D, #6296

  58. Ding, Y., Labbe, J., Kanie, O., & Hindsgaul, O. (1996) Towards oligosaccharide libraries: A study of the random galactosylation of unprotected N-acetylglucosamine. Bioorg. Med. Chem., 4, 683-692. #4626

  59. Dinh, T.Q., & Armstrong, R.W. (1996) Synthesis of ketones and aldehydes via reactions of Weinreb-type amides on solid support. Tetrahedron Lett., 37, 1161-1164. #3883

  60. Dorner, B., Husar, G.M., Ostresh, J.M., & Houghten, R.A. (1996) The synthesis of peptidomimetic combinatorial libraries through succesive amide alkylations. Bioorg. Med. Chem., 4, 709-715. #4629

  61. Dressman, B.A., Spangle, L.A., & Kaldor, S.W. (1996) Solid phase synthesis of hydantoins using a carbamate linker and a novel cyclization/cleavage step. Tetrahedron Lett., 37, 937-940. #3885

  62. Dygutsch, D.P., & Eilbracht, P. (1996) Synthesis of cyclopentanone derivatives with polystyrene-supported cyclopentadienyl rhodium catalysts. Tetrahedron, 52, 5461-5468. #5632

  63. Eggenweiler, H.M. & Bayer, E. (1996) Gel-phase (13)C-NMR monitoring of solid phase glycoside synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 363-366). Mayflower Scientific Limited, Birmingham. #8952

  64. Egner, B.J., Cardno, M., & Bradley, M. (1996) Linkers for combinatorial chemistry and reaction analysis using solid phase in situ mass spectrometry. J. Chem. Soc. Chem. Commun., 2163-2164. #4130

  65. Ellman, J. A. The solid phase synthesis of complex small molecules. . 1996. Lecture at the conference "Synthesis of Small Molecules on Solid Phase",Basel,1996. #8488

  66. Elofsson, M., Roy, S., Salvador, L.A., & Kihlberg, J. (1996) Building blocks for glycopeptide synthesis: Preparation of alpha-O-fucosylated Fmoc serine and threonine in one step from L-fucose tetraacetate. Tetrahedron Lett., 37, 7645-7648. #6347 4479

  67. Emery, F., Bisang, C., Favre, M., Jiang, L., & Robinson, J.A. (1996) A template for the solid-phase synthesis of conformationally restricted protein loop mimetics. Chem. Commun., 2155-2156. #5696

  68. Felder, E.R., Heizmann, G., Matthews, I.T., Rink, H., & Spieser, E. (1996) A new combination of protecting groups and links for encoded synthetic libraries suited for consecutive tests on the solid phase and in solution. Mol. Diversity, 1, 109-112. #4119 (Available on Internet)

  69. Fell, J.B., Chin, J.A., Shapiro, M.J. & Wareing, J.R. (1996) Analytical techniques in combinatorial chemistry: HPLC NMR of a mixture of positional isomers. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. ANYL-29. American Chemical Society,Washington,D, #6383

  70. Filippov, D., Meeuwenoord, N.J., van der Marel, G.A., Efimov, V.P., Kuyl-Yeheskiely, E., & van Boom, J.H. (1996) An approach to the solid phase synthesis of oligonucleotides containing N-acylphosphoramidate internucleosidic linkages. Synlett, 769-771. #5255

  71. Fitzgerald, M.C., Harris, K., Shevlin, C.G., & Siuzdak, G. (1996) Direct characterization of solid phase resin-bound molecules by mass spectrometry. Bioorg. Med. Chem. Lett., 6, 979-982. #5755

  72. Flegelova, Z., & Patek, M. (1996) Bis-allylic templates for Pd(O)-catalyzed solid phase synthesis of tertiary amines. J. Org. Chem., 61, 6735-6738. #5394

  73. Floyd, C.D., Lewis, C.N., Patel, S.R., & Whittaker, M. (1996) A method for the synthesis of hydroxamic acids on solid phase. Tetrahedron Lett., 37, 8045-8048. #5756

  74. Fruchtel, J.S. & Jung, G. (1996) Polymer supported organic synthesis: A review. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 19-78). VCH, Weinheim. #9664

  75. Fruchtel, J.S., & Jung, G. (1996) Organic chemistry on solid supports. Angew. Chem. Int. Ed., 35, 17-42. #3975

  76. Furka, A., Campian, E., Peterson, M., Saneii, H.H. & Chou, J. (1996) Combinatorial chemistry: Past and present developments. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 151-158). Mayflower Scientific Limited, Birmingham. #8916

  77. Garigipati, R.S., Adams, B., Adams, J.L., & Sarkar, S.K. (1996) Use of spin echo magic angle spinning H-1 NMR in reaction monitoring in combinatorial organic synthesis. J. Org. Chem., 61, 2911-2914. #4570

  78. Gayo, L.M., & Suto, M.J. (1996) Use of pentafluorophenyl esters for one-pot protectional/activation of amino and thiol carboxylic acids. Tetrahedron Lett., 37, 4915-4918. #5761

  79. Gerster, M., Bleicher, K. & Bayer, E. (1996) Comparison of several sulfurizing reagents for synthesis of phosphorothioate oligonucleotides on different supports. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 377-380). Mayflower Scientific Limited, Birmingham. #8955

  80. Goff, D.A., & Zuckermann, R.N. (1996) The synthesis of 2-oxopiperazines by intramolecular Michael addition on solid support. Tetrahedron Lett., 37, 6247-6250. #5252

  81. Gong, B., Chen, X., Cheng, M., Li, R., Kenyon, G.L. & Cohen, F.E. (1996) Structure-based design and solid phase synthesis of cysteine protease inhibitors for parasitic diseases. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. MEDI-39. American Chemical Society,Washington,D, #6534 4335

  82. Goodfellow, V.S., Laudeman, C.P., Gerrity, J.I., Burkhard, M., Strobel, E. & McLeod, D.A. (1996) Rationally designed diverse non-peptides: Variously substituted piperazine and piperazinedione libraries targeted for the discovery of bradykinin and other G-protein coupled receptor antagonists. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 381-384). Mayflower Scientific Limited, Birmingham. #3242

  83. Gooding, O., Hoeprich, P.D.Jr., Labadie, J.W., Porco, J.A.Jr., van Eikeren, P. & Wright, P. (1996) Boosting the productivity of medicinal chemistry through automation tools: Novel technological developments enable a wide range of automated synthetic procedures. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 199-206). American Chemical Society, Washington,DC. #5112

  84. Gordeev, M.F., Patel, D.V., Wu, J., & Gordon, E.M. (1996) Approaches to combinatorial synthesis of heterocycles: Solid phase synthesis of pyridines and pyrido[2,3-d]pyrimidines. Tetrahedron Lett., 37, 4643-4646. #4856

  85. Gordeev, M.F., Patel, D.V., & Gordon, E.M. (1996) Approaches to combinatorial synthesis of heterocycles: A solid- phase synthesis of 1,4-dihydropyridines. J. Org. Chem., 61, 924-928. #3758

  86. Gordon, E.M., Gallop, M.A., & Patel, D.V. (1996) Strategy and tactics in combinatorial organic synthesis. Applications to drug discovery. Account. Chem. Res., 29, 144-154. #3593

  87. Gosselin, F., Direnzo, M., Ellis, T.H., & Lubell, W.D. (1996) Photoacoustic FTIR spectroscopy, a nondestructive method for sensitive analysis of solid-phase organic chemistry. J. Org. Chem., 61, 7980-7981. #5767

  88. Gouilleux, L., Fehrentz, J.A., Winternitz, F., & Martinez, J. (1996) Solid phase synthesis of chiral 3-substituted quinazoline-2,4-diones. Tetrahedron Lett., 37, 7031-7034. #5466

  89. Gremlich, H.U., & Berets, S.L. (1996) Use of FT-IR internal reflection spectroscopy in combinatorial chemistry. Appl. Spectrosc., 50, 532-536. #4590

