Papers on solid phase organic synthesis published in 2000

This list is arranged by the name of the first author. Any omissions, mistakes and inconsistencies please communicate to the authors of compilation (michal@5z.com). (If you are pointing to any reference, please use its ID# -- the last number in the reference.) You are welcome to use this compilation in your work. Proper way to quote it in your paper is: Lebl M., Leblova Z.: Dynamic database of references in molecular diversity. Internet http://www.5z.com.

Recently added entries are marked in bold

1. Anonymous. (2000) Solid-phase synthesis of phenolic steroids. Drug Disc. Today, 5, 261. #14910

2. Abarbri, M., Thibonnet, J., Berillon, L., Dehmel, F., Rottlander, M., & Knochel, P. (2000) Preparation of new polyfunctional magnesiated heterocycles using a chlorine-, bromine-, or iodine-magnesium exchange. J. Org. Chem., 65, 4618-4634. #15817

3. Adinolfi, M., Barone, G., Guariniello, L., & Iadonisi, A. (2000) An easy and efficient approach for the installation of alkoxycarbonyl protecting groups on carbohydrate hydroxyls. Tetrahedron Lett., 41, 9305-9309. #16160

4. Akhtar, M., Kroll, F.E.K., & Gani, D. (2000) Solid-phase synthesis on functionalised fluoropolymer resins. Part 1. Nafion resin sulfonamide-immobilised carboxylic acid derivatives and aryl vinyl sulfones. Tetrahedron Lett., 41, 4487-4491. #14601

5. Albericio, F., Garcia, J., Michelotti, E.L., Nicolas, E., & Tice, C.M. (2000) Solid phase synthesis of sulfahydantoins. Tetrahedron Lett., 41, 3161-3163. #14552

6. Alfaro-Lopez, J., Okayama, T., Hosohata, K., Davis, P., Porreca, F., Yamamura, H.I. & Hruby, V.J. (2000) The fine tuning of high affinity and selective non-peptide agonists of the d-opioid receptor via solution and solid-phase. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 38-39). Kluwer Academic Publisher, Dordrecht. #15690

7. Alonso, C., Nantz, M.H., & Kurth, M.J. (2000) b-Dimethylphenylsilylethyl esters: A linker for solid-phase chemistry. Tetrahedron Lett., 41, 5617-5622. #15416

8. Altmann, K.H., Husken, D., Cuenoud, B., & Garcia-Echeverria, C. (2000) Synthesis and hybridization properties of polyamide based nucleic acid analogues incorporating pyrrolidine-derived nucleoamino acids. Bioorg. Med. Chem. Lett., 10, 929-933. #14916

9. Alvarez-Gutierrez, J.M., Nefzi, A., & Houghten, R.A. (2000) Solid phase synthesis of 1-substituted pyroglutamates. Tetrahedron Lett., 41, 851-854. #14261

10. Alvarez-Gutierrez, J.M., Nefzi, A., & Houghten, R.A. (2000) Solid phase synthesis of 1,3-disubstituted succinimides. Tetrahedron Lett., 41, 609-612. #13902

11. Ando, S., Nakahara, Y., Ito, Y., & Ogawa, T. (2000) Solid-phase synthesis of the glycopeptide of human glycophorin AM bearing the consecutive sialyl-T antigen. Carbohyd. Res., 329, 773-780. #16239

12. Antopolsky, M., & Azhayev, A. (2000) Stepwise solid-phase synthesis of peptide-oligonucleotide phosphorothioate conjugates employing Fmoc peptide chemistry. Tetrahedron Lett., 41, 9113-9117. #15823

13. Anwar, B., Grimsey, P., Hemming, K., Krajniewski, M., & Loukou, C. (2000) A thiazine-S-oxide, Staudinger/aza-Wittig based synthesis of benzodiazepines and benzothiadiazepines. Tetrahedron Lett., 41, 10107-10110. #16241

14. Arimori, S., Hartley, J.H., Bell, M.L., Oh, C.S., & James, T.D. (2000) 'Tailored' polymers for supported syntheses using boronic acids. Tetrahedron Lett., 41, 10291-10294. #16227

15. Arterburn, J.B., Rao, K.V., & Perry, M.C. (2000) Solid-supported hydrazine substrate for labeling estradiol ligands with rhenium. Angew. Chem. Int. Ed., 39, 771-772. #14312

16. Arya, D.P., & Bruice, T.C. (2000) Solid-phase synthesis of oligomeric deoxynucleic-thiourea (DNT) and deoxynucleic S-methylthiourea (DNmt): A neutral/polycationic analogue of DNA. Bioorg. Med. Chem. Lett., 10, 691-693. #14624

17. Arya, P., Rao, N.V., Singkhonrat, J., Alper, H., Bourque, S.C., & Manzer, L.E. (2000) A divergent, solid-phase approach to dendritic ligands on beads. Heterogeneous catalysis for hydroformylation reactions. J. Org. Chem., 65, 1881-1885. #14625

18. Arya, P., Kutterer, K.M.K., & Barkley, A. (2000) Glycomimetics: A programmed approach toward neoglycopeptide libraries. Journal of Combinatorial Chemistry, 2, 120-126. #14371

19. Atkinson, G.E., Fischer, P.M., & Chan, W.C. (2000) A versatile polymer-supported 4-(4-methylphenyl(chloro)methyl)phenoxy linker for solid-phase synthesis of pseudopeptides. J. Org. Chem., 65, 5048-5056. #15759

20. Atkinson, G.E., Fischer, P.M., & Chan, W.C. (2000) Versatile polymer-supported 4-(4-methylphenyl(chloro)methyl)phenoxy linker for solid-phase synthesis of pseudopeptides. (vol 65, pg 5048, 2000). J. Org. Chem., 65, 5076. #15824

21. Attardi, M.E., Porcu, G., & Taddei, M. (2000) Malachite green, a valuable reagent to monitor the presence of free COOH on the solid-phase. Tetrahedron Lett., 41, 7391-7394. #15632

22. Attardi, M.E., Falchi, A., & Taddei, M. (2000) A sensitive visual test for detection of OH groups on resin. Tetrahedron Lett., 41, 7395-7399. #15633

23. Aubert, Y., Bourgerie, S., Meunier, L., Mayer, R., Roche, A.C., Monsigny, M., Thuong, N.T., & Asseline, U. (2000) Optimized synthesis of phosphorothioate oligodeoxyribonucleotides substituted with a 5'-protected thiol function and a 3'-amino group. Nucl. Acid. Res., 28, 818-825. #14923

24. Aznar, F., Valdes, C., & Cabal, M.P. (2000) Enamines in solid-phase: Synthesis and reactivity towards electrophiles. Tetrahedron Lett., 41, 5683-5687. #15419

25. Baca, M., & Kent, S.B.H. (2000) Protein backbone engineering through total chemical synthesis: New insight into the mechanism of HIV-1 protease catalysis. Tetrahedron, 56, 9503-9513. #15826

26. Balalaie, S., Sharifi, A., & Ahangarian, B. (2000) Solid phase synthesis of isoxazole and pyrazole derivatives under microwave irradiation. Indian Journal of Heterocyclic Chemistry, 10, 149-150. #16246

27. Baldino, C.M. (2000) Perspective articles on the utility and application of solution-phase combinatorial chemistry. Journal of Combinatorial Chemistry, 2, 89-103. #14366

28. Bannwarth, W., & Felder, E. (2000) Combinatorial Chemistry: A Practical Approach. Wiley-VCH, Weinheim. ISBN 3527301860 #16212

29. Bannwarth, W. (2000) Solid-phase chemistry. In R. Mannhold, H. Kubinyi & H. Timmerman (Eds.), Combinatorial Chemistry: A Practical Approach. (pp. 47-208). Wiley-VCH, Weinheim. #16215

30. Barco, A., Benetti, S., De Risi, C., Marchetti, P., Pollini, G.P., & Zanirato, V. (2000) Solid-phase synthesis of indolizidine and quinolizidine derivatives. Journal of Combinatorial Chemistry, 2, 337-340. #14685

31. Bark, S.J., Schmid, S., & Hahn, K.M. (2000) A highly efficient method for site-specific modification of unprotected peptides after chemical synthesis. J. Amer. Chem. Soc., 122, 3567-3573. #14928

32. Barlos, K., Gatos, D., Mourtas, S., Nikoletou, A., Karavoltsos, M., Bali, D. & Shoina, V. (2000) Solid-phase synthesis of thiol and thioether functions containing peptides and complex organic molecules. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 198-199). Kluwer Academic Publisher, Dordrecht. #15729

33. Barnes, C., & Balasubramanian, S. (2000) Recent developments in the encoding and deconvolution of combinatorial libraries. Curr. Opin. Chem. Biol., 4, 346-350. #14929

34. Basso, A., Evans, B., Pegg, N., & Bradley, M. (2000) Solid-phase synthesis of aryl ethers on high loading dendrimer resin. Tetrahedron Lett., 41, 3763-3767. #14559

35. Basso, A., Pegg, N., Evans, B., & Bradley, M. (2000) Solid-phase synthesis of amidine-based GP IIb-IIIa antagonists on dendrimer resin beads. Eur. J. Org. Chem., 3887-3891. #16249

36. Batra, S., Rastogi, S.K., Kundu, B., Patra, A., & Bhaduri, A.P. (2000) A novel isoxazole-based scaffold for combinatorial chemistry. Tetrahedron Lett., 41, 5971-5974. #15426

37. Baxter, A.D., Boyd, E.A., Cox, P.B., Loh, V.M.Jr., Monteils, C., & Proud, A. (2000) 4,6-Dichloro-5-nitropyrimidine: A versatile building block for the solid phase synthesis of dihydropteridinones. Tetrahedron Lett., 41, 8177-8181. #15627

38. Beausoleil, E., & Lubell, W.D. (2000) An examination of the steric effects of 5-tert-butylproline on the conformation of polyproline and the cooperative nature of type II to type I helical interconversion. Biopolymers, 53, 249-256. #14933

39. Beilstein, A.E., & Grinstaff, M.W. (2000) On-column derivatization of oligodeoxynucleotides with ferrocene. Chem. Commun., 509-510. #14937

40. Beilstein, A.E., Tierney, M.T., & Grinstaff, M.W. (2000) Site-specifically labeled metallo-oligodeoxynucleotides. Comments on Inorganic Chemistry, 22, 105-127. #15834

41. Beletskaya, I.P., & Cheprakov, A.V. (2000) The Heck reaction as a sharpening stone of palladium catalysis. Chem. Rev., 100, 3009-3066. #15835

42. Belogi, G., Zhu, T., & Boons, G.J. (2000) Polystyrylboronic acid as a reusable polymeric support for oligosaccharide synthesis. Tetrahedron Lett., 41, 6965-6968. #15546

43. Belogi, G., Zhu, T., & Boons, G.J. (2000) Polymer-supported oligosaccharide synthesis by a loading-release-reloading strategy. Tetrahedron Lett., 41, 6969-6972. #15547

44. Bennett, W.M. (2000) Organic reactions on solid support. An overwiew. In H. Fenniri (Ed.), Combinatorial Chemistry: A Practical Approach. (pp. 139-262). Oxford University Press, Oxford. #15670

45. Benson, A.G., Kowalski, J.A. & Lipton, M.A. (2000) On-resin cyclization of the cyclic depsipeptide callipeltin B. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 186-188). Kluwer Academic Publisher, Dordrecht. #15724

46. Bergmeier, S.C., & Arason, K.M. (2000) A convenient one-step method for the deprotection and esterification of triphenylmethyl ethers. Tetrahedron Lett., 41, 5799-5802. #15424

47. Berkessel, A., & Riedl, R. (2000) Combinatorial de novo synthesis of catalysts: How much of a hit-structure is needed for activity? Journal of Combinatorial Chemistry, 2, 215-219. #14446

48. Beroza, P., & Suto, M.J. (2000) Designing chiral libraries for drug discovery. Drug Disc. Today, 5, 364-372. #15466

49. Berry, J.M., Howard, P.W., & Thurston, D.E. (2000) Solid-phase synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines. Tetrahedron Lett., 41, 6171-6174. #15521

50. Berst, F., Holmes, A.B., Ladlow, M., & Murray, P.J. (2000) A latent aryl hydrazine 'safety-catch' linker compatible with N-alkylation. Tetrahedron Lett., 41, 6649-6653. #15528

51. Besser, D., Muller, B., Agricola, I., & Reissmann, S. (2000) Synthesis of differentially protected N-acylated reduced pseudodipeptides as building units for backbone cyclic peptides. J. Peptide Sci., 6, 130-138. #14943

52. Bhat, A.S., Whetstone, J.L., & Brueggemeier, R.W. (2000) A method for the rapid synthesis of benzopyrone libraries employing a resin capture startegy. Journal of Combinatorial Chemistry, 2, 597-599. #15808

53. Bianco, A., Furrer, J., Limal, D., Guichard, G., Elbayed, K., Raya, J., Piotto, M., & Briand, J.P. (2000) Multistep synthesis of 2,5-diketopiperazines on different solid supports monitored by high resolution magic angle spinning NMR spectroscopy. Journal of Combinatorial Chemistry, 2, 681-690. #15838

54. Bianco, A., Sonksen, C.P., Roepstorff, P., & Briand, J.P. (2000) Solid-phase synthesis and structural characterization of highly substituted hydroxyproline-based 2,5-diketopiperazines. J. Org. Chem., 65, 2179-2187. #14628

55. Bienayme, H., Hulme, C., Oddon, G., & Schmitt, P. (2000) Maximizing synthetic efficiency: Multi-component transformations lead the way. Chem. Eur. J., 6, 3321-3329. #15839

56. Bilokin, Y.V., & Kovalenko, S.M. (2000) Solution and solid-phase approaches to quinconazole and fluquinconazole: Inhibitors of fungal ergosterol biosynthesis. Heterocyclic Communications, 6, 409-414. #16253

57. Blackburn, C., & Guan, B. (2000) A novel dealkylation affording 3-aminoimidazo[1,2-a]pyridines: Access to new substitution patterns by solid-phase synthesis. Tetrahedron Lett., 41, 1495-1500. #14332

58. Blanco, L., Bloch, R., Bugnet, E., & Deloisy, S. (2000) Solid phase Diels-Alder/retro Diels-Alder reactions. A new method for traceless linker strategy. Tetrahedron Lett., 41, 7875-7878. #15636

59. Blaney, P., Grigg, R., Rankovic, Z., & Thoroughgood, M. (2000) Solid-phase synthesis of tertiary methylamines via reductive alkylation-fragmenation using a hydroxylamine linker. Tetrahedron Lett., 41, 6635-6638. #15526

60. Blaney, P., Grigg, R., Rankovic, Z., & Thoroughgood, M. (2000) Application of Grignard reagents to the synthesis of tertiary methylamines via resin-bound oxyiminium ions. Tetrahedron Lett., 41, 6639-6642. #15527

61. Bleczinski, C.F., & Richert, C. (2000) Solid-phase synthesis of cyclic peptide-DNA hybrids. Organic Letters, 2, 1697-1700. #14564

62. Bleicher, K.H., Lutz, C., & Wuthrich, Y. (2000) New phenylfluorenyl based linkers for solid phase synthesis. Tetrahedron Lett., 41, 9037-9042. #15841

63. Bohm, H.J., & Stahl, M. (2000) Structure-based library design: Molecular modelling merges with combinatorial chemistry. Curr. Opin. Chem. Biol., 4, 283-286. #14949

64. Bolin, D.R., Swain, A.L., Sarabu, R., Berthel, S.J., Gillespie, P., Huby, N.J.S., Makofske, R., Orzechowski, L., Perrotta, A., Toth, K., Cooper, J.P., Jiang, N., Falcioni, F., Campbell, R., Cox, D., Gaizband, D., Belunis, C.J., Vidovic, D., Ito, K., Crowther, R., Kammlott, U., Zhang, X.L., Palermo, R., Weber, D., & Guenot, J. (2000) Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures. J. Med. Chem., 43, 2135-2148. #14950

65. Bologna, J.C., Imbach, J.L., & Morvan, F. (2000) A mild method for fluorescein labeling of base-sensitive oligonucleotides on solid support. Tetrahedron Lett., 41, 7317-7321. #15631

66. Bonnet, D., Bourel, L., Gras-Masse, H., & Melnyk, O. (2000) A novel lipophilic glyoxylic acid derivative for the lipidation of peptides using salt-free hydrazone ligation. Tetrahedron Lett., 41, 10003-10007. #16223

67. Boons, G.J., & Demchenko, A.V. (2000) Recent advances in O-sialylation. Chem. Rev., 100, 4539-4566. #16254

68. Borgia, J.A., & Fields, G.B. (2000) Chemical synthesis of proteins. Trends Biotech., 18, 243-251. #15497

69. Borgia, J.A., Oegema, T.R.Jr. & Fields, G.B. (2000) Synthesis and application of a glycoprotein derived from the proteoglycan linkage structure. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 773-774). Kluwer Academic Publisher, Dordrecht. #15751

70. Borman, S. (2000) Combinatorial encoding technique: A lucky charm. C&EN, 78, 40-41. #14805

71. Bosch, I., Costa, A.M., Martin, M., Urpi, F., & Vilarrasa, J. (2000) Reduction of azides to amines mediated by tin bis(1,2-benzenedithiolate). Organic Letters, 2, 397-399. #14954

72. Boysen, R.I., & Hearn, M.T.W. (2000) Direct characterisation by electrospray ionisation mass spectroscopy of mercuro-polypeptide complexes after deprotection of acetamidomethyl groups from protected cysteine residues of synthetic polypeptides. J. Biochem. Biophys. Meth., 45, 157-168. #15846

73. Brase, S., & Dahmen, S. (2000) Traceless linkers: Only disappearing links in solid-phase organic synthesis? Chem. Eur. J., 5, 1899-1905. #14568

74. Brase, S., Dahmen, S., & Pfefferkorn, M. (2000) Solid-phase synthesis of urea and amide libraries using the T2 triazene linker. Journal of Combinatorial Chemistry, 2, 710-715. #15847

75. Brase, S. (2000) New linkers for solid phase organic chemistry. Multidirectional (multifunctional), backbone amide, and traceless linker. Chim. Oggi, 18, 14-19. #15680

76. Brasun, J., Ciapetti, P., Kozlowski, H., Oldziej, S., Taddei, M., Valensin, D., Valensin, G., & Gaggelli, N. (2000) Chiral peptide nucleic acids having thymine and adenine in their side chain as specific ligands for Ni-II and Cu-II. Journal of the Chemical Society-Dalton Transactions, 2639-2644. #15848

77. Breitenbucher, J.G., & Figliozzi, G. (2000) Solid-phase synthesis of 4-aryl-1,4-dihydropyridines via the Hantzsch three component condensation. Tetrahedron Lett., 41, 4311-4315. #14598

78. Bremer, R.E., Szewczyk, J.W., Baird, E.E., & Dervan, P.B. (2000) Recognition of the DNA minor groove by pyrrole-imidazole polyamides: Comparison of desmethyl- and N-methylpyrrole. Bioorg. Med. Chem., 8, 1947-1955. #15849

79. Briehn, C.A., Kirschbaum, T., & Bauerle, P. (2000) Polymer-supported synthesis of regioregular head-to-tail-coupled oligo(3-arylthiophene)s utilizing a traceless silyl linker. J. Org. Chem., 65, 352-359. #13923

80. Brouwer, A.J., Van der Linden, H.J., & Liskamp, R.M.J. (2000) Combinatorial chemistry for ligand development in catalysis: Synthesis and catalysis screening of peptidosulfonamide tweezers on the solid phase. J. Org. Chem., 65, 1750-1757. #14631

81. Brouwer, A.J., Monnee, M.C.F., & Liskamp, R.M.J. (2000) An efficient synthesis of N-protected beta-aminoethanesulfonyl chlorides: Versatile building blocks for the synthesis of oligopeptidosulfonamides. Synthesis-Stuttgart, 1579-1584. #15850

82. Brown, B.J., Clemens, I.R., & Neesom, J.K. (2000) Diisopropylcarbodiimide: A novel reagent for the synthesis of 1,3,4-oxadiazoles on solid-phase. Synlett, 131-133. #14966

83. Brown, R.C.D., Keily, J., & Karim, R. (2000) Solid-phase synthesis of g-lactams, g-lactones and cyclobutane derivatives from common resin-bound intermediates. Tetrahedron Lett., 41, 3247-3251. #14555

84. Brown, R.C.D., Castro, J.L., & Moriggi, J.D. (2000) Solid-phase synthesis of cyclic sulfonamides employing a ring-closing metathesis-cleavage strategy. Tetrahedron Lett., 41, 3681-3685. #14558

