Solution-phase combinatorial chemistry

Diane M. Coe
Glaxo Wellcome Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K.

Richard Storer
BioChem Therapeutic Inc., 275 Boulevard Armand-Frappier, Laval, PQ, Canada H7V 4A7

Abstract
The use of solution phase techniques has been explored as an alternative to solid-phase chemistry approaches for the preparation of arrays of compounds in the drug discovery process. Solution-phase work is free from some of the constraints of solid-phase approaches but has disadvantages with respect to purification. This article will also illustrate some of the advances made in recent years in solution phase array chemistry including using supported reagents and simple extractive protocols for the effective preparation of high quality samples.

Keywords
library, polymer-supported reagents, solution phase