  90. Griffith, M.C., Dooley, C.T., Houghten, R.A. & Kiely, J.S. (1996) Solid-phase synthesis, characterization, and screening of a 43, 000-compound tetrahydroisoquinoline combinatorial library. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 50-57). American Chemical Society, Washington,DC. #5098

  91. Gude, M., Piarulli, U., Potenza, D., Salom, B., & Gennari, C. (1996) A new method for the solution and solid phase synthesis of chiral b -sulfonopeptides under mild conditions. Tetrahedron Lett., 37, 8589-8592. #5736

  92. Guiles, J.W., Johnson, S.G. & Murray, W.V. (1996) Solid phase Suzuki for C-C bond formation. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. ORGN-126. American Chemical Society,Washington,D, #6569

  93. Guiles, J.W., Johnson, S.G., & Murray, W.V. (1996) Solid-phase Suzuki coupling for C-C bond formation. J. Org. Chem., 61, 5169-5171. #5143

  94. Hamper, B.C., Dukesherer, D.R., & South, M.S. (1996) Solid-phase synthesis of proline analogs via a three component 1, 3-dipolar cycloaddition. Tetrahedron Lett., 37, 3671-3674. #4935

  95. Han, Y., Walker, S.D., & Young, R.N. (1996) Silicon directed ipso-subtitution of polymer bound arylsilanes: Preparation of biaryls via the Suzuki cross-coupling reaction. Tetrahedron Lett., 37, 2703-2706. #4742

  96. Hanessian, S., & Yang, R.Y. (1996) Solution and solid phase synthesis of 5-alkoxyhydantoin libraries with a three-fold functional diversity. Tetrahedron Lett., 37, 5835-5838. #5232

  97. Hanessian, S., & Devasthale, P.V. (1996) Generation of functional diversity via nitroaldol condensations of a-aminoacid aldehydes. A new and stereocontrolled route to acyclic 1,3-diamino-2-alcohols. Tetrahedron Lett., 37, 987-990. #3886

  98. Harness, J., Baker, W., and Towell, J. A workstation for performing all aspects of organic synthesis. In: Anonymous. (Eds.) American Chemical Society, Orlando p.MEDI 007 212th ACS National Meeting. #11422OLD

  99. Harness, J.R. (1996) Automation of high-throughput synthesis: Automated laboratory workstations designed to perform and support combinatorial chemistry. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 188-198). American Chemical Society, Washington,DC. #5107

  100. Hartsel, S.A., & Marshall, W.S. (1996) Solid-phase synthesis of carbohydrate and phosphodiester modified 2'- 5' oligoadenylate analogs. Bioorg. Med. Chem. Lett., 6, 2993-2998. #8258

  101. Hebert, N. (1996) Convergent solid-phase synthesis of phosphoramidate combinatorial libraries. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 40-49). American Chemical Society, Washington,DC. #3651

  102. Henkel, B. & Bayer, E. (1996) p-(5-Dibenzosuberenyl-5-hydroxy)-benzoic acid: A new linker for peptide synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 395-398). Mayflower Scientific Limited, Birmingham. #8957

  103. Hermkens, P.H.H., Ottenheijm, H.C.J., & Rees, D. (1996) Solid-phase organic reactions: A review of the recent literarure. Tetrahedron, 52, 4527-4554. #4298

  104. Hoeg-Jensen, T., Spatola, A.F., & Holm, A. (1996) Amino monothio acids in solid-phase synthesis of peptide thioamides. Int. J. Peptide Prot. Res., 47, 190-200. #4755

  105. Hoekstra, W.J., Maryanoff, B.E., Andrade-Gordon, P., Cohen, J.H., Costanzo, M.J., Damiano, B.P., Haertlein, B.J., Harris, B.D., Kauffman, J.A., Keane, P.M., McComsey, D.F., Villani, F.J., & Yabut, S.C. (1996) Solid-phase parallel synthesis applied to lead optimization: Discovery of potent analogues of the GPIIb/IIIa antagonist RWJ- 50042. Bioorg. Med. Chem. Lett., 6, 2371-2376. #6665

  106. Hoeprich, P.D.Jr. (1996) Automated solid phase synthesis of small organic molecules. Nat. Biotech., 14, 1311-1313. #6667

  107. Hogan, J.C.Jr. (1996) Directed combinatorial chemistry. Nature, 384, 17-19. #5772

  108. Hollinshead, S.P. (1996) Synthesis and reactions of heterocyclic libraries on a solid support. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-156. American Chemical Society,Washington,D, #6671

  109. Hollinshead, S.P. (1996) Stereoselective synthesis of highly functionalized pyrrolidines via 1,3-dipolar cycloaddition reactions on a solid support. Tetrahedron Lett., 37, 9157-9160. #8167

  110. Hughes, I. (1996) Application of polymer-bound phosphonium salts as traceless supports for solid phase synthesis. Tetrahedron Lett., 37, 7495-7498. #5540

  111. Hunt, J.A., & Roush, W.R. (1996) Solid-phase synthesis of 6-deoxyoligosaccharides. J. Amer. Chem. Soc., 118, 9998-9999. #5551

  112. Hutchins, S.M., & Chapman, K.T. (1996) Fischer indole synthesis on a solid support. Tetrahedron Lett., 37, 4869-4872. #4901

  113. Hutchins, S.M., & Chapman, K.T. (1996) Solid phase synthesis of tetrahydroisoquinolines & tetrahydroimidazopyridines. Tetrahedron Lett., 37, 4865-4868. #4900

  114. Ito, Y., Kanie, O., & Ogawa, T. (1996) Orthogonal glycosylation strategy for rapid assembly of oligosaccharides on a polymer support. Angew. Chem. Int. Ed., 35, 2510-2512. #8667

  115. Iwabuchi, H., Ishikawa, M., & Kohta, K. (1996) Analysis of antibacterial agents in meats by semi-micro HPLC combined with an automated on line solid-phase extraction system. Kuromatogurafi, 17, 334-335. #8463

  116. Iyer, R.P., Devlin, T., Habus, I., Ho, N.H., Yu, D., & Agrawal, S. (1996) N-Pent-4-enoyl nucleosides: Application in the synthesis of support-bound and free oligonucleotide analogs by the H-phosphonate approach. Tetrahedron Lett., 37, 1539-1542. #4058

  117. James, I. (1996) Solid Phase Chemistry Publications. Chiron Mimotopes, Clayton Victoria. #5563

  118. Johnson, C.R. & Zhang, B. (1996) Macrocycle synthesis on solid supports using the Horner-Wadsworth-Emmons reaction. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. ORGN-125. American Chemical Society,Washington,D, #6775

  119. Johnson, C.R. & Zhang, B. (1996) Horner-Wadsworth-Emmons alkene synthesis on solid phase monitoring by (31)P gel phase NMR. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 429-430). Mayflower Scientific Limited, Birmingham. #8965

  120. Jung, K.W., Zhao, X.Y., & Janda, K.D. (1996) A linker that allows efficient formation of aliphatic C-H bonds on polymeric supports. Tetrahedron Lett., 37, 6491-6494. #5250

  121. Kaljuste, K., & Und n, A. (1996) Solid-phase synthesis of peptide aminoalkylamides using an allyl linker. Tetrahedron Lett., 37, 3031-3034. #4748

  122. Kaspari, A., Schierhorn, A., & Schutkowski, M. (1996) Solid-phase synthesis of peptide-4-nitroanilides. Int. J. Peptide Prot. Res., 48, 486-494. #8183

  123. Kehler, J., Puschl, A., & Dahl, O. (1996) Solid phase synthesis of oligodeoxynucleoside phosphorodithioates by a phosphotriester method using a chemoselective coupling reagent. Tetrahedron Lett., 37, 8041-8044. #6834 4504

  124. Kehler, J., Eldrup, A.B., Felding, J. & Dahl, O. (1996) Use of tentagel support in the preparation of all sixteen 2'-deoxydinucleoside phosphorodithioates. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 437-440). Mayflower Scientific Limited, Birmingham. #8968