85. Bryan, W.M., Huffman, W.F., & Bhatnagar, P.K. (2000) Combinatorial chemistry. Preparation of phenoxypropanolamines. Tetrahedron Lett., 41, 6997-7000. #15550

86. Buchardt, J., & Meldal, M. (2000) Novel methodology for the solid-phase synthesis of phosphinic peptides. Journal of the Chemical Society-Perkin Transaction 1, 3306-3310. #15852

87. Buchardt, J., Schiodt, C.B., Krog-Jensen, C., Delaisse, J.M., Foged, N.T., & Meldal, M. (2000) Solid phase combinatorial library of phosphinic peptides for discovery of matrix metalloproteinase inhibitors. Journal of Combinatorial Chemistry, 2, 624-638. #15851

88. Buchardt, J., Schiodt, C.B., Ferreras, M., Foged, N.T., Delaisse, J.M. & Meldal, M. (2000) Combinatorial library of phosphinic peptides for discovery of MMP inhibitors on solid-phase. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 443-444). Kluwer Academic Publisher, Dordrecht. #15737

89. Burgess, K., & Cook, D. (2000) Syntheses of nucleoside triphosphates. Chem. Rev., 100, 2047-2059. #14570

90. Burgess, K. (2000) Solid-phase organic synthesis. John Wiley & Sons, New York. ISBN 0471318256 #14304

91. Burkett, B.A., & Chai, C.L.L. (2000) N-Fmoc-dehydroalanine: A versatile molecular scaffold for the rapid solid-phase synthesis of cycloaliphatic amino acids. Tetrahedron Lett., 41, 6661-6664. #15529

92. Cai, L.S., Han, Y., Ren, S.M., & Huang, L.F. (2000) Dication C(R-1)-N(R-2)(2) synthons and their use in the synthesis of formamidines, amidines, and alpha-aminonitriles. Tetrahedron, 56, 8253-8262. #15854

93. Cameron, A., Appel, J., Houghten, R.A., & Lindberg, I. (2000) Polyarginines are potent furin inhibitors. Journal of Biological Chemistry, 275, 36741-36749. #16262

94. Cannarsa, M.J. (2000) CombiCat 1999. A brief summary of papers presented. Chim. Oggi, 6, 22-25. #14707

95. Carlson, C.B., & Beal, P.A. (2000) Solid-phase synthesis of acridine-peptide conjugates and their analysis by tandem mass spectrometry. Organic Letters, 2, 1465-1468. #14975

96. Caulfield, T.J., Patel, S., Salvino, J.M., Liester, L., & Labaudiniere, R. (2000) Parallel solid-phase synthesis of peptidyl Michael acceptors. Journal of Combinatorial Chemistry, 2, 600-603. #15858

97. Chan, W.Y., Wo, N.C., Stoev, S., Cheng, L.L., & Manning, M. (2000) Discovery and design of novel and selective vasopressin and oxytocin agonists and antagonists: The role of bioassays. Experimental Physiology, 85, 7S-18S. #14977

98. Chandrasekhar, S., Padmaja, M.B., & Raza, A. (2000) A new cleavage strategy for ester linked polymer supports: Generation of a tertiary alcohol library. Journal of Combinatorial Chemistry, 2, 246-248. #14453

99. Cheguillaume, A., Doubli-Bounoua, I., Baudy-Floch, M., & Le Grel, P. (2000) New potential monomers for solid phase synthesis of hydrazinopeptoids: The N-alpha-substituted-N-beta-protected hydrazinoglycines and hydrazinoglycinals. Synlett, 331-334. #14979

100. Chen, D.J., & Chen, Z.C. (2000) Hypervalent iodine in synthesis 59: Application of polymeric diaryliodonium salts as aryl transfer reagents in SPOS. Synlett, 1175-1177. #15859

101. Chen, J., Pattarawarapan, M., Zhang, A.J., & Burgess, K. (2000) Solution- and solid-phase syntheses of substituted guanidinocarboxylic acids. Journal of Combinatorial Chemistry, 2, 276-281. #14458

102. Chen, Y., Yekta, S., Martyn, L.J.P., Zheng, J., & Yudin, A.K. (2000) Regioselective substitution of fluorine in F8BINOL as a versatile route to new ligands with axial chirality. Organic Letters, 2, 3433-3436. #15860

103. Cheng, Y., Lu, Z., Chapman, K.T., & Tata, J.R. (2000) Solid phase synthesis of indinavir and its analogues. Journal of Combinatorial Chemistry, 2, 445-446. #15594

104. Cheruvallath, Z.S., Sasmor, H., Cole, D.L., & Ravikumar, V.T. (2000) Influence of diastereomeric ratios of deoxyribonucleoside phosphoramidites on the synthesis of phosphorothioate oligonucleotides. Nucleosides, Nucleotides and Nucleic Acids, 19, 533-543. #14980

105. Cheruvallath, Z.S., Carty, R.L., Moore, M.N., Capaldi, D.C., Krotz, A.H., Wheeler, P.D., Turney, B.J., Craig, S.R., Gaus, H.J., Scozzari, A.N., Cole, D.L., & Ravikumar, V.T. (2000) Synthesis of antisense oligonucleotides: Replacement of 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage reagent) with phenylacetyl disulfide (PADS) as efficient sulfurization reagent: From bench to bulk manufacture of active pharmaceutical ingredient. Organic Process Research and Development, 4, 199-204. #14981

106. Chesney, A., Steel, P.G., & Stonehouse, D.F. (2000) High loading cellulose based poly(alkenyl) resins for resin capture applications in halogenation reactions. Journal of Combinatorial Chemistry, 2, 434-437. #15591

107. Chhabra, S.R., Khan, A.N., & Bycroft, B.W. (2000) Solid-phase synthesis of polyamines using a Dde-linker: Philanthotoxin-4.3.3 via an on-resin Mitsunobu reaction. Tetrahedron Lett., 41, 1099-1102. #14255

108. Chhabra, S.R., Khan, A.N., & Bycroft, B.W. (2000) Solid-phase synthesis of symmetrical and unsymmetrical polyamine analogues of philanthotoxins using a Dde-linker. Tetrahedron Lett., 41, 1095-1098. #14254

109. Chi, Y.C., & Sun, C.M. (2000) Soluble polymer-supported synthesis of a benzimidazole library. Synlett, 591-594. #14983

110. Chin, J., Chen, A., & Shapiro, M.J. (2000) Improved high-resolution diffusion filtered 1H MAS NMR. Magn. Reson. Chem., 38, 782-784. #15766

111. Chin, J.A., Chen, A., & Shapiro, M.J. (2000) SPEEDY: Spin-Echo Enhanced Diffusion Filtered Spectroscopy. A new tool for high resolution MAS NMR. Journal of Combinatorial Chemistry, 2, 293-296. #14460

112. Chucholowski, A., & Nettekoven, M. (2000) Resin capture techniques in combinatorial chemistry. Chim. Oggi, 18, 50-52. #14398

113. Ciobanu, L.C., Maltais, R., & Poirier, D. (2000) The sulfamate functional group as a new anchor for solid-phase organic synthesis. Organic Letters, 2, 445-448. #14985

114. Clapham, B., & Sutherland, A.J. (2000) Use of a scintillant-containing macroporous resin in both solid phase synthesis and subsequent on-bead scintillation-based analysis. Tetrahedron Lett., 41, 2257-2260. #14344

115. Clapham, B., & Sutherland, A.J. (2000) Synthesis and evaluation of a scintillant-containing solid support for use in combinatorial chemistry. Tetrahedron Lett., 41, 2253-2256. #14343

116. Coltart, D.M. (2000) Peptide segment coupling by prior ligation and proximity-induced intramolecular acyl transfer. Tetrahedron, 56, 3449-3491. #14990

117. Connolly, P.J., Beers, K.N., Wetter, S.K., & Murray, W.V. (2000) Solid-phase synthesis of Na-benzyl-Na-cinnamyl lysine and glutamic acid derivatives. Tetrahedron Lett., 41, 5187-5191. #14619

118. Cossy, J., Tresnard, L., & Pardo, D.G. (2000) Synthesis of amino alcohol derivatives from (L)-pyroglutamic acid on solid-phase. Synlett, 409-411. #14991

119. Crimmins, M.T., & Zuercher, W.J. (2000) Solid-phase synthesis of carbocyclic nucleosides. Organic Letters, 2, 1065-1067. #14998

120. Dahmen, S., & Brase, S. (2000) A novel solid-phase synthesis of highly diverse guanidines: Reactions of primary amines attached to the T2*linker. Organic Letters, 2, 3563-3565. #15866

121. Dahmen, S., & Brase, S. (2000) The first stable diazonium ion on solid support-investigations on stability and usage as linker and scavenger in solid-phase organic synthesis. Angew. Chem. Int. Ed., 39, 3681-3683. #15867

122. Dangel, B.D., & Polt, R. (2000) Catalysis by amino acid-derived tetracoordinate complexes: Enantioselective addition of dialkylzincs to aliphatic and aromatic aldehydes. Organic Letters, 2, 3003-3006. #15869

123. Dankwardt, S.M. (2000) Solid phase synthesis: Applications to combinatorial libraries. High Throughput Screening for Novel Anti-Inflamatories, 1-17. #14999

124. Dattilo, J., Goodman, B., Lum, C., Elliott, C., Deiparine, M., Beigel-Orme, S., Cunningham, D. & Young, J. (2000) The usage of a b-sheet template with diversity points to generate libraries using the Irori method. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 194-195). Kluwer Academic Publisher, Dordrecht. #15727

125. Davis, B.G. (2000) Recent developments in oligosaccharide synthesis. Journal of the Chemical Society-Perkin Transaction 1, 2137-2160. #15874

126. Davis, P.W., & Swayze, E.E. (2000) Automated solid-phase synthesis of linear nitrogen-linked compounds. Biotechnol. Bioeng., 71, 19-27. #13944

127. de Blas, J., Dominguez, E., & Ezquerra, J. (2000) Solid phase synthesis of glutamic acid derivatives via nucleophilic ring opening of N-Boc pyroglutamate with heteronucleophiles. Tetrahedron Lett., 41, 4567-4571. #14596

128. De Napoli, L., De Luca, S., Di Fabio, G., Messere, A., Montesarchio, D., Morelli, G., Piccialli, G., & Tesauro, D. (2000) A facile solid-phase strategy for the synthesis of oligonucleotide-tetraphenylporphprin conjugates. Eur. J. Org. Chem., 1013-1018. #15005

129. De, D., & Krogstad, D.J. (2000) Pd(DIPHOS)(2)-catalyzed cross-coupling reactions of organoborons with free or polymer-bound aryl halides. Organic Letters, 2, 879-882. #15006

130. del Fresno, M., El-Faham, A., Carpino, L.A., Royo, M., & Albericio, F. (2000) Substituted guanidines: Introducing diversity in combinatorial chemistry. Organic Letters, 2, 3539-3542. #15877

131. Derrick, W.B., Greef, C.H., Caruthers, M.H., & Uhlenbeck, O.C. (2000) Hammerhead cleavage of the phosphorodithioate linkage. Biochemistry, 39, 4947-4954. #15010

132. DeSilva, B.S., & Wilson, G.S. (2000) Synthesis of bifunctional antibodies for immunoassays. Methods (Duluth), 22, 33-43. #15879

133. Dey, S., & Garner, P. (2000) Synthesis of tert-butoxycarbonyl (Boc)-protected purines. J. Org. Chem., 65, 7697-7699. #15881

134. Di Lucrezia, R., Gilbert, I.H., & Floyd, C.D. (2000) Solid phase synthesis of purines from pyrimidines. Journal of Combinatorial Chemistry, 2, 249-253. #14454

135. Dinsmore, C.J., & Zartman, C.B. (2000) Efficient synthesis of substituted piperazinones via tandem reductive amination-cyclization. Tetrahedron Lett., 41, 6309-6312. #15532

136. Dolle, R.E. (2000) Comprehensive survey of combinatorial library synthesis: 1999. Journal of Combinatorial Chemistry, 2, 383-433. #15590

137. Dolle, R.E., Guo, J., O'Brien, L., Jin, Y., Piznik, M., Bowman, K.J., Li, W.N., Egan, W.J., Cavallaro, C.L., Roughton, A.L., Zhao, Q., Reader, J.C., Orlowski, M., Jacob-Samuel, B., & Carroll, C.D. (2000) A statistical-based approach to assessing the fidelity of combinatorial libraries encoded with electrophoric molecular tags. Development and application of tag decode-assisted single bead LC/MS analysis. Journal of Combinatorial Chemistry, 2, 716-731. #15885

138. Dombi, K.L., & Richert, C. (2000) Relative reactivities of activated carboxylic acids in amide-forming reactions employed for the synthesis of tetraphenylporphyrin libraries. Molecules, 5, 1265-1280. #16276

139. Domling, A., & Ugi, I. (2000) Multicomponent reactions with isocyanides. Angew. Chem. Int. Ed., 39, 3169-3210. #15886

140. Domling, A. (2000) The discovery of new isocyanide-based multi-component reactions. Curr. Opin. Chem. Biol., 4, 318-323. #15473

141. Dondas, H.A., Grigg, R., MacLachlan, W.S., MacPherson, D.T., Markandu, J., Sridharan, V., & Suganthan, S. (2000) Solid phase sequential 1,3-dipolar cycloaddition-Pictet-Spengler reactions. Tetrahedron Lett., 41, 967-970. #14264

142. Dorman, G., & Prestwich, G.D. (2000) Using photolabile ligands in drug discovery and development. Trends Biotech., 18, 64-77. #15482

143. Dorwald, F.Z. (2000) Organic Synthesis on Solid Phase: Supports, Linkers, Reactions. Wiley-VCH, Weinheim, New York. ISBN 3527299505 #14467

144. Drakopoulou, E., Tsivgoulis, G.M., Mukhopadhyay, A., & Brisson, A. (2000) Design and synthesis of multifunctional phospholipids. Tetrahedron Lett., 41, 4131-4134. #14593

145. Drew, M., Orton, E., Krolikowski, P., Salvino, J.M., & Kumar, N.V. (2000) A method for quantitation of solid-phase synthesis using F-19 NMR spectroscopy. Journal of Combinatorial Chemistry, 2, 8-9. #13953

146. Drewry, D.H., & Ghiron, C. (2000) Solid-phase synthesis of 2-aminoimidazolinones. Tetrahedron Lett., 41, 6989-6992. #15549

147. Dudziak, G., Bezay, N., Schwientek, T., Clausen, H., Kunz, H., & Liese, A. (2000) Cyclodextrin-assisted glycan chain extension on a protected glycosyl amino acid. Tetrahedron, 56, 5865-5869. #15888

148. Dunsdon, R.M., Greening, J.R., Jones, P.S., Jordan, S., & Wilson, F.X. (2000) Solid phase synthesis of aminoboronic acids: Potent inhibitors of the hepatitis C virus NS3 proteinase. Bioorg. Med. Chem. Lett., 10, 1577-1579. #15016

149. Eda, M., Kurth, M.J., & Nantz, M.H. (2000) The solid-phase Zincke reaction: Preparation of omega-hydroxy pyridinium salts in the search for CFTR activation. J. Org. Chem., 65, 5131-5135. #15768

150. Edmondson, S.D., Mastracchio, A., & Parmee, E.R. (2000) Palladium-catalyzed coupling of vinylogous amides with aryl halides: Applications to the synthesis of heterocycles. Organic Letters, 2, 1109-1112. #15018

151. Edvinsson, K.M., Herslof, M., Holm, P., Kann, N., Keeling, D.J., Mattsson, J.P., Norden, B., & Shcherbukhin, V. (2000) Solid phase synthesis of diamides as potential bone resorption inhibitors. Bioorg. Med. Chem. Lett., 10, 503-507. #14634

152. Edwards, P. (2000) Combinatorial chemistry: Matrix metalloprotease inhibitors. Drug Disc. Today, 5, 431-432. #15456

153. Edwards, P.D., Mauger, R.C., Cottrell, K.M., Morris, F.X., Pine, K.K., Sylvester, M.A., Scott, C.W., & Furlong, S.T. (2000) Synthesis and enzymatic evaluation of a P-1 arginine aminocoumarin substrate library for trypsin-like serine proteases. Bioorg. Med. Chem. Lett., 10, 2291-2294. #15893

154. Egusa, K., Fukase, K., Nakai, Y., & Kusumoto, S. (2000) Stereoselective glycosylation and oligosaccharide synthesis on solid support using a 4-azido-3-chiorobenzyl group for temporary protection. Synlett, 27-32. #15019

155. Eleuteri, A., Capaldi, D.C., Krotz, A.H., Cole, D.L., & Ravikumar, V.T. (2000) Pyridinium trifluoroacetate/N-methylimidazole as an efficient activator for oligonucleotide synthesis via the phosphoramidite method. Organic Process Research and Development, 4, 182-189. #15021

156. Elgie, K.J., Scobie, M., & Boyle, R.W. (2000) Application of combinatorial techniques in the synthesis of unsymmetrically substituted 5,15-dophenylporphyrins. Tetrahedron Lett., 41, 2753-2757. #14543

157. Enholm, E.J., Gallagher, M.E., Jiang, S.J., & Batson, W.A. (2000) Free radical allyl transfers utilizing soluble non-cross-linked polystyrene and carbohydrate scaffold supports. Organic Letters, 2, 3355-3357. #15896

158. Enjalbal, C., Martinez, J., & Aubagnac, J.L. (2000) Mass spectrometry in combinatorial chemistry. Mass Spectrom. Rev., 19, 139-161. #15022

159. Ermert, P., Obrecht, D., Obrecht, J.P., & Sekanina, K. (2000) Polyphor Ltd.: A Swiss start-up company in a growing field. Lead finding and optimization. Chimia, 54, 198-202. #15024

160. Fache, F., Schulz, E., Tommasino, M.L., & Lemaire, M. (2000) Nitrogen-containing ligands for asymmetric homogeneous and heterogeneous catalysis. Chem. Rev., 100, 2159-2231. #14572

161. Fagan, P.J., Hauptman, E., Shapiro, R., & Casalnuovo, A. (2000) Using intelligent/random library screening to design focused libraries for the optimization of homogeneous catalysts: Ullmann ether formation. J. Amer. Chem. Soc., 122, 5043-5051. #15025

162. Faita, G., Paio, A., Quadrelli, P., Rancati, F., & Seneci, P. (2000) (4S)-p-Hydroxybenzyl-1,3-oxazolidin-2-one as a solid-supported chiral chiral auxiliary in asymmetric 1,3-dipolar cycloadditions. Tetrahedron Lett., 41, 1265-1269. #14278

163. Fang, L., Wan, M., Pennacchio, M., & Pan, J. (2000) Evaluation of evaporative light-scattering detector for combinatorial library quantitation by reversed phase HPLC. Journal of Combinatorial Chemistry, 2, 254-257. #14455

164. Faroux-Corlay, B., Clary, L., Gadras, C., Hammache, D., Greiner, J., Santaella, C., Aubertin, A.M., Vierling, P., & Fantini, J. (2000) Synthesis of single- and double-chain fluorocarbon and hydrocarbon galactosyl amphiphiles and their anti-HIV-1 activity. Carbohyd. Res., 327, 223-260. #15898

165. Farrant, E., & Rahman, S.S. (2000) A solid-phase synthetic route to substituted 7-azabenzimidazoles suitable for combinatorial library synthesis. Tetrahedron Lett., 41, 5383-5386. #14617

166. Favre-Reguillon, A., Segat-Dioury, F., Nait-Bouda, L., Cosma, C., Siaugue, J.M., Foos, J., & Guy, A. (2000) A highly chemoselective protection and activation of primary amines in polyamine. Synlett, 868-870. #15029

167. Feng, Y.B., & Burgess, K. (2000) Resin effects in solid phase SNAr and SN2 macrocyclizations. Biotechnol. Bioeng., 71, 3-8. #14235

168. Fenniri, H. (2000) Combinatorial Chemistry: A Practical Approach. Oxford University Press, Oxford. ISBN 0199637547 #15663

169. Fenniri, H., Hedderich, H.G., Haber, K.S., Achkar, J., Taylor, B., & Ben-Amotz, D. (2000) Towards the DRED of resin-supported combinatorial libraries: A non-invasive methodology based on bead self-encoding and multispectral imaging. Angew. Chem. Int. Ed., 39, 4483. #16282

170. Fields, G.B., Tam, J.P., & Barany, G. (2000) Peptides for the New Millennium. Kluwer Academic Publisher, Dordrecht. ISBN 0792364457 #15688

171. Filippusson, H., Erlendsson, L.S., & Lowe, C.R. (2000) Design, synthesis and evaluation of biomimetic affinity ligands for elastases. J. Mol. Recog., 13, 370-381. #15899

172. Fletcher, A.J., & Christie, S.D.R. (2000) Cobalt mediated cyclisations. J. Chem. Soc. Perkin Trans. 1, 1657-1668. #15038

