Carbohydrate-based combinatorial libraries

Michael J. Sofia
Transcell Technologies Inc., 8 Cedar Brook Drive, Cranbury, NJ 08512, U.S.A.

Abstract
Carbohydrate-based combinatorial libraries are tremendously valuable for studying the role of sugars in biology and for expanding accessible molecular diversity needed in broad-based drug screening programs. This review discusses the issues that are relevant to the successful implementation of comprehensive carbohydrate-based combinatorial library programs. In addition, details of oligosaccharide and glycoconjugate libraries constructed using both solid phase and solution phase strategies are presented.

Keywords
carbohydrates, combinatorial, glycoconjugates, libraries, solid phase, solution phase