  125. Keifer, P.A., Baltusis, L., Rice, D.M., Tymiak, A.A., & Shoolery, J.N. (1996) A comparison of NMR spectra obtained for solid-phase-synthesis resins using conventional high-resolution, magic-angle-spinning, and high-resolution magic-angle-spinning probes. J. Magn. Resonance, 119, 65-75. #6835 4340

  126. Keifer, P.A. (1996) Influence of resin structure, tether length, and solvent upon the high-resolution (1)H NMR spectra of solid-phase-synthesis resins. J. Org. Chem., 61, 1558-1559. #4128

  127. Kempe, M. & Barany, G. (1996) Novel highly cross-linked supports for solid-phase applications. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 191-194). Mayflower Scientific Limited, Birmingham. #8921

  128. Kempin, U., Hennig, L., Muller, D., Markus, A., & Welzel, P. (1996) A selective reaction that can be used to attach moenomycin to solid supports and proteins. Tetrahedron Lett., 37, 5087-5090. #4930

  129. Khan, N.M., Arumugam, V., & Balasubramanian, S. (1996) Solid phase reductive alkylation of secondary amines. Tetrahedron Lett., 37, 4819-4822. #4854

  130. Kim, J.M., Bi, Y., Paikoff, S.J., & Schultz, P.G. (1996) The solid phase synthesis of oligoureas. Tetrahedron Lett., 37, 5305-5308. #5083

  131. Kim, J.M., Wilson, T.E., Norman, T.C., & Schulz, P.G. (1996) Synthesis of a cyclic urea as a nonnatural biopolymer scaffold. Tetrahedron Lett., 37, 5309-5312. #5084

  132. Kim, S.U., & Lee, E.J. (1996) What is combinatorial chemistry. Hwahak Sekye, 36, 35-44. #6860

  133. Klinguer, C., Melnyk, O., Loing, E., & Gras-Masse, H. (1996) Synthesis of hydrazinopeptides using solid phase N-amination. Application to chemical ligation. Tetrahedron Lett., 37, 7259-7262. #5530

  134. Kobayashi, S., Hachiya, I., & Yasuda, M. (1996) Aldol reactions on solid phase. Sc(OTf)3-Catalyzed Aldol reactions of polymer-supported silyl enol ethers with aldehydes providing convenient methods for the preparation of 1,3-diol, b-hydroxy carboxylic acid, and b-hydroxy aldehyde libraries. Tetrahedron Lett., 37, 5569-5572. #5079

  135. Kobayashi, S., Hachiya, I., Suzuki, S., & Moriwaki, M. (1996) Polymer-supported silyl enol ethers. Synthesis and reactions with imines for the preparation of an amino alcohol library. Tetrahedron Lett., 37, 2809-2812. #4607

  136. Kobayashi, S., Moriwaki, M., Akiyama, R., Suzuki, S., & Hachiya, I. (1996) Parallel synthesis using Mannich-type three-component reactions and "Field Synthesis" for the construction of an amino alcohol library. Tetrahedron Lett., 37, 7783-7786. #5752

  137. Koh, J.S., & Ellman, J.A. (1996) Palladium-mediated three-component coupling strategy for the solid-phase synthesis og tropane derivatives. J. Org. Chem., 61, 4494-4495. #4885

  138. Kolodziej, S.A., & Hamper, B.C. (1996) Solid-phase synthesis of 5,6-dihydropyrimidine-2,4-diones. Tetrahedron Lett., 37, 5277-5280. #5082

  139. Kowalski, J., & Lipton, M.A. (1996) Solid phase synthesis of a diketopiperazine catalyst contatining the unnatural amino acid (S)-norarginine. Tetrahedron Lett., 37, 5839-5840. #5233

  140. Kozal, M.J., Shah, N., Shen, N., Yang, R., Fucini, R., Merigan, T.C., & et al. (1996) Extensive polymorphism observed in HIV-1 clade B protease gene using high-density oligonucleotide arrays. Nat. Med., 2, 753-759. #11100

  141. Krchnak, V., Vagner, J., Flegelova, Z., Weichsel, A.S., Barany, G. & Lebl, M. (1996) Use of solid-phase Mitsunobu and Wittig reactions for contruction of peptide and non-peptide libraries. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 307-308). Mayflower Scientific Ltd., Kingswinford. #3640

  142. Krchnak, V. & Lebl, M. (1996) MARS: Multiple automatic robot synthesizer featuring a novel timing procedure and random access to reagents and reaction vessels. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 93-96). Mayflower Scientific Limited, Birmingham. #6934 3656

  143. Kurth, M.J. (1996) The solid-phase part of supported small-molecule synthesis. Chimia, 50, 261-266. #6969

  144. Kurth, M.J. (1996) Solid-phase chemistry: A C-C bond focus. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-153. American Chemical Society,Washington,D, #6968

  145. Kurth, M.J., Randall, L.A.A., & Takenouchi, K. (1996) Solid-phase combinatorial synthesis of polyisoxazolines: A two-reaction iterative protocol. J. Org. Chem., 61, 8755-8761. #8538

  146. Labadie, J.W., Deegan, T.L., Gooding, O.W., Heisler, K., Newcomb, W.S., Porco, J.A.Jr., Tran, T.H. & van Eikeren, P. (1996) New poly(styrene-oxyethylene) graft copolymers as supports for solid-phase organic synthesis. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. PMSE-250. American Chemical Society,Washington,D, #6973

  147. Lam, K.S. & Lebl, M. (1996) Combinatorial library based on the one-bead-one-compound concept. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 173-201). VCH, Weinheim. #2428

  148. Lam, K.S. (1996) Application of the "one-bead one-compound" combinatorial library method in basic research and drug discovery. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. I&EC-10. American Chemical Society,Washington,D, #6979

  149. Larhed, M., Lindeberg, G., & Hallberg, A. (1996) Rapid microwave-assisted Suzuki coupling on solid-phase. Tetrahedron Lett., 37, 8219-8222. #5744

  150. Le Bec, C., & Wickstrom, E. (1996) Stereospecific Grignard-activated solid phase synthesis of DNA methylphosphonate dimers. J. Org. Chem., 61, 510-513. #5660

  151. Lebl, M., Krchnak, V., Strop, P. & Lam, K.S. (1996) Construction and screening of peptide and nonpeptide libraries based on one-bead-one-compound principle. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 890-892). Mayflower Scientific Ltd., Kingswinford. #5057

  152. Lee, J.H., Griffin, J.H., & Nicas, T.I. (1996) Solid-phase total synthesis of bacitracin A. J. Org. Chem., 61, 3983-3986. #7009

  153. Lelievre, D., Daguet, D., Piller, F., Piller, V., Vassard, C. & Brack, A. (1996) An efficient three dimensional orthogonal strategy for solid-phase synthesis of a bifunctional peptide. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 459-460). Mayflower Scientific Limited, Birmingham. #9027

  154. Leon, S. (1996) Playing the chemical lottery. Chem. Ind. -London, 463-464. #7018

  155. Letulle, M.M., Collins, N., Davis, P., Knapp, R., Lee, K., Yamamura, H., Porreca, F. & Hruby, V.J. (1996) Solid phase synthesis of a directed small organic library: Discovery of a new class of delta opioid drug lead. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 281-284). Mayflower Scientific Limited, Birmingham. #8935

  156. Liang, R., Yan, L., Loebach, J., Uozumi, Y., Ge, M., Horan, N., Gildersleeve, J., Thompson, C. & Smith, A. (1996) Polymer-supported carbohydrate libraries. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-4. American Chemical Society,Washington,D, #7041

  157. Liang, R., Yan, L., Loebach, J., Ge, M., Uozumi, Y., Sekanina, K., Horan, N., Gildersleeve, J., Thompson, C., Smith, A., Biswas, K., Still, W.C., & Kahne, D. (1996) Parallel synthesis and screening of a solid phase carbohydrate library. Science, 274, 1520-1522. #8666

  158. Lin, M., & Shapiro, M.J. (1996) Mixture analysis in combinatorial chemistry. Application of diffusion-resolved NMR spectroscopy. J. Org. Chem., 61, 7617-7619. #5554