173. Franzen, R. (2000) The Suzuki, the Heck, and the Stille reaction: Three versatile methods for the introduction of new C-C bonds on solid support. Canadian Journal of Chemistry, 78, 957-962. #15770

174. Franzen, R.G. (2000) Utilization of Grignard reagents in solid-phase synthesis: A review of the literature. Tetrahedron, 56, 685-691. #14315

175. Franzen, R.G. (2000) Recent advances in the preparation of heterocycles on solid support: A review of the literature. Journal of Combinatorial Chemistry, 2, 195-214. #14444

176. Fritzen, E.L., Brightwell, A.S., Erickson, L.A., & Romero, D.L. (2000) The solid phase synthesis of tetrahydroisoquinolines having cdc25B inhibitory activity. Bioorg. Med. Chem. Lett., 10, 649-652. #14635

177. Fromont, C., & Bradley, M. (2000) High-loading resin beads for solid phase synthesis using triple branching symmetrical dendrimers. Chem. Commun., 283-284. #14316

178. Furka, A., Christensen, J.W., Healy, E., Tanner, H.R., & Saneii, H.H. (2000) String synthesis. A spatially adressable split procedure. Journal of Combinatorial Chemistry, 2, 220-223. #14447

179. Furka, A., Hamaker, L.K. & Peterson, M.L. (2000) Synthesis of combinatorial libraries using the portioning-mixing procedure. In H. Fenniri (Ed.), Combinatorial Chemistry: A Practical Approach. (pp. 1-32). Oxford University Press, Oxford. #15664

180. Furstner, A. (2000) Olefin metathesis and beyond. Angew. Chem. Int. Ed., 39, 3013-3043. #15905

181. Gagnon, R., Dory, Y.L., & Deslongchamps, P. (2000) Solid-phase synthesis of hydroxy-acids leading to macrolactones. Tetrahedron Lett., 41, 4751-4755. #14609

182. Ganesh, K.N., & Nielsen, P.E. (2000) Peptide nucleic acids: Analogs and derivatives. Current Organic Chemistry, 4, 931-943. #15906

183. Gao, Y., Luo, J., Yao, Z.J., Guo, R.B., Zou, H., Kelley, J., Voigt, J.H., Yang, D.J., & Burke, T.R. (2000) Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malollyl)phenylalanine as a potent phosphotyrosyl mimetic. J. Med. Chem., 43, 911-920. #15043

184. Gao, Y., & Burke, T.R. (2000) Stereoselective preparation of L-4-(2'-malonyl)phenylalanine suitably protected for Fmoc-based synthesis of potent signal transduction inhibitory ligands. Synlett, 134-136. #15044

185. Gasparutto, D., Bourdat, A.G., D'Ham, C., Duarte, V., Romieu, A., & Cadet, J. (2000) Repair and replication of oxidized DNA bases using modified oligodeoxyribonucleotides. Biochimie, 82, 19-24. #15047

186. Gauglitz, G. (2000) Optical detection methods for combinatorial libraries. Curr. Opin. Chem. Biol., 4, 351-355. #15048

187. Gelens, E., Koot, W.J., Menge, W.M.P.B., Ottenheijm, H.C.J., & Timmerman, H. (2000) Solid-phase synthesis of 4-substituted imidazoles using a scaffold approach. Bioorg. Med. Chem. Lett., 10, 1935-1938. #15771

188. Gendre, F., & Diaz, P. (2000) Coupling reaction of chalcogenyl halides with alkynes on a solid support. Synthesis of new selenium-containing retinoids. Tetrahedron Lett., 41, 5193-5197. #14620

189. Gerritz, S.W., & Sefler, A.M. (2000) 2,5-Dimethylfuran (DMFu): An internal standard for the "traceless" quantitation of unknown samples via H-1 NMR. Journal of Combinatorial Chemistry, 2, 39-41. #13978

190. Geyer, A., & Moser, F. (2000) Polyol peptidomimetics. Eur. J. Org. Chem., 1113-1120. #15050

191. Ghosh, P.K., Kumar, P., & Gupta, K.C. (2000) Recent advances in synthesis of modified oligonucleotides. J. Ind. Chem. Soc., 77, 109-132. #15051

192. Gibson, C., & Kessler, H. (2000) 2-Fluoropyrimidine as an efficient reagent in solid-phase synthesis of N-aryl- and N-alkyl-N-pyrimidin-2-ylamines. Tetrahedron Lett., 41, 1725-1728. #14338

193. Glatthar, R., & Giese, B. (2000) A new photocleavable linker in solid-phase chemistry for ether cleavage. Organic Letters, 2, 2315-2317. #15915

194. Golebiowski, A., Klopfenstein, S.R., Chen, J.J., & Shao, X. (2000) Solid supported high-throughput organic synthesis of peptide b-turn mimetics via Petasis reaction/diketopiperazine formation. Tetrahedron Lett., 41, 4841-4844. #14612

195. Gomez, L., Gellibert, F., Wagner, A., & Mioskowski, C. (2000) An original traceless linker strategy for solid-phase synthesis of N,N',N''-substituted guanidines. Chem. Eur. J., 6, 4016-4020. #15916

196. Gong, Y., Becker, M., Choi-Sledeski, Y.M., Davis, R.S., Salvino, J.M., Chu, V., Brown, K.D., & Pauls, H.W. (2000) Solid-phase parallel synthesis of azarene pyrrolidinones as factor Xa inhibitors. Bioorg. Med. Chem. Lett., 10, 1033-1036. #15455

197. Gopalsamy, A., Yang, H., Ellingboe, J.W., Kees, K.L., Yoon, J., & Murrills, R. (2000) Parallel solid-phase synthesis of vitronectin receptor (alpha v beta 3) inhibitors. Bioorg. Med. Chem. Lett., 10, 1715-1718. #15917

198. Gopalsamy, A., & Yang, H. (2000) Combinatorial synthesis of heterocycles: Solid-phase synthesis of 2-amino-4(1H)-quinazoline derivatives. Journal of Combinatorial Chemistry, 2, 378-381. #14691

199. Gordon, K., Bolger, M., Khan, N., & Balasubramanian, S. (2000) A stereoselective synthesis of 1,3,4-substituted b-lactams from polymer-supported chiral oxazolidine aldehyde. Tetrahedron Lett., 41, 8621-8625. #15803

200. Gotfredsen, C.H., Grotli, M., Willert, M., Meldal, M., & Duus, J.O. (2000) Single-bead structure elucidation. Requirements for analysis of combinatorial solid-phase libraries by Nanoprobe MAS-NMR spectroscopy. J. Chem. Soc. Perkin Trans. 1, 1167-1171. #14637

201. Gouault, N., Cupif, J.F., Sauleau, A., & David, M. (2000) g-Methyl-substituted-g-butyrolactones: Solid-phase synthesis employing a cyclisation-cleavage strategy. Tetrahedron Lett., 41, 7293-7297. #15630

202. Grabowska, U., Rizzo, A., Farnell, K., & Quibell, M. (2000) 5-(Hydroxymethyl)oxazoles: Versatile scaffolds for combinatorial solid-phase synthesis of 5-substituted oxazoles. Journal of Combinatorial Chemistry, 2, 475-490. #15600

203. Grandjean, C., Rommens, C., Gras-Masse, H., & Melnyk, O. (2000) One-pot synthesis of antigen-bearing, lysine-based cluster mannosides using two orthogonal chemoselective ligation reactions. Angew. Chem. Int. Ed., 39, 1068. #15061

204. Gravel, M., Berube, C.D., & Hall, D.G. (2000) Resin-to-resin Suzuki coupling of solid supported arylboronic acids. Journal of Combinatorial Chemistry, 2, 228-231. #14449

205. Graven, A., Grotli, M., & Meldal, M. (2000) Towards peptide isostere libraries: Aqueous aldol reactions on hydrophilic solid supports. J. Chem. Soc. Perkin Trans. 1, 955-962. #14638

206. Grether, U., & Waldmann, H. (2000) An enzyme-labile safety catch linker for combinatorial synthesis on a soluble polymeric support. Angew. Chem. Int. Ed., 39, 1629-1632. #14639

207. Gribble, G.W. (2000) Recent developments in indole ring synthesis-methodology and applications. J. Chem. Soc. Perkin Trans. 1, 1045-1075. #15063

208. Grice, P., Leach, A.G., Ley, S.V., Massi, A., & Mynett, D.M. (2000) Combined application of analytical techniques for the characterization of polymer supported species. Journal of Combinatorial Chemistry, 2, 491-495. #15601

209. Groger, H., Sans, J., & Guthner, T. (2000) 1,3,5-Triazines, versatile industrial building blocks: Synthetic approaches and applications. Chim. Oggi, 18, 12-16. #14397

210. Grondahl, L., Battersby, B.J., Bryant, D., & Trau, M. (2000) Encoding combinatorial libraries: A novel application of fluorescent silica colloids. Langmuir, 16, 9709-9715. #16293

211. Grotli, M., Gotfredsen, C.H., Rademann, J., Buchardt, J., Clark, A.J., Duus, J.O., & Meldal, M. (2000) Physical properties of poly(ethylene glycol) (PEG)-based resins for combinatorial solid phase organic chemistry: A comparison of PEG-cross-linked and PEG-grafted resins. Journal of Combinatorial Chemistry, 2, 108-119. #14372

212. Guan, Y., Green, M.A., & Bergstrom, D.E. (2000) Synthesis of compound libraries based on 3,4-diaminocyclopentanol scaffolds. Journal of Combinatorial Chemistry, 2, 297-300. #14679

213. Guichard, G. (2000) Solid-phase synthesis of pseudopeptides and oligomeric peptide backbone mimetics. Solid-Phase Synthesis: A Practical Guide, 649-703. #16295

214. Guichard, G., Semetey, V., Rodriguez, M., & Briand, J.P. (2000) Solid phase synthesis of oligoureas using O-succinimidyl-(9H-fluoren-9-ylmethoxycarbonylamino)ethylcarbamate derivatives as activated monomers. Tetrahedron Lett., 41, 1553-1557. #14334

215. Guillaumie, F., Kappel, J.C., Kelly, N.M., Barany, G., & Jensen, K.J. (2000) Solid-phase synthesis of C-terminal peptide aldehydes from amino acetals anchored to a backbone amide linker (BAL) handle. Tetrahedron Lett., 41, 6131-6135. #15518

216. Guillier, F., Orain, D., & Bradley, M. (2000) Linkers and cleavage strategies in solid-phase organic synthesis and combinatorial chemistry. Chem. Rev., 100, 2091-2057. #14571

217. Guillier, F., Orain, D., & Bradley, M. (2000) Linkers and cleavage strategies in solid-phase organic synthesis and combinatorial chemistry (vol 100, pg 2091, 2000). Chem. Rev., 100, 3859. #15920

218. Guthrie, E.J., Macritchie, J., & Hartley, R.C. (2000) Alkylidenation of esters on solid support and traceless synthesis of 2-substituted benzofurans. Tetrahedron Lett., 41, 4987-4990. #14615

219. Guzaev, A.P., & Manoharan, M. (2000) A novel phosphate protection for oligonucleotide synthesis: The 2-[(1-naphthyl)carbamoyloxy]ethyl (NCE) group. Tetrahedron Lett., 41, 5623-5626. #15417

220. Haase, W.C., & Seeberger, P.H. (2000) Recent progress in polymer-supported synthesis of oligosaccharides and carbohydrate libraries. Current Organic Chemistry, 4, 481-511. #15068

221. Hachtel, J., & Gais, H.J. (2000) A method for the conversion of sulfoximines to sulfones: Application to polymer-bound sulfoximines and to the synthesis of chiral sulfones. Eur. J. Org. Chem., 1457-1465. #15070

222. Halkes, K.M., St Hilaire, P.M., Jansson, A.M., Gotfredsen, C.H., & Meldal, M. (2000) Synthesis and application of sialic acid-containing building blocks for glycopeptide libraries. Establishing glycosylation conditions. J. Chem. Soc. Perkin Trans. 1, 13, 2127-2133. #15772

223. Hamper, B.C., Jerome, K.D., Yalamanchili, G., Walker, D.M., Chott, R.C., & Mischke, D.A. (2000) Synthesis of highly substituted 5-(trifluoromethyl)ketoimidazoles using a mixed-solid/solution phase motif. Biotechnol. Bioeng., 71, 28-37. #14002

224. Han, Y., Roy, A., & Giroux, A. (2000) A divergent protocol for solid-phase synthesis of highly substituted Bi-aryl furan derivatives. Tetrahedron Lett., 41, 5447-5451. #14807

225. Hanessian, S. (2000) Stereocontrolled glycosyl transfer reactions with unprotected glycosyl donors. Chem. Rev., 100, 4443-4463. #16155

226. Hanessian, S., Demont, E., & van Otterlo, W.A.L. (2000) From serine to functionalized enantiopure tetrahydroisoquinolines. Tetrahedron Lett., 41, 4999-5003. #14603

227. Hargittai, B., Sole, N.A., Groebe, D.R., Abramson, S.N., & Barany, G. (2000) Chemical syntheses and biological activities of lactam analogues of alpha-conotoxin SI. J. Med. Chem., 43, 4787-4792. #16297

228. Hari, A., & Miller, B.L. (2000) Rapid and efficient synthesis of 2-Amino-4H-benzothiazines. Organic Letters, 2, 3667-3670. #15924

229. Harikrishnan, L.S., & Showalter, H.D.H. (2000) A novel synthesis of 2,3-disubstituted benzopyran-4-ones and application to the solid phase. Tetrahedron, 56, 515-519. #14006

230. Harikrishnan, L.S., & Showalter, H.D.H. (2000) Synthesis and reactivity of a solid-supported dialkoxybenzaldehyde with an extended spacer. Synlett, 1339-1341. #15925

231. Harvey, A. (2000) Strategies for discovering drugs from previously unexplored natural products. Drug Disc. Today, 5, 294-300. #15074

232. Havranek, M., & Dvorak, D. (2000) 3-(Tributylstannyl)allyl alcohols: Useful building blocks for solid-phase synthesis of skipped dienes and trienes. Collect. Czech. Chem. Commun., 65, 434-454. #15075

233. Hecht, S.M. (2000) Bleomycin: New perspectives on the mechanism of action. Journal of Natural Products, 63, 158-168. #15077

234. Hegedus, L.S. (2000) Transition metals in organic synthesis: Highlights for the year 1998 - (25th Anniversary). Coord. Chem. Rev., 204, 199-307. #15080

235. Heinonen, P., Rosenberg, J., & Lonnberg, H. (2000) Synthesis of achiral alpha,alpha-bis(aminomethyl)-beta-alanines and their use in the preparation of branched beta-peptide conjugates of N-2-alkyl-1,2,3,4-tetrahydroisoquinolines on solid support. Eur. J. Org. Chem., 3647-3652. #15926

236. Heinze, K., Winterhalter, U., & Jannack, T. (2000) Development of an easy-to-use mass spectrometric technique to monitor solid-phase reactions on polystyrene supports. Chem. Eur. J., 6, 4203-4210. #16298

237. Hemming, K., Bevan, M.J., Loukou, C., Patel, S.D., & Renaudeau, D. (2000) A one-pot aza-Wittig based solution and polymer supported route to amines. Synlett, 1565-1568. #15928

238. Henkel, B., Stenzel, W., & Schotten, T. (2000) Stereo-random synthesis of highly functionalized proline analogues by azomethine cycloaddition. Bioorg. Med. Chem. Lett., 10, 975-977. #15082

239. Herdewijn, P. (2000) Heterocyclic modifications of oligonucleotides and antisense technology. Antisense Nucl. Acid Drug Devel., 10, 297-310. #15929

240. Herpin, T.F., Van Kirk, K.G., Salvino, J.M., Yu, S.T., & Labaudiniere, R.F. (2000) Synthesis of a 10 000 member 1,5-benzodiazepine-2-one library by the directed sorting method. Journal of Combinatorial Chemistry, 2, 513-521. #15604

241. Herzner, H., Reipen, T., Schultz, M., & Kunz, H. (2000) Synthesis of glycopeptides containing carbohydrate and peptide recognition motifs. Chem. Rev., 100, 4495-4537. #16156

242. Hirschmann, R., Ducry, L., & Smith, A.B. (2000) Development of an efficient, regio- and stereoselective route to libraries based on the beta-D-glucose scaffold. J. Org. Chem., 65, 8307-8316. #16300

243. Hodges, J.C. (2000) Covalent scavengers for primary and secondary amines. Synlett, 152-158. #15090

244. Hodges, J.C., Harikrishnan, L.S., & Ault-Justus, S. (2000) Preparation of designer resins via living free radical polymerization of functional monomers on solid support. Journal of Combinatorial Chemistry, 2, 80-88. #14016

245. Hojo, K., Maeda, M., Iguchi, S., Smith, T., Okamoto, H., & Kawasaki, K. (2000) Amino acids and peptides. XXXV. Facile preparation of p-nitroanilide analogs by the solid-phase method. Chem. Pharm. Bull. Tokyo, 48, 1740-1744. #15932

246. Holm, B., Broddefalk, J., Flodell, S., Wellner, E., & Kihlberg, J. (2000) An improved synthesis of a galactosylated hydroxylysine building block and its use in solid-phase glycopeptide synthesis. Tetrahedron, 56, 1579-1586. #14640

247. Homsi, F., Nozaki, K., & Hiyama, T. (2000) Solid-phase cross-coupling reaction of aryl(fluoro)silanes with 4-iodobenzoic acid. Tetrahedron Lett., 41, 5869-5872. #15425

248. Hone, N.D., & Payne, L.J. (2000) Solid-phase synthesis of Agel 416: A novel approach to modified polyamines. Tetrahedron Lett., 41, 6149-6152. #15519

249. Hong, B.C., Chen, Z.Y., & Chen, W.H. (2000) Traceless solid-phase synthesis of heterosteroid framework. Organic Letters, 2, 2647-2649. #15682

250. Horton, J.R., Stamp, L.M., & Routledge, A. (2000) A photolabile 'traceless' linker for solid-phase organic synthesis. Tetrahedron Lett., 41, 9181-9184. #15934

251. Houghten, R.A., Wilson, D.B., & Pinilla, C. (2000) Drug discovery and vaccine development using mixture-based synthetic combinatorial libraries. Drug Disc. Today, 5, 276-285. #15095

252. Houghten, R.A. (2000) Parallel array and mixture-based synthetic combinatorial chemistry: Tools for the next millennium. Annu. Rev. Pharmacol. Toxicol., 40, 273-282. #15096

253. Hu, X., Smith, G.D., Sykora, M., Lee, S.J., & Grinstaff, M.W. (2000) Automated solid-phase synthesis and photophysical properties of oligodeoxynucleotides labeled at 5'-aminothymidine with Ru(bpy)(2)(4-m-4'-cam-bpy)(2+). Inorg. Chem., 39, 2500-2504. #15098

254. Huang, L., Lee, A. & Ellman, J.A. (2000) Targeted libraries. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 161-163). Kluwer Academic Publisher, Dordrecht. #15714

255. Huang, W. & Scarborough, R.M. (2000) "Traceless" solid-phase synthesis of benzimidazole libraries. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 181-182). Kluwer Academic Publisher, Dordrecht. #15722

256. Huber, C.G., & Krajete, A. (2000) Comparison of direct infusion and on-line liquid chromatography/electrospray ionization mass spectrometry for the analysis of nucleic acids. J. Mass Spectrom., 35, 870-877. #15936

257. Hubner, H., Kraxner, J., & Gmeiner, P. (2000) Cyanoindole derivatives as highly selective dopamine D-4 receptor partial agonists: Solid-phase synthesis, binding assays, and functional experiments. J. Med. Chem., 43, 4563-4569. #15937

258. Hulme, C., Ma, L., Kumar, N.V., Krolikowski, P.H., Allen, A.C., & Labaudiniere, R. (2000) Novel applications of resin bound a-amino acids for the synthesis of benzodiazepines (via hydroxymethyl resin). Tetrahedron Lett., 41, 1509-1514. #14333

259. Hulme, C., Ma, L., Cherrier, M.P., Romano, J.J., Morton, G., Duquenne, C., Salvino, J., & Labaudiniere, R. (2000) Novel applications of convertible isonitriles for the synthesis of mono and bicyclic g-lactams via a UDC strategy. Tetrahedron Lett., 41, 1883-1887. #14345

260. Hulme, C., Ma, L., Romano, J.J., Morton, G., Tang, S.Y., Cherrier, M.P., Choi, S., Salvino, J., & Labaudiniere, R. (2000) Novel applications of carbon dioxide/MeOH for the synthesis of hydantoins and cyclic ureas via the Ugi reaction. Tetrahedron Lett., 41, 1889-1893. #15105

