[5Z.COM HOME]
[MOLECULAR DIVERSITY] [KLUWER PUBLICATIONS] [DIVERSITY INFORMATION PAGES]

[Aims & Scope] [Editors & Editorial Board] [Indexing & Abstracting] [Instructions for Authors]
[Kluwer Stylefiles] [Contact the Editor] [Subscription Info]

Volume 4, Issue 4, 1998, pp. 215-219

Application of an almost traceless linker in the synthesis of 2-alkylthiobenzimidazole combinatorial libraries

Rachel M. Slade, Margo A. Phillips, Joel G. Berger

Abstract
Resin-bound triphenylphosphine was coupled to 4-fluoro-3-nitrobenzyl bromide, and 2-alkylthiobenzimidazoles were synthesized on resin in 4 steps using standard chemistries. Cleavage of the compounds from the resin was achieved with 10% NaOH in MeOH to leave a methyl group at the attachment point. A total of 47 amines and 40 electrophiles were evaluated, defining the scope of the reactions, culminating in the synthesis of an 80-member test library of high purity as determined by HPLC.

Keywords
alkylthiobenzimidazole, combinatorial chemistry, phosphonium resin, solid phase synthesis, traceless linker

Full Article in PDF format