  159. Lloyd, A.W. (1996) Solid-phase synthesis in the development of small-molecule libraries. Drug Disc. Today, 1, 42-43. #7062 4378

  160. Lloyd, J., Schmidt, J.B., Hunt, J.T., Barrish, J.C., Little, D.K., & Tymiak, A.A. (1996) Solid phase synthesis of phosphinic acid endothelin converting enzyme inhibitors. Bioorg. Med. Chem. Lett., 6, 1323-1326. #7063 4363

  161. Lohray, B.B., Nandanan, E., & Bhushan, V. (1996) Catalytic asymmetric dihydroxylation of alkenes using silica gel supported cinchona alkaloid. Tetrahedron:Asymmetry, 7, 2805-2808. #8539

  162. Lorsbach, B.A., Miller, R.B., & Kurth, M.J. (1996) Reissert-based 'traceless' solid-phase synthesis: Isoquinoline and isoxazoline-containing heterocycles. J. Org. Chem., 61, 8716-8717. #8540

  163. Lukhtanov, E.A., Kutyavin, I.V., & Meyer, R.B. (1996) Direct, solid phase assembly of dihydropyrroloindole peptides with conjugated oligonucleotides. Bioconjug. Chem., 7, 564-567. #7080

  164. Lyttle, M.H., Hudson, D., & Cook, R.M. (1996) A new universal linker for solid phase DNA synthesis. Nucl. Acid. Res., 24, 2793-2798. #14218 NEWOLD

  165. MacDonald, A.A., DeWitt, S.H., Ghosh, S., Hogan, E.M., Kieras, L., Czarnik, A.W., & Ramage, R. (1996) The impact of polystyrene resins in solid-phase organic synthesis. Mol. Diversity, 1, 183-186. #4804 (Available on Internet)

  166. MacDonald, A.A., DeWitt, S.H., Hogan, E. & Ramage, R. (1996) Synthesis of quinolone antibiotics by DIVERSOMER(TM) technology. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 115-116). Mayflower Scientific Limited, Birmingham. #8908

  167. MacDonald, A.A., DeWitt, S.H., & Ramage, R. (1996) Consideration of solid phase synthesis with reference to quinolone antibiotics. Chimia, 50, 258-260. #8471

  168. MacDonald, A.A., DeWitt, S.H., Hogan, E.M., & Ramage, R. (1996) A solid phase approach to quinolones using the DIVERSOMER technology. Tetrahedron Lett., 37, 4815-4818. #4855

  169. Manchanda, R., Dunham, S.U., & Lippard, S.J. (1996) Automated solid-phase synthesis of site-specifically platinated oligodeoxyribonucleotides. J. Amer. Chem. Soc., 118, 5144-5145. #4934

  170. Marburg, S., Neckers, A.C., & Griffin, P.R. (1996) Introduction of the maleimide function onto resin-bound peptides: A simple, high-yield process useful for discriminating among several lysines. Bioconjug. Chem., 7, 612-616. #7111

  171. Marquais, S., & Arlt, M. (1996) Aryl-aryl cross coupling on a solid support using zinc organic reagents and palladium catalysis. Tetrahedron Lett., 37, 5491-5494. #5078

  172. Marsh, I., Smith, H., Leblanc, C. & Bradley, M. (1996) Solid phase polyamine linkers: Synthesis and combinatorial utility. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 111-114). Mayflower Scientific Limited, Birmingham. #8907

  173. Marsh, I.R., Smith, H., & Bradley, M. (1996) Solid phase polyamine linkers. Their utility in synthesis and the preparation of directed libraries against trypanothione reductase. J. Chem. Soc. Chem. Commun., 941-942. #7121

  174. Marsh, I.R. & Bradley, M. (1996) Solid phase polyamine chemistry: A route to antitrypanosomal compounds. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 463-464). Mayflower Scientific Limited, Birmingham. #8969

  175. Marsh, I.R. (1996) Solid phase polyamine chemistry: A route to antitrypanosomal compounds. University of Southampton,Southampton,UK; #8556

  176. Marzinzik, A.L., & Felder, E.R. (1996) Solid support synthesis of highly functionalized pyrazoles and isoxazoles; scaffolds for molecular diversity. Tetrahedron Lett., 37, 1003-1006. #3881

  177. Marzinzik, A. L. Solid-phase synthesis of five membered ring heterocycles. . 1996. Poster on Solid Phase Synthesis: Developing Small Molecule Libraries, February 1-2,1996, San Diego, California. #3660

  178. Mayer, J.P., Zhang, J., Bjergarde, K., Lenz, D.M., & Gaudino, J.J. (1996) Solid phase synthesis of 1,4-benzodiazepine-2,5-diones. Tetrahedron Lett., 37, 8081-8084. #7140 4510

  179. Mayer, J.P., Bankaitis-Davis, D., Zhang, J., Beaton, G., Bjergarde, K., Andersen, C.M., Goodman, B.A., & Herrera, C.J. (1996) Application of the Pictet-Spengler reaction in combinatorial chemistry. Tetrahedron Lett., 37, 5633-5636. #5132

  180. McGall, G., Labadie, J., Brock, P., Wallraff, G., Nguyen, T., & Hinsberg, W. (1996) Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists. Proc. Natl. Acad. Sci. USA, 93, 13555-13560. #9385

  181. McMinn, D.L., & Greenberg, M.M. (1996) Novel solid phase synthesis supports for the preparation of oligonucleotides containing 3'-alkyl amines. Tetrahedron, 52, 3827-3840. #4135

  182. Meinjohanns, E., Meldal, M., Schleyer, A., Paulsen, H., & Bock, K. (1996) Efficient syntheses of core 1, core 2, core 3 and core 4 building blocks for SPS of mucin O-glycopeptides based on the N- Dts-method. J. Chem. Soc. Perkin Trans. 1, 985-993. #7166

  183. Meisenbach, M. & Voelter, W. (1996) Comparative studies of methoxy-substituted 4-benzyloxytrytylamine linkers for solid phase synthesis of protected peptide amides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 473-476). Mayflower Scientific Limited, Birmingham. #8971

  184. Miller, S.J., Blackwell, H.E., & Grubbs, R.H. (1996) Application of ring-closing metathesis to the synthesis of rigidified amino acids and peptides. J. Amer. Chem. Soc., 118, 9606-9614. #7200

  185. Mjalli, A.M.M., & Harris, A.L. (1996) Lead generation using combinatorial chemistry in drug discovery. J. Biomol. Screen., 1, 17-18. #10036

  186. Mjalli, A.M.M., Sarshar, S., & Baiga, T.J. (1996) Solid phase synthesis of pyrroles derived from a four component condensation. Tetrahedron Lett., 37, 2943-2946. #4750

  187. Mjalli, A.M.M. & Toyonaga, B.E. (1996) Application of solid phase synthesized small molecule libraries in drug discovery. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. BIOT-119. American Chemical Society,Washington,D, #7211

  188. Mohan, R., Chou, Y.L., & Morrissey, M.M. (1996) Pictet-Spengler reaction on solid support: Synthesis of 1,2,3,4-tetrahydro-b-carboline libraries. Tetrahedron Lett., 37, 3963-3966. #4600

  189. Morphy, J.R., Rankovic, Z., & Rees, D.C. (1996) A novel linker strategy for solid-phase synthesis. Tetrahedron Lett., 37, 3209-3212. #4747

  190. Morvan, F., Sanghvi, Y.S., Perbost, M., Vasseur, J.J., & Bellon, L. (1996) Oligonucleotide mimics for antisense therapeutics: Solution phase and automated solid-support synthesis of MMI linked oligomers. J. Amer. Chem. Soc., 118, 255-256. #10541

  191. Motorina, I.A., Parly, F., & Grierson, D.S. (1996) Selective O-allylation of amidoalcohols on solid support. Synlett, 389-391. #4898