261. Hum, G., Grzyb, J., & Taylor, S.D. (2000) Synthesis of non-peptidyl a,a-difluoromethylenephosphonic acids on a soluble polymer support. Journal of Combinatorial Chemistry, 2, 234-242. #14451

262. Iida, H., & Sugiyama, H. (2000) Recognition of DNA sequences by pyrrole-imidazole polyamide: Rational drug design in the post-genome era [Japanese]. J. Syn. Org. Chem. Jpn., 58, 975-987. #15938

263. Ishii, A., Hojo, H., Kobayashi, A., Nakamura, K., Nakahara, Y., & Ito, Y. (2000) A facile silyl linker strategy for the solid-phase synthesis of protected glycopeptide: Synthesis of an N-terminal fragment of IL-2 (1-10). Tetrahedron, 56, 6235-6243. #15773

264. Iso, Y., Shindo, H., & Hamana, H. (2000) Efficient synthesis of resin-bound alpha-TMSdiazoketones and their use in solid-phase organic synthesis. Tetrahedron, 56, 5353-5361. #15111

265. Ivachtchenko, A., & Sepetov, N. (2000) Synthesis of combinatorial libraries utilizing 4-fluoro-3-nitrobenzoic acid. Chim. Oggi, 6, 19-21. #14706

266. Iwaoka, M., & Tomoda, S. (2000) Nucleophilic selenium. Organoselenium Chemistry: Modern Developments in Organic Synthesis, 208, 55-80. #15940

267. Jamieson, C., Congreve, M.S., Emiabata-Smith, D.F., & Ley, S.V. (2000) A rapid approach for the optimisation of polymer supported reagents in synthesis. Synlett, 1603-1607. #15942

268. Jammalamadaka, V., & Berger, J.G. (2000) Solid-phase synthesis of 2-aminotetrahydropyrimidines. Syn. Commun., 30, 2077-2082. #15115

269. Jarowicki, K., & Kocienski, P. (2000) Protecting groups. Journal of the Chemical Society-Perkin Transaction 1, 2495-2527. #15944

270. Jarvo, E.R., Vasbinder, M.M., & Miller, S.J. (2000) Asymmetric acylation reactions catalyzed by conformationally biased octapeptides. Tetrahedron, 56, 9773-9779. #16306

271. Jaschke, A., & Seelig, B. (2000) Evolution of DNA and RNA as catalysts for chemical reactions. Curr. Opin. Chem. Biol., 4, 257-262. #15474

272. Jefferson, E.A., Sprankle, K.G., & Swayze, E.E. (2000) Solid-phase synthesis of a heterocyclic ethylenediamine-derivatized library. Journal of Combinatorial Chemistry, 2, 441-444. #15593

273. Jeon, G.H., Yoon, J.Y., Kim, S., & Kim, S.S. (2000) Radical reaction of phenylsulfonyl oxime ethers on solid support: Application to the synthesis of alpha-amino esters. Synlett, 128-130. #15120

274. Jesberger, M., Jaunzems, J., Jung, A., Jas, G., Schonberger, A., & Kirschning, A. (2000) Soluble versus insoluble polymers as supports for the preparation of new glycosteroids. A practicability study. Synlett, 1289-1293. #15946

275. Jia, G.F., Iida, H., & Lown, J.W. (2000) Solid-phase synthesis of 1-chloromethyl-1,2-dihydro-3H-benz[e]indole (seco-CBI) and a polyamide conjugate. Synlett, 603-606. #15121

276. Jiaang, W.T., Tseng, P.H., & Chen, S.T. (2000) Facile solid phase synthesis of YEE(ah-GalNAc)(3), a ligand with known high affinity for the asialoglycoprotein receptor. Synlett, 797-800. #15123

277. Jiaang, W.T., Chang, M.Y., Tseng, P.H., & Chen, S.T. (2000) A concise synthesis of the O-glycosylated amino acid building block; using phenyl selenoglycoside as a glycosyl donor. Tetrahedron Lett., 41, 3127-3130. #15122

278. Jobron, L., & Hummel, G. (2000) Solid-phase synthesis of unprotected N-glycopeptide building blocks for SPOT synthesis of N-linked glycopeptides. Angew. Chem. Int. Ed., 39, 1621-1624. #14642

279. Jobron, L., & Hummel, G. (2000) Solid-phase synthesis of new S-glycoamino acid building blocks. Organic Letters, 2, 2265-2267. #15948

280. Kaboudin, B. (2000) Surface-mediated solid-phase reactions: The preparation of acyl phosphonates by oxidation of 1-hydroxyphosphonates on the solid surface. Tetrahedron Lett., 41, 3169-3171. #14553

281. Kalinovskaya, I.V., & Karasev, V.E. (2000) Solid-phase synthesis of europium and terbium complexes with nitrogen-containing heterocyclic compounds under mechanical activation. Russian Journal of Inorganic Chemistry, 45, 1360-1362. #15950

282. Kamei, K., Sato, S., Hamato, N., Takano, R., Ohshima, K., Yamamoto, R., Nishino, T., Kato, H., & Hara, S. (2000) Effect of P-2' site tryptophan and P-20' site deletion of Momordica charantia trypsin inhibitor II on inhibition of proteinases. Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology, 1480, 6-12. #15951

283. Kaminski, Z.J. (2000) Triazine-based condensing reagents. Biopolymers (Pept. Sci. ), 55, 140-164. #16435

284. Kanbara, T., Yokokawa, Y., & Hasegawa, K. (2000) Palladium-catalyzed modification of poly(p-bromostyrene) with carbazole and related heteroarenes containing an N-H bond and their properties. Journal of Polymer Science Part A-Polymer Chemistry, 38, 28-34. #15127

285. Kanie, O., Grotenbreg, G., & Wong, C.H. (2000) Removal of benzyl protecting groups from solid-supported compounds by hydrogenolysis using palladium nanoparticles. Angew. Chem. Int. Ed., 39, 4545. #16309

286. Kappe, C.O. (2000) Synthesis and reactions of Biginelli compounds. Part 17. Highly versatile solid phase synthesis of biofunctional 4-aryl-3,4-dihydropyrimidines using resin-bound isothiourea building blocks and multidirectional resin cleavage. Bioorg. Med. Chem. Lett., 10, 49-51. #14031

287. Kappe, C.O. (2000) Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog. Account. Chem. Res., 33, 879-888. #16310

288. Karan, C., & Miller, B.L. (2000) Dynamic diversity in drug discovery: Putting small-molecule evolution to work. Drug Disc. Today, 5, 67-75. #14032

289. Karigiannis, G., & Papaioannou, D. (2000) Structure, biological activity and synthesis of polyamine analogues and conjugates. Eur. J. Org. Chem., 1841-1863. #15128

290. Karim, C.B., Marquardt, C.G., Stamm, J.D., Barany, G., & Thomas, D.D. (2000) Synthetic null-cysteine phospholamban analogue and the corresponding transmembrane domain inhibit the Ca-ATPase. Biochemistry, 39, 10892-10897. #15952

291. Katritzky, A.R., Serdyuk, L., Chassaing, C., Toader, D., Wang, X., Forood, B., Flatt, B., Sun, C., & Vo, K. (2000) Syntheses of 2-alkylamino- and 2-dialkylamino-4,6-diarylpyridines and 2,4,6-trisubstituted pyrimidines using solid-phase-bound chalcones. Journal of Combinatorial Chemistry, 2, 182-185. #14382

292. Kayushin, A., Korosteleva, M., & Miroshnikov, A. (2000) Large-scale solid-phase preparation of 3'-unprotected trinucleotide phosphotriesters: Precursors for synthesis of trinucleotide phosphoramidites. Nucleosides, Nucleotides and Nucleic Acids, 19, 1967-1976. #16311

293. Kazmierski, W.M., & McDermed, J.D. (2000) A convenient synthesis of the orthogonally-protected benzodiazepine-2,5-dione scaffold. Syn. Commun., 30, 2629-2634. #15131

294. Kerr, C.E., Eaton, B.E., & Netzel, T.L. (2000) Synthesis of N,N-dialkylaniline-2'-deoxyuridine conjugates for DNA-mediated electron transfer studies. Nucleosides, Nucleotides and Nucleic Acids, 19, 851-866. #15135

295. Kessler, H., Kantlehner, M., Gibson, C., Haubner, R., Finsinger, D., Dechantsreiter, M., Planker, E., Wermuth, J., Schmitt, J.S., Meyer, J., Schaffner, P., Holzemann, G., Wiesner, M., Goodman, S.L., Hahn, D., Jonczyk, A., Wester, H.J. & Schwaiger, M. (2000) Recent progress in the field of aV-integrin antagonists. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 235-237). Kluwer Academic Publisher, Dordrecht. #15731

296. Ketcha, D.M., Wilson, L.J., & Portlock, D.E. (2000) The solid-phase Nenitzescu indole synthesis. Tetrahedron Lett., 41, 6253-6257. #15530

297. Kidwai, M., Misra, P., Bhushan, K.R., Saxena, R.K., & Singh, M. (2000) Microwave-assisted solid-phase synthesis of cephalosporin derivatives with antibacterial activity. Monatshefte fur Chemie, 131, 937-943. #15954

298. Kilburn, J.P., Lau, J., & Jones, R.C.F. (2000) Solid-phase synthesis of substituted 2-aminomethylbenzimidazoles. Tetrahedron Lett., 41, 5419-5421. #14618

299. Kim, H.O., & Kahn, M. (2000) A merger of rational drug design and combinatorial chemistry: Development and application of peptide secondary structure mimetics. Comb. Chem. High Throughput Screening, 3, 167-183. #15138

300. Kim, R.M. & Chang, J. (2000) Combinatorial synthesis on multivalent oligomeric supports. In H. Fenniri (Ed.), Combinatorial Chemistry: A Practical Approach. (pp. 353-372). Oxford University Press, Oxford. #15674

301. Kirschbaum, T., Briehn, C.A., & Bauerle, P. (2000) Efficient solid-phase synthesis of regioregular head-to-tail-coupled oligo(3-alkylthiophene)s up to a dodecamer. J. Chem. Soc. Perkin Trans. 1, 1211-1216. #14643

302. Kirschning, A., Monenschein, H., & Wittenberg, R. (2000) The "resin-capture-release" hybrid technique: A merger between solid- and solution-phase synthesis. Chem. Eur. J., 6, 4445-4450. #16312

303. Klopfenstein, S.R., Chen, J.J., Golebiowski, A., Li, M., Peng, S.X., & Shao, X. (2000) A practical synthesis of peptide mimetics via the solid-phase Petasis reaction. Tetrahedron Lett., 41, 4835-4839. #14611

304. Knerr, L., & Schmidt, R.R. (2000) Solid-phase synthesis of a branched hexasaccharide related to lacto-N-hexaose. Eur. J. Org. Chem., 2803-2808. #15956

305. Kobayashi, S. (2000) Immobilized catalysts in combinatorial chemistry. Curr. Opin. Chem. Biol., 4, 338-345. #15143

306. Kobayashi, S., Akiyama, R., & Kitagawa, H. (2000) Polymer-supported a-imino acetates. Versatile reagents for the synthesis of a-amino acid libraries. Journal of Combinatorial Chemistry, 2, 438-440. #15592

307. Kochetkov, N.K. (2000) Solid-phase synthesis of oligosaccharides and glycoconjugates [Russian]. Uspekhi Khimii, 69, 869-896. #15957

308. Koeller, K.M., Smith, M.E.B., & Wong, C.H. (2000) Tyrosine sulfation on a PSGL-1 glycopeptide influences the reactivity of glycosyltransferases responsible for synthesis of the attached O-glycan. J. Amer. Chem. Soc., 122, 742-743. #15146

309. Koeller, K.M., Smith, M.E.B., & Wong, C.H. (2000) Chemoenzymatic synthesis of PSGL-1 glycopeptides: Sulfation on tyrosine affects glycosyltransferase-catalyzed synthesis of the O-glycan. Bioorg. Med. Chem., 8, 1017-1025. #15145

310. Koeller, K.M., & Wong, C.H. (2000) Synthesis of complex carbohydrates and glycoconjugates: Enzyme-based and programmable one-pot strategies. Chem. Rev., 100, 4465-4493. #16315

311. Kojima, N., & Bruice, T.C. (2000) Replacement of the phosphorodiester linkages of RNA with guanidinium linkages: The solid-phase synthesis of ribonucleic guanidine. Organic Letters, 2, 81-84. #15149

312. Kondo, Y., Komine, T., & Sakamoto, T. (2000) Polymer support assisted selective functionalization of azoles using a palladium-catalyzed coupling reaction. Organic Letters, 2, 3111-3113. #15959

313. Kondo, Y., Inamoto, K., & Sakamoto, T. (2000) Photoinduced cyclorelease for condensed heteroaromatic synthesis. Journal of Combinatorial Chemistry, 2, 232-233. #14450

314. Kranich, R., Eis, K., Geis, O., Muhle, S., Bats, J.W., & Schmalz, H.G. (2000) A modular approach to structurally diverse bidentate chelate ligands for transition metal catalysis. Chem. Eur. J., 6, 2874-2894. #15962

315. Kraxner, J., Arlt, M., & Gmeiner, P. (2000) Traceless linking of indoles: General methodology and application to solid phase supported Mannich and Stille reactions. Synlett, 125-127. #15151

316. Krchnak, V., Szabo, L., & Vagner, J. (2000) A solid phase traceless synthesis of quinaxalinones. Tetrahedron Lett., 41, 2835-2838. #14540

317. Kuberan, B., & Lindhardt, R.J. (2000) Carbohydrate based vaccines. Current Organic Chemistry, 4, 653-677. #1310

318. Kuksa, V., Buchan, R., & Lin, P.K.T. (2000) Synthesis of polyamines, their derivatives, analogues and conjugates. Synthesis-Stuttgart, 1189-1207. #15963

319. Kupihar, Z., Varadi, G., Monostori, E., & Toth, G.K. (2000) Preparation of an asymmetrically protected phosphoramidite and its application in solid-phase synthesis of phosphopeptides. Tetrahedron Lett., 41, 4457-4461. #14600

320. Kurokawa, K., Kumihara, H., & Kondo, H. (2000) A solid-phase synthesis for b-turn mimetics of sialyl Lewis X. Bioorg. Med. Chem. Lett., 10, 1827-1830. #15774

321. Kuster, G.J., & Scheeren, H.W. (2000) The preparation of resin-bound nitroalkenes and some applications in high pressure promoted cycloadditions. Tetrahedron Lett., 41, 515-519. #13888

322. Lane, S.J., & Pipe, A. (2000) Single bead and hard tag decoding using accurate isotopic difference target analysis-encoded combinatorial libraries. Rapid Commun. Mass Spectrom., 14, 782-793. #14590

323. Lao, Y., Gomes, X.V., Ren, Y.J., Taylor, J.S., & Wold, M.S. (2000) Replication protein A interactions with DNA. III. Molecular basis of recognition of damaged DNA. Biochemistry, 39, 850-859. #999

324. Larksarp, C., & Alper, H. (2000) Palladium-catalyzed cyclocarbonylation of o-iodoanilines with heterocumulenes: Regioselective preparation of 4(3H)-quinazolinone derivatives. J. Org. Chem., 65, 2773-2777. #15156

325. Lazo, J.S., & Wipf, P. (2000) Combinatorial chemistry and contemporary pharmacology. J. Pharmacol. Exp. Ther., 293, 705-709. #14695

326. Leach, A.R., & Hann, M.M. (2000) The in silico world of virtual libraries. Drug Disc. Today, 5, 326-336. #15468

327. Leadbeater, N.E., Scott, K.A., & Scott, L.J. (2000) Preparation of a resin-bound arene-ruthenium complex and assessment of its use in enol formate synthesis and olefin cyclopropanation. J. Org. Chem., 65, 3231-3232. #15775

328. Lebl, M. (2000) New technique for high-throughput synthesis of peptides, peptidomimetics and nonpeptide small organic molecule arrrays. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 164-166). Kluwer Academic Publisher, Dordrecht. #15715

329. Leconte, S., Dujardin, G., & Brown, E. (2000) Solid-phase synthesis of dihydropyrans by Eu(fod)(3)-catalysed [4+2] heterocycloaddition of vinyl ethers with benzylidenepyruvic acid esters. Comparison with conventional homogeneous liquid phase conditions. Eur. J. Org. Chem., 639-643. #15159

330. Lee, C.L., & Sim, M.M. (2000) Solid-phase combinatorial synthesis of 5-arylalkylidene rhodanine. Tetrahedron Lett., 41, 5729-5732. #15420

331. Lee, C.Y., & Hanson, R.N. (2000) Solid phase synthesis of 17a-E/Z-(X-phenyl)-vinyl estradiols using the Stille coupling reaction. Tetrahedron, 56, 1623-1629. #14645

332. Lee, H.B., & Balasubramanian, S. (2000) Solid-phase synthesis of N-alkyl-N-(beta-keto)amides and 1,2,4,5-tetrasubstituted imidazoles using a traceless cleavage strategy. Organic Letters, 2, 323-326. #15162

333. Lee, Y., & Silverman, R.B. (2000) Traceless solid-phase synthesis of chiral 3-aryl beta-amino acid containing peptides using a side-chain-tethered beta-amino acid building block. Organic Letters, 2, 303-306. #15164

334. Lee, Y., & Silverman, R.B. (2000) Rapid, high-yield, solid-phase synthesis of the antitumor antibiotic sansalvamide A using a side-chain-tethered phenylalanine building block. Organic Letters, 2, 3743-3746. #15966

335. Leitheiser, C.J., Rishel, M.J., Wu, X.H., & Hecht, S.M. (2000) Solid-phase synthesis of bleomycin group antibiotics. Elaboration of deglycobleomycin A(5). Organic Letters, 2, 3397-3399. #15968

336. Lenz, G.R., Nash, H.M., & Jindal, S. (2000) Chemical ligands, genomics and drug discovery. Drug Disc. Today, 5, 145-156. #15167

337. Lepore, S.D., & Wiley, M.R. (2000) Studies on the synthetic compatibility of aryloxime linkers in the solid-phase synthesis of 3-aminobenzisoxazoles. J. Org. Chem., 65, 2924-2932. #15168

338. LeProust, E., Pellois, J.P., Yu, P., Zhang, H., Gao, X., Srivannavit, O., Gulari, E., & Zhou, X. (2000) Digital light-directed sythesis. A microarray platform that permits rapid reaction optimization on a combinatorial basis. Journal of Combinatorial Chemistry, 2, 349-354. #14687

339. Leznoff, C.C. (2000) 1999 Alfred Bader Award Lecture: From early developments in multi-step organic synthesis on solid phases to multi-nuclear phthalocyanines. Can. J. Chem., 78, 167-183. #14317

340. Li, P., & Xu, J.C. (2000) 1-Ethyl 2-halopyridinium salts, highly efficient coupling reagents for hindered peptide synthesis both in solution and the solid-phase. Tetrahedron, 56, 8119-8131. #15970

341. Li, W., Czarnik, A.W., Lillig, J., & Xiao, X.Y. (2000) Kinetic study of organic reactions on polystyrene grafted MicroTubes. Journal of Combinatorial Chemistry, 2, 224-227. #14448

342. Li, W.R., Hsu, N.M., Chou, H.H., Lin, S.T., & Lin, Y.S. (2000) Development of a novel oxidatively removable and recyclable linker for combinatorial solid phase synthesis. Chem. Commun., 401-402. #14318

343. Li, W.R., Lin, Y.S., & Yo, Y.C. (2000) Lewis acid-catalyzed cleavage of carbamate and carbonate resins. Tetrahedron Lett., 41, 6619-6622. #15525

344. Li, W.R., Yo, Y.C., & Lin, Y.S. (2000) Efficient one-pot formation of amides from benzyl carbamates: Application to solid-phase synthesis. Tetrahedron, 56, 8867-8875. #15971

345. Li, X.F., Zhang, L.S., Zhang, W., Hall, S.E., & Tam, J.P. (2000) Solid-phase synthesis of 1,2,3,4-tetrahydro-beta-carboline-containing peptidomimetics. Organic Letters, 2, 3075-3078. #15973

346. Liao, J.C., Beaird, J., McCartney, N., & DuPriest, M.T. (2000) An improved FTIR method for polymer resin beads analysis to support combinatorial solid-phase synthesis. Amer. Lab., 32, 16-20. #15173

347. Licha, K., Bhargava, S., Rheinlander, C., Becker, A., Schneider-Mergener, J., & Volkmer-Engert, R. (2000) Highly parallel nano-synthesis of cleavable peptide-dye conjugates on cellulose membranes. Tetrahedron Lett., 41, 1711-1715. #14337

348. Liley, M., & Johnson, T. (2000) Solid phase synthesis of azapeptides utilizing reversible amide bond protection to prevent hydantoin formation. Tetrahedron Lett., 41, 3983-3985. #14562

