Ring opening cross-metathesis on solid support: a combinatorial library synthesis of highly functionalized cyclopentanes

Jingrong Cao, Gregory D. Cuny, James R. Hauske
Sepracor Inc., 111 Locke Dr., Marlborough, MA 01752-7231, U.S.A.

Abstract
Ruthenium catalyzed ring opening cross-metathesis of resin-bound bicyclic alkenes with terminal aryl olefins was utilized for the construction of a combinatorial library containing highly functionalized cyclopentane derivatives. The technology described herein represents a convergent method for the diastereospecific synthesis of unique cyclopentane molecular scaffolds useful for exploratory medicinal chemistry.

Keywords
cyclopentanes, ring opening cross-methathesis, ruthenium, solid support