  192. Murphy, M.M., Schullek, J.R., Gordon, E.M., & Gallop, M.A. (1996) Combinatorial organic synthesis of highly functionalized pyrrolidines: Identification of a potent angiotensin converting enzyme inhibitor from a mercaptoacyl proline library. J. Amer. Chem. Soc., 118, 714-714. #4320

  193. Nakahara, Y., & Ogawa, T. (1996) Solid-phase synthesis of an O-linked glycopeptide based on a benzyl-protected glycan approach. Carbohyd. Res., 292, 71-81. #7267

  194. Nakano, H., Kawarasaki, Y., & Yamane, T. (1996) Recent advances in cell-free protein synthesis towards a protein biosynthesizer. Ann. New York Acad. Sci., 799, 406-412. #12258

  195. Nash, I.A., Bycroft, B.W., & Chan, W.C. (1996) Dde - a selective primary amine protecting group: A facile solid phase synthetic approach to polyamine conjugates. Tetrahedron Lett., 37, 2625-2628. #4744

  196. Nelson, J.C., Young, J.K., & Moore, J.S. (1996) Solid-phase synthesis of phenylacetylene oligomers utilizing a novel 3-propyl-3-(benzyl-supported) triazene linkage. J. Org. Chem., 61, 8160-8168. #8541

  197. Neuner, P. (1996) New non nucleosidic phosphoramidite reagent for solid phase synthesis of biotinylated oligonucleotides. Bioorg. Med. Chem. Lett., 6, 147-152. #7289

  198. Ni, Z.J., Maclean, D., Holmes, C.P., & Gallop, M.A. (1996) Encoded combinatorial chemistry: Binary coding using chemically robust secondary amine tags. Methods Enzymol., 267, 261-274. #4788

  199. Ni, Z.J., Maclean, D., Holmes, C.P., Murphy, M.M., Ruhland, B., Jacobs, J.W., Gordon, E.M., & Gallop, M.A. (1996) Versatile approach to encoding combinatorial organic syntheses using chemically robust secondary amine tags. J. Med. Chem., 39, 1601-1608. #4573

  200. Nielsen, J., & Rasmussen, P.H. (1996) Implementation of combinatorial cleavage and deprotection scheme.1.Synthesis of phthalhydrazide libraries. Tetrahedron Lett., 37, 3351-3354. #4609

  201. Nielsen, J., & Lyngso, L.O. (1996) Combinatorial solid-phase synthesis of balanol analogues. Tetrahedron Lett., 37, 8439-8442. #5746

  202. Norman, T.C., Gray, N.S., Koh, J.T., & Schultz, P.G. (1996) A structure-based library approach to kinase inhibitors. J. Amer. Chem. Soc., 118, 7430-7431. #5123

  203. Nova, M.P., Senyei, A.E., Parandoosh, Z., & Xiao, X.Y. (1996) L.J.C.U. Irori. Remotely programmable matrices with memories and uses thereof. WO PCT. 96/36436. US 96/06145, #12267

  204. Nowick, J.S., Mahrus, S., Smith, E.M., & Ziller, J.W. (1996) Triurea derivatives of diethylenetriamine as potential templates for the formation of artificial beta-sheets. J. Amer. Chem. Soc., 118, 1066-1072. #7337 3818

  205. Osborne, S.E., & Ellington, A.D. (1996) Incorporating disulfide cross-links at the terminus of oligonucleotides via solid-phase nucleic acid synthesis. Bioorg. Med. Chem. Lett., 6, 2339-2342. #5543

  206. Otvos, L.Jr., Urge, L., Szendrei, G.I., Cappelletto, B., Varga, I., Prammer, K.V. & Ertl, H.C.J. (1996) Exploring the diversity of mono- and oligosaccharide structures in the synthesis, conformational analysis and biomedical application of glycopeptides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 269-276). Mayflower Scientific Limited, Birmingham. #8933

  207. Paikoff, S.J., Wilson, T.E., Cho, C.Y., & Schultz, P.G. (1996) The solid phase synthesis of N-alkylcarbamate oligomers. Tetrahedron Lett., 37, 5653-5656. #5135

  208. Panek, J.S., & Zhu, B. (1996) Synthesis of aromatic 1,2-diazines by inverse electron demand Diels-Alder reaction of polymer-supported 1,2,4,5-tetrazines. Tetrahedron Lett., 37, 8151-8154. #5741

  209. Patel, D.V., & Gordon, E.M. (1996) Application of small-molecule combinatorial chemistry to drug discovery. Drug Disc. Today, 1, 134-144. #4979

  210. Patel, D.V., Gordeev, M.F., England, B.P. & Gordon, E.M. (1996) Solid-phase and combinatorial synthesis of heterocyclic scaffolds: Dihydropyridines, pyridines, and pyrido[2,3- d]pyrimidines. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 58-69). American Chemical Society, Washington,DC. #5099

  211. Pavia, M.R., Cohen, M.P., Dilley, G.J., Dubuc, G.R., Durgin, T.L., Forman, F.W., Hediger, M.E., Milot, G., Powers, T.S., Sucholeiki, I., Zhou, S., & Hangauer, D.G. (1996) The design and synthesis of substituted biphenyl libraries. Bioorg. Med. Chem., 4, 659-666. #4622

  212. Pearson, W.H. & Clark, R.B. (1996) Solid-phase synthesis of pyrrolidines via 2-azaallyl anion cycloadditions. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-305. American Chemical Society,Washington,D, #7415

  213. Pei, Y., Kiely, J.S. & Houghten, R.A. (1996) Combinatorial syntheses of 3,4-dihydro-2(1H)-quinolinones via beta-lactam intermediates on the solid-phase. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-155. American Chemical Society,Washington,D, #7418

  214. Perez, J.M., Lopez-Alvarado, P., Alonso, M.A., Avendano, C., & Men ndez, J.C. (1996) Silica gel-supported hetero Diels-Alder reactions of quinolinetriones. Tetrahedron Lett., 37, 6955-6958. #5461

  215. Perumattam, J., Chakravarty, S. & Suravajjala, S. (1996) Four-component assembly and rapid generation of small molecule organic libraries on solid support. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-86. American Chemical Society,Washington,D, #7434

  216. Peterson, M.L. (1996) The evolution of advanced synthetic automation for high-throughput organic synthesis. Amer. Biotechnol. Lab., 14, 66. #11424

  217. Phillips, G.B., & Wei, G.P. (1996) Solid phase synthesis of benzimidazoles. Tetrahedron Lett., 37, 4887-4890. #4902

  218. Pinilla, C., Appel, J.R., & Houghten, R.A. (1996) Tea bag synthesis of positional scanning synthetic combinatorial libraries and their use for mapping antigenic determinants. Methods Mol. Biol., 66, 171-179. #5592

  219. Pivonka, D.E., Russel, K., & Gero, T. (1996) Tools for combinatorial chemistry: In situ infrared analysis of solid-phase organic reactions. Appl. Spectrosc., 50, 1471-1478. #8661

  220. Pop, I.E., Dhalluin, C.F., Deprez, B.P., Melnyk, P.C., Lippens, G.M., & Tartar, A.L. (1996) Monitoring of a three-step solid phase synthesis involving a Heck reaction using magic angle spinning NMR spectroscopy. Tetrahedron, 52, 12209-12222. #5276

  221. Probert, J.M., Rennex, D., & Bradley, M. (1996) Lanthionines for solid phase synthesis. Tetrahedron Lett., 37, 1101-1104. #3887

  222. Pursch, M., Schlotterbeck, G., Tseng, L.H., & Albert, K. (1996) Monitoring the reaction progress in combinatorial chemistry: H-1 MAS NMR investigations on single macro beads in the suspended state. Angew. Chem. Int. Ed., 35, 2867-2869. #8240

  223. Qiu, W.M., & Burton, D.J. (1996) A facile and general preparation of alpha,alpha-difluoro benzylic phosphonates by the CuCl promoted coupling reaction of the (diethylphosphonyl)difluoromethylcadmium reagent with aryl iodides. Tetrahedron Lett., 37, 2745-2748. #7492