349. Lin, X., Dorr, H., & Nuss, J.M. (2000) Utilization of Fukuyama's sulfonamide protecting group for the synthesis of N-substituted a-amino acids and derivatives. Tetrahedron Lett., 41, 3309-3313. #14556

350. Lindsley, C.W., Hodges, J.C., Filzen, G.F., Watson, B.M., & Geyer, A.G. (2000) Rasta silanes: New silyl resins with novel macromolecular architecture via living free radical polymerization. Journal of Combinatorial Chemistry, 2, 550-559. #15608

351. Lindsley, C.W., Chan, L.K., Goess, B.C., Joseph, R., & Shair, M.D. (2000) Solid-phase biomimetic synthesis of carpanone-like molecules. J. Amer. Chem. Soc., 122, 422-423. #14242

352. Linkletter, B.A., & Bruice, T.C. (2000) Solid-phase synthesis of positively charged deoxynucleic guanidine (DNG) modified oligonucleotides containing neutral urea linkages: Effect of charge deletions on binding and fidelity. Bioorg. Med. Chem., 8, 1893-1901. #15976

353. Linton, B.R., Carr, A.J., Orner, B.P., & Hamilton, A.D. (2000) A versatile one-pot synthesis of 1,3-substituted guanidines from carbamoyl isothiocyanates. J. Org. Chem., 65, 1566-1568. #15178

354. Lipshutz, B.H., & Shin, Y.J. (2000) Polystyrene-bound cyclo-BINOLs. New heterogeneous ligands for asymmetric catalysis. Tetrahedron Lett., 41, 9515-9521. #16175

355. Liu, G. & Lam, K.S. (2000) One-bead one-compound combinatorial library method. In H. Fenniri (Ed.), Combinatorial Chemistry: A Practical Approach. (pp. 33-50). Oxford University Press, Oxford. #15665

356. Liu, G., Zhang, S.D., Xia, S.Q., & Ding, Z.K. (2000) Solid-phase synthesis of muramyl dipeptide (MDP) derivatives using a multipin method. Bioorg. Med. Chem. Lett., 10, 1361-1363. #15180

357. Liu, S., Akhtar, M., & Gani, D. (2000) Solid-phase synthesis on functionalised fluoropolymer resins. Part 2. Preparation and propeties of functional Merrifield-type resins possessing a perfluorinated polymer backbone. Tetrahedron Lett., 41, 4493-4497. #14602

358. Liu, X., & Balasubramanian, S. (2000) Strategies for the synthesis of fluorescently labelled PNA. Tetrahedron Lett., 41, 6153-6156. #15520

359. Lloyd, W., Reese, C.B., Song, Q.L., Vandersteen, A.M., Visintin, C., & Zhang, P.Z. (2000) Some observations relating to the use of 1-aryl-4-alkoxypiperidin-4-yl groups for the protection of the 2'-hydroxy functions in the chemical synthesis of oligoribonucleotides. J. Chem. Soc. Perkin Trans. 1, 165-176. #14060

360. Long, D.D., & Termin, A.P. (2000) Ring-closing metathesis to a divergent endocyclic sulfonamide template. Tetrahedron Lett., 41, 6743-6747. #15545

361. Lopez-Calle, E., Fries, J.R., Riester, D., & Winkler, D. (2000) A strategy for highly parallel synthesis of tyrosine- and histidine-reactive labeling reagents. Chim. Oggi, 6, 28-32. #14708

362. Lopez-Cremades, P., Molina, P., Aller, E., & Lorenzo, A. (2000) Solid-phase synthesis of bis(guanidines) based on an aza Wittig/carbodiimide-mediated annulation process. Synlett, 1411-1414. #15982

363. Lopez-Macia, A., Jimenez, J.C., Royo, M., Giralt, E., & Albericio, F. (2000) Kahalalide B. Synthesis of a natural cyclodepsipeptide. Tetrahedron Lett., 41, 9765-9769. #16171

364. Lopez-Rodriguez, M.L., Benhamu, B., Ayala, D., Rominguera, J.L., Murcia, M., Ramos, J.A., & Viso, A. (2000) Pd(0) amination of benzimidazoles as an efficient method towards new (benzimidazolyl)piperazines with high affinity for the 5-HT1A receptor. Tetrahedron, 56, 3245-3253. #15186

365. Lormann, M., Dahmen, S., & Brase, S. (2000) Hydro-dediazoniation of diazonium salts using trichlorosilane: New cleavage conditions for the T1 traceles linker. Tetrahedron Lett., 41, 3813-3816. #14560

366. Lorthioir, O., McKeown, S.C., Parr, N.J., Washington, M., & Watson, S.P. (2000) Practical synthesis of a new analytical construct: Thiopyrimidine safety-catch linker for facile monitoring of solid-phase chemistry. Tetrahedron Lett., 41, 8609-8613. #15802

367. Loughlin, W.A., Knevitt, S.A., Hosking, R.E., & Marshall, R.L. (2000) Approaches to the high-throughput synthesis of analogues of dihydroaeruginoic acid. Aust. J. Chem., 53, 457-462. #15984

368. Lowik, D.W.P.M., & Liskamp, R.M.J. (2000) Synthesis of alpha- and beta-substituted aminoethane sulfonamide arginine-glycine mimics. Eur. J. Org. Chem., 1219-1228. #15188

369. Lubineau, A., Malleron, A., & Le Narvor, C. (2000) Chemo-enzymatic synthesis of oligosaccharides using a dendritic soluble support. Tetrahedron Lett., 41, 8887-8891. #15794

370. Luedtke, N.W., & Tor, Y. (2000) A novel solid-phase assembly for identifying potent and selective RNA ligands. Angew. Chem. Int. Ed., 39, 1788-1790. #15778

371. Lynas, J.F., Martin, S.L., Walker, B., Baxter, A.D., Bird, J., Bhogal, R., Montana, J.G., & Owen, D.A. (2000) Solid-phase synthesis and biological screening of N-alpha-mercaptoamide template-based matrix metalloprotease inhibitors. Comb. Chem. High Throughput Screening, 3, 37-41. #15191

372. Ma, S.M., Duan, D.H., & Shi, Z.J. (2000) Palladium(0)-catalyzed cyclization reaction of polymer-supported aryl iodides with 1,2-allenyl carboxylic acids. A facile solid-phase synthesis of butenolides. Organic Letters, 2, 1419-1422. #15192

373. Maclean, D., Baldwin, J.J., Ivanov, V.T., Kato, Y., Shaw, A., Schneider, P., & Gordon, E.M. (2000) Glossary of terms used in combinatorial chemistry. Journal of Combinatorial Chemistry, 2, 562-578. #15806

374. Maiorana, S., Baldoli, C., Licandro, E., Casiraghi, L., de Magistris, E., Paio, A., Provera, S., & Seneci, P. (2000) New polymer-bound haloarene chromium dicarbonyl isocyanide complexes: A successful study validating their use in solid-phase chemistry. Tetrahedron Lett., 41, 7271-7275. #15566

375. Maison, W., Schlemminger, I., Westerhoff, O., & Martens, J. (2000) Multicomponent synthesis of novel amino acid-nucleobase chimeras: A versatile approach to PNA-monomers. Bioorg. Med. Chem., 8, 1343-1360. #15194

376. Makino, S., Suzuki, N., Nakanishi, E., & Tsuji, T. (2000) Efficient solid-phase synthesis of quinazoline-2-thioxo-4-ones with SynPhaseTM lanterns. Tetrahedron Lett., 41, 8333-8337. #15805

377. Makino, S., Suzuki, N., Nakanishi, E., & Tsuji, T. (2000) Efficient solid phase synthesis of diverse quinazolinones. Synlett, 1670-1672. #15989

378. Malkinson, J.P., Falconer, R.A., & Toth, I. (2000) Synthesis of C-terminal glycopeptides from resin-bound glycosyl azides via a modified Staudinger reaction. J. Org. Chem., 65, 5249-5252. #15779

379. Malo, S., & Geuna, A. (2000) Science-technology linkages in an emerging research platform: The case of combinatorial chemistry and biology. Scientometrics, 47, 303-321. #15990

380. Maltais, R., Tremblay, M.R., & Poirier, D. (2000) Solid-phase synthesis of hydroxysteroid derivatives using the diethylsilyloxy linker. Journal of Combinatorial Chemistry, 2, 604-614. #15991

381. Maltais, R., Berube, M., Marion, O., Labrecque, R., & Poirier, D. (2000) Efficient coupling and solid-phase synthesis of steroidal ketone derivative using polymer-bound glycerol. Tetrahedron Lett., 41, 1691-1694. #14336

382. Manabe, S., Nakahara, Y., & Ito, Y. (2000) Novel nitro Wang type linker for polymer support oligosaccharide synthesis. Polymer supported acceptor. Synlett, 1241-1244. #15992

383. Manfredini, S., Marastoni, M., Tomatis, R., Durini, E., Spisani, S., Pani, A., Marceddu, T., Musiu, C., Marongiu, M.E., & La Colla, P. (2000) Peptide T-araC conjugates: Solid-phase synthesis and biological activity of N-4-(acylpeptidyl)-araC. Bioorg. Med. Chem., 8, 539-547. #15195

384. Manzotti, R., Reger, T.S., & Janda, K.D. (2000) Improved synthesis of (4-ethenylphenyl)diphenyl methanol and its application in the preparation of trityl functionalized polystyrene resin containing tetrahydrofuran derived cross-linker. Tetrahedron Lett., 41, 8417-8420. #15797

385. Manzotti, R., & Janda, K.D. (2000) Solid and liquid phase chemistry: Development of new supports for solid phase organic synthesis and for liquid phase chemistry. Chim. Oggi, 18, 14-18. #15555

386. Mapp, A.K., & Dervan, P.B. (2000) Preparation of thioesters for the ligation of peptides with non-native substrates. Tetrahedron Lett., 41, 9451-9454. #16173

387. Marchan, V., Rodriguez-Tanty, C., Estrada, M., Pedroso, E., & Grandas, A. (2000) Alternative procedures for the synthesis of methionine-containing peptide-oligonucleotide hybrids. Eur. J. Org. Chem., 2495-2500. #15196

388. Marchand, G., Pilard, J.F., & Simonet, J. (2000) Solid phase chemistry at a modified cathode surface. First synthesis of a polyamine precursor. Tetrahedron Lett., 41, 883-885. #14263

389. Markiewicz, W.T., Astriab, A., Godzina, P., & Markiewicz, M. (2000) Synthetic oligonucleotide combinatorial libraries and their applications. Farmaco, 55, 174-177. #15198

390. Matsunaga, S., Ohshima, T., & Shibasaki, M. (2000) Immobilization of asymmetric multifunctional catalysts on an insoluble polymer. Tetrahedron Lett., 41, 8473-8478. #15798

391. Matsuura, K., Hibino, M., Kataoka, M., Hayakawa, Y., & Kobayashi, K. (2000) Phosphoramidite solid-phase synthesis of site-specifically glycosylated oligodeoxynucleotides. Tetrahedron Lett., 41, 7529-7533. #15994

392. Matzger, A.J., Lawrence, C.E., Grubbs, R.H., & Lewis, N.S. (2000) Combinatorial approaches to the synthesis of vapor detector arrays for use in an electronic nose. Journal of Combinatorial Chemistry, 2, 301-304. #14680

393. May, P.J., Bradley, M., Harrowven, D.C., & Pallin, D. (2000) A new method of forming resin bound thioesters and their use as 'traceless' linkers in solid phase synthesis. Tetrahedron Lett., 41, 1627-1630. #14335

394. Mazurov, A. (2000) Traceless synthesis of benzimidazoles on solid support. Bioorg. Med. Chem. Lett., 10, 67-70. #14243

395. Mazurov, A. (2000) Solid phase synthesis of 5,6,7,8-tetrahydro-1H-imidazo[4,5-g]quinoxalin-6-ones. Tetrahedron Lett., 41, 7-10. #13876

396. Mehta, S., & Whitfield, D.M. (2000) Polymer-supported synthesis of a branched trisaccharide of the type IA group B Streptococcus capsular polysaccharide: 3-Iodo-4-methoxybenzyl as a new O-protecting group. Tetrahedron, 56, 6415-6425. #15997

397. Meldal, M., Rademann, J., Grotli, M., Buchardt, J., Gotfredsen, C., Halkes, K., Sams, A.G., Duus, J.O., Miranda, L. & St.Hilaire, P.M. (2000) SPOCC resins: Polar and chemically inert resins for organic synthesis and library enzyme assays. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 176-178). Kluwer Academic Publisher, Dordrecht. #15720

398. Melean, L.G., Haase, W.C., & Seeberger, P.H. (2000) A novel 4,5-dibromooctane-1,8-diol linker for solid-phase oligosaccharide synthesis. Tetrahedron Lett., 41, 4329-4333. #14599

399. Melnyk, O., Fehrentz, J.A., Martinez, J., & Gras-Masse, H. (2000) Functionalization of peptides and proteins by aldehyde or keto groups. Biopolymers (Pept. Sci. ), 55, 165-186. #16436

400. Merrifield, B., Barany, G., Deber, C.M., Goodman, M., Hodges, R.S., Hruby, V.J., Muir, T.W., Offord, R., Spatola, A.F., Veber, D.F. & Fields, G.B. (2000) Perspectives for the new peptide millennium. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 797-804). Kluwer Academic Publisher, Dordrecht. #15754

401. Meseguer, B., Alonso-Diaz, D., Griebenow, N., Herget, T., & Waldmann, H. (2000) Solid-phase synthesis and biological evaluation of a teleocidin library-discovery of a selective PKC delta down regulator. Chem. Eur. J., 6, 3943-3957. #16000

402. Metcalf, C.A.I., Eyermann, C.J., Bohacek, R.S., Haraldson, C.A., Varkhedkar, V.M., Lynch, B.A., Bartlett, C., Violette, S.M., & Sawyer, T.K. (2000) Structure-based design and solid-phase parallel synthesis of phosphorylated nonpeptides to explore hydrophobic binding at the Src SH2 domain. Journal of Combinatorial Chemistry, 2, 305-313. #14681

403. Miao, H., & Yang, Z. (2000) Regiospecific carbonylative annulation of iodophenol acetates and acetylenes to construct the flavones by a new catalyst of palladium-thiourea-dppp complex. Organic Letters, 2, 1765-1768. #15395

404. Migawa, M.T., & Swayze, E.E. (2000) A solid-phase synthesis of N,N'-disubstituted ureas and perhydroimidazo[1,5-a]pyrazines via the Curtius rearrangement. Organic Letters, 2, 3309-3311. #16004

405. Millan, D.S., & Prager, R.H. (2000) Potential GABAB receptor antagonists. XI. Synthesis of a small library of sulfonamide analogues. Aust. J. Chem., 53, 615-618. #16005

406. Miller, W.H., Keenan, R.M., Willette, R.N., & Lark, M.W. (2000) Identification and in vivo efficacy of small-molecule antagonists of integrin aVb3 (the vitronectin receptor). Drug Disc. Today, 5, 397-408. #15573

407. Miranda, L.P., & Alewood, P.F. (2000) Challenges for protein chemical synthesis in the 21st century: Bridging genomics and proteomics. Biopolymers, 55, 217-226. #16344

408. Misra, A.K., Ding, Y.L., Lowe, J.B., & Hindsgaul, O. (2000) A concise synthesis of the 6-O- and 6'-O-sulfated analogues of the sialyl Lewis X tetrasaccharide. Bioorg. Med. Chem. Lett., 10, 1505-1509. #15207

409. Missio, A., Marchioro, C., Rossi, T., Panunzio, M., Selva, S., & Seneci, P. (2000) Polymer-supported silyl cyanide and silyl azide: Useful reagents for solid-phase applications. Biotechnol. Bioeng., 71, 38-43. #14244

410. Mohler, D.L., Shen, G., & Dotse, A.K. (2000) Solution- and solid-phase synthesis of peptide-substituted thiazolidinediones as potential PPAR ligands. Bioorg. Med. Chem. Lett., 10, 2239-2242. #16009

411. Mokhir, A.A., & Richert, C. (2000) Synthesis and monitored selection of 5'-nucleobase-capped oligodeoxyribonucleotides. Nucl. Acid. Res., 28, 4254-4265. #16010

412. Monnee, M.C.F., Marijne, M.F., Brouwer, A.J., & Liskamp, R.M.J. (2000) A practical solid phase synthesis of oligopeptidosulfonamide foldamers. Tetrahedron Lett., 41, 7991-7995. #15640

413. Morley, A.D. (2000) Allyloxycarbonyl: A useful protecting group for phenolic amino acids and applications on solid support. Tetrahedron Lett., 41, 7401-7404. #15634

414. Morley, A.D. (2000) Optimisation and synthesis of libraries derived from phenolic amino acid scaffolds. Tetrahedron Lett., 41, 7405-7408. #15635

415. Morton, G.C., Salvino, J.M., Labaudiniere, R.F., & Herpin, T.F. (2000) Novel solid-phase synthesis of 1,5-benzothiazepine-4-one derivatives. Tetrahedron Lett., 41, 3029-3033. #14551

416. Mourier, G., Servent, D., Zinn-Justin, S., & Menez, A. (2000) Chemical engineering of a three-fingered toxin with anti-a7 neuronal acetylcholine receptor activity. Protein Eng., 13, 217-225. #15781

417. Munoz, B., Chen, C.X., & McDonald, I.A. (2000) Resin activation capture technology: Libraries from stabilized acyl-pyridinium on solid support. Biotechnol. Bioeng., 71, 78-84. #14245

418. Murahashi, S.I., & Takaya, H. (2000) Low-valent ruthenium and iridium hydride complexes as alternatives to Lewis acid and base catalysis. Account. Chem. Res., 33, 225-233. #14351

419. Myers, R.M., Langston, S.P., Conway, S.P., & Abell, C. (2000) Reductive cleavage of N-O bonds using samarium(II) iodide in a traceless release strategy for solid-phase synthesis. Organic Letters, 2, 1349-1352. #15212

420. Nagy, I.B., Varga, I., & Hudecz, F. (2000) Preparation of indium-115-labeled diethylenetriaminetetraacetic acid monoacetamide peptides purified by 8-hydroxyquinoline. Anal. Biochem., 287, 17-24. #16350

421. Nakahara, Y., Ando, S., Itakura, M., Kumabe, N., Hojo, H., & Ito, Y. (2000) Solid-phase synthesis of serglycin glycopeptides on a new allyl ester linker. Tetrahedron Lett., 41, 6489-6493. #15536

422. Nanthakumar, A., Pon, R.T., Mazumder, A., Yu, S.Y., & Watson, A. (2000) Solid-phase oligonucleotide synthesis and flow cytometric analysis with microspheres encoded with covalently attached fluorophores. Bioconjug. Chem., 11, 282-288. #14649

423. Natarajan, A., & Madalengoitia, J.S. (2000) Optimization of variables for screening solid-supported metal complexes as oxidation catalysts. Tetrahedron Lett., 41, 5783-5787. #15421

424. Natarajan, A., & Madalengoitia, J.S. (2000) Molecular diversity approach to the synthesis of peptide-derived ruthenium complexes and their evaluation as oxidation catalysts. Tetrahedron Lett., 41, 5789-5793. #15422

425. Nefzi, A., Giulianotti, M.A., & Houghten, R.A. (2000) Solid-phase synthesis of substituted 2,3-diketopiperazines from reduced polyamides. Tetrahedron, 56, 3319-3326. #14650

426. Nefzi, A., Giulianotti, M.A., Ong, N.A., & Houghten, R.A. (2000) Solid-phase synthesis of bis-2-imidazolidinethiones from resin-bound tripeptides. Organic Letters, 2, 3349-3350. #16015

427. Nefzi, A., Ostresh, J.M., & Houghten, R.A. (2000) Solid-phase synthesis of heterocyclic compounds from amino acids and linear peptides. Solid-Phase Synthesis: A Practical Guide, 617-647. #16353

428. Nefzi, A., Giulianotti, M.A., Ong, N.A. & Houghten, R.A. (2000) Combinatorial chemistry: Solid-phase synthesis of heterocyclic compounds from Ca-functionalized amino acids. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 189-190). Kluwer Academic Publisher, Dordrecht. #15725

429. Nefzi, A., Ong, N.A., & Houghten, R.A. (2000) An efficient two-step synthesis of mono-, di- and triureas from resin-bound amides. Tetrahedron Lett., 41, 5441-5446. #14806

430. Nefzi, A., Giulianotti, M.A., & Houghten, R.A. (2000) Solid-phase synthesis of branched thiohydantoin benzimidazolinethiones and branched thiohydantoin tetrahydroquinoxalinediones. Tetrahedron Lett., 41, 2283-2287. #14544

