Solid phase synthesis of benzamidine-derived sulfonamide libraries

Sang Woong Kim, Chang Yong Hong, Jong Sung Koh, Koo Lee
Biotech Research Institute, LG Chemical Ltd./Research Park, Science Town, Taejon 305-380, Korea

Eun Ju Lee
Korea Advanced Institute of Science and Technology, Science Town, Taejon 306-701, Korea

Abstract
Using solid phase synthesis, a library has been constructed of benzamidine-derived sulfonamides which have strong inhibitory activity against blood coagulant thrombin. The library compounds were obtained in good yield and high purity.

Keywords
benzamidine-containing sulfonamide, solid phase synthesis, thrombin