  224. Rademann, J., & Schmidt, R.R. (1996) A new method for solid phase synthesis of oligosaccharides. Tetrahedron Lett., 37, 3989-3990. #4937

  225. Rapp, W. (1996) PEG grafted polystyrene tentacle polymers: Physico-chemical properties and application in chemical synthesis. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 425-464). VCH, Weinheim. #8193

  226. Rapp, W., Nicholson, G., Maier, M., Schlotterbeck, G., Pursch, M. & Albert, K. (1996) Miniaturization in chemistry: Chemical possibilities and physicochemical properties of polymeric microreactors. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 97-100). Mayflower Scientific Limited, Birmingham. #8904

  227. Reggelin, M., & Brenig, V. (1996) Towards polyketide libraries: Iterative, asymmetric aldol reactions on a solid support. Tetrahedron Lett., 37, 6851-6852. #5460

  228. Renil, M., & Meldal, M. (1996) POEPOP and POEPS: Inert polyethylene glycol crosslinked polymeric supports for solid synthesis. Tetrahedron Lett., 37, 6185-6188. #5228

  229. Richter, L.S., Spellmeyer, D.C., Martin, E.J., Figliozzi, G.M. & Zuckermann, R.N. (1996) Automated synthesis of nonnatural oligomer libraries: The peptoid concept. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 387-404). VCH, Weinheim. #10524

  230. Rinnova, M., Fusek, M. & Lebl, M. (1996) Use of methyl red in solid phase synthesis. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 509-510). Mayflower Scientific Limited, Birmingham. #3449

  231. Rivier, J.E., Jiang, G.C., Koerber, S.C., Porter, J., Simon, L., Craig, A.G., & Hoeger, C.A. (1996) Betidamino acids: Versatile and constrained scaffolds for drug discovery. Proc. Natl. Acad. Sci. USA, 93, 2031-2036. #7556

  232. Robinett, L.D., Yager, K.M. & Phelan, J.C. (1996) Solid-phase synthesis of dihydropyrimidine combinatorial libraries by the atwal modification of the Biginelli reaction. In Anonymous, Book of Abstracts, 211th ACS National Meeting, New Orleans, LA, March 24-28. (pp. ORGN-122. American Chemical Society,Washington,D, #7561

  233. Rockwell, A., Melden, M., Copeland, R.A., Hardman, K., Decicco, C.P., & DeGrado, W.F. (1996) Complementarity of combinatorial chemistry and structure-based ligand design: Applications to the discovery of novel inhibitors of matrix metalloproteinases. J. Amer. Chem. Soc., 118, 10337-10338. #5549

  234. Roelfing, K., Thiel, M., & Kuenzer, H. (1996) 1,2,6-Trisubstituted tetrahydroisoquinoline derivatives by solid-phase synthesis. Synlett, 1036-1038. #8543

  235. Rotella, D.P. (1996) Solid phase synthesis of olefin and hydroxyethylene peptidomimetics. J. Amer. Chem. Soc., 118, 12246-12247. #8158

  236. Rothe, M., Negele, A., Mohr, T. & Kneer, S. (1996) Cyclizations of peptides and oligoamides bound to silica gel as a rigid support. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 515-518). Mayflower Scientific Limited, Birmingham. #8975

  237. Routledge, A., Wallis, M.P., Ross, K.C. & Fraser, W. (1996) An efficient deprotection strategy for automated oligonucleotide synthesis using a novel silyl linked solid support. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 147-150). Mayflower Scientific Limited, Birmingham. #8915

  238. Ruhland, B., Bhandari, A., Gordon, E.M., & Gallop, M.A. (1996) Solid-supported combinatorial synthesis of structurally diverse b-lactams. J. Amer. Chem. Soc., 118, 253-254. #3862

  239. Ruhland, T., & Kunzer, H. (1996) Structurally diverse 2,6-disubstituted quinoline derivatives by solid-phase synthesis. Tetrahedron Lett., 37, 2757-2760. #4741

  240. Salo, H., Guzaev, A., Azhayev, A., & Lonnberg, H. (1996) Disulfide tethered solid supports for oligonucleotide synthesis: Preparation and a comparative study on the resistance to ammonolysis. Collect. Czech. Chem. Commun., 61, S110-S111. #5262

  241. Saneii, H.H., Hamker, L., Sun, X. & Peterson, M. (1996) Automated synthetic strategies: Process development for peptide and organic chemistry. In Anonymous, Peptide Chemistry. (pp. 93-96). Protein Research Foundation, London. #11423

  242. Saneii, H.H., Peterson, M.L., Anderson, H., Healy, E.T. & Bizanek, R.G. (1996) Advanced automation for peptides and non-peptidic molecules. In P.T.P. Kaumaya & R.S. Hodges (Eds.), Peptides:Chemistry,Structure and Biology,Proc.14.APS. (pp. 136-140). Mayflower Scientific Ltd., Kingswinford. #5035

  243. Sarkar, S.K., Garigipati, R.S., Adams, J.L., & Keifer, P.A. (1996) An NMR method to identify nondestructively chemical compounds bound to a single solid-phase-synthesis bead for combinatorial chemistry applications. J. Amer. Chem. Soc., 118, 2305-2306. #4132

  244. Sarshar, S., Siev, D., & Mjalli, A.M.M. (1996) Imidazole libraries on solid support. Tetrahedron Lett., 37, 835-838. #3637

  245. Schlessinger, R.H., & Bergstrom, C.P. (1996) Diastereoselective Diels-Alder reactions of nonracemic 3- and 4-amino furans bound to polystyrene. A comparison of these reactions to their solution state analogues. Tetrahedron Lett., 37, 2133-2136. #10086

  246. Schlick, S., Bortel, E., & Dyrek, K. (1996) Catalysis on polymer supports. Acta Polym., 47, 1-15. #8755

  247. Schliepe, J., Berghoff, U., Lippert, B., & Cech, D. (1996) Automated solid phase synthesis of platinated oligonucleotides via nucleoside phosphonates. Angew. Chem. Int. Ed., 35, 646-648. #4743

  248. Schmidt, S., Grenfell, R.L., Fogg, J., Smith, T.V., Grasby, J.A., Mersmann, K. & Gait, M.J. (1996) Solid phase synthesis of oligoribonucleotides containing site-specific modifications. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 11-18). Mayflower Scientific Limited, Birmingham. #8892

  249. Schuster, M., Pernerstorfer, J., & Blechert, S. (1996) Ruthenium-catalyzed metathesis of polymer-bound olefins. Angew. Chem. Int. Ed., 35, 1979-1980. #5542

  250. Scialdone, M.A. (1996) Combinatorial chemistry of polymer-bound isocyanates. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-186. American Chemical Society,Washington,D, #7680

  251. Scialdone, M.A. (1996) Diisocyanates as scaffolds for combinatorial libraries. The solid-phase synthesis of bis-ureas from polymer supported diisocyanates. Tetrahedron Lett., 37, 8141-8144. #5742

  252. Scott, B.O., Siegmund, A.C., Marlowe, C.K., Pei, Y., & Spear, K.L. (1996) Solid phase organic synthesis (SPOS): A novel route to diketopiperazines and diketomorpholines. Mol. Diversity, 1, 125-134. #3267 (Available on Internet)

  253. Seeberger, P.H., Jordan, J.L., Caruthers, M.H., Bankaitis-Davis, D.M., Heil, J.R., Munson, M.C. & Beaton, G. (1996) Solid phase synthesis of oligonucleotide and peptide dithiophosphanates. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 141-146). Mayflower Scientific Limited, Birmingham. #8914

  254. Seneci, P., Sizemore, C., Islam, K., & Kocis, P. (1996) Combinatorial chemistry and natural products. Teicoplanin aglycone as a molecular scaffold for solid phase synthesis of combinatorial libraries. Tetrahedron Lett., 37, 6319-6322. #5253

  255. Shah, V.J., Cerpa, R., Kuntz, I.D., & Kenyon, G.L. (1996) Solid-phase synthesis of peptide-derived enantiospecific nucleic acid analogs. Bioorg. Chem., 24, 201-206. #7708