431. Nestler, H.P. (2000) Combinatorial libraries and molecular recognition: Match or mismatch? Current Organic Chemistry, 4, 397-410. #15216

432. Newman, M.J., Rodarte, J.C., Benbatoul, K.D., Romano, S.J., Zhang, C.Z., Krane, S., Moran, E.J., Uyeda, R.T., Dixon, R., Guns, E.S., & Mayer, L.D. (2000) Discovery and characterization of OC144-093, a novel inhibitor of P-glycoprotein-mediated multidrug resistance. Cancer Res., 60, 2964-2972. #15217

433. Nicewonger, R.B., Ditto, L., & Varady, L. (2000) Alternative base matrices for solid phase quenching reagents. Tetrahedron Lett., 41, 2323-2326. #14545

434. Nicolaou, K.C., Pfefferkorn, J.A., Barluenga, S., Mitchell, H.J., Roecker, A.J., & Cao, G.Q. (2000) Natural product-like combinatorial libraries based on privileged structures. 3. The "libraries from libraries" principle for diversity enhancement of benzopyran libraries. J. Amer. Chem. Soc., 122, 9968-9976. #16020

435. Nicolaou, K.C., Mitchell, H.J., Fylaktakidou, K.C., Suzuki, H., & Rodriguez, R.M. (2000) 1,2-Seleno migrations in carbohydrate chemistry: Solution and solid-phase synthesis of 2-deoxy glycosides, orthoesters, and allyl orthoesters. Angew. Chem. Int. Ed., 39, 1089-1093. #14654

436. Nicolaou, K.C., Fylaktakidou, K.C., Mitchell, H.J., van Delft, F.L., Rodriguez, R.M., Conley, S.R., & Jin, Z.D. (2000) Total synthesis of everninomicin 13,384-1. Part 4. Explorations of methodology; Stereocontrolled synthesis of 1,1'-disaccharides, 1,2-seleno migrations in carbohydrates, and solution- and solid-phase synthesis of 2-deoxy glycosides and orthoesters. Chem. Eur. J., 6, 3166-3185. #16023

437. Nicolaou, K.C., Baran, P.S., & Zhong, Y.L. (2000) Novel solution- and solid-phase chemistry of alpha-sulfonated ketones applicable to combinatorial chemistry. J. Amer. Chem. Soc., 122, 10246-10248. #16021

438. Nicolaou, K.C., Roecker, A.J., Pfefferkorn, J.A., & Cao, G.Q. (2000) A novel strategy for the solid-phase synthesis of substituted indolines. J. Amer. Chem. Soc., 122, 2966-2967. #14652

439. Nicolaou, K.C., Snyder, S.A., Bigot, A., & Pfefferkorn, J.A. (2000) Solution and solid-phase synthesis of functionalized 3-arylbenzofurans by a novel cyclofragmentation-release pathway. Angew. Chem. Int. Ed., 39, 1093-1096. #14651

440. Nicolaou, K.C., Winssinger, N., Hughes, R., Smethurst, C., & Cho, S.Y. (2000) New selenium-based safety-catch linkers: Solid-phase semisynthesis of vancomycin. Angew. Chem. Int. Ed., 39, 1084-1088. #14653

441. Nicolaou, K.C., Pfefferkorn, J.A., Mitchell, H.J., Roecker, A.J., Barluenga, S., Cao, G.Q., Affleck, R.L., & Lillig, J.E. (2000) Natural product-like combinatorial libraries based on privileged structures. 2. Construction of a 10 000-membered benzopyran library by directed split-and-pool chemistry using NanoKans and optical encoding. J. Amer. Chem. Soc., 122, 9954-9967. #16019

442. Nicolaou, K.C., Pfefferkorn, J.A., Roecker, A.J., Cao, G.Q., Barluenga, S., & Mitchell, H.J. (2000) Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans. J. Amer. Chem. Soc., 122, 9939-9953. #16018

443. Nicolaou, K.C., Pfefferkorn, J.A., & Cao, G.Q. (2000) Selenium-based solid-phase synthesis of benzopyrans I: Applications to combinatorial synthesis of natural products. Angew. Chem. Int. Ed., 39, 734-739. #14321

444. Nicolaou, K.C., Pfefferkorn, J.A., Schuler, F., Roecker, A.J., Cao, G.Q., & Casida, J.E. (2000) Combinatorial synthesis of novel and potent inhibitors of NADH: Ubiquinone oxidoreductase. Chem. Biol., 7, 979-992. #16354

445. Nicolaou, K.C., Cao, G.Q., & Pfefferkorn, J.A. (2000) Selenium-based solid-phase synthesis of benzopyrans II: Applications to combinatorial synthesis of medicinally relevant small organic molecules. Angew. Chem. Int. Ed., 39, 739-743. #14322

446. Nifantiev, E.E., Grachev, M.K., & Burmistrov, S.Y. (2000) Amides of trivalent phosphorus acids as phosphorylating reagents for proton-donating nucleophiles. Chem. Rev., 100, 3755-3799. #16024

447. Nilsson, M., & Norberg, T. (2000) Synthesis of a spacer-containing disaccharide fragment of Bordetella pertussis lipopolysaccharide. Carbohyd. Res., 327, 261-267. #16026

448. Nishida, A., Fuwa, M., Naruto, S., Sugano, Y., Saito, H., & Nakagawa, M. (2000) Solid-phase synthesis of 5-(3-indolyl)oxazoles that inhibit lipid peroxidation. Tetrahedron Lett., 41, 4791-4794. #14610

449. O'Donnell, M.J., Drew, M.D., Pottorf, R.S., & Scott, W.L. (2000) UPS on Weinreb resin: A facile solid-phase route to aldehyde and ketone derivatives of "unnatural" amino acids and peptides. Journal of Combinatorial Chemistry, 2, 172-181. #14381

450. Ockey, D.A., Lane, D.R., Seeley, J.A., & Schore, N.E. (2000) Synthesis of cyclic ethers utilizing a cyclization-fragmentation strategy. Tetrahedron, 56, 711-717. #15225

451. Oertel, K., Zech, G., & Kunz, H. (2000) Stereoselective combinatorial Ugi-multicomponent synthesis on solid phase. Angew. Chem. Int. Ed., 39, 1431-1433. #14657

452. Oh, H.S., Hahn, H.G., Cheon, S.H., & Ha, D.C. (2000) Solid-phase synthesis of 1,3-oxazolidine derivatives. Tetrahedron Lett., 41, 5069-5072. #14605

453. Okayama, T., Burritt, A., & Hruby, V.J. (2000) 4-Alkoxy-2-hydroxybenzaldehyde (AHB): A versatile aldehyde linker for solid-phase synthesis of C-terminal modified peptides and peptidomimetics. Organic Letters, 2, 1787-1790. #15228

454. Okumoto, S., & Yamabe, S. (2000) A theoretical study of curing reactions of maleimide resins through Michael additions of amines. J. Org. Chem., 65, 1544-1548. #14658

455. Olsen, J.A., Jensen, K.J., & Nielsen, J. (2000) Combinatorial solid-phase synthesis of hapalosin mimetics. Journal of Combinatorial Chemistry, 2, 143-150. #14379

456. Olsson, R., Hansen, H.C., & Andersson, C.M. (2000) Microwave-assisted solvent-free parallel synthesis of thioamides. Tetrahedron Lett., 41, 7947-7950. #15637

457. Opatz, T., & Kunz, H. (2000) A facile cleavage of allyl ethers on solid phase. Tetrahedron Lett., 41, 10185-10188. #16226

458. Oscarsson, K., Classon, B., Kvarnstrom, I., Hallberg, A., & Samuelsson, B. (2000) Solid phase assisted synthesis of HIV-1 protease inhibitors. Expedient entry to unsymmetrical substitution of a C-2 symmetric template. Canadian Journal of Chemistry, 78, 829-837. #15233

459. Otaka, A., Mitsuyama, E., Watanabe, H., Tamamura, H., & Fujii, N. (2000) Development of new methodology for the synthesis of functionalized alpha-fluorophosphonates and its practical application to the preparation of phosphopeptide mimetics. Chem. Commun., 1081-1082. #15235

460. Ouyang, X.H., Chen, Z.D., Liu, L.B., Dominguez, C., & Kiselyov, A.S. (2000) Novel and highly efficient synthesis of substituted dibenz[b,g]1,5-oxazocines. A direct comparison of the solution versus solid-phase approach. Tetrahedron, 56, 2369-2377. #14659

461. Overkleeft, H.S., Bos, P.R., Hekking, B.G., Gordon, E.J., Ploegh, H.L., & Kessler, B.M. (2000) Solid phase synthesis of peptide vinyl sulfone and peptide epoxyketone proteasome inhibitors. Tetrahedron Lett., 41, 6005-6009. #15516

462. Palacios, F., Gil, M.J., de Marigorta, E.M., & Rodriguez, M. (2000) Synthesis and reactivity of imines derived from bisphosphonates and 3-phosphorylated 2-aza-1,3-dienes. Tetrahedron, 56, 6319-6330. #16033

463. Palacios, F., Aparicio, D., de los, S., Baceiredo, A., & Bertrand, G. (2000) Easy and efficient generation of reactive anions with free and supported ylides as neutral Bronsted bases. Tetrahedron, 56, 663-669. #14100

464. Palanisamy, U.D., Winzor, D.J., & Lowe, C.R. (2000) Synthesis and evaluation of affinity adsorbents for glycoproteins: An artificial lectin. Journal of Chromatography B, 746, 265-281. #16034

465. Paparin, J.L., Crevisy, C., & Gree, R. (2000) tert-Butoxycarbamate group: A useful protecting group for the synthesis of orthogonally protected 'tropane-like' scaffolds. Tetrahedron Lett., 41, 2343-2346. #14546

466. Park, K.H., & Kurth, M.J. (2000) Solid-phase synthesis of novel achiral hydantoin- and isoxazoline-substituted dispirocyclobutanoids. Chem. Commun., 1835-1836. #16036

467. Park, K.H., & Kurth, M.J. (2000) Diastereoselective synthesis of hydantoin- and isoxazoline-substituted dispirocyclobutanoids. J. Org. Chem., 65, 3520-3524. #15240

468. Park, K.H., & Kurth, M.J. (2000) Hydantoin formation by cyclo-elimination: Reactivity difference between Merrifield- and Wang-derived resins. Tetrahedron Lett., 41, 7409-7413. #16037

469. Parsch, U., & Engels, J.W. (2000) pH-Independent triple-helix formation with 6-oxocytidine as cytidine analogue. Chem. Eur. J., 6, 2409-2424. #15242

470. Patek, M., Smrcina, M., Nakanishi, E., & Izawa, H. (2000) Solid-phase synthesis of substituted guanidines using a novel acid labile linker. Journal of Combinatorial Chemistry, 2, 370-377. #14690

471. Paterson, I., Donghi, M., & Gerlach, K. (2000) A combinatorial approach to polyketide-type libraries by iterative asymmetric aldol reactions performed on solid support. Angew. Chem. Int. Ed., 39, 3315. #16040

472. Paulvannan, K., & Chen, T. (2000) Solid-phase synthesis of 1,2,3,4-tetrahydro-2-pyridones via aza-annulation of enamines. J. Org. Chem., 65, 6160-6166. #16041

473. Pegurier, C., Curtet, S., Nicolas, J.P., Boutin, J.A., Delagrange, P., Renard, P., & Langlois, M. (2000) Synthesis of a small library of phenylalkylamide derivatives as melatoninergic ligands for human mt(1) and MT2 receptors. Bioorg. Med. Chem., 8, 163-171. #14102

474. Peilstocker, K., & Kunz, H. (2000) Syntheses of sialyl Lewis A glycopeptides. A partial sequence of the P-selectin ligand PSGL-1. Synlett, 823-825. #15246

475. Perez, J.M., Wilhelm, E.J., & Sucholeiki, I. (2000) The use of power ultrasound coupled with magnetic separation for the solid phase synthesis of compound libraries. Bioorg. Med. Chem. Lett., 10, 171-174. #14105

476. Perez, R., Reyes, O., Suarez, M., Garay, H.E., Cruz, L.J., Rodriguez, H., Molero-Vilchez, M.D., & Ochoa, C. (2000) Solid phase synthesis of 3-(5'-carboxypentyl)-5-substituted tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives. Tetrahedron Lett., 41, 613-616. #14106

477. Peri, F., Cipolla, L., & Nicotra, F. (2000) Tin-mediated regioselective acylation of unprotected sugars on solid phase. Tetrahedron Lett., 41, 8587-8590. #15801

478. Petrova, L.A., Borisov, A.P., Aleshin, V.V., & Makhaev, V.D. (2000) Solid-phase synthesis of iron(III) acetylacetonate upon mechanical activation [Russian]. Zhurnal Neorganicheskoi Khimii, 45, 390-394. #15250

479. Pinilla, C., Appel, J.R., Blondelle, S.E., Dooley, C.T., Eichler, J., Nefzi, A., Ostresh, J.M., Martin, R., Wilson, D.B. & Houghten, R.A. (2000) Synthesis and screening of positional scanning synthetic combinatorial libraries. In H. Fenniri (Ed.), Combinatorial Chemistry: A Practical Approach. (pp. 51-74). Oxford University Press, Oxford. #15666

480. Pirrung, M.C., Drabik, S.J., Gothelf, K.V., James, K.D. & Pei, T. (2000) Preparation and incorporation into small peptides and combinatorial libraries of phosphohistidine analogs for study of prokaryotic two-component signal transduction systems. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 86-88). Kluwer Academic Publisher, Dordrecht. #15702

481. Pirrung, M.C., & Park, K. (2000) Discovery of selective metal-binding peptoids using F-19 encoded combinatorial libraries. Bioorg. Med. Chem. Lett., 10, 2115-2118. #16044

482. Pirrung, M.C., & Tumey, L.N. (2000) Oxazoline synthesis from hydroxyamides by resin capture and ring-forming release. Journal of Combinatorial Chemistry, 2, 675-680. #16131

483. Pivonka, D.E., & Sparks, R.B. (2000) Implementation of Raman spectroscopy as an analytical tool throughout the synthesis of solid-phase scaffolds. Appl. Spectrosc., 54, 1584-1590. #16164

484. Pivonka, D.E. (2000) On-bead quantitation of resin bound functional groups using analogue techniques with vibrational spectroscopy. Journal of Combinatorial Chemistry, 2, 33-38. #14107

485. Planas, M., Bardaji, E. & Barany, G. (2000) Chemical synthesis of cyclic peptide nucleic acid-peptide hybrids. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 786-787). Kluwer Academic Publisher, Dordrecht. #15753

486. Planas, M., Bardaji, E., & Barany, G. (2000) Synthesis of cyclic peptide hybrids with amino acid and nucleobase side-chains. Tetrahedron Lett., 41, 4097-4100. #14592

487. Plater, M.J., Murdoch, A.M., Morphy, J.R., Rankovic, Z., & Rees, D.C. (2000) Solid phase synthesis of tertiary amines on amide REM resins: Grignard and metal hydride compatible resins. Journal of Combinatorial Chemistry, 2, 508-512. #15603

488. Pons, J.F., Mishir, Q., Nouvet, A., & Brookfield, F. (2000) Thiazole formation via traceless cleavage of Rink resin. Tetrahedron Lett., 41, 4965-4968. #14614

489. Porco, J.A.Jr. (2000) Organic synthesis using chemical tags: The third Leg of parallel synthesis. Comb. Chem. High Throughput Screening, 3, 93-102. #14584

490. Pourbaix, C., Carreaux, F., Carboni, B., & Deleuze, H. (2000) Boronate linker for 'traceless' solid-phase synthesis. Chem. Commun., 1275-1276. #15257

491. Prakash, T.P., Manoharan, M., Fraser, A.S., Kawasaki, A.M., Lesnik, E.A., & Owens, S.R. (2000) Zwitterionic oligonucleotides with 2'-O-[3-(N,N-dimethylamino)propyl]-RNA modification: Synthesis and properties. Tetrahedron Lett., 41, 4855-4859. #14613

492. Procter, D.J. (2000) The synthesis of thiols, selenols, sulfides, selenides, sulfoxides, selenoxides, sulfones and selenones. J. Chem. Soc. Perkin Trans. 1, 835-871. #15259

493. Quiclet-Sire, B., Wilczewska, A., & Zard, S.Z. (2000) A practical process for polymer-supported synthesis. Tetrahedron Lett., 41, 5673-5677. #15418

494. Rabinowitz, M., Seneci, P., Rossi, T., Dal Cin, M., Deal, M., & Terstappen, G. (2000) Solid-phase/solution phase combinatorial synthesis of neuroimmunophilin ligands. Bioorg. Med. Chem. Lett., 10, 1007-1010. #15580

495. Rack, J.J., Krider, E.S., & Meade, T.J. (2000) Spectroscopy and electrochemistry of ruthenium-modified nucleic acids: Design of a novel metal-binding nucleoside. J. Amer. Chem. Soc., 122, 6287-6288. #15262

496. Rait, A., Pirollo, K., Will, D.W., Peyman, A., Rait, V., Uhlmann, E., & Chang, E.H. (2000) 3'-End conjugates of minimally phosphorothioate-protected oligonucleotides with 1-O-hexadecylglycerol: Synthesis and anti-ras activity in radiation-resistant cells. Bioconjug. Chem., 11, 153-160. #15264

497. Ramaseshan, M., Dory, Y.L., & Deslongchamps, P. (2000) Solid phase combinatorial synthesis of a library of macro-heterocycles and related acyclic compounds. Journal of Combinatorial Chemistry, 2, 615-623. #16046

498. Ramaseshan, M., Ellingboe, J.W., Dory, Y.L., & Deslongchamps, P. (2000) Design of an organic sequence suitable for the solid phase combinatorial synthesis of libraries of macro-heterocycles. Tetrahedron Lett., 41, 4743-4749. #14608

499. Ramjit, H.G., Kruppa, G.H., Spier, J.P., Ross, C.W., & Garsky, V.M. (2000) The significance of monoisotopic and carbon-13 isobars for the identification of a 19-component dodecapeptide library by positive ion electrospray Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun. Mass Spectrom., 14, 1368-1376. #16047

500. Rano, T.A., Cheng, Y., Huening, T.T., Zhang, F.Q., Schleif, W.A., Gabryelski, L., Olsen, D.B., Kuo, L.C., Lin, J.H., Xu, X., Olah, T.V., McLoughlin, D.A., King, R., Chapman, K.T., & Tata, J.R. (2000) Combinatorial diversification of indinavir: In vivo mixture dosing of an HIV protease inhibitor library. Bioorg. Med. Chem. Lett., 10, 1527-1530. #15265

501. Rapp, W.E. (2000) Diffusion phenomena and reactivity using polymer supports: A principal investigation. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 76-77). Kluwer Academic Publisher, Dordrecht. #15698

502. Rasoul, F., Ercole, F., Pham, Y., Bui, C.T., Wu, Z., James, S.N., Trainor, R.W., Wickham, G., & Maeji, N.J. (2000) Grafted supports in solid-phase synthesis. Biopolymers (Pept. Sci. ), 55, 207-216. #16438

503. Rasoul, F., Ercole, F., Pham, Y., Bui, C.T., Wu, Z.M., James, S.N., Trainor, R.W., Wickham, G., & Maeji, N.J. (2000) Grafted supports in solid-phase synthesis. Biopolymers, 55, 207-216. #16365

504. Rau, H.K., DeJonge, N., & Haehnel, W. (2000) Combinatorial synthesis of four-helix bundle hemoproteins for tuning of cofactor properties. Angew. Chem. Int. Ed., 39, 250-253. #14113

505. Rau, H.K., DeJonge, N. & Haehnel, W. (2000) Combinatorial synthesis of de novo metalloproteins with tuned redox potential. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 490-492). Kluwer Academic Publisher, Dordrecht. #15741

506. Reichel, F., Roelofsen, A.M., Geurts, H.P.M., van der Gaast, S.J., Feiters, M.C., & Boons, G.J. (2000) Synthesis and supramolecular characterization of a novel class of glycopyranosyl-containing amphiphiles. J. Org. Chem., 65, 3357-3366. #15266

507. Reineke, U., Sabat, R., Hoffmuller, U., Schmidt, M., Kurzhals, D., Wenschuh, H., Volk, H.D., Germeroth, L. & Schneider-Mergener, J. (2000) Identification of miniproteins using cellulose-bound duotope scans. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 167-169). Kluwer Academic Publisher, Dordrecht. #15716

508. Reixach, N., Crooks, E., Ostresh, J.M., Houghten, R.A., & Blondelle, S.E. (2000) Inhibition of beta-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library. Journal of Structural Biology, 130, 247-258. #16049

