Multiple solid-phase synthesis of hydantoins and thiohydantoins

Gurdip Bhalay, Daniel Cowell, Neal D. Hone, Martin Scobie, Anthony D. Baxter
Oxford Diversity, A Division of Oxford Asymmetry Ltd., 57 Milton Park, Abingdon, Oxon OX14 4RX, U.K.

Abstract
A novel general protocol for the construction of hydantoins and thiohydantoins on a solid support has been developed. Using this novel methodology, the synthesis of a diverse 96-compound library has been achieved. Resin-bound dipeptides are cyclised via the formation of an intermediate isocyanate or isothiocyanate on resin as the key step in the strategy.

Keywords
hydantoin, isocyanate, isothiocyanate, thiohydantoin