  256. Shapiro, M.J., Kumaravel, G., Petter, R.C., & Beveridge, R. (1996) 19F NMR monitoring of a S(N)Ar reaction on solid support. Tetrahedron Lett., 37, 4671-4674. #4857

  257. Sharma, S.K., Wu, A.D., & Chandramouli, N. (1996) Maleimide-assisted on-resin macrocyclization. Tetrahedron Lett., 37, 5665-5668. #5134

  258. Shimizu, H., Ito, Y., Kanie, O., & Ogawa, T. (1996) Solid phase synthesis of polylactosamine oligosaccharide. Bioorg. Med. Chem. Lett., 6, 2841-2846. #8544

  259. Short, K.M., Ching, B.W., & Mjalli, A.M.M. (1996) The synthesis of hydantoin 4-imides on solid support. Tetrahedron Lett., 37, 7489-7492. #5539

  260. Showalter, H.D.H. (1996) A silicon-based linker for traceless solid-phase synthesis. Photodetachable arylsilane polymer linkages for use in solid phase organic synthesis. Chemtracts:Org. Chem., 9, 231-236. #10065

  261. Smith, A.L., Thomson, C.G., & Leeson, P.D. (1996) An efficient solid phase synthetic route to 1,3-disubstituted 2, 4(1H,3H)-quinazolinediones suitable for combinatorial synthesis. Bioorg. Med. Chem. Lett., 6, 1483-1486. #4942

  262. Smith, J., Liras, J.L., Schneider, S.E., & Anslyn, E.V. (1996) Solid and solution phase organic syntheses of oligomeric thioureas. J. Org. Chem., 61, 8811-8818. #8545

  263. So, S.S., & Karplus, M. (1996) Genetic neural networks for quantitative structure-activity relationships: Improvements and application of benzodiazepine affinity for benzodiazepine/GABA(A) receptors. J. Med. Chem., 39, 5246-5256. #8263

  264. Sofia, M.J. (1996) Generation of oligosaccharide and glycoconjugate libraries for drug discovery (Review). Drug Disc. Today, 1, 27-34. #5692

  265. Stangier, P., & Hindsgaul, O. (1996) Solid-phase transimidation for the removal of N-phthalimido- and N-tetrachlorophthalimido protecting groups on carbohydrates. Synlett, 179-181. #4899

  266. Stankova, M., & Lebl, M. (1996) Library generation through successive substitution of trichlorotriazine. Mol. Diversity, 2, 75-80. #4844 (Available on Internet)

  267. Stankova, M., Strop, P., Chen, C. & Lebl, M. (1996) Mixtures of molecules versus mixtures of pure compounds on polymeric beads. In I.M. Chaiken & K.D. Janda (Eds.), Molecular Diversity and Combinatorial Chemistry. Libraries and Drug Discovery. (pp. 137-143). American Chemical Society, Washington,DC. #5103

  268. Stetsenko, D.A., Lubyako, E.N., Potapov, V.K., Azhikina, T.L., & Sverdlov, E.D. (1996) New approach to solid phase synthesis of polyamide nucleic acids analogues (PNA) and PNA-DNA conjugates. Tetrahedron Lett., 37, 3571-3574. #7790

  269. Strocker, A.M., Keating, T.A., Tempest, P.A., & Armstrong, R.W. (1996) Use of a convertible isocyanide for generation of Ugi reaction derivatives on solid support: Synthesis of a-acylaminoesters and pyrroles. Tetrahedron Lett., 37, 1149-1152. #3884

  270. Sucholeiki, I. (1996) The use of polymer-assisted organic synthesis for the production of small organic molecules. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 107-110). Mayflower Scientific Limited, Birmingham. #8906

  271. Sutherlin, D.P., Stark, T.M., Hughes, R., & Armstrong, R.W. (1996) Generation of C-glycoside peptide ligands for cell surface carbohydrate receptors using a four-component condensation on solid support. J. Org. Chem., 61, 8350-8354. #8138

  272. Svensson, A., Fex, T., & Kihlberg, J. (1996) Use of (19)F NMR spectroscopy to evaluate reactions in solid phase organic synthesis. Tetrahedron Lett., 37, 7649-7652. #5541

  273. Szardenings, A.K., Gordeev, M.F., & Patel, D.V. (1996) A general and convenient synthesis of novel phosphotyrosine mimetics. Tetrahedron Lett., 37, 3635-3638. #7818

  274. Szardenings, A.K., Burkoth, T.S., Look, G.C., & Campbell, D.A. (1996) A reductive alkylation procedure applicable to both solution-and solid-phase syntheses of secondary amines. J. Org. Chem., 61, 6720-6722. #7817

  275. Takanami, M., & Kotani, H. (1996) Progress in DNA sequencing technology. Seibutsu Shiryo Bunseki, 19, 152-158. #9645

  276. Tempest, P.A., Brown, S.D., & Armstrong, R.W. (1996) Solid-phase, parallel syntheses by Ugi multicomponent condensation. Angew. Chem. Int. Ed., 35, 640-642. #4585

  277. Thompson, L.A., & Ellman, J.A. (1996) Synthesis and application of small molecule libraries. Chem. Rev., 96, 555-600. #3665

  278. Tietze, L.F., & Steinmetz, A. (1996) A general and expedient method for the solid-phase synthesis of structurally diverse 1-phenyl-pyrazolone derivatives. Synlett, 667-668. #5109

  279. Tietze, L.F., & Steinmetz, A. (1996) Stereoselective solid-phase synthesis of cyclopentane and cyclohexane derivatives by two-component domino reactions: Generation of combinatorial libraries. Angew. Chem. Int. Ed., 35, 651-652. #4586

  280. Tietze, L.F., Hippe, T., & Steinmetz, A. (1996) Solid-phase three-component domino reactions: Combinatorial approach to substituted 3,4-dihydro-2H-pyrans. Synlett, 11, 1043-1043. #8191

  281. Tortolani, D.R., & Biller, S.A. (1996) A solid phase synthesis of miconazole analogs via an iodoetherification reaction. Tetrahedron Lett., 37, 5687-5690. #5133

  282. Tour, J.M. (1996) Conjugated macromolecules of precise length and constitution. Organic synthesis for the construction of nanoarchitectures. Chem. Rev., 96, 537. #14283 NEWOLD

  283. Tulinsky, J. & Chrusciel, R.A. (1996) The solid-phase synthesis of beta-ketoesters and amides via enolate acylation. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-187. American Chemical Society,Washington,D, #7894

  284. Urban, J., Vaisar, T., Shen, R., & Lee, M.S. (1996) Lability of N-alkylated peptides towards TFA cleavage. Int. J. Peptide Prot. Res., 47, 182-189. #3602

  285. Vagner, J., Krchnak, V., Lebl, M., & Barany, G. (1996) Solid-phase organic synthesis: Creation of carbon-carbon double bond under mild conditions by Wittig-type reactions. Collect. Czech. Chem. Commun., 61, 1697-1702. #7915

  286. Valerio, R.M., Bray, A.M., & Patsiouras, H. (1996) Multipin solid phase synthesis of ethers using modified Mitsunobu chemistry. Tetrahedron Lett., 37, 3019-3022. #4749

  287. van Aerschot, A., Hendrix, C., Verheggen, I. & Herdewijn, P. (1996) Physicochemical properties of 1,5-anhydrohexitol nucleic acids. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 69-72). Mayflower Scientific Limited, Birmingham. #8901

  288. van der Laan, A.C., van Amsterdam, I., Oosting, R.S., Brands, R., Meeuwenoord, N.J., Kuyl-Yeheskiely, E. & van Boom, J.H. (1996) Synthesis of new chiral PNA analogues. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 543-544). Mayflower Scientific Limited, Birmingham. #9030

  289. van Maarseveen, J.H., den Hartog, J.A.J., Engelen, V., Finner, E., Visser, G., & Kruse, C.G. (1996) Solid-phase ring-closing metathesis: Cyclization/cleavage approach towards a seven membered cycloolefin. Tetrahedron Lett., 37, 8249-8252. #5743