509. Reyes, S., Pattarawarapan, M., Roy, S., & Burgess, K. (2000) Preferred secondary structures as a possible driving force for macrocyclization. Tetrahedron, 56, 9809-9818. #16368

510. Rinnova, M., Hradilek, M., Barinka, C., Weber, J., Soucek, M., Vondrasek, J., Klimkait, T., & Konvalinka, J. (2000) A picomolar inhibitor of resistant strains of human immunodeficiency virus protease identified by a combinatorial approach. Arch. Biochem. Biophys., 382, 22-30. #16052

511. Rivero, I.A., & Heredia, S. (2000) Solid phase synthesis of cis-coniferyl alcohol. Syn. Commun., 30, 1351-1357. #14663

512. Roberge, J.Y. (2000) Solid-phase synthesis of oligosaccharides. Solid-Phase Synthesis: A Practical Guide, 579-615. #16370

513. Roberts, G.C.K. (2000) Applications of NMR in drug discovery. Drug Disc. Today, 5, 230-240. #15498

514. Robillard, M.S., Valentijn, A.R.P.M., Meeuwenoord, N.J., van der Marel, G.A., van Boom, J.H., & Reedijk, J. (2000) The first solid-phase synthesis of a peptide-tethered platinum(II) complex. Angew. Chem. Int. Ed., 39, 3096-3099. #16054

515. Robinson, D.E., & Holladay, M.W. (2000) Convenient preparation of O-linked polymer-bound N-substituted hydroxylamines, intermediates for synthesis of N-substituted hydroxamic acids. Organic Letters, 2, 2777-2779. #16055

516. Robinson, J.A. (2000) The design, synthesis and conformation of some new beta-hairpin mimetics: Novel reagents for drug and vaccine discovery. Synlett, 429-441. #15273

517. Romanelli, A., De Napoli, L., Messere, A., Montesarchio, D., Piccialli, G., Zaccaro, L., Pedone, C., Rossi, F. & Benedetti, E. (2000) Fully automated synthesis of peptide-oligonucleotide conjugates. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 784-785). Kluwer Academic Publisher, Dordrecht. #15752

518. Rose, K. & Vizzavona, J. (2000) Polyethyleneglycol-based chains of precise length for chemobodies. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 47-49). Kluwer Academic Publisher, Dordrecht. #15691

519. Rousselot-Pailley, P., Maux, D., Wieruszeski, J.M., Aubagnac, J.L., Martinez, J., & Lippens, G. (2000) Impurity detection in solid-phase organic chemistry: Scope and limits of HR MAS NMR. Tetrahedron, 56, 5163-5167. #15281

520. Rudolph, J. (2000) Facile access to N-thiazolyl alpha-amino acids from alpha-bromo ketones and alpha-amino acids. Tetrahedron, 56, 3161-3165. #16059

521. Russell, H.E., Luke, R.W.A., & Bradley, M. (2000) Thermally cleavable safety-catch linkers for solid phase chemistry. Tetrahedron Lett., 41, 5287-5290. #14621

522. Ryba, T.D., & Harran, P.G. (2000) Two useful photolabile surfaces for solid-phase synthesis. Organic Letters, 2, 851-853. #15287

523. Saha, A.K., Liu, L., Simoneaux, R.L., Kukla, M.J., Marichal, P., & Odds, F. (2000) Novel antifungals based on 4-substituted imidazole: A combinatorial chemistry approach to lead discovery and optimization. Bioorg. Med. Chem. Lett., 10, 2175-2178. #16062

524. Saha, A.K., Liu, L., Marichal, P., & Odds, F. (2000) Novel antifungals based on 4-substituted imidazole: Solid-phase synthesis of substituted aryl sulfonamides towards optimization of in vitro activity. Bioorg. Med. Chem. Lett., 10, 2735-2739. #16375

525. Sakakura, A., & Hayakawa, Y. (2000) A novel synthesis of oligonucleotide-peptide conjugates with a base-labile phosphate linker between the two components according to the allyl-protected phosphoramidite strategy. Tetrahedron, 56, 4427-4435. #15290

526. Salvino, J.M., Mathew, R., Kiesow, T., Narensingh, R., Mason, H.J., Dodd, A., Groneberg, R., Burns, C.J., McGeehan, G., Kline, J., Orton, E., Tang, S.Y., Morrisette, M., & Labaudininiere, R. (2000) Solid-phase synthesis of an arylsulfone hydroxamate library. Bioorg. Med. Chem. Lett., 10, 1637-1640. #16064

527. Salvino, J.M., Kumar, N.V., Orton, E., Airey, J., Kiesow, T., Crawford, K., Mathew, R., Krolikowski, P., Drew, M., Engers, D., Krolikowski, D., Herpin, T., Gardyan, M., McGeehan, G., & Labaudiniere, R. (2000) Polymer-supported tetrafluorophenol: A new activated resin for chemical library synthesis. Journal of Combinatorial Chemistry, 2, 691-697. #16063

528. Sanchez, R.M., Graybill, T.L., Moore, M.L. & Veber, D.F. (2000) The synthesis of matrix matalloprotease inhibitor libraries using a hybrid mix/split parallel approach. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 441-442). Kluwer Academic Publisher, Dordrecht. #15736

529. Sato, S., Kubota, Y., Kumagai, H., Kumazawa, T., Matsuba, S., Onodera, J., & Suzuki, M. (2000) Solid-phase synthesis of 2-phenyl-4-quinolinone library via flavylium salt. Heterocycles, 53, 1523-1532. #16067

530. Sauvagnat, B., Lamaty, F., Lazaro, R., & Martinez, J. (2000) Poly(ethylene glycol) as solvent and polymer support in the microwave assisted parallel synthesis of aminoacid derivatives. Tetrahedron Lett., 41, 6371-6375. #15534

531. Scannell-Lansky, A. & Zechel, C. (2000) Organic reactions on solid phase: A survey of the literature from 1970 to 1998. In R. Mannhold, H. Kubinyi & H. Timmerman (Eds.), Combinatorial Chemistry: A Practical Approach. (pp. 329-422). Wiley-VCH, Weinheim. #16220

532. Scaringe, S.A. (2000) Advanced 5'-silyl-2'-orthoester approach to RNA oligonucleotide synthesis. RNA-Ligand Interactions Part A:Structural Biology, 317, 3-18. #15295

533. Scharn, D., Wenschuh, H., Reineke, U., Schneider-Mergener, J., & Germeroth, L. (2000) Spatially addressed synthesis of amino- and amino-oxy-substituted 1,3,5-triazine arrays on polymeric membranes. Journal of Combinatorial Chemistry, 2, 361-369. #14689

534. Scheuerman, R.A., & Tumelty, D. (2000) The reduction of aromatic nitro groups on solid supports using sodium hydrosulfite (Na2S2O4). Tetrahedron Lett., 41, 6531-6535. #15522

535. Schlienger, N., Bryce, M.R., & Hansen, T.K. (2000) Immobilization of glyoxylic acid on Wang resin. Tetrahedron Lett., 41, 5147-5150. #14607

536. Schlienger, N., Bryce, M.R., & Hansen, T.K. (2000) The boronic Mannich reaction in a solid-phase approach. Tetrahedron, 56, 10023-10030. #16376

537. Schmidt, K.S., Filippov, D.V., Meeuwenoord, N.J., van der Marel, G.A., van Boom, J.H., Lippert, B., & Reedijk, J. (2000) Solid-phase synthesis of a monofunctional trans-a(2)Pt(II) complex tethered to a single-stranded oligonucleotide. Angew. Chem. Int. Ed., 39, 375-377. #14130

538. Schneider, S.E., O'Neil, S.N., & Anslyn, E.V. (2000) Coupling rational design with libraries leads to the production of an ATP selective chemosensor. J. Amer. Chem. Soc., 122, 542-543. #14131

539. Schnetz-Boutaud, N.C., Mao, H., Stone, M.P., & Marnett, L.J. (2000) Synthesis of oligonucleotides containing the alkali-labile pyrimidopurinone adduct, M(1)G. Chem. Res. Toxicol., 13, 90-95. #15298

540. Schreiber, S.L. (2000) Target-oriented and diversity-oriented organic synthesis in drug discovery. Science, 287, 1964-1969. #15300

541. Schultz, R.G., & Gryaznov, S.M. (2000) Arabino-fluorooligonucleotide N3'-->P5' phosphoramidates: Synthesis and properties. Tetrahedron Lett., 41, 1895-1899. #14346

542. Schulz, J., Beaton, M.W., & Gani, D. (2000) Synthesis of (+)-(1R,2R,4R,6S)-1,6-epoxy-4-benzyloxycyclohexan-2-ol, a key precursor to inositol monophosphatase inhibitors, from (-)-quinic acid. J. Chem. Soc. Perkin Trans. 1, 943-954. #15302

543. Schunk, S., & Enders, D. (2000) Solid-phase synthesis of beta-lactams via the ester enolate-imine condensation route. Organic Letters, 2, 907-910. #15304

544. Seeberger, P.H., & Haase, W.C. (2000) Solid-phase oligosaccharide synthesis and combinatorial carbohydrate libraries. Chem. Rev., 100, 4349-4393. #16154

545. Seela, F., Zulauf, M., & Debelak, H. (2000) Base-pairing properties of 8-aza-7-deazaadenine linked via the 8-position to the DNA backbone. Helv. Chim. Acta, 83, 1437-1453. #15308

546. Seela, F., & He, Y. (2000) 2'-Deoxyuridine and 2'-deoxyisocytidine as constituents of DNA with parallel chain orientation: The stabilization of the iC(d)center dot Gd base pair by the 5-methyl group. Helv. Chim. Acta, 83, 2527-2540. #16069

547. Sefler, A.M., & Gerritz, S.W. (2000) Using one- and two-dimensional NMR techniques to characterize reaction products bound to Chiron SynPhase crowns. Journal of Combinatorial Chemistry, 2, 127-133. #14373

548. Sekine, M., Kurasawa, O., Shohda, K., Seio, K., & Wada, T. (2000) Synthesis and properties of oligodeoxynucleotides incorporating a conformationally rigid uridine unit having a cyclic structure at the 5'-terminal site. J. Org. Chem., 65, 3571-3578. #15309

549. Shah, N., Gao, M., Tsutsui, K., Lu, A., Davis, J., Scheuerman, R., Fitch, W.L., & Wilgus, R.L. (2000) A novel approach to high-throughput quality control of parallel synthesis libraries. Journal of Combinatorial Chemistry, 2, 453-460. #15597

550. Shan, D.X., Zheng, A.L., Ballard, C.E., Wang, W., Borchardt, R.T., & Wang, B.H. (2000) A facilitated cyclic ether formation and its potential application in solid-phase peptide and organic synthesis. Chem. Pharm. Bull. Tokyo, 48, 238-244. #14325

551. Shao, H., Zhang, Q., Goodnow, R., Chen, L., & Tam, S. (2000) A new polymer-bound N-hydroxysuccinimidyl active ester linker. Tetrahedron Lett., 41, 4257-4260. #14597

552. Shibatomi, K., Nakahashi, T., & Uozumi, Y. (2000) Michael reactions in water using amphiphilic resin-supported quaternary ammonium hydroxides. Synlett, 1643-1645. #16071

553. Shuttleworth, S.J., Allin, S.M., Wilson, R.D., & Nasturica, D. (2000) Functionalised polymers in organic chemistry. Part 2. Synthesis-Stuttgart, 1035-1074. #15313

554. Simpson, J., Rathbone, D.L., & Billington, D.C. (2000) Corrigendum to "New solid phase Knoevenagel catalyst". Tetrahedron Lett., 41, 283-283. #13885

555. Singh, A., Yao, Q., Tong, L., Still, W.C., & Sames, D. (2000) Combinatorial approach to the development of fluorescent sensors for nanomolar aqueous copper. Tetrahedron Lett., 41, 9601-9605. #16176

556. Singh, L., Nakahara, Y., & Ito, Y. (2000) An efficient access to protected disialylated glycohexaosyl threonine present on the leukosialin of activated T-lymphocytes. Carbohyd. Res., 325, 132-142. #15315

557. Sjolin, P., & Kihlberg, J. (2000) Deacetylation of N-alpha-methylated glycopeptides reveals that aza-enolates provide protection against beta-elimination of carbohydrates O-linked to serine. Tetrahedron Lett., 41, 4435-4439. #15318

558. Smith, A.B., Liu, H., Okumura, H., Favor, D.A., & Hirschmann, R. (2000) Synthesis of polypyrrolinones on solid support. Organic Letters, 2, 2041-2044. #15320

559. Smith, A.L., Stevenson, G.I., Lewis, S., Patel, S., & Castro, J.L. (2000) Solid-phase synthesis of 2,3-disubstituted indoles: Discovery of a novel, high-affinity, selective h5-HT2A antagonist. Bioorg. Med. Chem. Lett., 10, 2693-2696. #16386

560. Snapper, M.L. & Hoveyda, A.H. (2000) Combinatorial approaches to chiral catalyst discovery. In H. Fenniri (Ed.), Combinatorial Chemistry: A Practical Approach. (pp. 433-456). Oxford University Press, Oxford. #15678

561. Snively, C.M., Oskarsdottir, G., & Lauterbach, J. (2000) Chemically sensitive high throughput parallel analysis of solid phase supported library members. Journal of Combinatorial Chemistry, 2, 243-245. #14452

562. Sojka, B., Piunno, P.A.E., Wust, C.C., & Krull, U.J. (2000) A novel phosphoramidite method for automated synthesis of oligonucleotides on glass supports for biosensor development. Appl. Biochem. Biotech., 89, 85-103. #16073

563. Soucy, P., Dory, Y.L., & Deslongchamps, P. (2000) Use of malonate connectors in solid phase organic chemistry. Application to the synthesis of macrocarbocycles. Synlett, 1123-1126. #16074

564. Spivey, A.C., Diaper, C.M., Adams, H., & Rudge, A.J. (2000) A new germanium-based linker for solid phase synthesis of aromatics: Synthesis of a pyrazole library. J. Org. Chem., 65, 5253-5263. #15783

565. Sproule, K., Morrill, P., Pearson, J.C., Burton, S.J., Hejnaes, K.R., Valore, H., Ludvigsen, S., & Lowe, C.R. (2000) New strategy for the design of ligands for the purification of pharmaceutical proteins by affinity chromatography. Journal of Chromatography B, 740, 17-33. #15324

566. St.Hilaire, P.M., Sanderson, S., Juliano, M.A., Willert, M., Mottram, J., Coombs, G., Juliano, L. & Meldal, M. (2000) A combinatorial approach to the identification of cysteine protease substrates and inhibitors by application of a solid-phase fluorescence quenching assay. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 456-458). Kluwer Academic Publisher, Dordrecht. #15738

567. Stasiak, M., Eguchi, M., Mehlin, C. & Kahn, M. (2000) Inhibition of a4b1 integrin receptor interactions by bicyclic b-turn mimetics. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 233-234). Kluwer Academic Publisher, Dordrecht. #15730

568. Stauffer, S.R., & Katzenellenbogen, J.A. (2000) Solid-phase synthesis of tetrasubstituted pyrazoles, novel ligands for the estrogen receptor. Journal of Combinatorial Chemistry, 2, 318-329. #14683

569. Stetsenko, D.A., & Gait, M.J. (2000) Efficient conjugation of peptides to oligonucleotides by "native ligation". J. Org. Chem., 65, 4900-4908. #16076

570. Stetsenko, D.A., & Gait, M.J. (2000) New phosphoramidite reagents for the synthesis of oligonucleotides containing a cysteine residue useful in peptide conjugation. Nucleosides, Nucleotides and Nucleic Acids, 19, 1751-1764. #16390

571. Stromgaard, K., Brier, T.J., Andersen, K., Mellor, I.R., Saghyan, A., Tikhonov, D., Usherwood, P.N.R., Krogsgaard-Larsen, P., & Jaroszewski, J.W. (2000) Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues. J. Med. Chem., 43, 4526-4533. #16081

572. Stromgaard, K., Bjornsdottir, I., Andersen, K., Brierley, M.J., Rizoli, S., Eldursi, N., Mellor, I.R., Usherwood, P.N.R., Hansen, S.H., Krogsgaard-Larsen, P., & Jaroszewski, J.W. (2000) Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12. Chirality, 12, 93-102. #14156

573. Subramanyam, C. (2000) Polymer bound iminodicarbonate: A new ammonia equivalent for solid-phase synthesis of primary amines. Tetrahedron Lett., 41, 6537-6540. #15523

574. Subramanyam, C., & Chang, S.P. (2000) Solid-phase synthesis of 1,3-diamino ketones. Tetrahedron Lett., 41, 7145-7149. #15564

575. Sun, S.G., Turchi, I.J., Xu, D.W., & Murray, W.V. (2000) Vinyl benzenes as dienes in mild solid-phase Diels-Alder reactions. J. Org. Chem., 65, 2555-2559. #14670

576. Svensson, A., Fex, T., & Kihlberg, J. (2000) Preparation of fluorinated linkers: Use of F-19 NMR spectroscopy to establish conditions for solid-phase synthesis of pilicide libraries. Journal of Combinatorial Chemistry, 2, 736-748. #16084

577. Tacke, R., Ulmer, B., Wagner, B., & Arlt, M. (2000) A novel silicon-based linkage and cleavage strategy for solid-phase synthesis: Formation of resin-linked zwitterionic pentacoordinate silicates as the key step and release of the target molecules in a traceless fashion. Organometallics, 19, 5297-5309. #16395

578. Tang, J.Y., Han, Y.X., Tang, J.X., & Zhang, Z.D. (2000) Large-scale synthesis of oligonucleotide phosphorothioates using 3-amino-1,2,4-dithiazole-5-thione as an efficient sulfur-transfer reagent. Organic Process Research and Development, 4, 194-198. #15331

579. Tang, Y.C., Tian, G.L., & Ye, Y.H. (2000) Progress in the study on synthetic method of cyclopeptide [Chinese]. Chem. J. Chin. Univ., 21, 1056-1063. #15332

580. Tao, B., & Timberlake, J.W. (2000) Synthesis of conformationally constrained spirohydantoins with a dibenzo[a,d]heptadiene ring. Synthesis-Stuttgart, 1449-1453. #16090

581. Taylor, R.E., Schmitt, M.J., & Yuan, H.Q. (2000) Structural diversity based on cyclopropane scaffolds. Organic Letters, 2, 601-603. #15333

582. Teague, S.J., & Walters, I.A.S. (2000) Library synthesis using solution phase capping of solid phase derived intermediates. Tetrahedron Lett., 41, 2023-2026. #14349

583. Terrett, N. (2000) Combinatorial chemistry. Drug Disc. Today, 5, 211-212. #15476

584. Terrett, N. (2000) Combinatorial chemistry. Drug Disc. Today, 5, 261-262. #15475

585. Terrett, N. (2000) Combinatorial chemistry. Drug Disc. Today, 5, 123-124. #15479

586. Terrett, N. (2000) Combinatorial chemistry. Drug Disc. Today, 5, 34-35. #15484

587. Theoclitou, M.E., Ostresh, J.M., Hamashin, V., & Houghten, R.A. (2000) Solid phase synthesis of styrylquinazolinones. Tetrahedron Lett., 41, 2051-2054. #14341

588. Theodoridis, G. (2000) Nitrogen protecting groups: Recent developments and new applications. Tetrahedron, 56, 2339-2358. #15334

589. Thorpe, D.S., & Walle, S. (2000) Combinatorial chemistry defines general properties of linkers for the optimal display of peptide ligands for binding soluble protein targets to TentaGel microscopic beads. Biochem. Biophys. Res. Commun., 269, 591-595. #14578

590. Thouin, E., & Lubell, W.D. (2000) Effective synthesis of enantiopure hydroxamates by displacement of resin-bound esters with hydroxylamine. Tetrahedron Lett., 41, 457-460. #13887

591. Tian, J., & Coates, G.W. (2000) Development of a diversity-based approach for the discovery of stereoselective polymerization catalysts: Identification of a catalyst for the synthesis of syndiotactic polypropylene. Angew. Chem. Int. Ed., 39, 3626-3629. #16094

592. Timar, Z., & Gallagher, T. (2000) Constructing the 2-(thiobenzyl)ethyl carbamate linker via thiyl radical addition. Tetrahedron Lett., 41, 3173-3176. #14554

593. Todd, M.H., & Abell, C. (2000) The attachment and cleavage of phenols from solid supports and their single bead mass spectral analysis. Tetrahedron Lett., 41, 8183-8187. #15628

594. Tohma, H., Takizawa, S., Maegawa, T., & Kita, Y. (2000) Facile and clean oxidation of alcohols in water using hypervalent iodine(III) reagents. Angew. Chem. Int. Ed., 39, 1306-1308. #14672