  290. Venkatesan, H., & Greenberg, M.M. (1996) Improved utility of photolabile solid phase synthesis supports for the synthesis of oligonucleotides containing 3'-hydroxyl termini. J. Org. Chem., 61, 525-529. #3726

  291. Virgilio, A.A., Schurer, S.C., & Ellman, J.A. (1996) Expedient solid-phase synthesis of putative b-turn mimetics incorporating the i+1, i+2 and i+3 sidechains. Tetrahedron Lett., 37, 6961-6964. #5463

  292. Voivodov, K.I., Ching, J., & Hutchens, T.W. (1996) Surface arrays of energy absorbing polymers enabling covalent attachment of biomolecules for subsequent laser-induced uncoupling/desorption. Tetrahedron Lett., 37, 5669-5672. #5164

  293. Vuljanic, T., Bergquist, K.E., Clausen, H., Roy, S., & Kihlberg, J. (1996) Piperidine is preferred to morpholine for Fmoc cleavage in solid- phase glycopeptide synthesis as exemplified by preparation of glycopeptides related to HIV gp 120 and mucins. Tetrahedron, 52, 7983-8000. #4939

  294. Ward, Y.D., & Farina, V. (1996) Solid phase synthesis of aryl amines via palladium catalyzed amination of resin-bound aromatic bromides. Tetrahedron Lett., 37, 6993-6996. #5465

  295. Wehler, T., & Westman, J. (1996) Magic angle spinning NMR: A valuable tool for monitoring the progress of reactions in solid phase synthesis. Tetrahedron Lett., 37, 4771-4774. #4858

  296. Weiler, J. & Pfleiderer, W. (1996) High-loaded supports and the NPE/NPEOC strategy: An efficient combination for large scale synthesis of oligonucleotides. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 239-242). Mayflower Scientific Limited, Birmingham. #8929

  297. Wijkmans, J.C.H.M., Meeuwenoord, N.J., Bloemhoff, W., van der Marel, G.A., & van Boom, J.H. (1996) Solid phase synthesis of alkylphosphonopeptides. Tetrahedron, 52, 2103-2112. #5733

  298. Will, D.W., Breipohl, G., Langner, D. & Uhlmann, E. (1996) Solid-phase synthesis of PNA-DNA chimeric oligomers. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 65-68). Mayflower Scientific Limited, Birmingham. #8900

  299. Willoughby, C.A., & Chapman, K.T. (1996) Solid phase synthesis of aryl amines. Tetrahedron Lett., 37, 7181-7184. #5528

  300. Winter, M. (1996) Supports for solid-phase organic synthesis. In G. Jung (Ed.), Combinatorial Peptide and Nonpeptide Libraries: A Handbook. (pp. 465-510). VCH, Weinheim. #10526

  301. Xiao, W., Player, M.R., Li, G., Zhang, W., Lesiak, K., & Torrence, P.F. (1996) Synthesis and characterization of composite nucleic acids containing 2',5'-oligoriboadenylate linked to antisense DNA. Antisense Nucl. Acid Drug Devel., 6, 247-258. #8465

  302. Xie, M., & Widlanski, T.S. (1996) A new protecting group for synthesis of complex sulfonates. Tetrahedron Lett., 37, 4443-4446. #4799

  303. Xu, Q., Musier-Forsyth, K., Hammer, R.P. & Barany, G. (1996) N-Dithiasuccinoyl (DTS)-amines: Novel sulfurizing reagents for the solid-phase preparation of thiophosphopeptides and oligodeoxyribonucleoside phosphorothioates. In R. Epton (Ed.), Innovation and Perspectives in Solid Phase Synthesis & Combinatorial Libraries. (pp. 561-564). Mayflower Scientific Limited, Birmingham. #8984

  304. Xu, Q.H., Musier-Forsyth, K., Hammer, R.P., & Barany, G. (1996) Use of 1,2,4-dithiazolidine-3,5-dione (DtsNH) and 3-ethoxy-1,2,4-dithiazoline-5-one (EDITH) for synthesis of phosphorothioate-containing oligodeoxyribonucleotides. Nucl. Acid. Res., 24, 1602-1607. #8051

  305. Yan, B., & Gstach, H. (1996) An indazole synthesis on solid support monitored by single bead FTIR microspectroscopy. Tetrahedron Lett., 37, 8325-8328. #5749

  306. Yan, B., & Kumaravel, G. (1996) Probing solid-phase reactions by monitoring the IR bands of compounds on a single "flattened" resin bead. Tetrahedron, 52, 843-848. #3865

  307. Yan, B., Sun, Q., Wareing, J.R., & Jewell, C.F. (1996) Real-time monitoring of the catalytic oxidation of alcohols to aldehydes and ketones on resin support by single-bead fourier transform infrared microspectroscopy. J. Org. Chem., 61, 8765-8770. #10057

  308. Yang, L., & Guo, L. (1996) Pictet-Spengler reaction on solid support. Tetrahedron Lett., 37, 5041-5044. #4929

  309. Ye, B., Otaka, A., & Burke, T.R.Jr. (1996) Preparation of Na-Boc-4-O-diethylphospho-L-azatyrosine, a reagent potentially useful for the synthesis of signal transduction related peptides. Synlett, 459-460. #4897

  310. Yokomatsu, T., Yamagishi, T., Matsumoto, K., & Shibuya, S. (1996) Stereocontrolled synthesis of hydroxymethylene phosphonate analogues of phosphorylated tyrosine and their conversion to monofluoromethylene phosphonate analogues. Tetrahedron, 52, 11725-11738. #8077

  311. Yun, W., & Mohan, R. (1996) Heck reaction on solid support: Synthesis of indole analogs. Tetrahedron Lett., 37, 7189-7192. #5529

  312. Zaragoza, F., & Petersen, S.V. (1996) Generation of rhodium carbenoids on a polystyrene support and their OH-insertion reaction with alcohols. Tetrahedron, 52, 5999-6002. #5754

  313. Zaragoza, F. (1996) Solid-phase synthesis of substituted 3-aminothiophenes and 2- methylene-2,3-dihydrothiazoles. Tetrahedron Lett., 37, 6213-6216. #5229

  314. Zaragoza, F. (1996) Solid-phase synthesis of substituted 3-aminothiophenes and 2- methylene-2,3-dihydrothiazoles (vol 37, pg 6213, 1996). Tetrahedron Lett., 37, 7865-7865. #8096

  315. Zaragoza, F., & Petersen, S.V. (1996) Solid-phase synthesis of substituted 1,2,3-triazoles. Tetrahedron, 52, 10823-10826. #5012

  316. Zhang, C., Moran, E.J., Woiwode, T.F., Short, K.M., & Mjalli, A.M.M. (1996) Synthesis of tetrasubstituted imidazoles via a-(N-acyl-N- alkylamino)-b-ketoamides on Wang resin. Tetrahedron Lett., 37, 751-754. #3869

  317. Zhang, C., & Mjalli, A.M.M. (1996) A combinatorial method for the solid phase synthesis of a-amino phosphonates and phosphonic acids. Tetrahedron Lett., 37, 5457-5460. #5075

  318. Zhang, H. & Maryanoff, B.E. (1996) Construction of indole and benzofuran systems on the solid phase via palladium-mediated intramolecular cyclization. In Anonymous, Book of Abstracts, 212th ACS National Meeting, Orlando, FL, August 25-29. (pp. ORGN-185. American Chemical Society,Washington,D, #8104

  319. Zhang, X., & Jones, R.A. (1996) A universal allyl linker for solid-phase synthesis. Tetrahedron Lett., 37, 3789-3790. #4602

  320. Zhao, B.P., Panigrahi, G.B., Sadowski, P.D., & Krepinsky, J.I. (1996) Syntheses of oligonucleotide-amino acid conjugates: Using TentaGel and CPG matrices for the synthesis of 3'- phosphoryltyrosine-terminated oligonucleotides. Tetrahedron Lett., 37, 3093-3096. #8109


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