595. Tois, J., Franzen, R., Aitio, O., Huikko, K., & Taskinen, J. (2000) Preparation of 5-substituted 2-carboxyindoles on solid support. Tetrahedron Lett., 41, 2443-2446. #14547

596. Tolbert, T.J., & Wong, C.H. (2000) Intein-mediated synthesis of proteins containing carbohydrates and other molecular probes. J. Amer. Chem. Soc., 122, 5421-5428. #15339

597. Tolborg, J.F., & Jensen, K.J. (2000) Solid-phase oligosaccharide synthesis with tris(alkoxy)benzyl amine (BAL) safety-catch anchoring. Chem. Commun., 147-148. #14250

598. Tong, X.H., & Hong, A. (2000) Solid phase synthesis of aspartyl peptide aldehydes. Tetrahedron Lett., 41, 8857-8860. #15793

599. Toth, G.K., Kele, Z., & Fulop, F. (2000) Synthesis of conformationally constrained peptides via solid-phase incorporation of the constrains. Tetrahedron Lett., 41, 10095-10098. #16224

600. Toy, P.H., Reger, T.S., & Janda, K.D. (2000) Soluble polymer bound cleavage reagents: A multipolymer strategy for the cleavage of tertiary amines from REM resin. Organic Letters, 2, 2205-2207. #16096

601. Tran, C.D. (2000) Visualising chemical composition and reaction kinetics by the near infrared multispectral imaging technique. Journal of Near Infrared Spectroscopy, 8, 87-99. #15343

602. Tremblay, M.R., & Poirier, D. (2000) Solid-phase synthesis of phenolic steroids: From optimization studies to a convenient procedure for combinatorial synthesis of biologically relevant estradiol derivatives. Journal of Combinatorial Chemistry, 2, 48-65. #14171

603. Tremblay, M.R., Wentworth, P., Lee, G.E., & Janda, K.D. (2000) Parallel solid-phase synthesis and structural characterization of a library of highly substituted chiral 1,3-oxazolidines. Journal of Combinatorial Chemistry, 2, 698-709. #16097

604. Tsuruoka, H., Shohda, K., Wada, T., & Sekine, M. (2000) Synthesis and conformational properties of oligonucleotides incorporating 2'-O-phosphorylated ribonucleotides as structural motifs of pre-tRNA splicing intermediates. J. Org. Chem., 65, 7479-7494. #16099

605. Tung, C.H., & Stein, S. (2000) Preparation and applications of peptide-oligonucleotide conjugates. Bioconjug. Chem., 11, 605-618. #16100

606. Ufret, M.D., & Imperiali, B. (2000) Probing the extended binding determinants of oligosaccharyl transferase with synthetic inhibitors of asparagine-linked glycosylation. Bioorg. Med. Chem. Lett., 10, 281-284. #14327

607. Usyatinsky, A.Y., & Khmelnitsky, Y.L. (2000) Microwave assisted synthesis of substituted imidazoles on a solid support under solvent-free conditions. Tetrahedron Lett., 41, 5031-5034. #14604

608. Vaino, A.R., Goodin, D.B., & Janda, K.D. (2000) Investigating resins for solid phase organic synthesis: The relationship between swelling and microenvironment as probed by EPR and fluorescence spectroscopy. Journal of Combinatorial Chemistry, 2, 330-336. #14684

609. Vaino, A.R., & Janda, K.D. (2000) Euclidean shape-encoded combinatorial chemical libraries. Proc. Natl. Acad. Sci. USA, 97, 7692-7696. #15349

610. Vaino, A.R., & Janda, K.D. (2000) Solid-phase organic synthesis: A critical understanding of the resin. Journal of Combinatorial Chemistry, 2, 579-596. #15807

611. Valler, M.J., & Green, D. (2000) Diversity screening versus focused screening in drug discovery. Drug Disc. Today, 5, 286-293. #15471

612. van Ameijde, J., & Liskamp, R.M.J. (2000) Peptidomimetic building blocks for the synthesis of sulfonamide peptoids. Tetrahedron Lett., 41, 1103-1106. #14256

613. van Well, R.M., Overkleeft, H.S., Overhand, M., Carstenen, E.V., van der Marel, G.A., & van Boom, J.H. (2000) Parallel synthesis of cyclic sugar amino acid/amino acid hybrid molecules. Tetrahedron Lett., 41, 9331-9335. #16104

614. Vanier, C., Lorge, F., Wagner, A., & Mioskowski, C. (2000) Traceless, solid-phase synthesis of biarylmethane structures through Pd-catalyzed release of supported benzylsulfonium salts. Angew. Chem. Int. Ed., 39, 1679-1683. #14673

615. Vauthey, I., Valot, F., Gozzi, C., Fache, F., & Lemaire, M. (2000) An environmentally benign access to carbamates and ureas. Tetrahedron Lett., 41, 6347-6350. #15533

616. Vayron, P., Renard, P.Y., Valleix, A., & Mioskowski, C. (2000) Design and synthesis of an alpha,alpha-difluorophosphinate hapten for antibody-catalyzed hydrolysis of organophosphorus nerve agents. Chem. Eur. J., 6, 1050-1063. #15351

617. Verheijen, J.C., van der Marel, G.A., van Boom, J.H., & Metzler-Nolte, N. (2000) Transition metal derivatives of peptide nucleic acid (PNA) oligomers-synthesis, characterization, and DNA finding. Bioconjug. Chem., 11, 741-743. #16403

618. Verheijen, J.C., Chen, L., Bayly, S.F., Torrence, P.F., van der Marel, G.A., & van Boom, J.H. (2000) Synthesis and RNase L binding and activation of a 2-5A-(5')-DNA-(3')-PNA chimera, a novel potential antisense molecule. Nucleosides, Nucleotides and Nucleic Acids, 19, 1821-1830. #16402

619. Verheijen, J.C., Deiman, B.A.L.M., Yeheskiely, E., van der Marel, G.A., & van Boom, J.H. (2000) Efficient hydrolysis of RNA by a PNA-diethylenetriamine adduct. Angew. Chem. Int. Ed., 39, 369-372. #14181

620. Vichier-Guerre, S., Lo-Man, R., Bay, S., Deriaud, E., Nakada, H., Leclerc, C., & Cantacuzene, D. (2000) Short synthetic glycopeptides successfully induce antibody responses to carcinoma-associated Tn antigen. J. Pept. Res., 55, 173-180. #15353

621. Vivanco, S., Lecea, B., Arrieta, A., Prieto, P., Morao, I., Linden, A., & Cossio, F.P. (2000) Origins of the loss of concertedness in pericyclic reactions: Theoretical prediction and direct observation of stepwise mechanisms in [3+2] thermal cycloadditions. J. Amer. Chem. Soc., 122, 6078-6092. #15354

622. Volonterio, A., Bravo, P., Moussier, N., & Zanda, M. (2000) Solid-phase synthesis of partially-modified retro and retro-inverso y[NHCH(CF3)]-peptides. Tetrahedron Lett., 41, 6517-6521. #15537

623. Vu, C.B. (2000) Recent advances in the design and synthesis of SH2 inhibitors of Src Grb2 and ZAP-70. Curr. Med. Chem., 7, 1081-1100. #16106

624. Wade, W.S., Yang, F., & Sowin, T.J. (2000) Application of base cleavable safety catch linkers to solid phase library production. Journal of Combinatorial Chemistry, 2, 266-275. #14457

625. Wagner, T., & Pfleiderer, W. (2000) Synthesis of 2'-deoxyribonucleoside 5'-phosphoramidites: New building blocks for the inverse (5'-3')-oligonucleotide approach. Helv. Chim. Acta, 83, 2023-2035. #16107

626. Wahhab, A., & Leban, J. (2000) A solid phase procedure for the synthesis of 6-methyl-1,3-disubstituted uracils. Tetrahedron Lett., 41, 1487-1490. #14331

627. Walter, A., & Westermann, B. (2000) Facile synthesis of building blocks for C-glycosidic neoglycoconjugates. Synlett, 1682-1684. #16108

628. Wang, C.L., Wang, X.X., Wang, Y.L., Wang, X.Y., & Wang, H. (2000) A practical procedure for the solid-phase synthesis of azo compounds in the undergraduate organic laboratory. J. Chem. Educ., 77, 903-904. #15357

629. Wang, H., & Ganesan, A. (2000) Total synthesis of the fumiquinazoline alkaloids: Solid-phase studies. Journal of Combinatorial Chemistry, 2, 186-194. #14383

630. Wang, H., Wang, Y.L., Zhang, G., Li, J.P., & Wang, X.Y. (2000) An efficient solid-phase method for the preparation of diaryl carbazones. Syn. Commun., 30, 1425-1429. #14674

631. Warrass, R., Wieruszeski, J.M., Boutillon, C., & Lippens, G. (2000) High-resolution magic angle spinning NMR study of resin-bound polyalanine peptides. J. Amer. Chem. Soc., 122, 1789-1795. #14676

632. Warrass, R., & Lippens, G. (2000) Quantitative monitoring of solid phase organic reactions by high-resolution magic angle spinning NMR spectroscopy. J. Org. Chem., 65, 2946-2950. #15360

633. Warrass, R., Boutillon, C., Wieruszeski, J.M. & Lippens, G. (2000) Studying structures attached to solid supports by high resolution magic angle spinning NMR (HR MAS NMR). In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 399-401). Kluwer Academic Publisher, Dordrecht. #15734

634. Washizuka, K.I., Nagai, K., Minakata, S., Ryu, I., & Komatsu, M. (2000) Generation and cycloaddition of polymer-supported azomethine imines: Traceless synthesis of pyrazole derivatives from alpha-silylnitrosoamide derivatives bound to resin. Tetrahedron Lett., 41, 691-695. #14186

635. Watt, A.P., Morrison, D., & Evans, D.C. (2000) Approaches to higher-throughput pharmacokinetics (HTPK) in drug discovery. Drug Disc. Today, 5, 17-24. #15485

636. Waybright, S.M., Singleton, C.P., Tour, J.M., Murphy, C.J., & Bunz, U.H.F. (2000) Synthesis and self-assembly of an oligonucleotide-modified cyclobutadiene complex. Organometallics, 19, 368-370. #15361

637. Weber, L. (2000) High-diversity combinatorial libraries. Curr. Opin. Chem. Biol., 4, 295-302. #15363

638. Wellner, E., Gustafsson, T., Backlund, J., Holmdahl, R., & Kihlberg, J. (2000) Synthesis of a C-glycoside analogue of beta-D-galactosyl hydroxynorvaline and its use in immunological studies. Chembiochem, 1, 272-280. #16406

639. Wendeborn, S., De Mesmaeker, A., Brill, W.K.D., & Berteina, S. (2000) Synthesis of diverse and complex molecules on the solid phase. Account. Chem. Res., 33, 215-224. #14350

640. Wendeborn, S. (2000) Solid phase synthesis of substituted 2,3-dihydroquinolin-4-ones. Synlett, 45-48. #15366

641. Wenschuh, H., Volkmer-Engert, R., Schmidt, M., Schulz, M., Schneider-Mergener, J., & Reineke, U. (2000) Coherent membrane supports for parallel microsynthesis and screening of bioactive peptides. Biopolymers, 55, 188-206. #16407

642. Wenschuh, H., Gausepohl, H., Germeroth, L., Ulbricht, M., Matuschewski, H., Kramer, A., Volkmer-Engert, R., Heine, N., Ast, T., Scharn, D. & Schneider-Mergener, J. (2000) Positionally addresable parallel synthesis on continuous membranes. In H. Fenniri (Ed.), Combinatorial Chemistry: A Practical Approach. (pp. 95-116). Oxford University Press, Oxford. #15668

643. Wessjohann, L.A. (2000) Synthesis of natural-product-based compound libraries. Curr. Opin. Chem. Biol., 4, 303-309. #15368

644. Williams, G.M., Carr, R.A.E., Congreve, M.S., Kay, C., McKeown, S.C., Murray, P.J., Scicinski, J.J., & Watson, S.P. (2000) Analysis of solid-phase reactions: Product identification and quantification by use of UV-chromophore-containing dual-linker analytical constructs. Angew. Chem. Int. Ed., 39, 3293. #16116

645. Winter, M. & Warrass, R. (2000) Resins and anchors for solid phase organic synthesis. In H. Fenniri (Ed.), Combinatorial Chemistry: A Practical Approach. (pp. 117-138). Oxford University Press, Oxford. #15669

646. Wipf, P., Aslan, D.C., Luci, D.K., Southwick, E.C., & Lazo, J.S. (2000) Synthesis and biological evaluation of a targeted library of protein phosphatase inhibitors. Biotechnol. Bioeng., 71, 58-70. #14193

647. Wittelsberger, A., Keller, M., Scarpellino, L., Patiny, L., Acha-Orbea, H., & Mutter, M. (2000) Pseudoprolines: Targeting a cis conformation in a mimetic of the gp120 v3 loop of HIV-1. Angew. Chem. Int. Ed., 39, 1111. #15376

648. Wittmann, V., & Seeberger, S. (2000) Combinatorial solid-phase synthesis of multivalent cyclic neoglycopeptides. Angew. Chem. Int. Ed., 39, 4348. #16408

649. Wu, S., & Janusz, J.M. (2000) Solid-phase synthesis of 3-aminohydantoin, dihydrouracil, thiohydantoin and dihydrothiouracil derivatives. Tetrahedron Lett., 41, 1165-1169. #14268

650. Wu, Z., Rea, P., & Wickham, G. (2000) 'One-pot' nitro reduction-cyclization solid phase route to benzimidazoles. Tetrahedron Lett., 41, 9871-9874. #16172

651. Wyrwa, R., Friedrich, M., Adelhelm, K., Riese, U., Thiericke, R., & Grabley, S. (2000) A novel method to identify chemical compounds of combinatorial libraries by the use of paramagnetic tags [German]. Zeitschrift fur Anorganische und Allgemeine Chemie, 626, 1905-1908. #16120

652. Xiao, X.Y. & Nicolaou, K.C. (2000) High-throughput combinatorial synthesis of discrete compounds in multimiligram quantities: Non-chemical encoding and directed sorting. In H. Fenniri (Ed.), Combinatorial Chemistry: A Practical Approach. (pp. 75-94). Oxford University Press, Oxford. #15667

653. Xiao, X.Y., Li, R.S., Zhuang, H., Ewing, B., Karunaratne, K., Lillig, J., Brown, R., & Nicolaou, K.C. (2000) Solid-phase combinatorial synthesis using MicroKan reactors, Rf tagging, and directed sorting. Biotechnol. Bioeng., 71, 44-50. #14197

654. Xu, W.Z., Springfield, S.A., & Koh, J.T. (2000) Highly efficient synthesis of 1-thioglycosides in solution and solid phase using iminophosphorane bases. Carbohyd. Res., 325, 169-176. #14677

655. Yan, B. (2000) Application of single bead FTIR in the optimization of solid-phase combinatorial and parallel syntheses. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 411-413). Kluwer Academic Publisher, Dordrecht. #15735

656. Yan, B., Chu, Y.H., Shapiro, M., Richmond, R., Chin, J., Liu, L. & Yu, Z. (2000) Analytical methods in combinatorial chemistry. In H. Fenniri (Ed.), Combinatorial Chemistry: A Practical Approach. (pp. 263-286). Oxford University Press, Oxford. #15671

657. Yan, F.Y., Wakarchuk, W.W., Gilbert, M., Richards, J.C., & Whitfield, D.M. (2000) Polymer-supported and chemoenzymatic synthesis of the Neisseria meningitidis pentasaccharide: a methodological comparison. Carbohyd. Res., 328, 3-16. #16123

658. Yang, L. (2000) Facile cleavage of the carbamate linker of hydroxymethyl resin and its application in syntheses requiring strongly acidis conditions. Tetrahedron Lett., 41, 6981-6984. #15548

659. Yang, R.Y., & Kaplan, A. (2000) A concise and efficient solid-phase synthesis of 2-amino-4(3H)-quinazolinones. Tetrahedron Lett., 41, 7005-7008. #15551

660. Yang, Y.S., Mitta, G., Chavanieu, A., Calas, B., Sanchez, J.F., Roch, P., & Aumelas, A. (2000) Solution structure and activity of the synthetic four-disulfide bond Mediterranean mussel defensin (MGD-1). Biochemistry, 39, 14436-14447. #16410

661. Ye, X.S., & Wong, C.H. (2000) Anomeric reactivity-based one-pot oligosaccharide synthesis: A rapid route to oligosaccharide libraries. J. Org. Chem., 65, 2410-2431. #15382

662. Yokum, T.S., Alsina, J., & Barany, G. (2000) Solid-phase syntheses of heterocycles containing the 2-aminothiophenol moiety. Journal of Combinatorial Chemistry, 2, 282-292. #14459

663. Yokum, T.S., Alsina, J. & Barany, G. (2000) Solid-phase syntheses of libraries derived from 2-amino-4-carboxy-thiophenol moiety. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 196-197). Kluwer Academic Publisher, Dordrecht. #15728

664. Yokum, T.S. & Barany, G. (2000) Preparation and application of a thioacetal handle for solid-phase synthesis. In G.B. Fields, J.P. Tam & G. Barany (Eds.), Peptides for the New Millennium. (pp. 179-180). Kluwer Academic Publisher, Dordrecht. #15721

665. Yoo, S.E., Gong, Y.D., Choi, M.Y., Seo, J.S., & Yi, K.Y. (2000) A new vinyl ether type linker for solid-phase synthesis. Tetrahedron Lett., 41, 6415-6418. #15535

666. Yu, Z., Alesso, S., Pears, D., Worthington, P.A., Luke, R.W.A., & Bradley, M. (2000) Acetoacetoxy ethyl methacrylate (AAEM) resin, a new scavenger for primary amines in the presence of secondary amines. Tetrahedron Lett., 41, 8963-8967. #15795

667. Zaragoza, F. (2000) New sulfur- and selenium-based traceless linkers. More than just linkers? Angew. Chem. Int. Ed., 39, 2077. #15386

668. Zaragoza, F., & Stephensen, H. (2000) Direct conversion of Fmoc-protected amines into O-alkyl carbamates by the Mitsunobu reaction: A practical strategy for the solid-phase synthesis of carbamates. Tetrahedron Lett., 41, 2015-2017. #14348

669. Zaragoza, F., & Stephensen, H. (2000) Sequential nucleophilic substitution: A powerful strategy for the solid-phase production of diverse compound libraries. Angew. Chem. Int. Ed., 39, 554-556. #14329

670. Zaragoza, F., & Stephensen, H. (2000) Intermolecular N-alkylation of amines under conditions of the Mitsunobu reaction: A new solid-phase synthesis of tertiary benzylamines. Tetrahedron Lett., 41, 1841-1844. #14340

671. Zechel, C. (2000) Automation and devices for combinatorial chemistry and parallel organic synthesis. In R. Mannhold, H. Kubinyi & H. Timmerman (Eds.), Combinatorial Chemistry: A Practical Approach. (pp. 243-276). Wiley-VCH, Weinheim. #16218

672. Zhang, J.H., Chung, T.D.Y., & Oldenburg, K.R. (2000) Confirmation of primary active substances from high throughput screening of chemical and biological populations: A statistical approach and practical considerations. Journal of Combinatorial Chemistry, 2, 258-265. #14456

673. Zhou, W., Roland, A., Jin, Y., & Iyer, R.P. (2000) Combinatorial synthesis using nucleic acid-based (NABTM) scaffold: Parallel solid-phase synthesis of nucleotide libraries. Tetrahedron Lett., 41, 441-445. #13886

674. Zhou, X.T., Rehman, A.U., Li, C.H., & Savage, P.B. (2000) Preparation of a protected triamino analogue of cholic acid and sequential incorporation of amino acids in solution and on a solid support. Organic Letters, 2, 3015-3018. #16125

675. Zhu, T., & Boons, G.J. (2000) A new set of orthogonal-protecting groups for oligosaccharide synthesis on a polymeric support. Tetrahedron-Asymmetry, 11, 199-205. #15391

676. Zhu, T., & Boons, G.J. (2000) A novel and efficient synthesis of a dimeric Le(x) oligosaccharide on polymeric support. J. Amer. Chem. Soc., 122, 10222-10223. #16126

677. Zhu, X.Z., Blough, B.E., & Carroll, F.I. (2000) Synthesis and reactions of a novel chlorostannane resin: Coupling with functionalized organozinc halides. Tetrahedron Lett., 41, 9219-9222. #16128

678. Zoller, T., Ducep, J.B., Tahtaoui, C., & Hibert, M. (2000) Cyclo-release synthesis of cyclic disulfides on solid phase. Tetrahedron Lett., 41, 9989-9992. #16222

679. Zoller, T., Ducep, J.B., & Hibert, M. (2000) Efficient synthesis of benzylic bromides under neutral conditions on solid support. Tetrahedron Lett., 41, 9985-9988. #16221